Entecavir (monohydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.279929
OXR1 oxidation resistance 1 0.103588
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.103294
AREG amphiregulin 0.0830044
PDE4B phosphodiesterase 4B, cAMP-specific 0.0820842
LMO7 LIM domain 7 0.0786359
EZR ezrin 0.0649535
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0634001
RNF43 ring finger protein 43 0.0623568
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0564406
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0553495
RUNX2 runt-related transcription factor 2 0.0543087
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0532542
KMT2C lysine (K)-specific methyltransferase 2C 0.0525949
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0514407
ZNRF3 zinc and ring finger 3 0.0510033
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0501941
TXNIP thioredoxin interacting protein 0.046693
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0463766
RBM25 RNA binding motif protein 25 0.0461207
ANXA1 annexin A1 0.0456806
PTBP2 polypyrimidine tract binding protein 2 0.0449322
NEK7 NIMA-related kinase 7 0.0445975
RBM39 RNA binding motif protein 39 0.042079
FAT1 FAT atypical cadherin 1 0.0416838
GOLGA4 golgin A4 0.0416158
MBNL1 muscleblind-like splicing regulator 1 0.0414687
EREG epiregulin 0.041311
MED13L mediator complex subunit 13-like 0.0412103
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0405948
GPHN gephyrin 0.0405722
RAD51B RAD51 paralog B 0.0405702
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0404775
STRN3 striatin, calmodulin binding protein 3 0.0403763
ITPRID2 ITPR interacting domain containing 2 0.0402699
KDM6A lysine (K)-specific demethylase 6A 0.0392701
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0379667
COG5 component of oligomeric golgi complex 5 0.0375225
PARD3 par-3 family cell polarity regulator 0.0372642
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0368652
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.036362
USP3 ubiquitin specific peptidase 3 0.0359715
BCL2L1 BCL2-like 1 0.0350319
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0349702
PCBP2 poly(rC) binding protein 2 0.0348446
USP6NL USP6 N-terminal like 0.0344456
NT5DC3 5'-nucleotidase domain containing 3 0.0343884
GARS1 glycyl-tRNA synthetase 1 0.0342798
ARL5B ADP-ribosylation factor-like 5B 0.0341216
ZMYM2 zinc finger, MYM-type 2 0.0338025
SBF2 SET binding factor 2 0.0336177
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.033163
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0328973
MSI2 musashi RNA-binding protein 2 0.0328155
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0326771
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0326441
WAC WW domain containing adaptor with coiled-coil 0.0318761
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0318646
FAM3C family with sequence similarity 3, member C 0.0312837
ZNF292 zinc finger protein 292 0.0309561
WDR43 WD repeat domain 43 0.0309343
UBA6 ubiquitin-like modifier activating enzyme 6 0.0307782
BBX bobby sox homolog (Drosophila) 0.0302011
BRWD1 bromodomain and WD repeat domain containing 1 0.0300957
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0293064
NFIA nuclear factor I/A 0.0290421
SPRED2 sprouty-related, EVH1 domain containing 2 0.0290349
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0283181
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0282565
ECT2 epithelial cell transforming 2 0.0281352
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0280962
TSC22D2 TSC22 domain family, member 2 0.0280466
ESRP1 epithelial splicing regulatory protein 1 0.0279199
DLG1 discs, large homolog 1 (Drosophila) 0.0278186
AXIN2 axin 2 0.0277741
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.027592
CPOX coproporphyrinogen oxidase 0.0275472
OSBPL3 oxysterol binding protein-like 3 0.0272507
ARHGAP32 Rho GTPase activating protein 32 0.0272496
SLMAP sarcolemma associated protein 0.0269177
RFX7 regulatory factor X, 7 0.0268467
SRSF11 serine/arginine-rich splicing factor 11 0.0266527
FAR1 fatty acyl CoA reductase 1 0.0265633
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0265563
ATP13A3 ATPase type 13A3 0.0265297
PUM2 pumilio RNA-binding family member 2 0.0264099
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0262988
ANXA11 annexin A11 0.0262631
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0262357
FRMD5 FERM domain containing 5 0.0261524
ANKRD11 ankyrin repeat domain 11 0.0260015
VMP1 vacuole membrane protein 1 0.0259602
PDLIM5 PDZ and LIM domain 5 0.0259521
DDIT4 DNA-damage-inducible transcript 4 0.0258856
TXNRD1 thioredoxin reductase 1 0.025843
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0258098
