Entecavir (monohydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0904926
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0807551
TXNIP thioredoxin interacting protein 0.0661335
CD109 CD109 molecule 0.0504759
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0452807
NRP1 neuropilin 1 0.0448633
TMEM156 transmembrane protein 156 0.0442549
RUNX2 runt-related transcription factor 2 0.043314
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0390309
PTBP3 polypyrimidine tract binding protein 3 0.0380069
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0368328
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0368152
RICTOR RPTOR independent companion of MTOR, complex 2 0.0320208
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0300564
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.029819
CCNL1 cyclin L1 0.0298115
UGCG UDP-glucose ceramide glucosyltransferase 0.0291721
RTN4 reticulon 4 0.0290891
FNDC3B fibronectin type III domain containing 3B 0.0289708
WDR26 WD repeat domain 26 0.0287732
FBXL5 F-box and leucine-rich repeat protein 5 0.0286246
RB1CC1 RB1-inducible coiled-coil 1 0.0275536
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0265168
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0261484
SPRED2 sprouty-related, EVH1 domain containing 2 0.0258668
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0252119
RNF145 ring finger protein 145 0.0251408
MIS18BP1 MIS18 binding protein 1 0.0250748
PELO pelota homolog (Drosophila) 0.0248198
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0247525
SSBP2 single-stranded DNA binding protein 2 0.0245845
LIFR leukemia inhibitory factor receptor alpha 0.0240526
UBA6 ubiquitin-like modifier activating enzyme 6 0.0238485
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0237972
MCTP2 multiple C2 domains, transmembrane 2 0.0237069
HELZ helicase with zinc finger 0.0235581
ADD3 adducin 3 (gamma) 0.0227412
ESYT2 extended synaptotagmin-like protein 2 0.0221873
ITGB5 integrin, beta 5 0.0219675
FAM13A family with sequence similarity 13, member A 0.0219373
CAB39 calcium binding protein 39 0.0217538
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0216818
SPRED1 sprouty-related, EVH1 domain containing 1 0.0214709
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0214564
ERBIN erbb2 interacting protein 0.0213472
NPC1 Niemann-Pick disease, type C1 0.0206806
USP12 ubiquitin specific peptidase 12 0.0203421
PRPF8 pre-mRNA processing factor 8 0.02014
COPA coatomer protein complex, subunit alpha 0.0199622
SEC23A Sec23 homolog A (S. cerevisiae) 0.0199499
UBE2H ubiquitin-conjugating enzyme E2H 0.0199412
CD46 CD46 molecule, complement regulatory protein 0.0198167
TENT2 terminal nucleotidyltransferase 2 0.019726
TM9SF3 transmembrane 9 superfamily member 3 0.0195003
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0194208
LRP5 low density lipoprotein receptor-related protein 5 0.0193892
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0193717
RBM39 RNA binding motif protein 39 0.0192701
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0191692
EWSR1 EWS RNA-binding protein 1 0.0191414
ETNK1 ethanolamine kinase 1 0.0189462
NPEPPS aminopeptidase puromycin sensitive 0.0189096
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0188568
PDE8A phosphodiesterase 8A 0.018813
FBXO32 F-box protein 32 0.0187036
ZNF292 zinc finger protein 292 0.0186464
SMOX spermine oxidase 0.0185443
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0185332
SNX13 sorting nexin 13 0.018287
RNF24 ring finger protein 24 0.018151
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0178853
CORO1C coronin, actin binding protein, 1C 0.0177553
TMEM87A transmembrane protein 87A 0.0176479
SOS1 son of sevenless homolog 1 (Drosophila) 0.0176023
DIAPH3 diaphanous-related formin 3 0.0174074
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0173304
PRELID2 PRELI domain containing 2 0.0170216
ZMYM2 zinc finger, MYM-type 2 0.0170004
KMT2E lysine (K)-specific methyltransferase 2E 0.0169246
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.016844
AFDN afadin, adherens junction formation factor 0.0168116
TXNRD1 thioredoxin reductase 1 0.0167532
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0167371
AHR aryl hydrocarbon receptor 0.0166616
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0166453
SETD5 SET domain containing 5 0.0163851
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.0161644
RAB8B RAB8B, member RAS oncogene family 0.0161426
DUSP5 dual specificity phosphatase 5 0.0160634
PTPRE protein tyrosine phosphatase, receptor type, E 0.0158749
PNISR PNN-interacting serine/arginine-rich protein 0.0158124
CCNJL cyclin J-like 0.0157229
CDC73 cell division cycle 73 0.0155943
PCBP2 poly(rC) binding protein 2 0.0155732
MSN moesin 0.0155569
ATL2 atlastin GTPase 2 0.0155521
ARL5B ADP-ribosylation factor-like 5B 0.0155111
