Entrectinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.126388
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0912968
PODXL podocalyxin-like 0.0737597
CD44 CD44 molecule (Indian blood group) 0.0675761
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.065612
NAV1 neuron navigator 1 0.0505907
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0466844
MAP1B microtubule-associated protein 1B 0.0408016
CENPF centromere protein F, 350/400kDa 0.0385751
FTH1 ferritin, heavy polypeptide 1 0.035095
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0321313
RUNX1 runt-related transcription factor 1 0.0271234
COL5A1 collagen, type V, alpha 1 0.0253327
VIM vimentin 0.025238
HDAC9 histone deacetylase 9 0.0244117
CDH13 cadherin 13 0.0241458
PLAT plasminogen activator, tissue 0.0234392
SMYD3 SET and MYND domain containing 3 0.0227776
C1D C1D nuclear receptor corepressor 0.0224074
RHOBTB3 Rho-related BTB domain containing 3 0.0223001
TPM3 tropomyosin 3 0.0219127
FNIP1 folliculin interacting protein 1 0.0217365
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0213885
SLC39A11 solute carrier family 39, member 11 0.0213637
FLNB filamin B, beta 0.021123
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0209066
MYH9 myosin, heavy chain 9, non-muscle 0.0205035
EGFR epidermal growth factor receptor 0.0204949
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0203801
MKI67 marker of proliferation Ki-67 0.0203523
NPC1 Niemann-Pick disease, type C1 0.0202564
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0198516
TIMP2 TIMP metallopeptidase inhibitor 2 0.0198058
MSN moesin 0.0189389
EFNA5 ephrin-A5 0.018271
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0181123
FLNA filamin A, alpha 0.0179782
PRELID2 PRELI domain containing 2 0.0177353
ITPRID2 ITPR interacting domain containing 2 0.0176442
SMC4 structural maintenance of chromosomes 4 0.0174072
MYO9A myosin IXA 0.0169846
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0168817
DIAPH3 diaphanous-related formin 3 0.0168557
GLS2 glutaminase 2 (liver, mitochondrial) 0.016814
VCL vinculin 0.0166422
PBX3 pre-B-cell leukemia homeobox 3 0.0162792
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0155219
APP amyloid beta (A4) precursor protein 0.0148652
SEPTIN9 septin 9 0.014657
FER fer (fps/fes related) tyrosine kinase 0.0144173
KIF14 kinesin family member 14 0.0142216
NFE2L1 nuclear factor, erythroid 2-like 1 0.0141833
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0141533
MYOF myoferlin 0.0140953
PRKCSH protein kinase C substrate 80K-H 0.0140794
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0139381
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0139373
SMAD3 SMAD family member 3 0.0139138
ANKRD36 ankyrin repeat domain 36 0.0137579
CKAP5 cytoskeleton associated protein 5 0.0137259
NOTCH2 notch 2 0.0137156
SUCNR1 succinate receptor 1 0.0135625
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0134824
SPDL1 spindle apparatus coiled-coil protein 1 0.0133895
TOX thymocyte selection-associated high mobility group box 0.0133506
PRPF8 pre-mRNA processing factor 8 0.0130534
DGKG diacylglycerol kinase, gamma 90kDa 0.0130191
E2F7 E2F transcription factor 7 0.0129489
TPX2 TPX2, microtubule-associated 0.0129028
DCLK2 doublecortin-like kinase 2 0.0127107
TUBB4B tubulin, beta 4B class IVb 0.0126412
FRMD4A FERM domain containing 4A 0.012496
FAM219A family with sequence similarity 219, member A 0.0124423
CHD3 chromodomain helicase DNA binding protein 3 0.0122632
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0121861
HSPA8 heat shock 70kDa protein 8 0.0120424
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0120324
CDK19 cyclin-dependent kinase 19 0.0119908
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0117604
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.011709
PRRC2C proline-rich coiled-coil 2C 0.0116919
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0115595
DSPP dentin sialophosphoprotein 0.0114519
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0114466
ANLN anillin, actin binding protein 0.0112966
SRRM2 serine/arginine repetitive matrix 2 0.0111944
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0110882
DCAF10 DDB1 and CUL4 associated factor 10 0.0110639
MYO19 myosin XIX 0.0110054
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0109701
FADS2 fatty acid desaturase 2 0.0109134
ANO6 anoctamin 6 0.0108492
MB21D2 Mab-21 domain containing 2 0.0107607
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0107219
CENPE centromere protein E, 312kDa 0.0106616
EIF4H eukaryotic translation initiation factor 4H 0.0106227
CAPN2 calpain 2, (m/II) large subunit 0.0106068
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0104939
CTSB cathepsin B 0.0103133
MCL1 myeloid cell leukemia 1 0.0102722

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.227199
AKAP12 A kinase (PRKA) anchor protein 12 -0.159028
