Entecavir (monohydrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.129629
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.116752
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.114501
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0994877
RBM39 RNA binding motif protein 39 0.0890825
NAMPT nicotinamide phosphoribosyltransferase 0.0844636
GOLGA4 golgin A4 0.0806329
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0787462
SETD5 SET domain containing 5 0.0760801
NUP58 nucleoporin 58 0.0758121
WAC WW domain containing adaptor with coiled-coil 0.0726726
ZNF292 zinc finger protein 292 0.0725212
ANXA2 annexin A2 0.0661951
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0642968
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.062479
ANXA1 annexin A1 0.0595021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0539731
RSRC2 arginine/serine-rich coiled-coil 2 0.0530889
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.049413
DSCAM Down syndrome cell adhesion molecule 0.0479042
EIF1 eukaryotic translation initiation factor 1 0.047674
PRRC2C proline-rich coiled-coil 2C 0.0473771
ERRFI1 ERBB receptor feedback inhibitor 1 0.0464077
KIF5B kinesin family member 5B 0.0460356
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0456332
TXNRD1 thioredoxin reductase 1 0.0456271
FXR1 fragile X mental retardation, autosomal homolog 1 0.0451672
CCNL1 cyclin L1 0.0444021
ANKRD11 ankyrin repeat domain 11 0.0438728
IGFBP3 insulin-like growth factor binding protein 3 0.043821
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0435737
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0433309
MED13 mediator complex subunit 13 0.0432936
SPAG9 sperm associated antigen 9 0.0430525
RPL23 ribosomal protein L23 0.0427849
BIRC3 baculoviral IAP repeat containing 3 0.0426702
CXCL8 chemokine (C-X-C motif) ligand 8 0.0421605
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0418398
PUM2 pumilio RNA-binding family member 2 0.0414377
ITCH itchy E3 ubiquitin protein ligase 0.0410127
FNDC3B fibronectin type III domain containing 3B 0.0409583
JMJD1C jumonji domain containing 1C 0.0403211
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0402773
YBX3 Y box binding protein 3 0.0398824
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0393934
TFG TRK-fused gene 0.0393288
NAP1L1 nucleosome assembly protein 1-like 1 0.0389391
LDHA lactate dehydrogenase A 0.0385309
GSK3B glycogen synthase kinase 3 beta 0.0384819
ATP13A3 ATPase type 13A3 0.0383396
PCBP2 poly(rC) binding protein 2 0.0380951
RNF145 ring finger protein 145 0.03806
COG5 component of oligomeric golgi complex 5 0.0377603
HOOK2 hook microtubule-tethering protein 2 0.0372501
AHCTF1 AT hook containing transcription factor 1 0.0370592
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0369302
MARCHF6 membrane associated ring-CH-type finger 6 0.0367097
ESYT2 extended synaptotagmin-like protein 2 0.0364355
MATR3 matrin 3 0.0364003
RAB6A RAB6A, member RAS oncogene family 0.0362609
SMC4 structural maintenance of chromosomes 4 0.035884
RPL26 ribosomal protein L26 0.0358833
UGCG UDP-glucose ceramide glucosyltransferase 0.0358184
BRD2 bromodomain containing 2 0.0353101
RPS12 ribosomal protein S12 0.0347738
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0345131
LCORL ligand dependent nuclear receptor corepressor-like 0.0344984
TSC22D2 TSC22 domain family, member 2 0.0339317
RB1CC1 RB1-inducible coiled-coil 1 0.0338807
RPLP0 ribosomal protein, large, P0 0.0338004
POTEF POTE ankyrin domain family, member F 0.0333444
TBK1 TANK-binding kinase 1 0.0333213
SEC23A Sec23 homolog A (S. cerevisiae) 0.0330195
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0330113
QKI QKI, KH domain containing, RNA binding 0.0329244
CLINT1 clathrin interactor 1 0.0328818
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.032759
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0324744
WSB1 WD repeat and SOCS box containing 1 0.032252
MORF4L2 mortality factor 4 like 2 0.0320942
ANXA5 annexin A5 0.0320835
XPO1 exportin 1 0.0319263
CHD1 chromodomain helicase DNA binding protein 1 0.0318061
GARS1 glycyl-tRNA synthetase 1 0.0312966
SNX14 sorting nexin 14 0.0312296
HBP1 HMG-box transcription factor 1 0.0311879
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0311065
MYH9 myosin, heavy chain 9, non-muscle 0.031101
RBM33 RNA binding motif protein 33 0.0310516
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0308096
EVI5 ecotropic viral integration site 5 0.030781
RICTOR RPTOR independent companion of MTOR, complex 2 0.0307169
NUP153 nucleoporin 153kDa 0.0307152
ECT2 epithelial cell transforming 2 0.0306721
NF1 neurofibromin 1 0.030548
SEC24A SEC24 family member A 0.0304831
MT2A metallothionein 2A 0.0302038
HELZ helicase with zinc finger 0.0301247
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0299217
BIRC2 baculoviral IAP repeat containing 2 0.0299078

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.0764437
