Entecavir (monohydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.0897755
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0824568
NAMPT nicotinamide phosphoribosyltransferase 0.0818284
ASPH aspartate beta-hydroxylase 0.0626891
ELL2 elongation factor, RNA polymerase II, 2 0.0616897
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0607763
TRIO trio Rho guanine nucleotide exchange factor 0.0585129
FNDC3B fibronectin type III domain containing 3B 0.0567752
NEK7 NIMA-related kinase 7 0.054074
TXNRD1 thioredoxin reductase 1 0.0508729
AGFG1 ArfGAP with FG repeats 1 0.0447224
CXCL8 chemokine (C-X-C motif) ligand 8 0.0424197
SPAG9 sperm associated antigen 9 0.0410409
RBM39 RNA binding motif protein 39 0.0376266
PDLIM5 PDZ and LIM domain 5 0.0372314
KYNU kynureninase 0.0361707
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0360576
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0359263
ERRFI1 ERBB receptor feedback inhibitor 1 0.0329366
DOCK4 dedicator of cytokinesis 4 0.0322368
ESYT2 extended synaptotagmin-like protein 2 0.0306241
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0304595
GRAMD1B GRAM domain containing 1B 0.0302074
RTN4 reticulon 4 0.0301023
KDM6A lysine (K)-specific demethylase 6A 0.0295701
EZR ezrin 0.0294258
SOD2 superoxide dismutase 2, mitochondrial 0.0287149
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0286087
USP9X ubiquitin specific peptidase 9, X-linked 0.0281332
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0280375
TGFBR1 transforming growth factor, beta receptor 1 0.0275777
PDE4D phosphodiesterase 4D, cAMP-specific 0.0259723
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0258633
NBAS neuroblastoma amplified sequence 0.0258286
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0257941
MYOF myoferlin 0.0252384
CDC73 cell division cycle 73 0.0250827
BIRC6 baculoviral IAP repeat containing 6 0.0250059
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0247232
NT5C2 5'-nucleotidase, cytosolic II 0.0243363
FLNB filamin B, beta 0.0242265
ANXA5 annexin A5 0.0240832
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.024083
WDR43 WD repeat domain 43 0.0237488
ATP13A3 ATPase type 13A3 0.0234546
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.023312
HELZ helicase with zinc finger 0.023232
OGA O-GlcNAcase 0.0231634
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0230634
KMT2C lysine (K)-specific methyltransferase 2C 0.0229585
NUP58 nucleoporin 58 0.0228943
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0227144
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0225151
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0224874
CD109 CD109 molecule 0.0222942
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0221832
COL8A1 collagen, type VIII, alpha 1 0.0218782
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0218655
COL4A6 collagen, type IV, alpha 6 0.0216079
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0215506
COL4A5 collagen, type IV, alpha 5 0.0214694
PDE10A phosphodiesterase 10A 0.0210032
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0209063
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0208549
TNPO1 transportin 1 0.0204919
TSC22D2 TSC22 domain family, member 2 0.0204876
PRELID2 PRELI domain containing 2 0.0202253
TRA2A transformer 2 alpha homolog (Drosophila) 0.0201432
GDA guanine deaminase 0.0198956
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0198312
RICTOR RPTOR independent companion of MTOR, complex 2 0.0195538
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0193902
MARCHF6 membrane associated ring-CH-type finger 6 0.0193666
USP3 ubiquitin specific peptidase 3 0.0193043
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0192719
AKAP13 A kinase (PRKA) anchor protein 13 0.0192699
PUM2 pumilio RNA-binding family member 2 0.0190427
PTK2 protein tyrosine kinase 2 0.0189066
ZSWIM6 zinc finger, SWIM-type containing 6 0.0187939
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0187319
BRWD3 bromodomain and WD repeat domain containing 3 0.018677
SAMD4A sterile alpha motif domain containing 4A 0.0185175
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0182656
RUNX1 runt-related transcription factor 1 0.0181839
WAC WW domain containing adaptor with coiled-coil 0.018134
UBA6 ubiquitin-like modifier activating enzyme 6 0.0180832
PM20D1 peptidase M20 domain containing 1 0.0179233
BZW1 basic leucine zipper and W2 domains 1 0.0178774
FAM13A family with sequence similarity 13, member A 0.0177354
USP34 ubiquitin specific peptidase 34 0.0177331
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0177327
ZEB2 zinc finger E-box binding homeobox 2 0.0175468
NRCAM neuronal cell adhesion molecule 0.017523
MED13 mediator complex subunit 13 0.0175148
