Entecavir (monohydrate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0968243
FNDC3B fibronectin type III domain containing 3B 0.0729207
TSC22D2 TSC22 domain family, member 2 0.0716523
ZEB2 zinc finger E-box binding homeobox 2 0.0594727
COL5A2 collagen, type V, alpha 2 0.0576693
PHIP pleckstrin homology domain interacting protein 0.0556944
ENAH enabled homolog (Drosophila) 0.0532233
PUM1 pumilio RNA-binding family member 1 0.0518755
MED13L mediator complex subunit 13-like 0.0518722
PEG10 paternally expressed 10 0.0470321
STRN3 striatin, calmodulin binding protein 3 0.0465365
STAG2 stromal antigen 2 0.0435191
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0407552
PGAP1 post-GPI attachment to proteins 1 0.0385421
PRTG protogenin 0.0378524
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0375352
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0366308
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0356766
KMT2C lysine (K)-specific methyltransferase 2C 0.0352014
ZFAND3 zinc finger, AN1-type domain 3 0.0348297
USP25 ubiquitin specific peptidase 25 0.0347417
PUM2 pumilio RNA-binding family member 2 0.034183
ITGAV integrin, alpha V 0.0323557
PRPF8 pre-mRNA processing factor 8 0.031898
FUBP1 far upstream element (FUSE) binding protein 1 0.0308973
CDC73 cell division cycle 73 0.0295626
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0287108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0285668
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0285625
PICALM phosphatidylinositol binding clathrin assembly protein 0.0283476
PLPP1 phospholipid phosphatase 1 0.0282783
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.028139
HDAC9 histone deacetylase 9 0.0281208
NCKAP1 NCK-associated protein 1 0.0273191
USP3 ubiquitin specific peptidase 3 0.0272287
FOXP2 forkhead box P2 0.0271379
CHD7 chromodomain helicase DNA binding protein 7 0.0270473
MTF2 metal response element binding transcription factor 2 0.0269455
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0267408
MEMO1 mediator of cell motility 1 0.0267169
WSB1 WD repeat and SOCS box containing 1 0.0264957
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.026092
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0242858
ECT2 epithelial cell transforming 2 0.0242076
ZNF608 zinc finger protein 608 0.0235646
XPO1 exportin 1 0.0234001
MTCL1 microtubule crosslinking factor 1 0.0233508
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0233249
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.023099
CAMTA1 calmodulin binding transcription activator 1 0.022953
TMEM64 transmembrane protein 64 0.0229423
CCNL1 cyclin L1 0.0229117
TLK2 tousled-like kinase 2 0.0227626
RHOH ras homolog family member H 0.0225521
TPD52 tumor protein D52 0.022249
FOXJ3 forkhead box J3 0.022084
NUP153 nucleoporin 153kDa 0.0220081
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0219335
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0216692
BRWD1 bromodomain and WD repeat domain containing 1 0.02134
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0210265
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0209275
CDC14A cell division cycle 14A 0.0209233
ADAM9 ADAM metallopeptidase domain 9 0.0208965
HP1BP3 heterochromatin protein 1, binding protein 3 0.0207849
SHROOM3 shroom family member 3 0.0207764
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0207652
PCBP2 poly(rC) binding protein 2 0.0207574
NRG1 neuregulin 1 0.0207563
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0206147
THOC2 THO complex 2 0.0204199
OSBPL10 oxysterol binding protein-like 10 0.0201818
KIF13A kinesin family member 13A 0.0201169
CCN2 cellular communication network factor 2 0.0199698
GPC4 glypican 4 0.0199166
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.0198685
PHF21A PHD finger protein 21A 0.0194927
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0194496
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0194389
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0193452
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0192868
MDN1 MDN1, midasin homolog (yeast) 0.0191879
TLK1 tousled-like kinase 1 0.019015
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0190012
RTTN rotatin 0.01893
ANKRD33B ankyrin repeat domain 33B 0.0189289
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.018862
GLS2 glutaminase 2 (liver, mitochondrial) 0.018817
TRA2A transformer 2 alpha homolog (Drosophila) 0.0187682
CECR2 cat eye syndrome chromosome region, candidate 2 0.0187339
TJP1 tight junction protein 1 0.0185891
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0185611
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.018421
BCLAF1 BCL2-associated transcription factor 1 0.0183746
INTS13 integrator complex subunit 13 0.0183277
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0181966
