Entecavir (monohydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.188942
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.104819
SYNE2 spectrin repeat containing, nuclear envelope 2 0.103395
GRAMD1B GRAM domain containing 1B 0.0978539
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0905973
RAD51B RAD51 paralog B 0.0845586
AKAP12 A kinase (PRKA) anchor protein 12 0.0819226
ERRFI1 ERBB receptor feedback inhibitor 1 0.0785188
RTN4 reticulon 4 0.0771313
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0768669
PCBP2 poly(rC) binding protein 2 0.0683739
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0586961
CCNL1 cyclin L1 0.0574065
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0521925
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0501071
RUSC2 RUN and SH3 domain containing 2 0.0487697
YBX3 Y box binding protein 3 0.0485094
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0470394
TBK1 TANK-binding kinase 1 0.0448014
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0445823
KDM2A lysine (K)-specific demethylase 2A 0.0444329
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0426782
EXOC6B exocyst complex component 6B 0.0424003
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0419372
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0413548
EEF2 eukaryotic translation elongation factor 2 0.041277
PHIP pleckstrin homology domain interacting protein 0.0412654
JMJD1C jumonji domain containing 1C 0.0408106
NIPBL Nipped-B homolog (Drosophila) 0.0404032
EGR1 early growth response 1 0.0390829
ADAM17 ADAM metallopeptidase domain 17 0.0387134
XPO1 exportin 1 0.0386215
CTTNBP2NL CTTNBP2 N-terminal like 0.0385128
LATS2 large tumor suppressor kinase 2 0.0384881
ELL2 elongation factor, RNA polymerase II, 2 0.0383416
MSH6 mutS homolog 6 0.0381436
RNF38 ring finger protein 38 0.0379876
CSNK1A1 casein kinase 1, alpha 1 0.0372167
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0369863
EIF4B eukaryotic translation initiation factor 4B 0.0367928
ANXA5 annexin A5 0.0363942
POTEF POTE ankyrin domain family, member F 0.036163
ADAR adenosine deaminase, RNA-specific 0.0360536
DIAPH3 diaphanous-related formin 3 0.0358837
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0358354
YAP1 Yes-associated protein 1 0.0356886
ZFAND3 zinc finger, AN1-type domain 3 0.0353006
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0349553
VMP1 vacuole membrane protein 1 0.0345937
TPM3 tropomyosin 3 0.0338506
ANKRD36 ankyrin repeat domain 36 0.0337759
MELK maternal embryonic leucine zipper kinase 0.033373
PCNX1 pecanex 1 0.0326458
MARCHF4 membrane associated ring-CH-type finger 4 0.0323964
GATAD2B GATA zinc finger domain containing 2B 0.0320894
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.031886
KTN1 kinectin 1 (kinesin receptor) 0.0316839
WDR26 WD repeat domain 26 0.0314718
PDE4D phosphodiesterase 4D, cAMP-specific 0.0314182
SFPQ splicing factor proline/glutamine-rich 0.0311899
MKI67 marker of proliferation Ki-67 0.0311799
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0311143
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0310353
GPHN gephyrin 0.0309394
HIPK3 homeodomain interacting protein kinase 3 0.0306953
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0306103
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0305166
NUP153 nucleoporin 153kDa 0.0304312
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.030253
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0302015
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0298917
NCAPG2 non-SMC condensin II complex, subunit G2 0.0298787
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0298591
KLF7 Kruppel-like factor 7 (ubiquitous) 0.029725
ZNF292 zinc finger protein 292 0.029508
AVL9 AVL9 homolog (S. cerevisiase) 0.0294929
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0292445
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0291277
RASAL2 RAS protein activator like 2 0.0286833
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0286824
TMEM165 transmembrane protein 165 0.0285521
IL6ST interleukin 6 signal transducer 0.0282226
TPI1 triosephosphate isomerase 1 0.028196
TFPI2 tissue factor pathway inhibitor 2 0.0281503
MSN moesin 0.0280101
ANKRD17 ankyrin repeat domain 17 0.0279636
TMEM41B transmembrane protein 41B 0.0279235
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0279053
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0278867
EML4 echinoderm microtubule associated protein like 4 0.0278762
CEP192 centrosomal protein 192kDa 0.027814
WNK1 WNK lysine deficient protein kinase 1 0.0275456
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0275389
KDM7A lysine (K)-specific demethylase 7A 0.0275139
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0274977
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0274432