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0257565
ATXN1 ataxin 1 0.0256108
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 0.0255711
PHIP pleckstrin homology domain interacting protein 0.0254314

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.170029
ACTG1 actin gamma 1 -0.168334
IER3 immediate early response 3 -0.101798
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100591
LAMB3 laminin, beta 3 -0.0859218
HMGA2 high mobility group AT-hook 2 -0.0842924
RPS6 ribosomal protein S6 -0.0808285
TPT1 tumor protein, translationally-controlled 1 -0.0751861
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.073134
LAMA4 laminin, alpha 4 -0.0713111
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0689868
KLF5 Kruppel-like factor 5 (intestinal) -0.066092
RCOR1 REST corepressor 1 -0.0620234
GPC5 glypican 5 -0.0588543
PTMA prothymosin, alpha -0.0579601
RPS8 ribosomal protein S8 -0.0552389
TMSB10 thymosin beta 10 -0.0540572
EGR1 early growth response 1 -0.0508131
RPLP1 ribosomal protein, large, P1 -0.0487207
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0426345
MPRIP myosin phosphatase Rho interacting protein -0.0385577
ANXA2 annexin A2 -0.0374064
CD9 CD9 molecule -0.0369172
RPL31 ribosomal protein L31 -0.03641
RPL12 ribosomal protein L12 -0.0354147
ITPKC inositol-trisphosphate 3-kinase C -0.0353204
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0348969
CDK13 cyclin-dependent kinase 13 -0.0341734
EMP1 epithelial membrane protein 1 -0.0334906
SQSTM1 sequestosome 1 -0.0331805
RPS17 ribosomal protein S17 -0.0330147
VCL vinculin -0.0325185
CANX calnexin -0.0322848
HDLBP high density lipoprotein binding protein -0.0309834
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0308646
ABR active BCR-related -0.030799
RPS25 ribosomal protein S25 -0.0295858
NUP50 nucleoporin 50kDa -0.0295692
RACK1 receptor for activated C kinase 1 -0.0292942
RPS12 ribosomal protein S12 -0.0291896
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0288385
RPL34 ribosomal protein L34 -0.0287944
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0286462
RPL37A ribosomal protein L37a -0.0277722
CREB5 cAMP responsive element binding protein 5 -0.0276741
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0272905
CUX1 cut-like homeobox 1 -0.0272226
RPS29 ribosomal protein S29 -0.0264317
FTH1 ferritin, heavy polypeptide 1 -0.0259063
RPS3 ribosomal protein S3 -0.0258126
KRT18 keratin 18, type I -0.025452
FLOT1 flotillin 1 -0.0250427
RPL10A ribosomal protein L10a -0.0241918
RPL5 ribosomal protein L5 -0.0237767
RPS27A ribosomal protein S27a -0.0236167
RPS13 ribosomal protein S13 -0.0234074
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0233629
HSPA8 heat shock 70kDa protein 8 -0.0231321
RPL35A ribosomal protein L35a -0.0230796
JARID2 jumonji, AT rich interactive domain 2 -0.0226585
RPL38 ribosomal protein L38 -0.0226578
RPS19 ribosomal protein S19 -0.0225314
DSPP dentin sialophosphoprotein -0.0224868
NTSR1 neurotensin receptor 1 (high affinity) -0.0224519
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0220319
RPL7 ribosomal protein L7 -0.0214259
RPL4 ribosomal protein L4 -0.0210267
RPL8 ribosomal protein L8 -0.0209917
UGDH UDP-glucose 6-dehydrogenase -0.0209894
FTL ferritin, light polypeptide -0.0208058
BICD1 bicaudal D homolog 1 (Drosophila) -0.0204305
RPS24 ribosomal protein S24 -0.0202216
SGMS2 sphingomyelin synthase 2 -0.0201822
CCND1 cyclin D1 -0.0200467
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0198652
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0191623
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0190294
PCNX4 pecanex 4 -0.0190058
RPL26 ribosomal protein L26 -0.0189949
CMIP c-Maf inducing protein -0.0189053
RPL15 ribosomal protein L15 -0.0188275
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.018781
EHBP1 EH domain binding protein 1 -0.0187788
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0186905
FHL2 four and a half LIM domains 2 -0.0186859
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0183954
PDIA4 protein disulfide isomerase family A, member 4 -0.0180279
FERMT1 fermitin family member 1 -0.0178932
BPTF bromodomain PHD finger transcription factor -0.0177861
LEMD1 LEM domain containing 1 -0.0177766
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0177419
EXT1 exostosin glycosyltransferase 1 -0.0173553
RPL27 ribosomal protein L27 -0.0172954
LOC112694756 uncharaterized LOC112694756 -0.0171697
RPS10 ribosomal protein S10 -0.0169468
S100A6 S100 calcium binding protein A6 -0.0167834
RPS5 ribosomal protein S5 -0.0167798
KRT19 keratin 19, type I -0.0166995
LSMEM2 leucine-rich single-pass membrane protein 2 -0.0166556
AHNAK AHNAK nucleoprotein -0.0166467