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0181718
ANXA1 annexin A1 0.0181063
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.018058
DST dystonin 0.0180123

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.245895
PTMA prothymosin, alpha -0.177161
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.133352
TMSB10 thymosin beta 10 -0.126819
RPS16 ribosomal protein S16 -0.0999983
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0990922
CADM2 cell adhesion molecule 2 -0.0979584
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0967762
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0924592
RPS8 ribosomal protein S8 -0.0922454
RPS6 ribosomal protein S6 -0.0876594
COL11A1 collagen, type XI, alpha 1 -0.0817952
PCLO piccolo presynaptic cytomatrix protein -0.0817325
TPT1 tumor protein, translationally-controlled 1 -0.0814534
PCDH9 protocadherin 9 -0.074715
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0738949
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0727336
RPL19 ribosomal protein L19 -0.069244
COL3A1 collagen, type III, alpha 1 -0.0683319
ACTG1 actin gamma 1 -0.0653982
RPLP1 ribosomal protein, large, P1 -0.0632921
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.061605
RPL35A ribosomal protein L35a -0.0592128
RPL31 ribosomal protein L31 -0.054625
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0542429
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0539349
MDK midkine (neurite growth-promoting factor 2) -0.0532219
B2M beta-2-microglobulin -0.0508507
RPS19 ribosomal protein S19 -0.0504915
RPL26 ribosomal protein L26 -0.0500374
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0499724
RPS21 ribosomal protein S21 -0.0498035
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0496744
RPL11 ribosomal protein L11 -0.047555
NPAS3 neuronal PAS domain protein 3 -0.0470232
SPAG9 sperm associated antigen 9 -0.0451427
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0448584
HMGB1 high mobility group box 1 -0.0447076
RPL12 ribosomal protein L12 -0.0444226
CALR calreticulin -0.0443998
RPL5 ribosomal protein L5 -0.0436702
RPS27A ribosomal protein S27a -0.043509
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0419479
RPS12 ribosomal protein S12 -0.0417702
RPS25 ribosomal protein S25 -0.0415578
RPLP0 ribosomal protein, large, P0 -0.0414326
RPL34 ribosomal protein L34 -0.0413976
RPS13 ribosomal protein S13 -0.0409708
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0408956
RPS24 ribosomal protein S24 -0.0404333
TMSB4X thymosin beta 4, X-linked -0.0401756
RPL23 ribosomal protein L23 -0.0400751
RAD51B RAD51 paralog B -0.0399296
MYL12B myosin, light chain 12B, regulatory -0.0384933
ANKRD12 ankyrin repeat domain 12 -0.0381603
NACA nascent polypeptide-associated complex alpha subunit -0.0381407
GNAS GNAS complex locus -0.0374699
FTL ferritin, light polypeptide -0.0373219
RPS3 ribosomal protein S3 -0.0362928
RPLP2 ribosomal protein, large, P2 -0.0360919
CBX3 chromobox homolog 3 -0.0351907
RPL37A ribosomal protein L37a -0.0351435
EMP1 epithelial membrane protein 1 -0.0349267
S100A10 S100 calcium binding protein A10 -0.0346859
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0345158
FN1 fibronectin 1 -0.0344454
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0340831
S100A9 S100 calcium binding protein A9 -0.034003
CUX1 cut-like homeobox 1 -0.0338836
LRRC4C leucine rich repeat containing 4C -0.0337741
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0335439
HSPB1 heat shock 27kDa protein 1 -0.0335389
NAP1L1 nucleosome assembly protein 1-like 1 -0.0332285
RPL28 ribosomal protein L28 -0.0332009
MKI67 marker of proliferation Ki-67 -0.0327499
RPL37 ribosomal protein L37 -0.0320795
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0320218
TTC3 tetratricopeptide repeat domain 3 -0.0317564
TUBA1B tubulin, alpha 1b -0.0307288
RPL27A ribosomal protein L27a -0.0304137
ADGRL2 adhesion G protein-coupled receptor L2 -0.0301034
AKAP12 A kinase (PRKA) anchor protein 12 -0.0294374
HMGA2 high mobility group AT-hook 2 -0.0292734
DEK DEK proto-oncogene -0.0288265
RPS2 ribosomal protein S2 -0.0288016
RACK1 receptor for activated C kinase 1 -0.0286634
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0283973
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0278772
EIF1 eukaryotic translation initiation factor 1 -0.027715
RPL9 ribosomal protein L9 -0.0276952
TNRC6B trinucleotide repeat containing 6B -0.0276906
AHNAK AHNAK nucleoprotein -0.0275068
RPL4 ribosomal protein L4 -0.0272562
MORF4L2 mortality factor 4 like 2 -0.0271059
PARD3B par-3 family cell polarity regulator beta -0.0270662
MT2A metallothionein 2A -0.026932
CDH19 cadherin 19, type 2 -0.0268185
CSDE1 cold shock domain containing E1, RNA-binding -0.0266301
RPS11 ribosomal protein S11 -0.0264904
KPNB1 karyopherin (importin) beta 1 -0.0264482