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109678
TMSB10 thymosin beta 10 -0.107549
IGFBP3 insulin-like growth factor binding protein 3 -0.0968848
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0963746
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0958481
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0560655
CANX calnexin -0.0514714
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0502998
SOD2 superoxide dismutase 2, mitochondrial -0.0501286
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0499226
S100A6 S100 calcium binding protein A6 -0.0495342
COL8A1 collagen, type VIII, alpha 1 -0.0483832
UBC ubiquitin C -0.0450684
S100A10 S100 calcium binding protein A10 -0.0441519
NDRG1 N-myc downstream regulated 1 -0.040016
CALR calreticulin -0.0397552
LDHA lactate dehydrogenase A -0.0392692
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0383181
AUTS2 autism susceptibility candidate 2 -0.037906
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0372171
HILPDA hypoxia inducible lipid droplet-associated -0.0370763
MT2A metallothionein 2A -0.0361554
AHNAK AHNAK nucleoprotein -0.0352734
FBN1 fibrillin 1 -0.0352639
FNDC3B fibronectin type III domain containing 3B -0.0352528
WSB1 WD repeat and SOCS box containing 1 -0.0349339
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0338692
LMNA lamin A/C -0.032429
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0305325
SQSTM1 sequestosome 1 -0.0303565
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0300191
GARS1 glycyl-tRNA synthetase 1 -0.0280358
B2M beta-2-microglobulin -0.0280314
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0278454
PKM pyruvate kinase, muscle -0.0277852
RIGI RNA sensor RIG-I -0.0268082
SAMD9 sterile alpha motif domain containing 9 -0.0263599
HLA-E major histocompatibility complex, class I, E -0.0261981
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0253866
MEIS2 Meis homeobox 2 -0.0252166
PDIA3 protein disulfide isomerase family A, member 3 -0.0252144
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0248473
SPAG9 sperm associated antigen 9 -0.0245098
WTAP Wilms tumor 1 associated protein -0.024462
MXI1 MAX interactor 1, dimerization protein -0.0242801
NAV2 neuron navigator 2 -0.0240227
NAMPT nicotinamide phosphoribosyltransferase -0.0237885
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0237637
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0237204
JAZF1 JAZF zinc finger 1 -0.0236103
COL1A2 collagen, type I, alpha 2 -0.0234678
IFI16 interferon, gamma-inducible protein 16 -0.023207
ADM adrenomedullin -0.0229589
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226505
PGK1 phosphoglycerate kinase 1 -0.0225319
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0225304
PTMA prothymosin, alpha -0.02246
COL5A2 collagen, type V, alpha 2 -0.0222339
OGA O-GlcNAcase -0.021952
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0216316
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0215818
SP100 SP100 nuclear antigen -0.0213006
HLA-C major histocompatibility complex, class I, C -0.0211591
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0211567
RAB1A RAB1A, member RAS oncogene family -0.0211023
WDFY1 WD repeat and FYVE domain containing 1 -0.0210861
ADAM9 ADAM metallopeptidase domain 9 -0.020914
LMAN1 lectin, mannose-binding, 1 -0.0208981
MARCHF6 membrane associated ring-CH-type finger 6 -0.0208482
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0206281
CD99 CD99 molecule -0.0202134
IFIH1 interferon induced with helicase C domain 1 -0.0200931
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0196
GOLGA4 golgin A4 -0.019328
INSIG1 insulin induced gene 1 -0.0191197
MX2 MX dynamin-like GTPase 2 -0.0183063
WARS1 tryptophanyl-tRNA synthetase 1 -0.0182317
IFITM1 interferon induced transmembrane protein 1 -0.0180096
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0179778
PCGF5 polycomb group ring finger 5 -0.0174764
FGFR1 fibroblast growth factor receptor 1 -0.0174272
DDIT4 DNA-damage-inducible transcript 4 -0.0172821
SPNS2 spinster homolog 2 (Drosophila) -0.0172591
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0169948
RPL26 ribosomal protein L26 -0.0169476
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.016946
CCL5 chemokine (C-C motif) ligand 5 -0.0168583
ARL15 ADP-ribosylation factor-like 15 -0.016858
CCND1 cyclin D1 -0.0168125
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.016658
IFITM3 interferon induced transmembrane protein 3 -0.0166254
TPT1 tumor protein, translationally-controlled 1 -0.0165802
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -0.0165624
UGCG UDP-glucose ceramide glucosyltransferase -0.0164592
SDK1 sidekick cell adhesion molecule 1 -0.0164164
SH3KBP1 SH3-domain kinase binding protein 1 -0.0162688
PDIA6 protein disulfide isomerase family A, member 6 -0.0162602
WAC WW domain containing adaptor with coiled-coil -0.0161558