Entrectinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.13116
VIM vimentin 0.0836897
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0704563
AKAP12 A kinase (PRKA) anchor protein 12 0.0553287
PDE4D phosphodiesterase 4D, cAMP-specific 0.0550708
MT2A metallothionein 2A 0.051264
STC1 stanniocalcin 1 0.0487526
FDPS farnesyl diphosphate synthase 0.0462329
PYGL phosphorylase, glycogen, liver 0.0444303
IGFBP3 insulin-like growth factor binding protein 3 0.0401345
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0399868
NEBL nebulette 0.0372203
IDI1 isopentenyl-diphosphate delta isomerase 1 0.0312374
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0300708
DOCK5 dedicator of cytokinesis 5 0.0274732
FTL ferritin, light polypeptide 0.0273015
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0268584
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0261169
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.025847
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0258129
SRRM2 serine/arginine repetitive matrix 2 0.0252037
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.024992
KIAA0319 KIAA0319 0.0249281
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0243511
MUSK muscle, skeletal, receptor tyrosine kinase 0.0240997
SQLE squalene epoxidase 0.0229042
SNX14 sorting nexin 14 0.0225738
PFN1 profilin 1 0.0219949
IGF2 insulin-like growth factor 2 0.0219749
GLG1 golgi glycoprotein 1 0.0216826
FADS2 fatty acid desaturase 2 0.0216635
IER3 immediate early response 3 0.0214658
ARHGAP26 Rho GTPase activating protein 26 0.0213052
ENO1 enolase 1, (alpha) 0.021018
KTN1 kinectin 1 (kinesin receptor) 0.0210174
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0205253
UBASH3B ubiquitin associated and SH3 domain containing B 0.020452
SOX4 SRY (sex determining region Y)-box 4 0.0202992
MSN moesin 0.0202756
NBEAL1 neurobeachin-like 1 0.0195129
NPC1 Niemann-Pick disease, type C1 0.019252
ACLY ATP citrate lyase 0.0191527
ANKRD12 ankyrin repeat domain 12 0.0190385
C15ORF48 chromosome 15 open reading frame 48 0.0189854
CFDP1 craniofacial development protein 1 0.0189503
RPL3 ribosomal protein L3 0.0188206
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0186385
ANGPTL4 angiopoietin-like 4 0.0184176
ZBTB20 zinc finger and BTB domain containing 20 0.0182073
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0182071
SOAT2 sterol O-acyltransferase 2 0.0180855
MYH9 myosin, heavy chain 9, non-muscle 0.0180051
UBE4B ubiquitination factor E4B 0.0177836
CUX1 cut-like homeobox 1 0.0175865
S100A11 S100 calcium binding protein A11 0.0174937
ATXN1 ataxin 1 0.0172043
HM13 histocompatibility (minor) 13 0.016806
MCL1 myeloid cell leukemia 1 0.0167164
BPTF bromodomain PHD finger transcription factor 0.0166368
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0164707
SREBF2 sterol regulatory element binding transcription factor 2 0.016337
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0162936
XDH xanthine dehydrogenase 0.01625
EGFR epidermal growth factor receptor 0.0161059
TGM2 transglutaminase 2 0.0156856
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.0154953
PACS1 phosphofurin acidic cluster sorting protein 1 0.0154904
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0154746
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0153889
SRSF4 serine/arginine-rich splicing factor 4 0.0151675
CMIP c-Maf inducing protein 0.0149143
FBXO27 F-box protein 27 0.0149111
PFKP phosphofructokinase, platelet 0.0149037
CCL5 chemokine (C-C motif) ligand 5 0.0148524
ITGA6 integrin, alpha 6 0.0148326
LMNA lamin A/C 0.0147955
IL6 interleukin 6 0.0147899
EPAS1 endothelial PAS domain protein 1 0.0147291
TENT5A terminal nucleotidyltransferase 5A 0.0147015
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0145591
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0145469
TMF1 TATA element modulatory factor 1 0.0145319
P3H2 prolyl 3-hydroxylase 2 0.014457
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0144331
ZMYND8 zinc finger, MYND-type containing 8 0.014257
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0141404
CDCP1 CUB domain containing protein 1 0.0140858
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0140582
RAB6A RAB6A, member RAS oncogene family 0.0139784
MYO1E myosin IE 0.0138678
IGFBP4 insulin-like growth factor binding protein 4 0.0138415
ITGAV integrin, alpha V 0.013778
MVD mevalonate (diphospho) decarboxylase 0.0137666
MKI67 marker of proliferation Ki-67 0.0136284
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0135731
HLA-B major histocompatibility complex, class I, B 0.013542
GOLGB1 golgin B1 0.0134893
BRD2 bromodomain containing 2 0.0134661
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0134302
CENPF centromere protein F, 350/400kDa 0.0134065

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.138148
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.120039
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103203
