Entrectinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0778243
PTBP3 polypyrimidine tract binding protein 3 0.0456285
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0367837
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0337368
RNF43 ring finger protein 43 0.0319776
FTH1 ferritin, heavy polypeptide 1 0.0312009
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0294194
NRIP1 nuclear receptor interacting protein 1 0.029021
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0268435
IFNGR1 interferon gamma receptor 1 0.0268376
YAP1 Yes-associated protein 1 0.0249315
RAD51B RAD51 paralog B 0.0244202
STK24 serine/threonine kinase 24 0.0236606
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0231531
PRKG1 protein kinase, cGMP-dependent, type I 0.0223835
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0219199
TMEM62 transmembrane protein 62 0.0213491
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0210152
SPRED1 sprouty-related, EVH1 domain containing 1 0.0208691
CD46 CD46 molecule, complement regulatory protein 0.0203096
PDZD8 PDZ domain containing 8 0.0203003
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0200474
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0197654
CERS6 ceramide synthase 6 0.0194735
VCL vinculin 0.0179963
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0177803
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0177197
ETNK1 ethanolamine kinase 1 0.0175562
ABHD2 abhydrolase domain containing 2 0.0173431
GSK3B glycogen synthase kinase 3 beta 0.0172576
NCKAP5 NCK-associated protein 5 0.0168041
SERINC5 serine incorporator 5 0.0164499
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0161725
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0155522
ATP10B ATPase, class V, type 10B 0.0150922
FAT1 FAT atypical cadherin 1 0.0150789
SP3 Sp3 transcription factor 0.0150585
DST dystonin 0.0150068
PRELID2 PRELI domain containing 2 0.0148422
MYH9 myosin, heavy chain 9, non-muscle 0.014686
ARGLU1 arginine and glutamate rich 1 0.0145838
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0145577
ZSWIM5 zinc finger, SWIM-type containing 5 0.0145093
ZBTB20 zinc finger and BTB domain containing 20 0.0144761
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.014406
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0138198
USP54 ubiquitin specific peptidase 54 0.0137024
TC2N tandem C2 domains, nuclear 0.0134306
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0133709
NCOA2 nuclear receptor coactivator 2 0.0133337
FAAH2 fatty acid amide hydrolase 2 0.0130978
BICRAL BICRA like chromatin remodeling complex associated protein 0.0129631
SH3RF1 SH3 domain containing ring finger 1 0.0126481
H1-0 H1.0 linker histone 0.0126132
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0124542
PTK2 protein tyrosine kinase 2 0.0123786
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0122923
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0122882
BCL2L1 BCL2-like 1 0.0121893
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0121601
FRK fyn-related Src family tyrosine kinase 0.0120315
ZDHHC20 zinc finger, DHHC-type containing 20 0.0119569
SCAPER S-phase cyclin A-associated protein in the ER 0.0119303
DENND4C DENN/MADD domain containing 4C 0.0119227
SREBF1 sterol regulatory element binding transcription factor 1 0.0118693
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0114773
PANK3 pantothenate kinase 3 0.0114303
WDFY3 WD repeat and FYVE domain containing 3 0.0112766
SORBS1 sorbin and SH3 domain containing 1 0.0110739
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0110599
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0108817
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0108625
PEX7 peroxisomal biogenesis factor 7 0.0107609
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0105587
ZFP36 ZFP36 ring finger protein 0.0104339
ANXA11 annexin A11 0.0104121
RFX7 regulatory factor X, 7 0.0104077
KDM6A lysine (K)-specific demethylase 6A 0.0102973
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0102936
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0102835
AOPEP aminopeptidase O (putative) 0.0100092
NDFIP2 Nedd4 family interacting protein 2 0.00998633
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.00995947
FKBP9 FK506 binding protein 9, 63 kDa 0.00971832
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 0.0095761
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.00935541
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.00932165
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00930536
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.00928724
BRWD3 bromodomain and WD repeat domain containing 3 0.00928125
UTRN utrophin 0.0092347
FBXL17 F-box and leucine-rich repeat protein 17 0.00922421
MARCHF7 membrane associated ring-CH-type finger 7 0.00920063
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.00918301