DST dystonin -0.0743899
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0631179
INTS6 integrator complex subunit 6 -0.0598278
PRSS23 protease, serine, 23 -0.0570717
NAV2 neuron navigator 2 -0.0560813
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0544836
MACF1 microtubule-actin crosslinking factor 1 -0.0492159
ZBTB20 zinc finger and BTB domain containing 20 -0.0483805
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0459383
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0442979
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0442245
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0429714
RIGI RNA sensor RIG-I -0.042064
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0411473
EXOC4 exocyst complex component 4 -0.0405342
PRH1 proline-rich protein HaeIII subfamily 1 -0.039589
FLNB filamin B, beta -0.0376782
PTPRK protein tyrosine phosphatase, receptor type, K -0.0368314
BICD1 bicaudal D homolog 1 (Drosophila) -0.0353278
THSD4 thrombospondin, type I, domain containing 4 -0.0342019
EGFR epidermal growth factor receptor -0.0337603
PRKCA protein kinase C, alpha -0.0334926
NINL ninein-like -0.032288
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0322404
RAD51B RAD51 paralog B -0.0318056
RAI14 retinoic acid induced 14 -0.0314429
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.031391
AK1 adenylate kinase 1 -0.0308306
VCL vinculin -0.029251
KLHL29 kelch-like family member 29 -0.0290116
GPATCH2L G patch domain containing 2-like -0.0282404
FOXP1 forkhead box P1 -0.0278371
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.027509
WWOX WW domain containing oxidoreductase -0.0262058
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0258641
ITGB4 integrin, beta 4 -0.0257999
AEBP2 AE binding protein 2 -0.0257171
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0253326
PCNX2 pecanex 2 -0.0251764
GPC6 glypican 6 -0.0248711
NAV3 neuron navigator 3 -0.0246293
KIAA1671 KIAA1671 -0.0245529
ETV6 ets variant 6 -0.0243379
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0240067
TIMP1 TIMP metallopeptidase inhibitor 1 -0.023787
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0236498
TBCA tubulin folding cofactor A -0.0235219
ATM ATM serine/threonine kinase -0.0233549
ZEB1 zinc finger E-box binding homeobox 1 -0.0232332
PCED1B PC-esterase domain containing 1B -0.0232149
ARMH4 armadillo like helical domain containing 4 -0.0231056
RIMS2 regulating synaptic membrane exocytosis 2 -0.0230252
SMAD2 SMAD family member 2 -0.0229224
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0228557
RIC8B RIC8 guanine nucleotide exchange factor B -0.022766
CMIP c-Maf inducing protein -0.0226098
JARID2 jumonji, AT rich interactive domain 2 -0.0225925
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.022523
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0221535
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0220687
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0217603
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0216922
FAM120B family with sequence similarity 120B -0.0211933
RAB10 RAB10, member RAS oncogene family -0.0211068
DPYD dihydropyrimidine dehydrogenase -0.0210368
NT5E 5'-nucleotidase, ecto (CD73) -0.0208399
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0207955
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0207299
ABR active BCR-related -0.0206066
EGR1 early growth response 1 -0.0204551
SIK2 salt-inducible kinase 2 -0.0203897
BBS9 Bardet-Biedl syndrome 9 -0.0202366
TNRC18 trinucleotide repeat containing 18 -0.0201562
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0201187
CEP112 centrosomal protein 112kDa -0.0197552
NCOA2 nuclear receptor coactivator 2 -0.0197411
SKIL SKI-like proto-oncogene -0.0197339
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0196671
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0196007
OASL 2'-5'-oligoadenylate synthetase-like -0.0195656
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0194679
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0192722
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0192429
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0191874
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0191823
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0189268
NLK nemo-like kinase -0.018822
AHNAK2 AHNAK nucleoprotein 2 -0.0187814
RGS17 regulator of G-protein signaling 17 -0.0187603
OSMR oncostatin M receptor -0.0187374
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0187366
KIAA1549L KIAA1549-like -0.0184581
BICRAL BICRA like chromatin remodeling complex associated protein -0.0184064
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0182486
NCOR2 nuclear receptor corepressor 2 -0.0182404
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.0181595
SNED1 sushi, nidogen and EGF-like domains 1 -0.018128
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.017955
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.017916