| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Entrectinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Entrectinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0907168 |
| FMN1 | formin 1 | 0.065911 |
| PGK1 | phosphoglycerate kinase 1 | 0.0594161 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.058725 |
| COPA | coatomer protein complex, subunit alpha | 0.0553703 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0543943 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0525947 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0506289 |
| NFIB | nuclear factor I/B | 0.0479259 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.047802 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0473502 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0403866 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0392169 |
| RBM39 | RNA binding motif protein 39 | 0.0370653 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0370622 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0361696 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0360593 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0356961 |
| ENAH | enabled homolog (Drosophila) | 0.0354581 |
| RHEB | Ras homolog enriched in brain | 0.0349814 |
| PRELID2 | PRELI domain containing 2 | 0.0348161 |
| GLG1 | golgi glycoprotein 1 | 0.0336794 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0333918 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0333193 |
| PALLD | palladin, cytoskeletal associated protein | 0.0325563 |
| CTBP2 | C-terminal binding protein 2 | 0.0319162 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0314737 |
| RAB18 | RAB18, member RAS oncogene family | 0.0311356 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0305953 |
| WDR45B | WD repeat domain 45B | 0.0305754 |
| ZNF292 | zinc finger protein 292 | 0.0305222 |
| FUS | FUS RNA binding protein | 0.0302529 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0301566 |
| RASAL2 | RAS protein activator like 2 | 0.0300777 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0299684 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0295503 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0295078 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0290376 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0288718 |
| CD44 | CD44 molecule (Indian blood group) | 0.0284809 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0277643 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.027525 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0272737 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0271588 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0271318 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0271081 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0270937 |
| HMGA2 | high mobility group AT-hook 2 | 0.0269319 |
| ATP13A3 | ATPase type 13A3 | 0.0268607 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0267855 |
| ZNF148 | zinc finger protein 148 | 0.0267684 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.026389 |
| TLN1 | talin 1 | 0.0263885 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0262302 |
| ABI1 | abl-interactor 1 | 0.0261607 |
| HELZ | helicase with zinc finger | 0.0259352 |
| CTTN | cortactin | 0.0256491 |
| SQSTM1 | sequestosome 1 | 0.0255835 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0255795 |
| RYBP | RING1 and YY1 binding protein | 0.0254946 |
| MEIS2 | Meis homeobox 2 | 0.0254019 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0253134 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0249993 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0249677 |
| MORF4L2 | mortality factor 4 like 2 | 0.0249422 |
| FRMD4A | FERM domain containing 4A | 0.024914 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0248621 |
| GOLGA4 | golgin A4 | 0.0246231 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0245605 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0245405 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0243949 |
| PDE8A | phosphodiesterase 8A | 0.0241904 |
| TNPO3 | transportin 3 | 0.0241063 |
| FBXO34 | F-box protein 34 | 0.0237379 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0236769 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0235161 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0234416 |
| SUCO | SUN domain containing ossification factor | 0.0232541 |
| QKI | QKI, KH domain containing, RNA binding | 0.0231831 |
| POGZ | pogo transposable element with ZNF domain | 0.0231307 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.022884 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0227806 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0227603 |
| CLU | clusterin | 0.0226527 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0225698 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0224836 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0224779 |
| MCL1 | myeloid cell leukemia 1 | 0.0224575 |
| MTDH | metadherin | 0.0223131 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0222716 |
| CDC73 | cell division cycle 73 | 0.0221835 |
