Entecavir (monohydrate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.221164
FN1 fibronectin 1 0.108817
CXCL8 chemokine (C-X-C motif) ligand 8 0.102481
ERRFI1 ERBB receptor feedback inhibitor 1 0.0881267
TIMP3 TIMP metallopeptidase inhibitor 3 0.0828247
CDH13 cadherin 13 0.077866
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0682621
COL6A3 collagen, type VI, alpha 3 0.0601089
TM4SF1 transmembrane 4 L six family member 1 0.0586994
TRIO trio Rho guanine nucleotide exchange factor 0.0568081
COL1A2 collagen, type I, alpha 2 0.0555502
PRSS23 protease, serine, 23 0.0542055
LAMB3 laminin, beta 3 0.0538935
FAM13A family with sequence similarity 13, member A 0.0509717
LOX lysyl oxidase 0.0499392
LOXL2 lysyl oxidase-like 2 0.0491377
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0476648
VIM vimentin 0.0475919
F3 coagulation factor III (thromboplastin, tissue factor) 0.0473394
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0463695
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0459311
TENT5A terminal nucleotidyltransferase 5A 0.0454677
LDHA lactate dehydrogenase A 0.0427882
NCOA3 nuclear receptor coactivator 3 0.0426273
FNDC3B fibronectin type III domain containing 3B 0.0413106
NRXN3 neurexin 3 0.0407376
EFNA5 ephrin-A5 0.0391807
ENO1 enolase 1, (alpha) 0.0390153
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0387366
ASPH aspartate beta-hydroxylase 0.0382689
DLG1 discs, large homolog 1 (Drosophila) 0.0381813
HMGA2 high mobility group AT-hook 2 0.0369605
COL1A1 collagen, type I, alpha 1 0.0367055
FLNB filamin B, beta 0.0351974
RICTOR RPTOR independent companion of MTOR, complex 2 0.03489
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0348317
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0339842
SPAG9 sperm associated antigen 9 0.0335812
HELZ helicase with zinc finger 0.0331137
FTO fat mass and obesity associated 0.0330125
ATP13A3 ATPase type 13A3 0.0321925
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.030986
PRELID2 PRELI domain containing 2 0.0307913
ENO2 enolase 2 (gamma, neuronal) 0.0306118
STC1 stanniocalcin 1 0.0303729
COL5A1 collagen, type V, alpha 1 0.0302525
NAMPT nicotinamide phosphoribosyltransferase 0.0301195
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0298762
PSD3 pleckstrin and Sec7 domain containing 3 0.029446
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.029156
BIRC3 baculoviral IAP repeat containing 3 0.0290881
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0290627
RUNX1 runt-related transcription factor 1 0.0286982
TNS3 tensin 3 0.0285936
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0285192
EZR ezrin 0.0281813
ASXL1 additional sex combs like transcriptional regulator 1 0.0280703
IL6 interleukin 6 0.0278473
FTH1 ferritin, heavy polypeptide 1 0.0277481
BABAM2 BRISC and BRCA1 A complex member 2 0.0274577
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0272975
ABLIM3 actin binding LIM protein family, member 3 0.0269973
SAMD4A sterile alpha motif domain containing 4A 0.0268467
PTPRM protein tyrosine phosphatase, receptor type, M 0.0267628
RAB1A RAB1A, member RAS oncogene family 0.0267107
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0267084
SMC4 structural maintenance of chromosomes 4 0.0265924
KDM2A lysine (K)-specific demethylase 2A 0.0265282
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0263024
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0262826
KTN1 kinectin 1 (kinesin receptor) 0.0262631
COL6A2 collagen, type VI, alpha 2 0.0256334
PDE4D phosphodiesterase 4D, cAMP-specific 0.0254552
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0250341
MLEC malectin 0.0248714
LIMS1 LIM and senescent cell antigen-like domains 1 0.024515
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0244612
NUCB2 nucleobindin 2 0.0244504
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0240598
ANO6 anoctamin 6 0.0240279
AHNAK AHNAK nucleoprotein 0.0238047
ZNF638 zinc finger protein 638 0.0237699
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0236327
MAP2K1 mitogen-activated protein kinase kinase 1 0.0233781
ACTN1 actinin, alpha 1 0.0233303
TUBB tubulin, beta class I 0.0232432
SBF2 SET binding factor 2 0.0232137
MTSS1 metastasis suppressor 1 0.0231989
UGCG UDP-glucose ceramide glucosyltransferase 0.0230169
FBXL20 F-box and leucine-rich repeat protein 20 0.0229776
UTRN utrophin 0.0229681
SFTPA2 surfactant protein A2 0.0229103
SEPTIN9 septin 9 0.0228548
APLP2 amyloid beta (A4) precursor-like protein 2 0.02284
CBX5 chromobox homolog 5 0.0226541
C1D C1D nuclear receptor corepressor 0.0226052
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0225439
BMERB1 bMERB domain containing 1 0.022269
CD59 CD59 molecule, complement regulatory protein 0.0220807
SLC38A2 solute carrier family 38, member 2 0.0219573

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.124369
HLA-B major histocompatibility complex, class I, B -0.0636235