KMT2C lysine (K)-specific methyltransferase 2C 0.027254
COG5 component of oligomeric golgi complex 5 0.0270368
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0269585
RNF145 ring finger protein 145 0.026909

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.179193
PTMA prothymosin, alpha -0.124722
TMSB10 thymosin beta 10 -0.105062
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0867936
TPT1 tumor protein, translationally-controlled 1 -0.0737725
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0714327
RPS8 ribosomal protein S8 -0.0631712
VIM vimentin -0.0615152
HMGA2 high mobility group AT-hook 2 -0.0600582
ACTG1 actin gamma 1 -0.0595812
THSD4 thrombospondin, type I, domain containing 4 -0.0564574
RPL37 ribosomal protein L37 -0.0560338
RPL35A ribosomal protein L35a -0.0484859
RPS27A ribosomal protein S27a -0.0457094
GNAS GNAS complex locus -0.0446759
RPS19 ribosomal protein S19 -0.0437463
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0436346
RPS21 ribosomal protein S21 -0.0434476
CANX calnexin -0.0428475
RPS29 ribosomal protein S29 -0.0425559
RPS3 ribosomal protein S3 -0.0413941
PRH1 proline-rich protein HaeIII subfamily 1 -0.0407375
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0405744
AEBP2 AE binding protein 2 -0.0404061
RPL12 ribosomal protein L12 -0.0397271
WNT2B wingless-type MMTV integration site family, member 2B -0.0391884
RPL26 ribosomal protein L26 -0.038551
RYR3 ryanodine receptor 3 -0.0381716
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0375083
RPLP1 ribosomal protein, large, P1 -0.0370232
PDIA4 protein disulfide isomerase family A, member 4 -0.0356104
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0346886
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0328001
FTL ferritin, light polypeptide -0.0327439
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0324947
RPL38 ribosomal protein L38 -0.0323964
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0319407
INTS6 integrator complex subunit 6 -0.0310568
RPS15 ribosomal protein S15 -0.0308054
AFF3 AF4/FMR2 family, member 3 -0.0306544
RPL34 ribosomal protein L34 -0.0303018
RPL31 ribosomal protein L31 -0.0301839
RPL19 ribosomal protein L19 -0.0285973
MT2A metallothionein 2A -0.0285772
NAP1L1 nucleosome assembly protein 1-like 1 -0.0282538
ATXN1 ataxin 1 -0.028003
RPL37A ribosomal protein L37a -0.0279878
RPL5 ribosomal protein L5 -0.0278897
RPL23 ribosomal protein L23 -0.0278351
RPL32 ribosomal protein L32 -0.027657
RPLP2 ribosomal protein, large, P2 -0.0276515
TAS2R14 taste receptor, type 2, member 14 -0.0274783
RIMS2 regulating synaptic membrane exocytosis 2 -0.0271834
S100A10 S100 calcium binding protein A10 -0.0269576
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0261063
RPS25 ribosomal protein S25 -0.0256081
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0256057
RPL36 ribosomal protein L36 -0.025248
MYL12B myosin, light chain 12B, regulatory -0.0250502
AHNAK AHNAK nucleoprotein -0.0248463
RPL11 ribosomal protein L11 -0.024716
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0245302
NTSR1 neurotensin receptor 1 (high affinity) -0.0243791
WWTR1 WW domain containing transcription regulator 1 -0.0243494
CCND1 cyclin D1 -0.0242568
PDE10A phosphodiesterase 10A -0.0242149
RPS24 ribosomal protein S24 -0.0239277
HLA-B major histocompatibility complex, class I, B -0.0238522
FNDC3B fibronectin type III domain containing 3B -0.0238196
KDM4B lysine (K)-specific demethylase 4B -0.0237204
NEK10 NIMA-related kinase 10 -0.0234932
OSMR oncostatin M receptor -0.023155
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0231478
IER3 immediate early response 3 -0.0225188
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0222974
IGF1R insulin-like growth factor 1 receptor -0.0220649
RPS27 ribosomal protein S27 -0.0220121
FUS FUS RNA binding protein -0.0218074
NCOA7 nuclear receptor coactivator 7 -0.0212301
FMNL2 formin-like 2 -0.021172
RAD21 RAD21 homolog (S. pombe) -0.0211259
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.020962
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0209562
RPS6 ribosomal protein S6 -0.0209196
RYK receptor-like tyrosine kinase -0.0206698
RPL8 ribosomal protein L8 -0.0201986
RPS20 ribosomal protein S20 -0.0200733
PDLIM5 PDZ and LIM domain 5 -0.019896
H1-0 H1.0 linker histone -0.0198206
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0197901
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0196327
TBC1D22A TBC1 domain family, member 22A -0.0194461
CAVIN1 caveolae associated protein 1 -0.0193612
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.019097
CFAP44 cilia and flagella associated protein 44 -0.0187256
TRIM59 tripartite motif containing 59 -0.0186713
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0186466
CALR calreticulin -0.018415
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0183478