Entecavir (monohydrate)_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.138725
FN1 fibronectin 1 0.124641
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.074163
NAMPT nicotinamide phosphoribosyltransferase 0.0722603
CXCL8 chemokine (C-X-C motif) ligand 8 0.0694629
ATP13A3 ATPase type 13A3 0.061
ASPH aspartate beta-hydroxylase 0.0562779
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0544414
PSD3 pleckstrin and Sec7 domain containing 3 0.0543383
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0498483
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0484744
ZNF292 zinc finger protein 292 0.0441794
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0428677
RTN4 reticulon 4 0.041437
SOD2 superoxide dismutase 2, mitochondrial 0.041082
TFPI2 tissue factor pathway inhibitor 2 0.0403545
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0402782
TRIO trio Rho guanine nucleotide exchange factor 0.0400166
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0395824
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0393775
GSK3B glycogen synthase kinase 3 beta 0.0393117
UBA6 ubiquitin-like modifier activating enzyme 6 0.0391616
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0387642
PTK2 protein tyrosine kinase 2 0.0382727
JMJD1C jumonji domain containing 1C 0.0373659
MSN moesin 0.0368962
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0367024
THBS1 thrombospondin 1 0.035109
RUNX1 runt-related transcription factor 1 0.0347805
CCNL1 cyclin L1 0.03444
NAV2 neuron navigator 2 0.0341749
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0339318
SETD5 SET domain containing 5 0.0338883
NRP1 neuropilin 1 0.0337515
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0334368
TFG TRK-fused gene 0.0332406
COL1A2 collagen, type I, alpha 2 0.0317938
POTEF POTE ankyrin domain family, member F 0.0314176
RBM39 RNA binding motif protein 39 0.0312911
MBNL1 muscleblind-like splicing regulator 1 0.0311281
CD44 CD44 molecule (Indian blood group) 0.0308993
GLS2 glutaminase 2 (liver, mitochondrial) 0.0308414
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.030763
KMT2E lysine (K)-specific methyltransferase 2E 0.0306961
IL1B interleukin 1, beta 0.0303066
ZEB1 zinc finger E-box binding homeobox 1 0.0301677
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0300772
EML5 echinoderm microtubule associated protein like 5 0.0300509
CLIC4 chloride intracellular channel 4 0.0298851
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0298496
WAC WW domain containing adaptor with coiled-coil 0.0297377
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0296707
COL1A1 collagen, type I, alpha 1 0.0290245
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0289669
MEF2A myocyte enhancer factor 2A 0.0286478
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0284855
FRMD4A FERM domain containing 4A 0.028439
RAD51B RAD51 paralog B 0.028422
KDM6A lysine (K)-specific demethylase 6A 0.0282134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281205
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0276538
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.027649
CDC73 cell division cycle 73 0.027618
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0276004
FNIP1 folliculin interacting protein 1 0.0275794
FLNB filamin B, beta 0.0272698
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0271767
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0271717
PUM2 pumilio RNA-binding family member 2 0.0268418
QKI QKI, KH domain containing, RNA binding 0.0267218
FHIT fragile histidine triad 0.026721
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0265515
SFPQ splicing factor proline/glutamine-rich 0.0261433
USP9X ubiquitin specific peptidase 9, X-linked 0.0260836
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0260799
YEATS2 YEATS domain containing 2 0.0258794
FMNL2 formin-like 2 0.0256565
PLSCR1 phospholipid scramblase 1 0.0255996
CDH13 cadherin 13 0.0255112
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0253835
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0248725
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0245128
ZBTB20 zinc finger and BTB domain containing 20 0.0244677
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0242829
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0242613
TOP1 topoisomerase (DNA) I 0.0242516
WDR43 WD repeat domain 43 0.0242144
MED13L mediator complex subunit 13-like 0.0239556
BIRC6 baculoviral IAP repeat containing 6 0.0239018
XPO1 exportin 1 0.0237825
HDAC9 histone deacetylase 9 0.0237534
TRA2B transformer 2 beta homolog (Drosophila) 0.0236617
TENT5A terminal nucleotidyltransferase 5A 0.0236267
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0235945
ZFAND3 zinc finger, AN1-type domain 3 0.0233773
FKBP1A FK506 binding protein 1A, 12kDa 0.0233702