B2M beta-2-microglobulin -0.0620124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0586438
ANKRD17 ankyrin repeat domain 17 -0.0526486
IGFBP7 insulin-like growth factor binding protein 7 -0.0495464
H3-3B H3.3 histone B -0.0453122
COG5 component of oligomeric golgi complex 5 -0.0421084
RPS2 ribosomal protein S2 -0.0402037
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0394746
TRA2A transformer 2 alpha homolog (Drosophila) -0.0371578
RNF24 ring finger protein 24 -0.0360692
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0358418
MATR3 matrin 3 -0.0354199
PDIA4 protein disulfide isomerase family A, member 4 -0.0351517
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0350422
COL6A1 collagen, type VI, alpha 1 -0.0347584
CALD1 caldesmon 1 -0.0346399
RPL11 ribosomal protein L11 -0.0334196
HDLBP high density lipoprotein binding protein -0.0331031
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0330798
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329597
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0311231
AFF4 AF4/FMR2 family, member 4 -0.0310762
TPM3 tropomyosin 3 -0.0308684
DPYD dihydropyrimidine dehydrogenase -0.0307106
LAMB1 laminin, beta 1 -0.0305584
NDRG1 N-myc downstream regulated 1 -0.030525
RPL26 ribosomal protein L26 -0.0301575
ELL2 elongation factor, RNA polymerase II, 2 -0.0299944
FUS FUS RNA binding protein -0.0296565
TNPO1 transportin 1 -0.0295975
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0295803
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0288997
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0287648
CSDE1 cold shock domain containing E1, RNA-binding -0.028717
RINT1 RAD50 interactor 1 -0.0287109
TFG TRK-fused gene -0.0286386
SETD5 SET domain containing 5 -0.0285325
TOP2B topoisomerase (DNA) II beta 180kDa -0.0284163
BTBD9 BTB (POZ) domain containing 9 -0.0283489
RPL32 ribosomal protein L32 -0.0282807
ANLN anillin, actin binding protein -0.028145
ARRDC3 arrestin domain containing 3 -0.0281197
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0277484
SMYD3 SET and MYND domain containing 3 -0.0275832
SRPK2 SRSF protein kinase 2 -0.0272783
SDC4 syndecan 4 -0.0271079
HIP1 huntingtin interacting protein 1 -0.0271062
RSRP1 arginine/serine-rich protein 1 -0.0270951
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0267284
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0264467
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0263854
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.026156
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.026048
KIF5B kinesin family member 5B -0.0260162
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0260039
ZNF292 zinc finger protein 292 -0.0259464
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0254886
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0254623
WDR45B WD repeat domain 45B -0.0253666
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.025353
RYBP RING1 and YY1 binding protein -0.0251501
FAM13B family with sequence similarity 13, member B -0.0249682
PTN pleiotrophin -0.0246057
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0245955
KIF1B kinesin family member 1B -0.0245687
GLG1 golgi glycoprotein 1 -0.024502
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0244302
PTGES2 prostaglandin E synthase 2 -0.0244197
IARS1 isoleucyl-tRNA synthetase 1 -0.0244135
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0242644
MAP1B microtubule-associated protein 1B -0.0242114
MRTFA myocardin related transcription factor A -0.0241909
APP amyloid beta (A4) precursor protein -0.0240885
CHD9 chromodomain helicase DNA binding protein 9 -0.0239664
ANKRD11 ankyrin repeat domain 11 -0.0238926
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0238866
PUM1 pumilio RNA-binding family member 1 -0.0237755
RNF130 ring finger protein 130 -0.0236754
ANKRD33B ankyrin repeat domain 33B -0.0236523
UBAP2 ubiquitin associated protein 2 -0.0235969
SUB1 SUB1 homolog (S. cerevisiae) -0.0235353
ACTG1 actin gamma 1 -0.0234899
CKAP5 cytoskeleton associated protein 5 -0.0233882
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0232983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.02328
GOLGA4 golgin A4 -0.0231528
MXD1 MAX dimerization protein 1 -0.0230917
IFRD1 interferon-related developmental regulator 1 -0.0229765
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0228938
SCAF8 SR-related CTD-associated factor 8 -0.0226903
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0226093
WDPCP WD repeat containing planar cell polarity effector -0.0225845
SFXN1 sideroflexin 1 -0.0224548
SPATS2 spermatogenesis associated, serine-rich 2 -0.022113
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0219765
TGFB1 transforming growth factor, beta 1 -0.0217439
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.0217171
TRIM23 tripartite motif containing 23 -0.0216932