Entecavir (monohydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.108999
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0975355
EIF1 eukaryotic translation initiation factor 1 0.0900596
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0840955
TXNRD1 thioredoxin reductase 1 0.0800219
RPL23 ribosomal protein L23 0.0793946
BACE2 beta-site APP-cleaving enzyme 2 0.0788292
IGFBP3 insulin-like growth factor binding protein 3 0.0781076
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0716671
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.070398
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0697157
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0690114
LMO7 LIM domain 7 0.0676543
PTMA prothymosin, alpha 0.0665564
B2M beta-2-microglobulin 0.0644907
NDRG1 N-myc downstream regulated 1 0.0606837
KMT2E lysine (K)-specific methyltransferase 2E 0.06051
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0602417
MTUS1 microtubule associated tumor suppressor 1 0.0593346
FMN1 formin 1 0.0566583
RPL11 ribosomal protein L11 0.0565104
BTG1 B-cell translocation gene 1, anti-proliferative 0.0563755
SLC38A1 solute carrier family 38, member 1 0.0544597
KMT2C lysine (K)-specific methyltransferase 2C 0.0537663
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0523039
TPT1 tumor protein, translationally-controlled 1 0.0507543
RPS19 ribosomal protein S19 0.0505581
CXCL8 chemokine (C-X-C motif) ligand 8 0.0482219
MYOF myoferlin 0.0478958
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0468677
UBE2K ubiquitin-conjugating enzyme E2K 0.0466747
SLK STE20-like kinase 0.0465119
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0451487
ATP11A ATPase, class VI, type 11A 0.0450117
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0448992
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0446841
EPS8 epidermal growth factor receptor pathway substrate 8 0.0446163
IFIH1 interferon induced with helicase C domain 1 0.0430385
FOXO3 forkhead box O3 0.0423812
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0421809
RPS25 ribosomal protein S25 0.0411797
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0411059
DSG2 desmoglein 2 0.040893
MT2A metallothionein 2A 0.0404202
ZFP36 ZFP36 ring finger protein 0.0397886
RPS6 ribosomal protein S6 0.039739
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0394928
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0388325
HLA-A major histocompatibility complex, class I, A 0.0382786
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0380451
TOP1 topoisomerase (DNA) I 0.0373305
PNISR PNN-interacting serine/arginine-rich protein 0.0372557
ZMYND8 zinc finger, MYND-type containing 8 0.0371729
ESYT2 extended synaptotagmin-like protein 2 0.0368972
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0364331
RPL37A ribosomal protein L37a 0.0363733
PIAS1 protein inhibitor of activated STAT, 1 0.0352348
USP34 ubiquitin specific peptidase 34 0.0347307
CALR calreticulin 0.0347053
FOXP1 forkhead box P1 0.0342075
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0340949
POTEF POTE ankyrin domain family, member F 0.0340868
PTGR1 prostaglandin reductase 1 0.033884
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0338799
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0338382
H3-3B H3.3 histone B 0.033407
ZNF644 zinc finger protein 644 0.0333767
RAD23B RAD23 homolog B (S. cerevisiae) 0.0333597
RPL9 ribosomal protein L9 0.0327843
BTBD9 BTB (POZ) domain containing 9 0.0327135
LCOR ligand dependent nuclear receptor corepressor 0.032574
KRT17 keratin 17, type I 0.0323765
SON SON DNA binding protein 0.0323331
NAP1L1 nucleosome assembly protein 1-like 1 0.0322372
MCTP2 multiple C2 domains, transmembrane 2 0.0320638
TMEM165 transmembrane protein 165 0.031988
AGO2 argonaute RISC catalytic component 2 0.0315877
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0309297
RPS16 ribosomal protein S16 0.0308335
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0308152
SNX9 sorting nexin 9 0.0307933
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0307842
MTMR3 myotubularin related protein 3 0.0306931
LGALS3 lectin, galactoside-binding, soluble, 3 0.0306412
GPHN gephyrin 0.0306391
YAP1 Yes-associated protein 1 0.0305963
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0305258
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0304506
RHEB Ras homolog enriched in brain 0.0303478
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0298354
AKAP13 A kinase (PRKA) anchor protein 13 0.0295918
ENO1 enolase 1, (alpha) 0.0295834
ATOSA atos homolog A 0.0292454
CSTB cystatin B (stefin B) 0.0286456
FNBP1L formin binding protein 1-like 0.0285373
RIOK3 RIO kinase 3 0.0284634
S100A6 S100 calcium binding protein A6 0.0283059
ZNF638 zinc finger protein 638 0.0280747
MARCHF7 membrane associated ring-CH-type finger 7 0.0280209
GCLC glutamate-cysteine ligase, catalytic subunit 0.0280131

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.131757
SAMD4A sterile alpha motif domain containing 4A -0.130657
CEMIP cell migration inducing protein, hyaluronan binding -0.10507
