Entecavir (monohydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entecavir (monohydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Entecavir (monohydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INHBA inhibin, beta A 0.106525
SOD2 superoxide dismutase 2, mitochondrial 0.0842898
SPAG9 sperm associated antigen 9 0.0757138
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0653286
FAM13A family with sequence similarity 13, member A 0.0628414
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0627472
GOLGA4 golgin A4 0.0580054
TRIO trio Rho guanine nucleotide exchange factor 0.0561248
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.055771
FMNL2 formin-like 2 0.0523685
ARHGAP21 Rho GTPase activating protein 21 0.0519909
FNDC3B fibronectin type III domain containing 3B 0.0499262
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0496553
ELL2 elongation factor, RNA polymerase II, 2 0.049173
HELZ helicase with zinc finger 0.0436637
TTC3 tetratricopeptide repeat domain 3 0.0422583
STC1 stanniocalcin 1 0.0418522
ZNF292 zinc finger protein 292 0.0413767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0412915
UBA6 ubiquitin-like modifier activating enzyme 6 0.041245
NUP58 nucleoporin 58 0.0400759
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0395429
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0393419
COPA coatomer protein complex, subunit alpha 0.0366271
POTEF POTE ankyrin domain family, member F 0.0366231
ADAM9 ADAM metallopeptidase domain 9 0.0365455
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0361588
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0358929
ATP13A3 ATPase type 13A3 0.0358593
RASA2 RAS p21 protein activator 2 0.0344702
SEC24D SEC24 family member D 0.0338112
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0335088
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.032786
SUCO SUN domain containing ossification factor 0.0327589
USP3 ubiquitin specific peptidase 3 0.0325552
TFPI2 tissue factor pathway inhibitor 2 0.032377
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0322655
WAC WW domain containing adaptor with coiled-coil 0.0322418
TFG TRK-fused gene 0.0319648
SEC31A SEC31 homolog A (S. cerevisiae) 0.031525
CLINT1 clathrin interactor 1 0.031479
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.031405
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0305622
RAB1A RAB1A, member RAS oncogene family 0.0304389
SETD5 SET domain containing 5 0.0302969
OGA O-GlcNAcase 0.0300161
NAMPT nicotinamide phosphoribosyltransferase 0.029018
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289148
GPHN gephyrin 0.0288473
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0285262
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0282512
PICALM phosphatidylinositol binding clathrin assembly protein 0.027895
FNIP1 folliculin interacting protein 1 0.027847
ZCCHC7 zinc finger, CCHC domain containing 7 0.0275845
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0272032
MMP12 matrix metallopeptidase 12 0.0270576
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.026353
NBEAL1 neurobeachin-like 1 0.0262238
DSCAM Down syndrome cell adhesion molecule 0.0258574
NKTR natural killer cell triggering receptor 0.0258263
NBAS neuroblastoma amplified sequence 0.025813
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0257172
PDIA3 protein disulfide isomerase family A, member 3 0.0256401
RBM39 RNA binding motif protein 39 0.0256322
NGLY1 N-glycanase 1 0.0254955
ANXA5 annexin A5 0.0254515
TMEM263 transmembrane protein 263 0.0248978
NAV2 neuron navigator 2 0.0248165
JARID2 jumonji, AT rich interactive domain 2 0.0245823
MMP1 matrix metallopeptidase 1 0.0240913
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0240641
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0237968
COG6 component of oligomeric golgi complex 6 0.0237933
TMF1 TATA element modulatory factor 1 0.0235689
GREM1 gremlin 1, DAN family BMP antagonist 0.0233549
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0231097
CHD1 chromodomain helicase DNA binding protein 1 0.0230324
TMEM165 transmembrane protein 165 0.0229409
WDR43 WD repeat domain 43 0.0228812
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0227847
SRP54 signal recognition particle 54kDa 0.0227769
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0226373
CDC27 cell division cycle 27 0.0226145
RNF145 ring finger protein 145 0.0224168
SNX9 sorting nexin 9 0.0223891
BIRC6 baculoviral IAP repeat containing 6 0.0223384
SEC24A SEC24 family member A 0.0223288
CDC73 cell division cycle 73 0.0221941
UFM1 ubiquitin-fold modifier 1 0.0219596
LRRC49 leucine rich repeat containing 49 0.0219431
ELP2 elongator acetyltransferase complex subunit 2 0.021824
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.021556
CRY1 cryptochrome circadian clock 1 0.0214941
TBC1D23 TBC1 domain family, member 23 0.0212778
