Entrectinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.168848
FTH1 ferritin, heavy polypeptide 1 0.0910548
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0887618
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0663617
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0590979
INSIG1 insulin induced gene 1 0.0552748
GPHN gephyrin 0.0426797
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0388957
FTL ferritin, light polypeptide 0.0345707
RPL12 ribosomal protein L12 0.0327941
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0318718
S100P S100 calcium binding protein P 0.0284722
RNF43 ring finger protein 43 0.0279849
ABHD2 abhydrolase domain containing 2 0.027913
H1-0 H1.0 linker histone 0.0277866
AREG amphiregulin 0.0265815
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0262402
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0253094
RPL7 ribosomal protein L7 0.0240756
RNF145 ring finger protein 145 0.0236833
CLDN4 claudin 4 0.0233873
TRIM2 tripartite motif containing 2 0.0233507
FDPS farnesyl diphosphate synthase 0.0227682
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0221645
RPL11 ribosomal protein L11 0.0219998
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0219628
EEF2 eukaryotic translation elongation factor 2 0.0214833
PCDHB16 protocadherin beta 16 0.0213655
RPL3 ribosomal protein L3 0.0211692
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0211427
EIF1 eukaryotic translation initiation factor 1 0.0209674
CD46 CD46 molecule, complement regulatory protein 0.0206376
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0203717
CEMIP2 cell migration inducing hyaluronidase 2 0.0202795
CD44 CD44 molecule (Indian blood group) 0.0202386
PTPRR protein tyrosine phosphatase, receptor type, R 0.0200216
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0198649
RPL32 ribosomal protein L32 0.0192536
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0192441
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0183487
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0183343
TXNIP thioredoxin interacting protein 0.018053
RPL21 ribosomal protein L21 0.0179447
PRELID2 PRELI domain containing 2 0.0177702
VEGFA vascular endothelial growth factor A 0.0177486
MUC13 mucin 13, cell surface associated 0.0176819
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.017614
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0174965
PTEN phosphatase and tensin homolog 0.0174036
MSMO1 methylsterol monooxygenase 1 0.0173085
RPS19 ribosomal protein S19 0.0171406
RPS3 ribosomal protein S3 0.0169778
DDIT4 DNA-damage-inducible transcript 4 0.0163679
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0163563
ZFP36 ZFP36 ring finger protein 0.0162516
RPS23 ribosomal protein S23 0.0161383
RPL19 ribosomal protein L19 0.0159299
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0157443
RACK1 receptor for activated C kinase 1 0.0155906
DSCAM Down syndrome cell adhesion molecule 0.0154635
RPL18 ribosomal protein L18 0.0153351
VMP1 vacuole membrane protein 1 0.0150028
LOC102724023 ES1 protein homolog, mitochondrial 0.0149097
PLS1 plastin 1 0.0148827
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0148663
RPL36 ribosomal protein L36 0.0148544
SOX9 SRY (sex determining region Y)-box 9 0.0147548
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0147048
RPL8 ribosomal protein L8 0.0146491
GSTP1 glutathione S-transferase pi 1 0.0145517
CLIC1 chloride intracellular channel 1 0.0141734
LGALS4 lectin, galactoside-binding, soluble, 4 0.0141717
NDRG1 N-myc downstream regulated 1 0.0141429
RPS8 ribosomal protein S8 0.0141393
S100A14 S100 calcium binding protein A14 0.0141327
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0138875
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0136544
EGR1 early growth response 1 0.0135543
TNS4 tensin 4 0.0134025
PCBP2 poly(rC) binding protein 2 0.0133506
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0131819
RPL28 ribosomal protein L28 0.0131545
PTBP3 polypyrimidine tract binding protein 3 0.0129973
PFN1 profilin 1 0.0127581
ATF4 activating transcription factor 4 0.012609
CEMIP cell migration inducing protein, hyaluronan binding 0.012602
RPL13A ribosomal protein L13a 0.0123389
RPS14 ribosomal protein S14 0.0122926
TXNRD1 thioredoxin reductase 1 0.0122541
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0122113
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0119221
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0119165
AKAP9 A kinase (PRKA) anchor protein 9 0.0118035
CDK19 cyclin-dependent kinase 19 0.0117716
APLP2 amyloid beta (A4) precursor-like protein 2 0.0116563
RPS11 ribosomal protein S11 0.011291
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0112076
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0110521
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0110389
KRT19 keratin 19, type I 0.0108931

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113423
