Entecavir (monohydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0800768
TRIO trio Rho guanine nucleotide exchange factor 0.0780496
MYO6 myosin VI 0.0755634
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0686325
RBM39 RNA binding motif protein 39 0.05587
EZR ezrin 0.0543925
PTK2 protein tyrosine kinase 2 0.050434
CCNL1 cyclin L1 0.0499175
DLG1 discs, large homolog 1 (Drosophila) 0.0489379
JMJD1C jumonji domain containing 1C 0.0485826
NRIP1 nuclear receptor interacting protein 1 0.0476404
MACF1 microtubule-actin crosslinking factor 1 0.0476048
RUNX1 runt-related transcription factor 1 0.0472032
ZFAND3 zinc finger, AN1-type domain 3 0.0456448
FAM3C family with sequence similarity 3, member C 0.0443298
OGA O-GlcNAcase 0.0433533
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0419005
SMAD3 SMAD family member 3 0.0411505
SPAG9 sperm associated antigen 9 0.040853
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0401084
ECT2 epithelial cell transforming 2 0.0399896
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.039294
NAV2 neuron navigator 2 0.0384536
NF1 neurofibromin 1 0.0382874
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0369524
EPS8 epidermal growth factor receptor pathway substrate 8 0.0368548
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0362712
NAMPT nicotinamide phosphoribosyltransferase 0.0358753
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.035809
KDM6A lysine (K)-specific demethylase 6A 0.035031
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0347021
CTNND1 catenin (cadherin-associated protein), delta 1 0.0344113
DIAPH3 diaphanous-related formin 3 0.0334592
AFDN afadin, adherens junction formation factor 0.0332993
EMP1 epithelial membrane protein 1 0.0321713
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0321136
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.031571
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0313585
UBE2H ubiquitin-conjugating enzyme E2H 0.0309301
ARHGAP26 Rho GTPase activating protein 26 0.0308543
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0306049
DST dystonin 0.0305966
PICALM phosphatidylinositol binding clathrin assembly protein 0.0302882
ITCH itchy E3 ubiquitin protein ligase 0.0299397
ANLN anillin, actin binding protein 0.0294792
LAMB3 laminin, beta 3 0.0294766
FXR1 fragile X mental retardation, autosomal homolog 1 0.0290242
MAML2 mastermind-like 2 (Drosophila) 0.0286411
USP9X ubiquitin specific peptidase 9, X-linked 0.0283557
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.028315
PARD3 par-3 family cell polarity regulator 0.0283072
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.028193
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0280678
SAMD4A sterile alpha motif domain containing 4A 0.0279977
BIRC6 baculoviral IAP repeat containing 6 0.0277985
RASA2 RAS p21 protein activator 2 0.0276918
CANX calnexin 0.027648
RSRC1 arginine/serine-rich coiled-coil 1 0.0273784
ATP13A3 ATPase type 13A3 0.0273767
PCBP2 poly(rC) binding protein 2 0.0273561
OSBPL3 oxysterol binding protein-like 3 0.0273338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0273319
XPO1 exportin 1 0.0273102
NPEPPS aminopeptidase puromycin sensitive 0.0272463
AHNAK AHNAK nucleoprotein 0.0267421
RICTOR RPTOR independent companion of MTOR, complex 2 0.0266869
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0266681
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0265771
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0264827
MBNL2 muscleblind-like splicing regulator 2 0.026286
UGCG UDP-glucose ceramide glucosyltransferase 0.0261371
TRA2A transformer 2 alpha homolog (Drosophila) 0.0260426
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0257037
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0256018
SENP6 SUMO1/sentrin specific peptidase 6 0.0253415
ZMYM2 zinc finger, MYM-type 2 0.0251985
MBNL1 muscleblind-like splicing regulator 1 0.0251671
EIF4A2 eukaryotic translation initiation factor 4A2 0.0249722
WAC WW domain containing adaptor with coiled-coil 0.0247478
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0245974
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0245824
NIPBL Nipped-B homolog (Drosophila) 0.0245242
GOLGA4 golgin A4 0.0244417
NCKAP1 NCK-associated protein 1 0.0244086
GPHN gephyrin 0.0244071
GSK3B glycogen synthase kinase 3 beta 0.0243457
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0240843
ARHGAP29 Rho GTPase activating protein 29 0.0239942
BIRC3 baculoviral IAP repeat containing 3 0.0237758
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0237505
TMCC1 transmembrane and coiled-coil domain family 1 0.0235473
UBA6 ubiquitin-like modifier activating enzyme 6 0.0235351
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0235184