WDFY1 WD repeat and FYVE domain containing 1 0.0211106
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0210521
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0210251
KDM3A lysine (K)-specific demethylase 3A 0.0210145
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0209537
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0203982

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304189
COL6A3 collagen, type VI, alpha 3 -0.183855
FTL ferritin, light polypeptide -0.114073
VIM vimentin -0.0739101
MT2A metallothionein 2A -0.0722373
PRKG1 protein kinase, cGMP-dependent, type I -0.0692289
NALF1 NALCN channel auxiliary factor 1 -0.0685286
AKAP12 A kinase (PRKA) anchor protein 12 -0.0678391
TMSB10 thymosin beta 10 -0.0644242
ADGRB3 adhesion G protein-coupled receptor B3 -0.0620798
CD44 CD44 molecule (Indian blood group) -0.0586643
RPS19 ribosomal protein S19 -0.0566377
HMGA2 high mobility group AT-hook 2 -0.0550466
RPL35A ribosomal protein L35a -0.0550224
RPLP1 ribosomal protein, large, P1 -0.0541391
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0483577
FRMD4A FERM domain containing 4A -0.0462761
OXR1 oxidation resistance 1 -0.0457358
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0434451
RPS6 ribosomal protein S6 -0.0427079
EXT1 exostosin glycosyltransferase 1 -0.0424292
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0409865
EGFR epidermal growth factor receptor -0.0408097
EIF1 eukaryotic translation initiation factor 1 -0.0405325
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0390363
RPLP2 ribosomal protein, large, P2 -0.0384607
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0365121
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0359863
RPS13 ribosomal protein S13 -0.033836
GLIS3 GLIS family zinc finger 3 -0.0335142
COL1A2 collagen, type I, alpha 2 -0.0334633
RPL12 ribosomal protein L12 -0.0334235
RPS29 ribosomal protein S29 -0.0330556
ARHGAP24 Rho GTPase activating protein 24 -0.0314145
RPL23 ribosomal protein L23 -0.0310348
RPL35 ribosomal protein L35 -0.0303371
RAI14 retinoic acid induced 14 -0.0287641
RPL32 ribosomal protein L32 -0.0285788
RPL28 ribosomal protein L28 -0.028321
COL6A1 collagen, type VI, alpha 1 -0.028187
RPS27 ribosomal protein S27 -0.0280824
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0275464
AHNAK AHNAK nucleoprotein -0.0275037
EGR1 early growth response 1 -0.0272874
RPS3 ribosomal protein S3 -0.0272482
MYO10 myosin X -0.0265753
LOC112694756 uncharaterized LOC112694756 -0.0263432
NRP1 neuropilin 1 -0.0262795
RPL27 ribosomal protein L27 -0.0258357
SASH1 SAM and SH3 domain containing 1 -0.0257614
SMAD3 SMAD family member 3 -0.0253945
RPL19 ribosomal protein L19 -0.0251729
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0249543
COL5A3 collagen, type V, alpha 3 -0.0241991
IFITM3 interferon induced transmembrane protein 3 -0.0241866
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0229184
RPS23 ribosomal protein S23 -0.0225922
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0224203
SEPTIN11 septin 11 -0.0220965
RPL7 ribosomal protein L7 -0.0218692
RPL36 ribosomal protein L36 -0.0212356
RRBP1 ribosome binding protein 1 -0.0211678
NAV1 neuron navigator 1 -0.0209023
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0207954
RPS20 ribosomal protein S20 -0.0206818
RPS16 ribosomal protein S16 -0.0202663
CAV1 caveolin 1, caveolae protein, 22kDa -0.0197554
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0196971
ITGA11 integrin, alpha 11 -0.0193473
RPL11 ribosomal protein L11 -0.0191524
RPS10 ribosomal protein S10 -0.0187603
RPL27A ribosomal protein L27a -0.0185354
OAZ1 ornithine decarboxylase antizyme 1 -0.0183809
S100A9 S100 calcium binding protein A9 -0.0180287
PTMA prothymosin, alpha -0.017814
RPL38 ribosomal protein L38 -0.017766
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0177138
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0176279
PLPP3 phospholipid phosphatase 3 -0.017587
RPL8 ribosomal protein L8 -0.0174192
RPS15 ribosomal protein S15 -0.0171772
RPL13A ribosomal protein L13a -0.0170621
RPS17 ribosomal protein S17 -0.0169387
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.016857
TPI1 triosephosphate isomerase 1 -0.016849
COL5A1 collagen, type V, alpha 1 -0.0168152
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0165925
RPS5 ribosomal protein S5 -0.016567
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0165593
TXNIP thioredoxin interacting protein -0.0165105
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0160714
MAML2 mastermind-like 2 (Drosophila) -0.0160488
LOXL2 lysyl oxidase-like 2 -0.015904
SEC61G Sec61 gamma subunit -0.0156129
RPL31 ribosomal protein L31 -0.015582
PRR16 proline rich 16 -0.0154007
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0152993
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0152677
RPS21 ribosomal protein S21 -0.0151333
B2M beta-2-microglobulin -0.0150656