| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Entrectinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Entrectinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.367413 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0966439 |
| C3 | complement component 3 | 0.0946566 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0815505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0521533 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0372364 |
| RPL3 | ribosomal protein L3 | 0.0296534 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0282511 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0268336 |
| ZFP36 | ZFP36 ring finger protein | 0.0268249 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.025098 |
| TNS1 | tensin 1 | 0.0243709 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0242655 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0239381 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0238388 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0230416 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0223021 |
| SVIL | supervillin | 0.0221754 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0217853 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0216379 |
| TCIM | transcriptional and immune response regulator | 0.0209047 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0202693 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0193842 |
| RTN4 | reticulon 4 | 0.0192795 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | 0.0182741 |
| VEGFA | vascular endothelial growth factor A | 0.0182028 |
| FNIP1 | folliculin interacting protein 1 | 0.0178711 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0176434 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0172218 |
| EGR1 | early growth response 1 | 0.0172113 |
| CENPF | centromere protein F, 350/400kDa | 0.0163725 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0162584 |
| BCL2L1 | BCL2-like 1 | 0.0162021 |
| TOP1 | topoisomerase (DNA) I | 0.01612 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0159476 |
| MKI67 | marker of proliferation Ki-67 | 0.01592 |
| ORM1 | orosomucoid 1 | 0.0155556 |
| RHOB | ras homolog family member B | 0.0150422 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.014841 |
| VCAN | versican | 0.0147385 |
| CRY1 | cryptochrome circadian clock 1 | 0.014657 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0144046 |
| NDRG1 | N-myc downstream regulated 1 | 0.0143768 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0142914 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0139718 |
| DSPP | dentin sialophosphoprotein | 0.0128348 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0123638 |
| LMO7 | LIM domain 7 | 0.0123155 |
| SYF2 | SYF2 pre-mRNA-splicing factor | 0.0122984 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0122838 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0121693 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0117027 |
| PLXDC2 | plexin domain containing 2 | 0.011642 |
| STK38L | serine/threonine kinase 38 like | 0.01151 |
| PAPOLA | poly(A) polymerase alpha | 0.0113845 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0113438 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0111561 |
| ITGAV | integrin, alpha V | 0.0110826 |
| IFNGR1 | interferon gamma receptor 1 | 0.0109393 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0107428 |
| STK35 | serine/threonine kinase 35 | 0.0106721 |
| FAF2 | Fas associated factor family member 2 | 0.0106371 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | 0.0106327 |
| KIF13B | kinesin family member 13B | 0.0105988 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0104812 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0104664 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0104566 |
| SLC1A2 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | 0.0104534 |
| ANXA5 | annexin A5 | 0.0103143 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0102449 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.0102336 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0101325 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0101133 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.00998296 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.00997481 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | 0.00990816 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.00977642 |
| A1CF | APOBEC1 complementation factor | 0.00969915 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.00967718 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.00966934 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.00963597 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.00942943 |
| KYNU | kynureninase | 0.00940177 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | 0.00935081 |
| CRLS1 | cardiolipin synthase 1 | 0.00930287 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.00925178 |
| FRK | fyn-related Src family tyrosine kinase | 0.00923473 |
| MTX2 | metaxin 2 | 0.00923001 |
| SKIL | SKI-like proto-oncogene | 0.00909778 |
| NSMAF | neutral sphingomyelinase (N-SMase) activation associated factor | 0.00906221 |
| CLIC1 | chloride intracellular channel 1 | 0.00903972 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.00897982 |
| FZD5 | frizzled class receptor 5 | 0.00896306 |
| PRXL2A | peroxiredoxin like 2A | 0.00892214 |
| FAXDC2 | fatty acid hydroxylase domain containing 2 | 0.00878268 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0087673 |
| PRELID2 | PRELI domain containing 2 | 0.00868614 |
| IL17RB | interleukin 17 receptor B | 0.00868344 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 0.008683 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.00867804 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.15342 |
| MT2A | metallothionein 2A | -0.108348 |
| GPC3 | glypican 3 | -0.0955537 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0851138 |
| EHBP1 | EH domain binding protein 1 | -0.0825522 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0822418 |
| GPC6 | glypican 6 | -0.0815678 |
| ENO1 | enolase 1, (alpha) | -0.0799586 |
| AHSG | alpha-2-HS-glycoprotein | -0.0757105 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0755753 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.075229 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0742856 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0692007 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0688984 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0681034 |
| GNAS | GNAS complex locus | -0.0627709 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.062668 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0611989 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.060742 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0596005 |
| TMEM123 | transmembrane protein 123 | -0.0589999 |
| RBM39 | RNA binding motif protein 39 | -0.0578586 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0571901 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0545809 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0538494 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0513589 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0513326 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0512074 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0507537 |
| TF | transferrin | -0.0496651 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0490209 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0488282 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0470438 |
| RPS24 | ribosomal protein S24 | -0.046839 |
| APOE | apolipoprotein E | -0.0454264 |
| TRIM26 | tripartite motif containing 26 | -0.0445944 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0445827 |
| RPS6 | ribosomal protein S6 | -0.0440156 |
| PEG3 | paternally expressed 3 | -0.0434025 |
| RPL5 | ribosomal protein L5 | -0.0420563 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0418299 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0415116 |
| NPAS2 | neuronal PAS domain protein 2 | -0.041419 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0407571 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0392962 |
| RPS8 | ribosomal protein S8 | -0.0392062 |
| PARD3 | par-3 family cell polarity regulator | -0.0391459 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0390221 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0387536 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0379991 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.037959 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0378332 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0376761 |
| TMSB10 | thymosin beta 10 | -0.0374042 |
| RPL23 | ribosomal protein L23 | -0.0364143 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0363161 |
| ITGA1 | integrin, alpha 1 | -0.0360953 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0359151 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0358001 |
| WDR45B | WD repeat domain 45B | -0.0355443 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0354693 |
| FRMD5 | FERM domain containing 5 | -0.0348112 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0341507 |
| FAM135A | family with sequence similarity 135, member A | -0.0335117 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.032503 |
| LYZ | lysozyme | -0.032486 |
| LDHA | lactate dehydrogenase A | -0.0321182 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.031822 |
| MSI2 | musashi RNA-binding protein 2 | -0.0317615 |
| RPL35A | ribosomal protein L35a | -0.0316801 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0316711 |
| CANX | calnexin | -0.031559 |
| FN1 | fibronectin 1 | -0.031091 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0310492 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0308156 |
| GK | glycerol kinase | -0.0305101 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0301278 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0298251 |
| RPL37A | ribosomal protein L37a | -0.0294744 |
| CP | ceruloplasmin (ferroxidase) | -0.0294005 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0291979 |
| USP34 | ubiquitin specific peptidase 34 | -0.0291094 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0290849 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0289487 |
| RPLP1 | ribosomal protein, large, P1 | -0.0288639 |
| FTL | ferritin, light polypeptide | -0.0284316 |
| FMNL2 | formin-like 2 | -0.0282089 |
| PGK1 | phosphoglycerate kinase 1 | -0.0281801 |
| CCNY | cyclin Y | -0.0281149 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0279126 |
| RNF213 | ring finger protein 213 | -0.0278919 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0278815 |
| SDC4 | syndecan 4 | -0.0278447 |
| DST | dystonin | -0.0276814 |
| HELZ | helicase with zinc finger | -0.0276665 |
| NHSL1 | NHS-like 1 | -0.0275796 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0273233 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0272815 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.027256 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0272232 |