MYO1E myosin IE -0.0920463
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0884543
ADGRB3 adhesion G protein-coupled receptor B3 -0.0861145
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0821138
MAML2 mastermind-like 2 (Drosophila) -0.079069
RORA RAR-related orphan receptor A -0.0724362
INTS6 integrator complex subunit 6 -0.0721946
COL6A3 collagen, type VI, alpha 3 -0.0714074
MMP1 matrix metallopeptidase 1 -0.0689566
NALF1 NALCN channel auxiliary factor 1 -0.0679766
GLS2 glutaminase 2 (liver, mitochondrial) -0.067917
ASPH aspartate beta-hydroxylase -0.0657611
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0640528
FNDC3B fibronectin type III domain containing 3B -0.0636664
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0598216
ABI3BP ABI family, member 3 (NESH) binding protein -0.0596648
ZSWIM6 zinc finger, SWIM-type containing 6 -0.059407
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.057196
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.056966
RBM47 RNA binding motif protein 47 -0.0565267
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.05539
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0550879
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0545376
FN1 fibronectin 1 -0.054437
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0541753
LAMC2 laminin, gamma 2 -0.0527821
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0515626
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0511005
NABP1 nucleic acid binding protein 1 -0.0506898
MCL1 myeloid cell leukemia 1 -0.0505517
WARS1 tryptophanyl-tRNA synthetase 1 -0.0502439
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0501518
AKAP12 A kinase (PRKA) anchor protein 12 -0.049892
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0498513
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0484193
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0470196
GRAMD1B GRAM domain containing 1B -0.0466698
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0466264
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0462705
TRPS1 trichorhinophalangeal syndrome I -0.0462046
MBNL1 muscleblind-like splicing regulator 1 -0.0458399
EXT1 exostosin glycosyltransferase 1 -0.0457292
HOMER1 homer scaffolding protein 1 -0.045599
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0454779
SEPTIN10 septin 10 -0.0452621
EMP1 epithelial membrane protein 1 -0.0451703
METTL15 methyltransferase like 15 -0.0446768
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0431828
FRMD5 FERM domain containing 5 -0.0429435
ELL2 elongation factor, RNA polymerase II, 2 -0.0428567
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.042817
MAML3 mastermind-like 3 (Drosophila) -0.0427321
C1D C1D nuclear receptor corepressor -0.0426128
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0421978
TAS2R14 taste receptor, type 2, member 14 -0.0419604
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0416697
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0399749
SACK1A scaffolding CK1 anchoring protein A -0.039957
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0396463
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0396264
TRIO trio Rho guanine nucleotide exchange factor -0.0393029
SHB Src homology 2 domain containing adaptor protein B -0.0381803
ATG7 autophagy related 7 -0.0380868
SDC4 syndecan 4 -0.0380235
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0363925
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0362888
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0360262
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0353104
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0342314
WSB1 WD repeat and SOCS box containing 1 -0.0341429
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0339973
KDM4C lysine (K)-specific demethylase 4C -0.0339737
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0336657
HPCAL1 hippocalcin-like 1 -0.033475
ZFAND3 zinc finger, AN1-type domain 3 -0.0330516
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.032672
MXD1 MAX dimerization protein 1 -0.032662
PAIP2 poly(A) binding protein interacting protein 2 -0.0321672
ARB2A ARB2 cotranscriptional regulator A -0.0317693
MYO10 myosin X -0.0317459
MBD5 methyl-CpG binding domain protein 5 -0.0316934
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0313944
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0313184
SOD2 superoxide dismutase 2, mitochondrial -0.0311332
SEC24A SEC24 family member A -0.0311219
ARHGAP12 Rho GTPase activating protein 12 -0.0310386
RUNX1 runt-related transcription factor 1 -0.0310159
FER fer (fps/fes related) tyrosine kinase -0.0307161
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0307142
HDLBP high density lipoprotein binding protein -0.0305472
STAU1 staufen double-stranded RNA binding protein 1 -0.0302834
OSMR oncostatin M receptor -0.0302735
ANKRD28 ankyrin repeat domain 28 -0.0298729
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029629
PARD3 par-3 family cell polarity regulator -0.0296255
CDH13 cadherin 13 -0.0296245
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0292913