Entecavir (monohydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entecavir (monohydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.144456
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.130184
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.129433
NAV2 neuron navigator 2 0.117836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.108638
ESYT2 extended synaptotagmin-like protein 2 0.0951293
ITGA6 integrin, alpha 6 0.0892214
AKAP12 A kinase (PRKA) anchor protein 12 0.0885583
PCBP2 poly(rC) binding protein 2 0.0877623
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0809638
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0779676
ASPH aspartate beta-hydroxylase 0.0731382
ANLN anillin, actin binding protein 0.0679553
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0673083
ANXA2 annexin A2 0.0648344
SDK1 sidekick cell adhesion molecule 1 0.0612123
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0607832
FLNB filamin B, beta 0.0575329
USP34 ubiquitin specific peptidase 34 0.056033
EMP1 epithelial membrane protein 1 0.0558904
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0554453
TOP2A topoisomerase (DNA) II alpha 170kDa 0.054936
ETNK1 ethanolamine kinase 1 0.0545602
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0543309
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0543094
ZNF292 zinc finger protein 292 0.0540994
BIRC6 baculoviral IAP repeat containing 6 0.0540372
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0520222
ANO1 anoctamin 1, calcium activated chloride channel 0.0513529
MACF1 microtubule-actin crosslinking factor 1 0.0509959
JMJD1C jumonji domain containing 1C 0.0492469
DIAPH3 diaphanous-related formin 3 0.0488934
UBA6 ubiquitin-like modifier activating enzyme 6 0.0485146
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0473248
ARF4 ADP-ribosylation factor 4 0.0472559
RBM39 RNA binding motif protein 39 0.0468041
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0466999
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0461801
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0459006
PDGFA platelet-derived growth factor alpha polypeptide 0.0456551
MED13 mediator complex subunit 13 0.0455466
SBF2 SET binding factor 2 0.0451829
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0447279
FRMD5 FERM domain containing 5 0.0447246
NF1 neurofibromin 1 0.0446272
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0442653
MSN moesin 0.0441655
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.044011
ATXN1 ataxin 1 0.0439876
COG5 component of oligomeric golgi complex 5 0.04396
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0433415
TRIO trio Rho guanine nucleotide exchange factor 0.0428486
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0422488
RUNX1 runt-related transcription factor 1 0.0421746
SNX9 sorting nexin 9 0.0420564
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0411511
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.041123
KDM6A lysine (K)-specific demethylase 6A 0.040199
KMT2E lysine (K)-specific methyltransferase 2E 0.039795
PIBF1 progesterone immunomodulatory binding factor 1 0.039748
CCNL1 cyclin L1 0.0395686
FNIP1 folliculin interacting protein 1 0.0393311
ZBTB20 zinc finger and BTB domain containing 20 0.0391963
TNIK TRAF2 and NCK interacting kinase 0.0388991
AKAP13 A kinase (PRKA) anchor protein 13 0.0385439
DLG1 discs, large homolog 1 (Drosophila) 0.038299
MBNL1 muscleblind-like splicing regulator 1 0.0382537
VMP1 vacuole membrane protein 1 0.0375351
KMT2C lysine (K)-specific methyltransferase 2C 0.0375198
PTBP3 polypyrimidine tract binding protein 3 0.0373232
KRT8 keratin 8, type II 0.0372982
RTN4 reticulon 4 0.037169
SRPK2 SRSF protein kinase 2 0.0371072
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0368296
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0364518
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0362363
NUP58 nucleoporin 58 0.0357848
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0353527
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0352554
FXR1 fragile X mental retardation, autosomal homolog 1 0.0351372
TMCC1 transmembrane and coiled-coil domain family 1 0.0350328
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0346853
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0344973
OSBPL3 oxysterol binding protein-like 3 0.0344768
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.03437
TRA2B transformer 2 beta homolog (Drosophila) 0.0343598
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0343489
ITCH itchy E3 ubiquitin protein ligase 0.0342462
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0341375
MED13L mediator complex subunit 13-like 0.0338404
ZNF638 zinc finger protein 638 0.0335066
BACE2 beta-site APP-cleaving enzyme 2 0.0333052
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0325102