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0973025
ZFAND3 zinc finger, AN1-type domain 3 -0.0709597
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0694682
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0676569
RBM39 RNA binding motif protein 39 -0.0667081
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0660511
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0571697
APP amyloid beta (A4) precursor protein -0.0566679
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0546371
PTK2 protein tyrosine kinase 2 -0.0526722
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0522957
TFPI2 tissue factor pathway inhibitor 2 -0.0518029
TXNRD1 thioredoxin reductase 1 -0.0505306
GRAMD1B GRAM domain containing 1B -0.0496849
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0496625
RAD21 RAD21 homolog (S. pombe) -0.0494907
USP3 ubiquitin specific peptidase 3 -0.048535
PM20D1 peptidase M20 domain containing 1 -0.0481337
CYRIB CYFIP related Rac1 interactor B -0.0479238
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0478834
ACTG1 actin gamma 1 -0.0467977
TMSB10 thymosin beta 10 -0.0464341
WDR43 WD repeat domain 43 -0.0461997
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0460145
RTN4 reticulon 4 -0.044957
PARD3 par-3 family cell polarity regulator -0.044259
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0442051
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0438961
ANKRD11 ankyrin repeat domain 11 -0.0430413
TRA2A transformer 2 alpha homolog (Drosophila) -0.0417037
PUM2 pumilio RNA-binding family member 2 -0.0413481
PDLIM5 PDZ and LIM domain 5 -0.0413273
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0410331
RPL23 ribosomal protein L23 -0.040593
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0405801
NOP58 NOP58 ribonucleoprotein -0.0399085
RPL19 ribosomal protein L19 -0.038928
TRIO trio Rho guanine nucleotide exchange factor -0.0383127
RHEB Ras homolog enriched in brain -0.0379918
ASPH aspartate beta-hydroxylase -0.0379074
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0375648
ENAH enabled homolog (Drosophila) -0.0364671
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0364573
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0363744
PUM1 pumilio RNA-binding family member 1 -0.0362135
ELL2 elongation factor, RNA polymerase II, 2 -0.0358958
ADAM9 ADAM metallopeptidase domain 9 -0.0357694
YBX3 Y box binding protein 3 -0.0353554
ZNF207 zinc finger protein 207 -0.0347312
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0344064
JAK1 Janus kinase 1 -0.033876
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0335908
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0327983
CHN1 chimerin 1 -0.0326774
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0326501
YBX1 Y box binding protein 1 -0.0325329
EIF1 eukaryotic translation initiation factor 1 -0.0324858
EWSR1 EWS RNA-binding protein 1 -0.0321091
MARCHF6 membrane associated ring-CH-type finger 6 -0.031844
OLA1 Obg-like ATPase 1 -0.0313868
UGCG UDP-glucose ceramide glucosyltransferase -0.0311614
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0311437
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0307116
RBM33 RNA binding motif protein 33 -0.0306317
RHOA ras homolog family member A -0.0305686
MTMR3 myotubularin related protein 3 -0.0301264
PAWR PRKC, apoptosis, WT1, regulator -0.0301012
ZNF644 zinc finger protein 644 -0.0299101
SPAG9 sperm associated antigen 9 -0.029687
ZFR zinc finger RNA binding protein -0.0296175
FNBP1L formin binding protein 1-like -0.0294565
RPL4 ribosomal protein L4 -0.029104
THSD4 thrombospondin, type I, domain containing 4 -0.0290956
ANXA2 annexin A2 -0.0290249
MORF4L1 mortality factor 4 like 1 -0.0288442
NAP1L1 nucleosome assembly protein 1-like 1 -0.0287396
LPP LIM domain containing preferred translocation partner in lipoma -0.0286022
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0285467
WAC WW domain containing adaptor with coiled-coil -0.0279686
CUL3 cullin 3 -0.0277261
MTF2 metal response element binding transcription factor 2 -0.027578
ZNF292 zinc finger protein 292 -0.0274387
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0272726
ECT2 epithelial cell transforming 2 -0.0271535
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0268345
KIF5B kinesin family member 5B -0.0265237
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.026172
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0261529
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0261496
PDIA6 protein disulfide isomerase family A, member 6 -0.0260719
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0258205
AGO2 argonaute RISC catalytic component 2 -0.0256881
SMAD2 SMAD family member 2 -0.0255674
GNAS GNAS complex locus -0.0255181
DENND4A DENN/MADD domain containing 4A -0.0255156
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0254544
AK1 adenylate kinase 1 -0.0254115