Entecavir (monohydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0940173
ADAM10 ADAM metallopeptidase domain 10 0.0784228
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0750511
BMP10 bone morphogenetic protein 10 0.0709982
PDE4B phosphodiesterase 4B, cAMP-specific 0.0703461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0688677
DLG1 discs, large homolog 1 (Drosophila) 0.0671829
MKI67 marker of proliferation Ki-67 0.0596995
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0594876
CENPF centromere protein F, 350/400kDa 0.0571685
KPNB1 karyopherin (importin) beta 1 0.0552983
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.053648
VCL vinculin 0.0529417
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0526373
SMC3 structural maintenance of chromosomes 3 0.0517628
AHNAK AHNAK nucleoprotein 0.0509709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.049094
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0489699
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0488705
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0476761
CAMKMT calmodulin-lysine N-methyltransferase 0.0472265
DIAPH3 diaphanous-related formin 3 0.0469114
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0446386
CCNL1 cyclin L1 0.0393426
BMP2K BMP2 inducible kinase 0.0386719
GPHN gephyrin 0.0382931
EPS8 epidermal growth factor receptor pathway substrate 8 0.0374699
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0370818
PCBP2 poly(rC) binding protein 2 0.0369151
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0368745
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0368045
MYOF myoferlin 0.0365716
EIF4A2 eukaryotic translation initiation factor 4A2 0.0365587
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0364863
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0353463
FOXP1 forkhead box P1 0.03409
SMYD3 SET and MYND domain containing 3 0.033883
PDS5B PDS5 cohesin associated factor B 0.0336641
NIPBL Nipped-B homolog (Drosophila) 0.0336459
LPP LIM domain containing preferred translocation partner in lipoma 0.0335863
FAF1 Fas (TNFRSF6) associated factor 1 0.0334753
KIF5B kinesin family member 5B 0.0333064
XPO1 exportin 1 0.0329478
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0328233
EML4 echinoderm microtubule associated protein like 4 0.0325825
SCAF11 SR-related CTD-associated factor 11 0.0324162
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.03217
WAC WW domain containing adaptor with coiled-coil 0.0316446
APP amyloid beta (A4) precursor protein 0.0315406
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0309741
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0305336
NAMPT nicotinamide phosphoribosyltransferase 0.0296423
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0295532
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0295382
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0294461
CCND1 cyclin D1 0.0292191
SLMAP sarcolemma associated protein 0.029159
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0283334
ZNF638 zinc finger protein 638 0.0283174
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0282791
CSDE1 cold shock domain containing E1, RNA-binding 0.0282053
RHOA ras homolog family member A 0.0280812
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0280553
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0276477
NAP1L1 nucleosome assembly protein 1-like 1 0.0275702
TPX2 TPX2, microtubule-associated 0.0272094
RFC3 replication factor C (activator 1) 3, 38kDa 0.0270991
WSB1 WD repeat and SOCS box containing 1 0.0270923
JMJD1C jumonji domain containing 1C 0.0270226
SOX6 SRY (sex determining region Y)-box 6 0.0269517
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0268984
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0268933
SDK1 sidekick cell adhesion molecule 1 0.0267427
SENP5 SUMO1/sentrin specific peptidase 5 0.0265398
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.026527
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0263558
SSBP2 single-stranded DNA binding protein 2 0.0263243
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0263227
SET SET nuclear proto-oncogene 0.0260447
ANKRD36 ankyrin repeat domain 36 0.0259835
ZNF609 zinc finger protein 609 0.0259443
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0257316
PHIP pleckstrin homology domain interacting protein 0.0253394
ZNF292 zinc finger protein 292 0.025336
HDAC9 histone deacetylase 9 0.0253195
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0251351
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0251328
SSR1 signal sequence receptor, alpha 0.0251033
CUX1 cut-like homeobox 1 0.0249434
USP3 ubiquitin specific peptidase 3 0.0247474
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0246241
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0243962
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0243658
