Entecavir (monohydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.151847
FNDC3B fibronectin type III domain containing 3B 0.142428
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.136511
LPP LIM domain containing preferred translocation partner in lipoma 0.12136
NAMPT nicotinamide phosphoribosyltransferase 0.0951056
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0886792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.084375
TSC22D2 TSC22 domain family, member 2 0.0809794
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0808202
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0766589
NDRG1 N-myc downstream regulated 1 0.0763049
GRB10 growth factor receptor-bound protein 10 0.0761955
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0746735
TRIO trio Rho guanine nucleotide exchange factor 0.072779
MYO6 myosin VI 0.071378
FAM13A family with sequence similarity 13, member A 0.0705924
LIMCH1 LIM and calponin homology domains 1 0.0704432
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0694615
AHNAK AHNAK nucleoprotein 0.0684991
CANX calnexin 0.0684103
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0678308
ASPH aspartate beta-hydroxylase 0.0678242
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0673447
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0672175
WSB1 WD repeat and SOCS box containing 1 0.0644012
SQSTM1 sequestosome 1 0.0643866
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0617199
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0604554
TOP1 topoisomerase (DNA) I 0.0572976
NPEPPS aminopeptidase puromycin sensitive 0.0566068
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0563129
PTMA prothymosin, alpha 0.0560074
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0549884
DSPP dentin sialophosphoprotein 0.0538347
FBXO32 F-box protein 32 0.053019
LDHA lactate dehydrogenase A 0.051509
ZFP36L1 ZFP36 ring finger protein-like 1 0.0514508
PTK2 protein tyrosine kinase 2 0.0511789
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0495712
PGK1 phosphoglycerate kinase 1 0.0479988
ENO1 enolase 1, (alpha) 0.0473005
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0469936
SAMD4A sterile alpha motif domain containing 4A 0.0466893
FHIT fragile histidine triad 0.046124
IQGAP1 IQ motif containing GTPase activating protein 1 0.0446036
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0443293
APLP2 amyloid beta (A4) precursor-like protein 2 0.0440895
EZR ezrin 0.0438095
TMSB4X thymosin beta 4, X-linked 0.0432967
RNF213 ring finger protein 213 0.042786
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0424376
BZW1 basic leucine zipper and W2 domains 1 0.0421759
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0413423
TXNRD1 thioredoxin reductase 1 0.041112
NAV2 neuron navigator 2 0.0407244
PARD3 par-3 family cell polarity regulator 0.040459
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0402889
RAI14 retinoic acid induced 14 0.0397595
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394164
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0393513
FN1 fibronectin 1 0.0392169
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0392159
ELL2 elongation factor, RNA polymerase II, 2 0.039115
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0389355
IFI16 interferon, gamma-inducible protein 16 0.038514
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0384188
EFNA5 ephrin-A5 0.0379281
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0376845
MYH9 myosin, heavy chain 9, non-muscle 0.0369198
RAB1A RAB1A, member RAS oncogene family 0.0363248
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0359394
PUM1 pumilio RNA-binding family member 1 0.0355958
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.035225
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0347754
MACF1 microtubule-actin crosslinking factor 1 0.0343773
AKAP13 A kinase (PRKA) anchor protein 13 0.0335279
ITCH itchy E3 ubiquitin protein ligase 0.0329457
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0329228
KMT2C lysine (K)-specific methyltransferase 2C 0.0328715
TMEM123 transmembrane protein 123 0.0327373
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0327074
RCOR1 REST corepressor 1 0.0326422
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0322931
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0320624
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0320212
CALR calreticulin 0.0319913
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0318954
CD46 CD46 molecule, complement regulatory protein 0.0316121
FXR1 fragile X mental retardation, autosomal homolog 1 0.0315033
CCND1 cyclin D1 0.0314677
MX1 MX dynamin-like GTPase 1 0.0310755
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0309573
RBM39 RNA binding motif protein 39 0.0309367
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0300363
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.02984
MYOF myoferlin 0.0297387
SSBP2 single-stranded DNA binding protein 2 0.0296022