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0233419
ELL2 elongation factor, RNA polymerase II, 2 0.0233067
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0229112
TGM2 transglutaminase 2 0.0228503

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.233614
MT2A metallothionein 2A -0.183522
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177386
FTL ferritin, light polypeptide -0.142739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.100082
TMSB10 thymosin beta 10 -0.0840963
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0599608
RPLP1 ribosomal protein, large, P1 -0.0535344
PTMA prothymosin, alpha -0.0533118
RPS19 ribosomal protein S19 -0.0522407
CALR calreticulin -0.0442242
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0387512
RPS13 ribosomal protein S13 -0.0379101
S100A10 S100 calcium binding protein A10 -0.0349826
SERF2 small EDRK-rich factor 2 -0.0344843
RPL31 ribosomal protein L31 -0.0342692
RPS21 ribosomal protein S21 -0.0325851
RPL35A ribosomal protein L35a -0.0316425
S100A9 S100 calcium binding protein A9 -0.031119
RPS6 ribosomal protein S6 -0.0305098
RPLP2 ribosomal protein, large, P2 -0.0299265
B2M beta-2-microglobulin -0.0294482
RPS8 ribosomal protein S8 -0.0290317
RPL36 ribosomal protein L36 -0.0289778
S100A6 S100 calcium binding protein A6 -0.0287215
RPS27A ribosomal protein S27a -0.0284197
RPL28 ribosomal protein L28 -0.028369
LOC112694756 uncharaterized LOC112694756 -0.028318
PKM pyruvate kinase, muscle -0.0281848
TPT1 tumor protein, translationally-controlled 1 -0.0277671
IFITM3 interferon induced transmembrane protein 3 -0.0275453
SEC61G Sec61 gamma subunit -0.0271214
HLA-B major histocompatibility complex, class I, B -0.0262375
RPS11 ribosomal protein S11 -0.0252114
RPL34 ribosomal protein L34 -0.0247618
RPL32 ribosomal protein L32 -0.0246077
RPL8 ribosomal protein L8 -0.0233514
ENO1 enolase 1, (alpha) -0.0226501
TPM4 tropomyosin 4 -0.0219252
EGR1 early growth response 1 -0.0216343
RPL19 ribosomal protein L19 -0.0214723
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0213139
RPS29 ribosomal protein S29 -0.0212148
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0211892
LMNA lamin A/C -0.021014
RPL12 ribosomal protein L12 -0.0208703
RPL23 ribosomal protein L23 -0.0206694
RPS25 ribosomal protein S25 -0.0206377
RPS27 ribosomal protein S27 -0.0205973
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0199882
GNAS GNAS complex locus -0.0198745
RPS23 ribosomal protein S23 -0.0194961
RPS16 ribosomal protein S16 -0.0191945
RPS3 ribosomal protein S3 -0.0189485
EIF1 eukaryotic translation initiation factor 1 -0.0189094
IFI6 interferon, alpha-inducible protein 6 -0.0188459
ACTG1 actin gamma 1 -0.0188409
RPL7A ribosomal protein L7a -0.0186524
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.018575
HILPDA hypoxia inducible lipid droplet-associated -0.0184778
RPL13A ribosomal protein L13a -0.0184354
ADM adrenomedullin -0.0183985
FAM162A family with sequence similarity 162, member A -0.018378
MT1E metallothionein 1E -0.0180862
RPL37A ribosomal protein L37a -0.0179703
TPI1 triosephosphate isomerase 1 -0.0177568
RPL11 ribosomal protein L11 -0.0177433
MT1X metallothionein 1X -0.0173597
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0173445
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0164513
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0163689
RPL37 ribosomal protein L37 -0.0161499
H1-0 H1.0 linker histone -0.0161024
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0160088
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0159442
CST3 cystatin C -0.0158543
RPL18 ribosomal protein L18 -0.0156929
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0156103
MYDGF myeloid-derived growth factor -0.0154515
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0153914
RPL35 ribosomal protein L35 -0.0152289
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.015005
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0149801
RPS14 ribosomal protein S14 -0.0145599
ATP5F1E ATP synthase F1 subunit epsilon -0.0144435
OAZ1 ornithine decarboxylase antizyme 1 -0.0142259
HDLBP high density lipoprotein binding protein -0.0140207
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0139484
RPL5 ribosomal protein L5 -0.0139385
S100A11 S100 calcium binding protein A11 -0.013929
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0139274
CTSB cathepsin B -0.0137943
SELENOK selenoprotein K -0.0137188
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0136788
RPL38 ribosomal protein L38 -0.0136658
ICAM1 intercellular adhesion molecule 1 -0.0135988
JUN jun proto-oncogene -0.0135218
EEF2 eukaryotic translation elongation factor 2 -0.0134611
LOC102724023 ES1 protein homolog, mitochondrial -0.013433
VDAC1 voltage-dependent anion channel 1 -0.0132216