Entrectinib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.0585278
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0405141
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0341909
NHSL1 NHS-like 1 0.0249365
RPL7 ribosomal protein L7 0.0229533
NEBL nebulette 0.0221684
MGAT4C MGAT4 family, member C 0.0219274
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0215504
RPL21 ribosomal protein L21 0.0186737
KDM4C lysine (K)-specific demethylase 4C 0.0185711
ZBTB20 zinc finger and BTB domain containing 20 0.0183294
MBD5 methyl-CpG binding domain protein 5 0.0171718
FTH1 ferritin, heavy polypeptide 1 0.0162838
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0155872
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0149577
PRELID2 PRELI domain containing 2 0.0138721
CPOX coproporphyrinogen oxidase 0.0136384
AKAP13 A kinase (PRKA) anchor protein 13 0.0134323
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0130736
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.01297
WWOX WW domain containing oxidoreductase 0.0129175
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0124554
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0123484
TNRC6B trinucleotide repeat containing 6B 0.011993
TRAPPC9 trafficking protein particle complex 9 0.0119801
FASN fatty acid synthase 0.0116577
MAP2K4 mitogen-activated protein kinase kinase 4 0.0116073
RPL3 ribosomal protein L3 0.0115275
TBC1D5 TBC1 domain family, member 5 0.0111538
ZSWIM5 zinc finger, SWIM-type containing 5 0.0111474
ZNF292 zinc finger protein 292 0.0110701
EHBP1 EH domain binding protein 1 0.0109983
PNN pinin, desmosome associated protein 0.0106242
FBXL4 F-box and leucine-rich repeat protein 4 0.0104895
WDPCP WD repeat containing planar cell polarity effector 0.0101778
FAM162A family with sequence similarity 162, member A 0.00999991
CCSER1 coiled-coil serine-rich protein 1 0.00980851
VCAN versican 0.00973407
SET SET nuclear proto-oncogene 0.00963793
RIC1 RAB6A GEF complex partner 1 0.00961408
TLN1 talin 1 0.00951827
TMF1 TATA element modulatory factor 1 0.00924898
SFTPA2 surfactant protein A2 0.00923016
YIPF5 Yip1 domain family, member 5 0.00922385
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.00919868
HCFC1 host cell factor C1 0.00909759
KIF5C kinesin family member 5C 0.00890098
EIF4B eukaryotic translation initiation factor 4B 0.00882441
YEATS2 YEATS domain containing 2 0.00863868
CDC25C cell division cycle 25C 0.0085285
NFIA nuclear factor I/A 0.00852561
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.00851746
ATAD1 ATPase family, AAA domain containing 1 0.00849518
RPL27 ribosomal protein L27 0.00835111
POM121 POM121 transmembrane nucleoporin 0.00834077
KMT2D lysine (K)-specific methyltransferase 2D 0.00830136
RPL32 ribosomal protein L32 0.0082953
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.00827815
NDRG3 NDRG family member 3 0.00825487
SGCZ sarcoglycan, zeta 0.00816705
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.00812226
MAP1B microtubule-associated protein 1B 0.00801052
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.00800533
APLP2 amyloid beta (A4) precursor-like protein 2 0.00798574
MBD6 methyl-CpG binding domain protein 6 0.00798553
PPID peptidylprolyl isomerase D 0.00794997
CS citrate synthase 0.0079135
NCOR2 nuclear receptor corepressor 2 0.00789594
SPATA6 spermatogenesis associated 6 0.0078608
N4BP2L2 NEDD4 binding protein 2-like 2 0.00782787
SRSF9 serine/arginine-rich splicing factor 9 0.00781351
SPATS2 spermatogenesis associated, serine-rich 2 0.00778446
PATJ PATJ crumbs cell polarity complex component 0.00777679
MXI1 MAX interactor 1, dimerization protein 0.00776019
GYS1 glycogen synthase 1 (muscle) 0.00775673
FADS2 fatty acid desaturase 2 0.00775589
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.00772736
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.00771238
FGF14 fibroblast growth factor 14 0.00768594
HMGXB3 HMG box domain containing 3 0.00767271
EXOC6B exocyst complex component 6B 0.00759515
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00758977
ZFC3H1 zinc finger, C3H1-type containing 0.00753067
RNMT RNA (guanine-7-) methyltransferase 0.00751977
ERRFI1 ERBB receptor feedback inhibitor 1 0.00750384
EIF3L eukaryotic translation initiation factor 3, subunit L 0.00747511
IST1 increased sodium tolerance 1 homolog (yeast) 0.00747336
ZNF652 zinc finger protein 652 0.00746054
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.00742424
ASPH aspartate beta-hydroxylase 0.00741007
MAPK8 mitogen-activated protein kinase 8 0.0073945
PTPRF protein tyrosine phosphatase, receptor type, F 0.00738742
PNISR PNN-interacting serine/arginine-rich protein 0.00738594
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 0.00738584
BLTP1 bridge-like lipid transfer protein family member 1 0.00735215
FAM193A family with sequence similarity 193, member A 0.00730579
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.00729467
STC2 stanniocalcin 2 0.00726736
PMPCB peptidase (mitochondrial processing) beta 0.00726405
DHCR7 7-dehydrocholesterol reductase 0.00723515