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0997763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0754598
NPSR1 neuropeptide S receptor 1 -0.0738109
PTMA prothymosin, alpha -0.064127
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0539818
NALF1 NALCN channel auxiliary factor 1 -0.052505
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0513604
TPT1 tumor protein, translationally-controlled 1 -0.0495117
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0491418
ACTG1 actin gamma 1 -0.0443213
TPM4 tropomyosin 4 -0.0429812
FLNB filamin B, beta -0.0406375
GREB1L growth regulation by estrogen in breast cancer-like -0.0392446
ALCAM activated leukocyte cell adhesion molecule -0.0386562
ANTXR2 anthrax toxin receptor 2 -0.0377413
ANXA2 annexin A2 -0.0372508
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.037057
AHNAK AHNAK nucleoprotein -0.0341049
SLC35F3 solute carrier family 35, member F3 -0.0330322
ONECUT3 one cut homeobox 3 -0.0327968
RNF217 ring finger protein 217 -0.0310864
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0287881
PSD3 pleckstrin and Sec7 domain containing 3 -0.027141
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0262694
GRB10 growth factor receptor-bound protein 10 -0.0259644
CCND1 cyclin D1 -0.0259494
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0254657
PARD3 par-3 family cell polarity regulator -0.025429
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0252435
PTPRK protein tyrosine phosphatase, receptor type, K -0.0251164
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0248945
MAML3 mastermind-like 3 (Drosophila) -0.022586
EGFR epidermal growth factor receptor -0.0223607
TFF1 trefoil factor 1 -0.021995
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0217752
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0216885
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0209434
FHIT fragile histidine triad -0.0204864
SOX4 SRY (sex determining region Y)-box 4 -0.0203371
BZW1 basic leucine zipper and W2 domains 1 -0.0202514
LAMA4 laminin, alpha 4 -0.0201147
EHBP1 EH domain binding protein 1 -0.0197633
SMYD3 SET and MYND domain containing 3 -0.0191516
S100A6 S100 calcium binding protein A6 -0.0191316
IER3 immediate early response 3 -0.0188009
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0186286
GMDS GDP-mannose 4,6-dehydratase -0.0183662
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.018358
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0181231
FERMT1 fermitin family member 1 -0.0179364
RIN2 Ras and Rab interactor 2 -0.0175935
MSI2 musashi RNA-binding protein 2 -0.0171509
KPNB1 karyopherin (importin) beta 1 -0.0171252
LPP LIM domain containing preferred translocation partner in lipoma -0.0171006
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0168659
BACE2 beta-site APP-cleaving enzyme 2 -0.0167666
PATJ PATJ crumbs cell polarity complex component -0.0166309
FRMD5 FERM domain containing 5 -0.0165715
F3 coagulation factor III (thromboplastin, tissue factor) -0.0164873
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0164694
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0162952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0162058
RIGI RNA sensor RIG-I -0.0161811
SAMD5 sterile alpha motif domain containing 5 -0.01595
SVIL supervillin -0.0158513
HDAC2 histone deacetylase 2 -0.0158453
DENND1A DENN/MADD domain containing 1A -0.0157588
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0156034
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0155455
KDM3A lysine (K)-specific demethylase 3A -0.0150633
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0150292
NSD2 nuclear receptor binding SET domain protein 2 -0.0149849
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0149575
FAF1 Fas (TNFRSF6) associated factor 1 -0.014728
MAML2 mastermind-like 2 (Drosophila) -0.0146964
PPARG peroxisome proliferator-activated receptor gamma -0.0146898
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0146285
FBXO11 F-box protein 11 -0.0144222
MPRIP myosin phosphatase Rho interacting protein -0.014288
FMNL2 formin-like 2 -0.0142779
MTAP methylthioadenosine phosphorylase -0.0142514
HMGB1 high mobility group box 1 -0.0142352
RABGAP1L RAB GTPase activating protein 1-like -0.0142257
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0141599
APP amyloid beta (A4) precursor protein -0.0141145
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0138516
TRAPPC9 trafficking protein particle complex 9 -0.0137765
AFG2A AFG2 AAA ATPase homolog A -0.0136301
CANX calnexin -0.0136247
GTF2IRD1 GTF2I repeat domain containing 1 -0.0134891
LAMB3 laminin, beta 3 -0.0134621
TMCC1 transmembrane and coiled-coil domain family 1 -0.0133539
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0132411
TMSB10 thymosin beta 10 -0.0131589
KLK10 kallikrein-related peptidase 10 -0.0131393
DIAPH2 diaphanous-related formin 2 -0.0131311
IGF1R insulin-like growth factor 1 receptor -0.0131266
NAP1L4 nucleosome assembly protein 1-like 4 -0.0130285
LIMCH1 LIM and calponin homology domains 1 -0.0129929