Entrectinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.215308
FTH1 ferritin, heavy polypeptide 1 0.155473
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0716045
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.044154
IGFBP5 insulin-like growth factor binding protein 5 0.039185
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0389856
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0388047
NDRG1 N-myc downstream regulated 1 0.036952
CPE carboxypeptidase E 0.0367454
CAV2 caveolin 2 0.0348861
EGR1 early growth response 1 0.0332609
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0331763
RPS3 ribosomal protein S3 0.032536
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0286564
SRRM2 serine/arginine repetitive matrix 2 0.028131
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0270357
LMO7 LIM domain 7 0.0269044
DSPP dentin sialophosphoprotein 0.0264958
LDHA lactate dehydrogenase A 0.0261494
GCLC glutamate-cysteine ligase, catalytic subunit 0.0248466
PCBP2 poly(rC) binding protein 2 0.024839
S100A10 S100 calcium binding protein A10 0.0245554
MKI67 marker of proliferation Ki-67 0.0242794
CAV1 caveolin 1, caveolae protein, 22kDa 0.0230688
TMSB10 thymosin beta 10 0.0222203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0205359
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0205126
FTL ferritin, light polypeptide 0.0201402
ANXA1 annexin A1 0.020078
HMGA1 high mobility group AT-hook 1 0.0198225
MCL1 myeloid cell leukemia 1 0.0184274
POTEF POTE ankyrin domain family, member F 0.0181398
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0180676
RPL7 ribosomal protein L7 0.0177098
RAB27B RAB27B, member RAS oncogene family 0.0176175
CST3 cystatin C 0.0172433
SCEL sciellin 0.0172195
S100P S100 calcium binding protein P 0.0169118
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0168845
MSN moesin 0.0167173
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0166182
KRT7 keratin 7, type II 0.0166113
WASF2 WAS protein family, member 2 0.0159812
SPIRE1 spire-type actin nucleation factor 1 0.0157147
TPT1 tumor protein, translationally-controlled 1 0.0156975
SLC38A1 solute carrier family 38, member 1 0.0154938
LAMC2 laminin, gamma 2 0.0154176
PTEN phosphatase and tensin homolog 0.0153155
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0152694
LRP1B low density lipoprotein receptor-related protein 1B 0.014944
GOLGB1 golgin B1 0.01482
IRS2 insulin receptor substrate 2 0.0142371
ADGRF1 adhesion G protein-coupled receptor F1 0.0139655
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0137742
SLC38A2 solute carrier family 38, member 2 0.0137709
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0136966
CSDE1 cold shock domain containing E1, RNA-binding 0.0136206
ARHGAP32 Rho GTPase activating protein 32 0.0134582
MGAT4C MGAT4 family, member C 0.0133821
LIMCH1 LIM and calponin homology domains 1 0.0133462
MAML3 mastermind-like 3 (Drosophila) 0.0133003
AKAP13 A kinase (PRKA) anchor protein 13 0.0130778
TMEM45B transmembrane protein 45B 0.0130672
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0129845
RPS14 ribosomal protein S14 0.0129237
AKAP9 A kinase (PRKA) anchor protein 9 0.0128798
RPL8 ribosomal protein L8 0.0128681
PACS1 phosphofurin acidic cluster sorting protein 1 0.0127569
PFN1 profilin 1 0.0127377
RPL21 ribosomal protein L21 0.0126719
RACK1 receptor for activated C kinase 1 0.0125233
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0124312
SLK STE20-like kinase 0.0123029
PKM pyruvate kinase, muscle 0.0122902
TPM3 tropomyosin 3 0.0122719
KMT2D lysine (K)-specific methyltransferase 2D 0.0122126
STC1 stanniocalcin 1 0.0122043
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0121782
ZBTB20 zinc finger and BTB domain containing 20 0.0120656
TAPBP TAP binding protein (tapasin) 0.012005
JUP junction plakoglobin 0.0119869
S100A6 S100 calcium binding protein A6 0.0119356
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0119221
FLNB filamin B, beta 0.0119086
KRT19 keratin 19, type I 0.0118593
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0117831
PERP PERP, TP53 apoptosis effector 0.011701
DNER delta/notch-like EGF repeat containing 0.0116978
RPL3 ribosomal protein L3 0.0116891
VEGFA vascular endothelial growth factor A 0.011657
FNDC3B fibronectin type III domain containing 3B 0.0116437
SFTPA2 surfactant protein A2 0.0114269
KMT2A lysine (K)-specific methyltransferase 2A 0.011374
BCL9L B-cell CLL/lymphoma 9-like 0.0113684
MT2A metallothionein 2A 0.0113156
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0113127
RIN2 Ras and Rab interactor 2 0.0112399
ATOSA atos homolog A 0.0112395
MYOF myoferlin 0.0112389
CES1 carboxylesterase 1 0.011002

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.059512
OSMR oncostatin M receptor -0.0529628
SPAG9 sperm associated antigen 9 -0.0441771
GRAMD1B GRAM domain containing 1B -0.0415181