EHF ets homologous factor 0.0234993
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0234414
ATP11B ATPase, class VI, type 11B 0.0234227
MYOF myoferlin 0.0233826
CLTC clathrin, heavy chain (Hc) 0.0233699
SLTM SAFB-like, transcription modulator 0.023275
ZNF292 zinc finger protein 292 0.0232311

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.24811
TMSB10 thymosin beta 10 -0.137043
RPL35A ribosomal protein L35a -0.0922219
PTMA prothymosin, alpha -0.0913435
MT2A metallothionein 2A -0.0868226
RPS19 ribosomal protein S19 -0.0820145
KRT19 keratin 19, type I -0.0789548
TPT1 tumor protein, translationally-controlled 1 -0.0785123
RPS6 ribosomal protein S6 -0.0775301
RPL23 ribosomal protein L23 -0.07673
FTL ferritin, light polypeptide -0.0764131
RPS8 ribosomal protein S8 -0.07389
IFI27 interferon, alpha-inducible protein 27 -0.063007
RPS13 ribosomal protein S13 -0.0613314
RPS29 ribosomal protein S29 -0.0605826
RPLP1 ribosomal protein, large, P1 -0.0596438
HMGA1 high mobility group AT-hook 1 -0.0593287
B2M beta-2-microglobulin -0.0527354
RPL19 ribosomal protein L19 -0.0523613
HLA-B major histocompatibility complex, class I, B -0.0522662
RPS3 ribosomal protein S3 -0.049014
NDRG1 N-myc downstream regulated 1 -0.0469223
RPL12 ribosomal protein L12 -0.0463869
RPL8 ribosomal protein L8 -0.0455853
IFITM1 interferon induced transmembrane protein 1 -0.0452639
ACTG1 actin gamma 1 -0.0449982
RPL31 ribosomal protein L31 -0.0449735
IFITM3 interferon induced transmembrane protein 3 -0.044716
G0S2 G0/G1 switch 2 -0.0426102
RPL34 ribosomal protein L34 -0.0410722
RPS21 ribosomal protein S21 -0.0408059
RPS14 ribosomal protein S14 -0.040527
RPL37A ribosomal protein L37a -0.0391981
RPS27 ribosomal protein S27 -0.0389733
HLA-A major histocompatibility complex, class I, A -0.0387375
RPLP2 ribosomal protein, large, P2 -0.0387159
WFDC2 WAP four-disulfide core domain 2 -0.0383046
RPL32 ribosomal protein L32 -0.0375805
S100A9 S100 calcium binding protein A9 -0.0375714
RPL28 ribosomal protein L28 -0.0373017
RPL36 ribosomal protein L36 -0.037087
S100A6 S100 calcium binding protein A6 -0.0348691
EGR1 early growth response 1 -0.0344077
RACK1 receptor for activated C kinase 1 -0.0343557
RPS27A ribosomal protein S27a -0.0342306
LOC102724023 ES1 protein homolog, mitochondrial -0.0342205
RPS23 ribosomal protein S23 -0.0327603
RPS25 ribosomal protein S25 -0.0311681
RPL5 ribosomal protein L5 -0.0309427
RPS11 ribosomal protein S11 -0.030505
SOX4 SRY (sex determining region Y)-box 4 -0.0304339
FTH1 ferritin, heavy polypeptide 1 -0.0301778
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0295577
RPL35 ribosomal protein L35 -0.0293023
POTEF POTE ankyrin domain family, member F -0.0285267
LY6E lymphocyte antigen 6 complex, locus E -0.0279633
RPS15 ribosomal protein S15 -0.0273317
RPL11 ribosomal protein L11 -0.0272532
RPS5 ribosomal protein S5 -0.0271012
TPI1 triosephosphate isomerase 1 -0.0270232
LOC112694756 uncharaterized LOC112694756 -0.0270153
RPL38 ribosomal protein L38 -0.0264062
S100A10 S100 calcium binding protein A10 -0.0263991
S100A11 S100 calcium binding protein A11 -0.0261088
RPL36A ribosomal protein L36a -0.025924
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0257814
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0251971
ENO1 enolase 1, (alpha) -0.0250079
RPL18 ribosomal protein L18 -0.0248181
CLDN4 claudin 4 -0.0247099
RPL9 ribosomal protein L9 -0.0245512
MT1X metallothionein 1X -0.0243468
RPL37 ribosomal protein L37 -0.0238577
C3 complement component 3 -0.0237469
MUC4 mucin 4, cell surface associated -0.0234269
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0231219
RPL36AL ribosomal protein L36a-like -0.0230445
RPS10 ribosomal protein S10 -0.0227307
EIF1 eukaryotic translation initiation factor 1 -0.0227096
RPL27 ribosomal protein L27 -0.02254
RPL13A ribosomal protein L13a -0.0224047
F3 coagulation factor III (thromboplastin, tissue factor) -0.0218421
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0216312
IFI6 interferon, alpha-inducible protein 6 -0.0212741
RPL15 ribosomal protein L15 -0.0210733
RPS16 ribosomal protein S16 -0.0209096
C15ORF48 chromosome 15 open reading frame 48 -0.0206284
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0201781
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.020135
SQSTM1 sequestosome 1 -0.0200258
RPL10A ribosomal protein L10a -0.0195265
ISG15 ISG15 ubiquitin-like modifier -0.0187071
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0186199
TXNIP thioredoxin interacting protein -0.0179882
RPL7A ribosomal protein L7a -0.0176257
RPS28 ribosomal protein S28 -0.0175999
ENO2 enolase 2 (gamma, neuronal) -0.0172818
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0172714
PKM pyruvate kinase, muscle -0.0172255
INTS6 integrator complex subunit 6 -0.0171933