RCOR3 REST corepressor 3 0.015482
PTBP2 polypyrimidine tract binding protein 2 0.0154658
AVL9 AVL9 homolog (S. cerevisiase) 0.0154182

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.269737
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.249669
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.196089
PTMA prothymosin, alpha -0.177175
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.146328
NRG1 neuregulin 1 -0.142353
SQSTM1 sequestosome 1 -0.137677
CANX calnexin -0.127577
VIM vimentin -0.105372
S100A6 S100 calcium binding protein A6 -0.0904013
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.090284
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0884545
FN1 fibronectin 1 -0.0884152
TMSB10 thymosin beta 10 -0.0877908
HLA-B major histocompatibility complex, class I, B -0.081425
HMGA2 high mobility group AT-hook 2 -0.0797088
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0787759
TMSB4X thymosin beta 4, X-linked -0.0783656
ASPH aspartate beta-hydroxylase -0.0768769
TPT1 tumor protein, translationally-controlled 1 -0.0761822
FTL ferritin, light polypeptide -0.0721647
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0658935
ENO1 enolase 1, (alpha) -0.062449
EXT1 exostosin glycosyltransferase 1 -0.061602
RPS27A ribosomal protein S27a -0.0595987
RACK1 receptor for activated C kinase 1 -0.058989
RPL26 ribosomal protein L26 -0.058344
MT2A metallothionein 2A -0.058172
ACTG1 actin gamma 1 -0.0578649
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0541192
INTS6 integrator complex subunit 6 -0.0526233
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0521343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.050213
UBC ubiquitin C -0.0498273
S100A10 S100 calcium binding protein A10 -0.0491923
RPS8 ribosomal protein S8 -0.0488039
AEBP2 AE binding protein 2 -0.0481094
RPL37A ribosomal protein L37a -0.0477067
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0472606
LIMCH1 LIM and calponin homology domains 1 -0.0463922
TM4SF1 transmembrane 4 L six family member 1 -0.0453883
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0452039
CALR calreticulin -0.0449664
PALLD palladin, cytoskeletal associated protein -0.0445572
VCL vinculin -0.0444181
RPLP1 ribosomal protein, large, P1 -0.0440126
RPS12 ribosomal protein S12 -0.0436381
SFTPA2 surfactant protein A2 -0.0421701
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0420763
IER3 immediate early response 3 -0.0416488
RAI14 retinoic acid induced 14 -0.0416232
NAP1L1 nucleosome assembly protein 1-like 1 -0.0414011
AHNAK AHNAK nucleoprotein -0.0408371
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0408234
RPL31 ribosomal protein L31 -0.0408227
RPS24 ribosomal protein S24 -0.0402626
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0395571
TFPI2 tissue factor pathway inhibitor 2 -0.0387322
LRRC23 leucine rich repeat containing 23 -0.0385806
LMNA lamin A/C -0.0379249
B2M beta-2-microglobulin -0.0372901
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0368335
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0367782
RPL38 ribosomal protein L38 -0.0359866
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.035874
PDIA4 protein disulfide isomerase family A, member 4 -0.0358344
RPL9 ribosomal protein L9 -0.0354558
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0352954
RPL34 ribosomal protein L34 -0.0350529
H1-0 H1.0 linker histone -0.0349699
BZW1 basic leucine zipper and W2 domains 1 -0.0344336
HDLBP high density lipoprotein binding protein -0.0341859
RPL37 ribosomal protein L37 -0.0341618
RPS6 ribosomal protein S6 -0.0333829
RPS19 ribosomal protein S19 -0.0329109
SLC38A2 solute carrier family 38, member 2 -0.0319179
GNAS GNAS complex locus -0.0318158
SPDYA speedy/RINGO cell cycle regulator family member A -0.0312735
RPS29 ribosomal protein S29 -0.0312057
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0309824
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0309774
RPL35A ribosomal protein L35a -0.0303345
RPS5 ribosomal protein S5 -0.0300537
HMGA1 high mobility group AT-hook 1 -0.0299797
MTDH metadherin -0.0297835
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0296877
MRPS6 mitochondrial ribosomal protein S6 -0.0296133
RPS27 ribosomal protein S27 -0.0294882
RPS3 ribosomal protein S3 -0.0293363
POTEF POTE ankyrin domain family, member F -0.0289359
TRIO trio Rho guanine nucleotide exchange factor -0.0288499
SOX4 SRY (sex determining region Y)-box 4 -0.0287081
IFI6 interferon, alpha-inducible protein 6 -0.0286505
RPL19 ribosomal protein L19 -0.0283426
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0281248
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0280688
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0279121
S100A9 S100 calcium binding protein A9 -0.0278355
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0277355
RPS21 ribosomal protein S21 -0.0275438