LCORL ligand dependent nuclear receptor corepressor-like 0.0241176
TAS2R14 taste receptor, type 2, member 14 0.0240052
DOCK1 dedicator of cytokinesis 1 0.0239125
KDM3A lysine (K)-specific demethylase 3A 0.0238927
TNPO1 transportin 1 0.0238828
U2SURP U2 snRNP-associated SURP domain containing 0.023821
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0237908

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185534
RPS19 ribosomal protein S19 -0.080176
PDE4D phosphodiesterase 4D, cAMP-specific -0.0759537
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0754236
EGFR epidermal growth factor receptor -0.0690394
S100A6 S100 calcium binding protein A6 -0.066659
RPS23 ribosomal protein S23 -0.061932
RPLP1 ribosomal protein, large, P1 -0.0595732
FTL ferritin, light polypeptide -0.0590512
RPL23 ribosomal protein L23 -0.0542047
RPL35A ribosomal protein L35a -0.0529022
RPL11 ribosomal protein L11 -0.050872
PKM pyruvate kinase, muscle -0.0506025
MT2A metallothionein 2A -0.0482024
TMSB10 thymosin beta 10 -0.0478323
RPL32 ribosomal protein L32 -0.0459592
RPS13 ribosomal protein S13 -0.0429587
RPL36 ribosomal protein L36 -0.0426227
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0418292
RPLP2 ribosomal protein, large, P2 -0.0404485
RPS6 ribosomal protein S6 -0.0396972
RPS21 ribosomal protein S21 -0.0376964
PRDX2 peroxiredoxin 2 -0.0374354
RPS29 ribosomal protein S29 -0.0365972
RPS25 ribosomal protein S25 -0.0364938
PDGFC platelet derived growth factor C -0.0363546
RPL9 ribosomal protein L9 -0.0352195
RPL13A ribosomal protein L13a -0.0347005
RPL31 ribosomal protein L31 -0.0334385
RPL12 ribosomal protein L12 -0.032456
ZBTB20 zinc finger and BTB domain containing 20 -0.0307937
NCEH1 neutral cholesterol ester hydrolase 1 -0.0294203
RPL34 ribosomal protein L34 -0.0289533
RPL28 ribosomal protein L28 -0.0271757
RPS11 ribosomal protein S11 -0.0267278
TJP1 tight junction protein 1 -0.0258862
RPS27A ribosomal protein S27a -0.0257928
RPL19 ribosomal protein L19 -0.0254794
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0254606
NACA nascent polypeptide-associated complex alpha subunit -0.0251962
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0251165
RPL26 ribosomal protein L26 -0.0249606
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0247322
RPS16 ribosomal protein S16 -0.0240524
RPS15 ribosomal protein S15 -0.0235078
RTN4 reticulon 4 -0.0233821
RPL27 ribosomal protein L27 -0.0231476
PFN1 profilin 1 -0.02243
S100A9 S100 calcium binding protein A9 -0.0222784
ANK2 ankyrin 2, neuronal -0.0221764
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0216596
SERF2 small EDRK-rich factor 2 -0.0215497
RPL18 ribosomal protein L18 -0.0213387
RPS8 ribosomal protein S8 -0.0211236
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0207963
RPL7 ribosomal protein L7 -0.0206386
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0206241
RAB27B RAB27B, member RAS oncogene family -0.0205172
MT1X metallothionein 1X -0.0201923
SPOP speckle-type POZ protein -0.020087
B2M beta-2-microglobulin -0.0200009
RPS27 ribosomal protein S27 -0.0198276
RPL5 ribosomal protein L5 -0.019781
ATF4 activating transcription factor 4 -0.0195768
ACTG1 actin gamma 1 -0.0191298
RPL37A ribosomal protein L37a -0.0189639
RPL35 ribosomal protein L35 -0.0188319
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0187573
RPL8 ribosomal protein L8 -0.0187397
CARS1 cysteinyl-tRNA synthetase 1 -0.0187275
LOC112694756 uncharaterized LOC112694756 -0.0186594
RPS17 ribosomal protein S17 -0.0186195
RPS3 ribosomal protein S3 -0.0186022
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0185544
GARS1 glycyl-tRNA synthetase 1 -0.018471
ATP9B ATPase, class II, type 9B -0.0183334
PDE10A phosphodiesterase 10A -0.0183287
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0180019
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0176375
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0176316
RPS5 ribosomal protein S5 -0.0173653
ATP5F1E ATP synthase F1 subunit epsilon -0.0172184
ACBD3 acyl-CoA binding domain containing 3 -0.0168223
ENO2 enolase 2 (gamma, neuronal) -0.0163897
POTEF POTE ankyrin domain family, member F -0.0161125
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0161076
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0160573
S100A11 S100 calcium binding protein A11 -0.0160439
RPL27A ribosomal protein L27a -0.0159708
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0159664
CPNE1 copine I -0.0158694
ZDHHC21 zinc finger, DHHC-type containing 21 -0.0156928
HSPB1 heat shock 27kDa protein 1 -0.0156736
KIF16B kinesin family member 16B -0.0156657
PDIA5 protein disulfide isomerase family A, member 5 -0.015635
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0154924
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.0154266
HLA-A major histocompatibility complex, class I, A -0.0153571
RPS10 ribosomal protein S10 -0.0153076
IFITM1 interferon induced transmembrane protein 1 -0.0153054