Entecavir (monohydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.13001
NAMPT nicotinamide phosphoribosyltransferase 0.106081
FN1 fibronectin 1 0.0946364
UGCG UDP-glucose ceramide glucosyltransferase 0.0939156
SOD2 superoxide dismutase 2, mitochondrial 0.0841253
ELL2 elongation factor, RNA polymerase II, 2 0.0708572
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0683095
ZNF292 zinc finger protein 292 0.0638571
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0626353
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0587951
RB1CC1 RB1-inducible coiled-coil 1 0.0547654
ATP13A3 ATPase type 13A3 0.0507763
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.050568
FNDC3B fibronectin type III domain containing 3B 0.0471532
OGA O-GlcNAcase 0.0470244
GOLGA4 golgin A4 0.0455592
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0447771
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0428922
UBA6 ubiquitin-like modifier activating enzyme 6 0.0425155
EIF1 eukaryotic translation initiation factor 1 0.0420177
SPAG9 sperm associated antigen 9 0.0419909
TENT5A terminal nucleotidyltransferase 5A 0.0402389
ARRDC3 arrestin domain containing 3 0.0397525
PCBP2 poly(rC) binding protein 2 0.0389986
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0359575
RTN4 reticulon 4 0.0356669
ANLN anillin, actin binding protein 0.035448
MXI1 MAX interactor 1, dimerization protein 0.0351848
TSC22D2 TSC22 domain family, member 2 0.0347848
MATR3 matrin 3 0.0342581
CCNL1 cyclin L1 0.0341565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0339953
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0339314
RPS6 ribosomal protein S6 0.0336994
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0326944
RBM39 RNA binding motif protein 39 0.0325692
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0320715
EEF2 eukaryotic translation elongation factor 2 0.0314402
HELZ helicase with zinc finger 0.0313208
WTAP Wilms tumor 1 associated protein 0.0311928
WDFY1 WD repeat and FYVE domain containing 1 0.0311458
PTBP3 polypyrimidine tract binding protein 3 0.0308776
PHIP pleckstrin homology domain interacting protein 0.0300249
NT5C2 5'-nucleotidase, cytosolic II 0.0291882
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0288971
POTEF POTE ankyrin domain family, member F 0.0286604
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0283802
MYH9 myosin, heavy chain 9, non-muscle 0.0278094
DSTN destrin (actin depolymerizing factor) 0.0276165
USP9X ubiquitin specific peptidase 9, X-linked 0.0274189
TXNIP thioredoxin interacting protein 0.0273708
DIAPH3 diaphanous-related formin 3 0.0268693
NAP1L1 nucleosome assembly protein 1-like 1 0.0267103
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0266691
PGK1 phosphoglycerate kinase 1 0.0266079
SRGN serglycin 0.0264568
SNX9 sorting nexin 9 0.0260763
B2M beta-2-microglobulin 0.025529
PNISR PNN-interacting serine/arginine-rich protein 0.0254178
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0253102
RPS4X ribosomal protein S4, X-linked 0.0252946
ANXA2 annexin A2 0.0250287
NPEPPS aminopeptidase puromycin sensitive 0.0247855
RPL23 ribosomal protein L23 0.0247231
ARL5B ADP-ribosylation factor-like 5B 0.0247186
FXR1 fragile X mental retardation, autosomal homolog 1 0.0246482
LAMP2 lysosomal-associated membrane protein 2 0.0245309
RPLP0 ribosomal protein, large, P0 0.0244
SERINC1 serine incorporator 1 0.0242944
BCLAF1 BCL2-associated transcription factor 1 0.0242064
RLF rearranged L-myc fusion 0.0240733
MSN moesin 0.0238323
ESYT2 extended synaptotagmin-like protein 2 0.0237197
SFTPA2 surfactant protein A2 0.023459
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0234066
ANXA5 annexin A5 0.0226018
TMEM123 transmembrane protein 123 0.0224769
TFG TRK-fused gene 0.0223852
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0223665
JMJD1C jumonji domain containing 1C 0.0223351
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0218978
LCORL ligand dependent nuclear receptor corepressor-like 0.0217177
DEK DEK proto-oncogene 0.0214322
NUP153 nucleoporin 153kDa 0.0213285
CKAP5 cytoskeleton associated protein 5 0.0211783
MARCHF6 membrane associated ring-CH-type finger 6 0.0211419
NEK7 NIMA-related kinase 7 0.021136
UBE2H ubiquitin-conjugating enzyme E2H 0.0210794
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0210709
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0210554
RICTOR RPTOR independent companion of MTOR, complex 2 0.0209877
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0207421
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0205379
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0203792
DENND4C DENN/MADD domain containing 4C 0.0203408
CSDE1 cold shock domain containing E1, RNA-binding 0.0202342
EZR ezrin 0.0201956
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0200595
BHLHE40 basic helix-loop-helix family, member e40 0.02005
KLF6 Kruppel-like factor 6 0.0199879