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.228179
NLGN1 neuroligin 1 -0.152204
PDE4D phosphodiesterase 4D, cAMP-specific -0.10859
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0967517
MMP12 matrix metallopeptidase 12 -0.0949185
DST dystonin -0.086219
BIRC3 baculoviral IAP repeat containing 3 -0.0858012
TMSB10 thymosin beta 10 -0.0814657
CELF2 CUGBP, Elav-like family member 2 -0.0788942
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0772699
SLC38A2 solute carrier family 38, member 2 -0.0749135
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0699391
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0648989
DLC1 DLC1 Rho GTPase activating protein -0.0630306
ACTG1 actin gamma 1 -0.0582365
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0549883
TMEM41B transmembrane protein 41B -0.0479755
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0474595
ERBIN erbb2 interacting protein -0.0471784
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0471453
PCDH7 protocadherin 7 -0.0458912
DPYD dihydropyrimidine dehydrogenase -0.0442069
NAP1L1 nucleosome assembly protein 1-like 1 -0.0440428
YAP1 Yes-associated protein 1 -0.0436914
VIM vimentin -0.043539
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0421087
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0420431
ZNF804A zinc finger protein 804A -0.0402357
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0401706
ADGRG6 adhesion G protein-coupled receptor G6 -0.0399487
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0393201
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.03881
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0388095
MYPN myopalladin -0.0383449
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0372516
SMC4 structural maintenance of chromosomes 4 -0.0371998
TAS2R14 taste receptor, type 2, member 14 -0.0357708
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0356333
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0354464
EDARADD EDAR-associated death domain -0.0352387
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.034881
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0348406
SLC38A1 solute carrier family 38, member 1 -0.0344681
PTMA prothymosin, alpha -0.0343952
VMP1 vacuole membrane protein 1 -0.0341357
CMIP c-Maf inducing protein -0.0339256
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0338474
OSBPL8 oxysterol binding protein-like 8 -0.0333337
RPLP1 ribosomal protein, large, P1 -0.0325688
CCND1 cyclin D1 -0.032319
TMEM123 transmembrane protein 123 -0.0320494
MARCHF4 membrane associated ring-CH-type finger 4 -0.0312729
GJA1 gap junction protein, alpha 1, 43kDa -0.0309459
ATP5F1B ATP synthase F1 subunit beta -0.030849
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.030649
CDK17 cyclin-dependent kinase 17 -0.0305516
JMJD1C jumonji domain containing 1C -0.0305134
ZFAND3 zinc finger, AN1-type domain 3 -0.0305122
BIRC6 baculoviral IAP repeat containing 6 -0.0301415
HMGA2 high mobility group AT-hook 2 -0.0299481
BCHE butyrylcholinesterase -0.029927
SQSTM1 sequestosome 1 -0.0299041
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0297732
ECT2 epithelial cell transforming 2 -0.0292117
PUM2 pumilio RNA-binding family member 2 -0.0287348
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0282869
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0281981
RPL23 ribosomal protein L23 -0.0281943
CLDN1 claudin 1 -0.0281029
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0279538
PDGFC platelet derived growth factor C -0.027912
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0278464
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0277294
SETD5 SET domain containing 5 -0.0276804
RASAL2 RAS protein activator like 2 -0.0275728
LMO7 LIM domain 7 -0.0275118
HDAC9 histone deacetylase 9 -0.0274309
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0273067
NCEH1 neutral cholesterol ester hydrolase 1 -0.0268607
FBXO11 F-box protein 11 -0.0268209
ADIPOR2 adiponectin receptor 2 -0.0267441
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0267247
WAC WW domain containing adaptor with coiled-coil -0.0266605
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0264792
RAB1A RAB1A, member RAS oncogene family -0.026427
LPP LIM domain containing preferred translocation partner in lipoma -0.0264082
TGM2 transglutaminase 2 -0.0263036
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0262713
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0261855
YBX3 Y box binding protein 3 -0.0260142
CDK6 cyclin-dependent kinase 6 -0.0256579
MKI67 marker of proliferation Ki-67 -0.0255852
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0253598
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0251812
MED13L mediator complex subunit 13-like -0.0250075
FNDC3B fibronectin type III domain containing 3B -0.0249868
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0249396
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0249289
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0246252
AFF4 AF4/FMR2 family, member 4 -0.0245122