PHC2 polyhomeotic homolog 2 (Drosophila) 0.00912403
TMEM51 transmembrane protein 51 0.00906982
SRRM2 serine/arginine repetitive matrix 2 0.00897628
LPIN1 lipin 1 0.0089638
MALT1 MALT1 paracaspase 0.00895683
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00891963

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.192035
B2M beta-2-microglobulin -0.183055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.166754
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150419
PTMA prothymosin, alpha -0.113109
LMO7 LIM domain 7 -0.109173
HLA-B major histocompatibility complex, class I, B -0.107422
LCN2 lipocalin 2 -0.0984936
SQSTM1 sequestosome 1 -0.087419
EZR ezrin -0.0837855
ANXA2 annexin A2 -0.0798526
PKM pyruvate kinase, muscle -0.075259
EGR1 early growth response 1 -0.0733506
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0714714
RNF213 ring finger protein 213 -0.0676273
MBNL2 muscleblind-like splicing regulator 2 -0.0664164
CALR calreticulin -0.0658829
CANX calnexin -0.0651987
AHI1 Abelson helper integration site 1 -0.0649394
GCLC glutamate-cysteine ligase, catalytic subunit -0.063343
FTL ferritin, light polypeptide -0.0633041
EIF1 eukaryotic translation initiation factor 1 -0.0605212
RPS6 ribosomal protein S6 -0.0597632
PERP PERP, TP53 apoptosis effector -0.059754
RPL35A ribosomal protein L35a -0.0597287
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0594405
IFI6 interferon, alpha-inducible protein 6 -0.058409
INTS6 integrator complex subunit 6 -0.05771
EPSTI1 epithelial stromal interaction 1 (breast) -0.0569221
IRF1 interferon regulatory factor 1 -0.0562204
RAB7A RAB7A, member RAS oncogene family -0.0560989
NDRG1 N-myc downstream regulated 1 -0.0553324
MORF4L2 mortality factor 4 like 2 -0.0550111
TMSB10 thymosin beta 10 -0.0542037
STAT1 signal transducer and activator of transcription 1, 91kDa -0.054054
GMDS GDP-mannose 4,6-dehydratase -0.0533642
RPLP1 ribosomal protein, large, P1 -0.0531796
RPL23 ribosomal protein L23 -0.0525057
RRBP1 ribosome binding protein 1 -0.0512629
SEC31A SEC31 homolog A (S. cerevisiae) -0.0507406
RPL34 ribosomal protein L34 -0.050652
UBC ubiquitin C -0.0501838
LYZ lysozyme -0.0501299
HLA-E major histocompatibility complex, class I, E -0.0493982
PDIA3 protein disulfide isomerase family A, member 3 -0.04866
SP100 SP100 nuclear antigen -0.0481966
LOC102724023 ES1 protein homolog, mitochondrial -0.0473429
HLA-C major histocompatibility complex, class I, C -0.0472229
RIGI RNA sensor RIG-I -0.0468613
ACTG1 actin gamma 1 -0.0465905
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0464741
GOLGB1 golgin B1 -0.0457646
S100A6 S100 calcium binding protein A6 -0.0455359
MX2 MX dynamin-like GTPase 2 -0.0453334
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0433925
S100A10 S100 calcium binding protein A10 -0.0430067
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0424763
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0422764
RAB1A RAB1A, member RAS oncogene family -0.0416648
IFI27 interferon, alpha-inducible protein 27 -0.040973
ENO1 enolase 1, (alpha) -0.0398216
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0389429
RPL19 ribosomal protein L19 -0.0389303
HLA-A major histocompatibility complex, class I, A -0.0388946
C6ORF132 chromosome 6 open reading frame 132 -0.0380516
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.038045
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0377883
RPS8 ribosomal protein S8 -0.0377019
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0376947
RPS24 ribosomal protein S24 -0.0373524
ITGA6 integrin, alpha 6 -0.0369635
GOLGA4 golgin A4 -0.0364786
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0354568
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0353121
WDR45B WD repeat domain 45B -0.0352923
UGDH UDP-glucose 6-dehydrogenase -0.0348138
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0345915
RPS19 ribosomal protein S19 -0.0344538
TTC3 tetratricopeptide repeat domain 3 -0.0340359
RPL26 ribosomal protein L26 -0.0336047
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0332599
PRRC2C proline-rich coiled-coil 2C -0.032584
RPL31 ribosomal protein L31 -0.0325784
HM13 histocompatibility (minor) 13 -0.0322924
MYO1E myosin IE -0.0321326
MX1 MX dynamin-like GTPase 1 -0.0320376
TSC22D1 TSC22 domain family, member 1 -0.0319106
ARF1 ADP-ribosylation factor 1 -0.0314911
HDLBP high density lipoprotein binding protein -0.0313985
EPHB2 EPH receptor B2 -0.0312314
SPDYA speedy/RINGO cell cycle regulator family member A -0.0312142
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.031205
KDM3A lysine (K)-specific demethylase 3A -0.0311812
AREG amphiregulin -0.0311756
FUS FUS RNA binding protein -0.0310832
VDAC1 voltage-dependent anion channel 1 -0.030998
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0307303
RPL12 ribosomal protein L12 -0.030528
MT2A metallothionein 2A -0.0303021