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.150014
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.140163
GLIS3 GLIS family zinc finger 3 -0.126573
HMGA2 high mobility group AT-hook 2 -0.0935767
COL6A3 collagen, type VI, alpha 3 -0.0904366
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0806069
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0772877
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0664686
CDH13 cadherin 13 -0.0633899
IGFBP3 insulin-like growth factor binding protein 3 -0.0626416
AKAP12 A kinase (PRKA) anchor protein 12 -0.0621088
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0579296
INTS6 integrator complex subunit 6 -0.0567868
EXT1 exostosin glycosyltransferase 1 -0.0552818
NAV1 neuron navigator 1 -0.05192
VCL vinculin -0.0515315
HDAC9 histone deacetylase 9 -0.0508146
PDE10A phosphodiesterase 10A -0.0503446
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0499457
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0497894
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0497259
DST dystonin -0.0481459
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0480176
CD44 CD44 molecule (Indian blood group) -0.047802
BICC1 BicC family RNA binding protein 1 -0.0472781
TNS3 tensin 3 -0.0469716
EGFR epidermal growth factor receptor -0.0462261
SDK1 sidekick cell adhesion molecule 1 -0.0422723
DIAPH2 diaphanous-related formin 2 -0.0407551
COL5A1 collagen, type V, alpha 1 -0.0406173
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0399618
RAI14 retinoic acid induced 14 -0.0390045
TMEM132D transmembrane protein 132D -0.0386645
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.038491
PTPRK protein tyrosine phosphatase, receptor type, K -0.0384489
ATXN1 ataxin 1 -0.0380564
FRMPD4 FERM and PDZ domain containing 4 -0.0375985
ASPH aspartate beta-hydroxylase -0.0361518
ZMYND8 zinc finger, MYND-type containing 8 -0.0355256
IER3 immediate early response 3 -0.0351829
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348028
AFF3 AF4/FMR2 family, member 3 -0.0337088
FAM20C family with sequence similarity 20, member C -0.0332859
ADAM12 ADAM metallopeptidase domain 12 -0.033126
SLC35F3 solute carrier family 35, member F3 -0.0326704
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0313786
TRIO trio Rho guanine nucleotide exchange factor -0.0313277
RAD51B RAD51 paralog B -0.0306846
MACF1 microtubule-actin crosslinking factor 1 -0.0304616
HLA-B major histocompatibility complex, class I, B -0.0300807
SQSTM1 sequestosome 1 -0.0280385
EFNA5 ephrin-A5 -0.0277682
EPAS1 endothelial PAS domain protein 1 -0.0276719
KYNU kynureninase -0.0271152
PSD3 pleckstrin and Sec7 domain containing 3 -0.0268336
NABP1 nucleic acid binding protein 1 -0.0268275
RNF213 ring finger protein 213 -0.0267579
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0266914
FBXL7 F-box and leucine-rich repeat protein 7 -0.0264998
SAMD3 sterile alpha motif domain containing 3 -0.0260437
ZBTB20 zinc finger and BTB domain containing 20 -0.025959
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0254605
SOX5 SRY (sex determining region Y)-box 5 -0.025415
NCKAP5 NCK-associated protein 5 -0.0250993
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.025043
ZHX2 zinc fingers and homeoboxes 2 -0.0249176
TMSB10 thymosin beta 10 -0.0245347
TPT1 tumor protein, translationally-controlled 1 -0.0239209
EHBP1 EH domain binding protein 1 -0.0238945
SEPTIN9 septin 9 -0.0237137
VEGFA vascular endothelial growth factor A -0.0236301
MAML2 mastermind-like 2 (Drosophila) -0.0224602
C3 complement component 3 -0.0224423
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0220176
AHNAK AHNAK nucleoprotein -0.0218166
JARID2 jumonji, AT rich interactive domain 2 -0.0216709
TENM2 teneurin transmembrane protein 2 -0.0216708
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.021465
CLMP CXADR-like membrane protein -0.0209674
WFDC10B WAP four-disulfide core domain 10B -0.0209343
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0208105
SVIL supervillin -0.0208012
CTSD cathepsin D -0.0207977
COL6A2 collagen, type VI, alpha 2 -0.0206795
TPM1 tropomyosin 1 (alpha) -0.0204422
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0202148
FBXO11 F-box protein 11 -0.0199995
GOLGB1 golgin B1 -0.0199892
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0199198
PALLD palladin, cytoskeletal associated protein -0.0199183
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0197857
PRKCA protein kinase C, alpha -0.0197776
BNC2 basonuclin 2 -0.0195407
MLPH melanophilin -0.019201
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0190603
ARHGAP22 Rho GTPase activating protein 22 -0.0189328
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0188661
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0188407
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0187855
PRKG1 protein kinase, cGMP-dependent, type I -0.0187216