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0400529
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0398458
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0382669
AGO2 argonaute RISC catalytic component 2 -0.0373944
NABP1 nucleic acid binding protein 1 -0.0359884
RUNX1 runt-related transcription factor 1 -0.034367
SLTM SAFB-like, transcription modulator -0.0343056
ELL2 elongation factor, RNA polymerase II, 2 -0.0342761
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.029166
SP100 SP100 nuclear antigen -0.0283377
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.025428
WDR45B WD repeat domain 45B -0.0248262
RAP1B RAP1B, member of RAS oncogene family -0.0245593
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0244006
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0242902
ANKRD10 ankyrin repeat domain 10 -0.0232068
GSK3B glycogen synthase kinase 3 beta -0.0231831
BMAL2 basic helix-loop-helix ARNT like 2 -0.0231751
KDM3A lysine (K)-specific demethylase 3A -0.022694
TBC1D22A TBC1 domain family, member 22A -0.0220523
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.02198
CANX calnexin -0.0219794
PGK1 phosphoglycerate kinase 1 -0.0219364
LOC112694756 uncharaterized LOC112694756 -0.0213853
OGA O-GlcNAcase -0.0211758
RNF213 ring finger protein 213 -0.0209299
ZC3H11A zinc finger CCCH-type containing 11A -0.0208304
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0207328
ZFAND6 zinc finger, AN1-type domain 6 -0.0202561
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0201068
LAMA4 laminin, alpha 4 -0.0200568
BLZF1 basic leucine zipper nuclear factor 1 -0.020055
DTNA dystrobrevin, alpha -0.0194249
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0193118
HELZ helicase with zinc finger -0.0192815
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0189361
RIGI RNA sensor RIG-I -0.018903
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0188828
SOD2 superoxide dismutase 2, mitochondrial -0.0188248
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0183959
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0179721
SAMD4A sterile alpha motif domain containing 4A -0.0178663
BZW1 basic leucine zipper and W2 domains 1 -0.0174846
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0169461
BRWD3 bromodomain and WD repeat domain containing 3 -0.0169113
RAB1A RAB1A, member RAS oncogene family -0.016719
UVRAG UV radiation resistance associated -0.0167147
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0165915
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0164952
MORF4L2 mortality factor 4 like 2 -0.0164819
SEC61G Sec61 gamma subunit -0.0161182
TSC22D2 TSC22 domain family, member 2 -0.01602
SEPTIN10 septin 10 -0.0159653
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0159137
WSB1 WD repeat and SOCS box containing 1 -0.0158277
RLF rearranged L-myc fusion -0.0156555
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0155002
KCMF1 potassium channel modulatory factor 1 -0.0153975
TRAPPC9 trafficking protein particle complex 9 -0.0151745
JMJD1C jumonji domain containing 1C -0.0151398
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0150683
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0150354
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0150336
TOP1 topoisomerase (DNA) I -0.014908
GM2A GM2 ganglioside activator -0.0147243
AHNAK AHNAK nucleoprotein -0.014693
DSCAM Down syndrome cell adhesion molecule -0.0144301
YEATS2 YEATS domain containing 2 -0.014329
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0139752
RNMT RNA (guanine-7-) methyltransferase -0.013835
NGLY1 N-glycanase 1 -0.0138231
IER3 immediate early response 3 -0.0138096
SEC31A SEC31 homolog A (S. cerevisiae) -0.0138004
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0137702
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0137153
FBXO11 F-box protein 11 -0.013633
SENP5 SUMO1/sentrin specific peptidase 5 -0.0134255
USP34 ubiquitin specific peptidase 34 -0.0134114
SMAD3 SMAD family member 3 -0.0133139
CSNK1A1 casein kinase 1, alpha 1 -0.0132379
RNF24 ring finger protein 24 -0.0132377
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0131678
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0131017
RAB10 RAB10, member RAS oncogene family -0.0130982
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0130229
EXT1 exostosin glycosyltransferase 1 -0.0129473
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0127626
ABLIM1 actin binding LIM protein 1 -0.0127362
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0125733
EFNA5 ephrin-A5 -0.0125586
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0125229
NPC1 Niemann-Pick disease, type C1 -0.0125191
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0124233
GPATCH2L G patch domain containing 2-like -0.0122203
ANKRD37 ankyrin repeat domain 37 -0.012046
PDE8A phosphodiesterase 8A -0.0120432