RAD21 RAD21 homolog (S. pombe) 0.0294883
RHOA ras homolog family member A 0.0294647
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0290774

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.169078
TMSB10 thymosin beta 10 -0.0928118
MT2A metallothionein 2A -0.0792834
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0736936
POTEF POTE ankyrin domain family, member F -0.0683391
HMGA1 high mobility group AT-hook 1 -0.0633758
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0453279
RPS19 ribosomal protein S19 -0.0346945
EGR1 early growth response 1 -0.031333
IFITM3 interferon induced transmembrane protein 3 -0.0305931
RPL35A ribosomal protein L35a -0.0300732
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0262574
EIF1 eukaryotic translation initiation factor 1 -0.0246277
CLDN4 claudin 4 -0.0240893
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0229761
RPL32 ribosomal protein L32 -0.022539
G0S2 G0/G1 switch 2 -0.0204786
LOC112694756 uncharaterized LOC112694756 -0.0197442
ACTG1 actin gamma 1 -0.0197317
RPLP1 ribosomal protein, large, P1 -0.0189504
RPL11 ribosomal protein L11 -0.0185715
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.01788
RPS29 ribosomal protein S29 -0.0168904
TUBB4B tubulin, beta 4B class IVb -0.0166029
RPL36 ribosomal protein L36 -0.0164491
RPS23 ribosomal protein S23 -0.0156403
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0155933
MYL12B myosin, light chain 12B, regulatory -0.0155324
RPS13 ribosomal protein S13 -0.015498
RPL31 ribosomal protein L31 -0.0153289
LAMB3 laminin, beta 3 -0.0151342
CSTB cystatin B (stefin B) -0.0149082
ALCAM activated leukocyte cell adhesion molecule -0.0147121
RPS10 ribosomal protein S10 -0.0141459
IFITM1 interferon induced transmembrane protein 1 -0.0140367
USP15 ubiquitin specific peptidase 15 -0.0136871
RPL5 ribosomal protein L5 -0.013675
GPX4 glutathione peroxidase 4 -0.0135844
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0132287
HLA-B major histocompatibility complex, class I, B -0.0132136
OXSR1 oxidative stress responsive 1 -0.0129608
HDAC9 histone deacetylase 9 -0.0128557
RPS8 ribosomal protein S8 -0.0125402
RPS3 ribosomal protein S3 -0.0125287
EPS8 epidermal growth factor receptor pathway substrate 8 -0.012307
ISG15 ISG15 ubiquitin-like modifier -0.0122171
PFN1 profilin 1 -0.0121857
NIPBL Nipped-B homolog (Drosophila) -0.0121684
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -0.0121601
RPS27 ribosomal protein S27 -0.0120091
OAZ1 ornithine decarboxylase antizyme 1 -0.0118192
VGLL3 vestigial-like family member 3 -0.0117718
PTTG1 pituitary tumor-transforming 1 -0.0115444
WWC1 WW and C2 domain containing 1 -0.0114782
ATP5F1E ATP synthase F1 subunit epsilon -0.011409
RPL13A ribosomal protein L13a -0.0113649
SH3RF2 SH3 domain containing ring finger 2 -0.0112376
RPL27 ribosomal protein L27 -0.0110736
S100A11 S100 calcium binding protein A11 -0.0110245
FOXO3 forkhead box O3 -0.0108551
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0107095
MT1X metallothionein 1X -0.0106878
RPL35 ribosomal protein L35 -0.0106063
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0105659
RPL36AL ribosomal protein L36a-like -0.0102488
COX17 COX17 cytochrome c oxidase copper chaperone -0.0102076
RNF145 ring finger protein 145 -0.00998956
RPL19 ribosomal protein L19 -0.00996842
COX7C cytochrome c oxidase subunit VIIc -0.00983739
RACK1 receptor for activated C kinase 1 -0.00980826
SLC38A1 solute carrier family 38, member 1 -0.00976696
GUK1 guanylate kinase 1 -0.00948094
RPL10A ribosomal protein L10a -0.00945194
GSTP1 glutathione S-transferase pi 1 -0.00941421
BCAR3 breast cancer anti-estrogen resistance 3 -0.0093357
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.00931522
RPS5 ribosomal protein S5 -0.0092312
RPL34 ribosomal protein L34 -0.00920406
MAST4 microtubule associated serine/threonine kinase family member 4 -0.00908546
S100A9 S100 calcium binding protein A9 -0.00902613
UBL5 ubiquitin-like 5 -0.00876921
FAM135A family with sequence similarity 135, member A -0.00875586
RPS14 ribosomal protein S14 -0.00870319
KAT6A K(lysine) acetyltransferase 6A -0.00870105
SEM1 SEM1 26S proteasome subunit -0.00869168
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.00868857
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00865868
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta -0.00856208
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00855423
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.00855183
RPL37 ribosomal protein L37 -0.00855106
ANKRD10 ankyrin repeat domain 10 -0.008527
ZFC3H1 zinc finger, C3H1-type containing -0.00845672
RPLP2 ribosomal protein, large, P2 -0.00845092
RPL38 ribosomal protein L38 -0.00842277
UBE2C ubiquitin-conjugating enzyme E2C -0.00841314
FLNA filamin A, alpha -0.00839883
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00822678
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.00817829
ANKRD37 ankyrin repeat domain 37 -0.00814594