CUL3 cullin 3 0.0173008
CSNK1A1 casein kinase 1, alpha 1 0.0172116
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0172018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0170052
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0168592
COG5 component of oligomeric golgi complex 5 0.0168162

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226883
TMSB10 thymosin beta 10 -0.168215
VIM vimentin -0.144868
FTL ferritin, light polypeptide -0.108878
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103076
RPS6 ribosomal protein S6 -0.100036
PTMA prothymosin, alpha -0.0918953
RPLP1 ribosomal protein, large, P1 -0.0753788
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0741234
RPL35A ribosomal protein L35a -0.0696015
TPT1 tumor protein, translationally-controlled 1 -0.0681046
MT2A metallothionein 2A -0.0675119
RPS8 ribosomal protein S8 -0.0673358
RPS19 ribosomal protein S19 -0.0646461
RPL31 ribosomal protein L31 -0.0632654
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0632519
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0610028
RPL19 ribosomal protein L19 -0.0584222
RPL12 ribosomal protein L12 -0.0576515
FN1 fibronectin 1 -0.0565512
S100A6 S100 calcium binding protein A6 -0.0561817
IGFBP3 insulin-like growth factor binding protein 3 -0.0537628
RPS23 ribosomal protein S23 -0.0531101
RPL37A ribosomal protein L37a -0.0516897
B2M beta-2-microglobulin -0.0491952
RPS3 ribosomal protein S3 -0.0440888
RPL26 ribosomal protein L26 -0.0437155
RPLP2 ribosomal protein, large, P2 -0.042946
RPL7A ribosomal protein L7a -0.0427923
RPS29 ribosomal protein S29 -0.0427797
RPL36A ribosomal protein L36a -0.0412041
RPL23 ribosomal protein L23 -0.0406724
RPS27 ribosomal protein S27 -0.0401117
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0400278
RPL11 ribosomal protein L11 -0.0394137
RPL9 ribosomal protein L9 -0.0378471
RPS14 ribosomal protein S14 -0.0377477
RPL36 ribosomal protein L36 -0.0376926
HLA-A major histocompatibility complex, class I, A -0.0376374
RPS21 ribosomal protein S21 -0.0375565
RPL37 ribosomal protein L37 -0.03629
HLA-B major histocompatibility complex, class I, B -0.0360646
RPL32 ribosomal protein L32 -0.0359528
RPL34 ribosomal protein L34 -0.0352394
RPS13 ribosomal protein S13 -0.0351186
RPS27A ribosomal protein S27a -0.0344231
S100A10 S100 calcium binding protein A10 -0.0334593
SOX4 SRY (sex determining region Y)-box 4 -0.0326644
CTSL cathepsin L -0.0320514
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0318761
EGR1 early growth response 1 -0.0318182
GNAS GNAS complex locus -0.0316314
RPS25 ribosomal protein S25 -0.0314782
RACK1 receptor for activated C kinase 1 -0.0313031
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0312484
RPS16 ribosomal protein S16 -0.0309979
RPS4X ribosomal protein S4, X-linked -0.0309123
RPS12 ribosomal protein S12 -0.030815
EIF1 eukaryotic translation initiation factor 1 -0.0299538
LMNA lamin A/C -0.0296517
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0294618
ENO1 enolase 1, (alpha) -0.0293991
RPS24 ribosomal protein S24 -0.0293952
RPLP0 ribosomal protein, large, P0 -0.0293498
EEF2 eukaryotic translation elongation factor 2 -0.0291256
RPL35 ribosomal protein L35 -0.0280303
RPL5 ribosomal protein L5 -0.0277568
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0276587
MAML3 mastermind-like 3 (Drosophila) -0.0272786
RPL38 ribosomal protein L38 -0.0271344
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0270769
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0268531
TIMP1 TIMP metallopeptidase inhibitor 1 -0.026582
RPS11 ribosomal protein S11 -0.0265537
STC1 stanniocalcin 1 -0.026258
RPL13A ribosomal protein L13a -0.0261405
IL6 interleukin 6 -0.0259785
VDAC1 voltage-dependent anion channel 1 -0.025585
SRGN serglycin -0.025545
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0255264
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0253185
RPL8 ribosomal protein L8 -0.0249821
PFN1 profilin 1 -0.0246958
ATP5F1E ATP synthase F1 subunit epsilon -0.0243929
ACTG1 actin gamma 1 -0.0243715
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0243065
PSD3 pleckstrin and Sec7 domain containing 3 -0.024168
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0239828
RPL18 ribosomal protein L18 -0.022857
ASTN2 astrotactin 2 -0.0228107
RPS10 ribosomal protein S10 -0.022524
TPI1 triosephosphate isomerase 1 -0.0221835
RPS15 ribosomal protein S15 -0.0220501
PGK1 phosphoglycerate kinase 1 -0.0217289
PBX1 pre-B-cell leukemia homeobox 1 -0.020788
RPS5 ribosomal protein S5 -0.0207456
NCKAP5 NCK-associated protein 5 -0.0206978
RPS17 ribosomal protein S17 -0.0206624
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0204483
WARS1 tryptophanyl-tRNA synthetase 1 -0.020005