ARHGAP26 Rho GTPase activating protein 26 0.0324436
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0321464
IPO7 importin 7 0.0321385
SFPQ splicing factor proline/glutamine-rich 0.0321168
HELZ helicase with zinc finger 0.0319896
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0319715
ZFP36L1 ZFP36 ring finger protein-like 1 0.0319312

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.182702
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113811
TMSB10 thymosin beta 10 -0.104862
RPL35A ribosomal protein L35a -0.0751034
RPS6 ribosomal protein S6 -0.0605233
MT2A metallothionein 2A -0.0588096
RPS19 ribosomal protein S19 -0.0517512
RPS3 ribosomal protein S3 -0.0477392
RPL19 ribosomal protein L19 -0.0417331
RPL32 ribosomal protein L32 -0.0399404
RPL12 ribosomal protein L12 -0.0370569
AOPEP aminopeptidase O (putative) -0.0365481
RPL36A ribosomal protein L36a -0.0357349
RPL23 ribosomal protein L23 -0.0356306
RPL11 ribosomal protein L11 -0.0354257
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0344778
RPLP1 ribosomal protein, large, P1 -0.0327778
RPL34 ribosomal protein L34 -0.0327061
RPS8 ribosomal protein S8 -0.0315003
RPL31 ribosomal protein L31 -0.0312763
RPL38 ribosomal protein L38 -0.0305646
RPLP2 ribosomal protein, large, P2 -0.0304805
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0298258
RPS29 ribosomal protein S29 -0.0290128
RPL9 ribosomal protein L9 -0.0288574
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0286375
RPL5 ribosomal protein L5 -0.0272676
RACK1 receptor for activated C kinase 1 -0.0268455
RPL13A ribosomal protein L13a -0.0264552
RPS11 ribosomal protein S11 -0.0261294
RPS4X ribosomal protein S4, X-linked -0.0255195
FTL ferritin, light polypeptide -0.025288
SEC61G Sec61 gamma subunit -0.0252201
PCLO piccolo presynaptic cytomatrix protein -0.0249669
ENO1 enolase 1, (alpha) -0.0244197
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0243042
RPS13 ribosomal protein S13 -0.0242865
RPS24 ribosomal protein S24 -0.0232233
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0231003
PROX1 prospero homeobox 1 -0.0228069
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0225077
SYK spleen tyrosine kinase -0.0220546
RPS27A ribosomal protein S27a -0.021774
RPL8 ribosomal protein L8 -0.0208167
RPL36 ribosomal protein L36 -0.0206926
SYT1 synaptotagmin I -0.0202617
SOX4 SRY (sex determining region Y)-box 4 -0.019423
ACTN4 actinin, alpha 4 -0.0192591
RPL35 ribosomal protein L35 -0.0190581
RRBP1 ribosome binding protein 1 -0.0187054
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0186333
RPL26 ribosomal protein L26 -0.0185392
RPS21 ribosomal protein S21 -0.0185361
RPS23 ribosomal protein S23 -0.018319
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0178716
RPS14 ribosomal protein S14 -0.0177295
RPL7A ribosomal protein L7a -0.0176092
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0173419
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0173094
EEF2 eukaryotic translation elongation factor 2 -0.0171552
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0171549
RPS25 ribosomal protein S25 -0.0168696
UBB ubiquitin B -0.0168233
LOC102724023 ES1 protein homolog, mitochondrial -0.0168179
BMP5 bone morphogenetic protein 5 -0.016226
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0162072
RPL37 ribosomal protein L37 -0.0160306
RPS27 ribosomal protein S27 -0.0159191
RPS16 ribosomal protein S16 -0.0155703
SLC38A1 solute carrier family 38, member 1 -0.0150366
RPL18 ribosomal protein L18 -0.0150092
TPT1 tumor protein, translationally-controlled 1 -0.0149124
IER3 immediate early response 3 -0.0148553
RPL4 ribosomal protein L4 -0.0146192
RPS5 ribosomal protein S5 -0.0145885
RHOBTB3 Rho-related BTB domain containing 3 -0.0145613
RPS15 ribosomal protein S15 -0.0141734
RPL28 ribosomal protein L28 -0.0140811
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0139266
OXR1 oxidation resistance 1 -0.0139141
GARS1 glycyl-tRNA synthetase 1 -0.0138427
ACTG1 actin gamma 1 -0.0137734
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.013771
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0137344
MT1X metallothionein 1X -0.0136574
SPATA13 spermatogenesis associated 13 -0.0135272
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.013281
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0131611
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0130577
TNS3 tensin 3 -0.0129625
NDUFA4 NDUFA4, mitochondrial complex associated -0.0128252
ATP5F1E ATP synthase F1 subunit epsilon -0.0128028
FOXP1 forkhead box P1 -0.0127345
H1-0 H1.0 linker histone -0.0126573
RPL7 ribosomal protein L7 -0.0126343
RPL37A ribosomal protein L37a -0.0126189
EGR1 early growth response 1 -0.0124976
IGF2R insulin-like growth factor 2 receptor -0.0124963
STARD7 StAR-related lipid transfer (START) domain containing 7 -0.0124352
RAD21 RAD21 homolog (S. pombe) -0.012412