| NUMB | numb homolog (Drosophila) | 0.0219377 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0218764 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0218482 |
| RAD51B | RAD51 paralog B | 0.0217299 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0217123 |
| COG5 | component of oligomeric golgi complex 5 | 0.0214654 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0214585 |
| XPO1 | exportin 1 | 0.0213677 |
| USP3 | ubiquitin specific peptidase 3 | 0.0213591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0758618 |
| FTL | ferritin, light polypeptide | -0.0683 |
| MYO1E | myosin IE | -0.0654586 |
| TMSB10 | thymosin beta 10 | -0.0645104 |
| KRT17 | keratin 17, type I | -0.0600546 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0585222 |
| VIM | vimentin | -0.0571721 |
| MUC16 | mucin 16, cell surface associated | -0.0571239 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0504157 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.050082 |
| RPS8 | ribosomal protein S8 | -0.049166 |
| RPL35A | ribosomal protein L35a | -0.0483313 |
| ACTG1 | actin gamma 1 | -0.0482523 |
| LAMB3 | laminin, beta 3 | -0.048168 |
| RPLP0 | ribosomal protein, large, P0 | -0.0479222 |
| RPS16 | ribosomal protein S16 | -0.0465634 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0459721 |
| POTEF | POTE ankyrin domain family, member F | -0.0441631 |
| RPL26 | ribosomal protein L26 | -0.0440004 |
| SVIL | supervillin | -0.0438924 |
| TJP1 | tight junction protein 1 | -0.0426408 |
| ERBIN | erbb2 interacting protein | -0.0424768 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0414712 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0411607 |
| ATOSA | atos homolog A | -0.0408443 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0408059 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0407601 |
| ASPH | aspartate beta-hydroxylase | -0.0405236 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0398088 |
| S100A6 | S100 calcium binding protein A6 | -0.0395641 |
| B2M | beta-2-microglobulin | -0.0387232 |
| RPS6 | ribosomal protein S6 | -0.0383592 |
| USP34 | ubiquitin specific peptidase 34 | -0.0382369 |
| LMO7 | LIM domain 7 | -0.0380229 |
| S100A9 | S100 calcium binding protein A9 | -0.0378206 |
| RPLP2 | ribosomal protein, large, P2 | -0.0375585 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0371581 |
| ANXA2 | annexin A2 | -0.0367466 |
| DSPP | dentin sialophosphoprotein | -0.0360389 |
| PTMA | prothymosin, alpha | -0.0359937 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0356498 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0352575 |
| RPL23 | ribosomal protein L23 | -0.0348971 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0343357 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0342401 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0342121 |
| LAMC2 | laminin, gamma 2 | -0.0337531 |
| PKM | pyruvate kinase, muscle | -0.0329052 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0327519 |
| RPS17 | ribosomal protein S17 | -0.0322318 |
| EFNA5 | ephrin-A5 | -0.0321521 |
| RPL19 | ribosomal protein L19 | -0.0319483 |
| TPM4 | tropomyosin 4 | -0.0313534 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0312221 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.031218 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0304378 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.030274 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0302715 |
| UBC | ubiquitin C | -0.0301977 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0299666 |
| RPL31 | ribosomal protein L31 | -0.0293617 |
| RPL15 | ribosomal protein L15 | -0.0291033 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0287595 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0285021 |
| GNAS | GNAS complex locus | -0.0284495 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0282085 |
| RPL36 | ribosomal protein L36 | -0.0277416 |
| RPL34 | ribosomal protein L34 | -0.0273684 |
| RPL28 | ribosomal protein L28 | -0.0271114 |
| RPS27A | ribosomal protein S27a | -0.0266959 |
| RPS24 | ribosomal protein S24 | -0.0266701 |
| WASF2 | WAS protein family, member 2 | -0.0264349 |
| RPS12 | ribosomal protein S12 | -0.0263961 |
| RACK1 | receptor for activated C kinase 1 | -0.0263214 |
| CD2AP | CD2-associated protein | -0.025898 |
| RPS23 | ribosomal protein S23 | -0.0258649 |
| RPS25 | ribosomal protein S25 | -0.0258574 |
| CSTB | cystatin B (stefin B) | -0.0251563 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0249626 |
| RPS11 | ribosomal protein S11 | -0.0249254 |
| RPL37A | ribosomal protein L37a | -0.0244764 |
| BPTF | bromodomain PHD finger transcription factor | -0.0244297 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0243454 |
| KYNU | kynureninase | -0.0242793 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0235073 |
| RRBP1 | ribosome binding protein 1 | -0.0233989 |
| PARD3 | par-3 family cell polarity regulator | -0.0229839 |
| TXNRD1 | thioredoxin reductase 1 | -0.0228165 |
| MXD1 | MAX dimerization protein 1 | -0.0227109 |
| ABHD17C | abhydrolase domain containing 17C | -0.0226951 |
| RPS3 | ribosomal protein S3 | -0.0225717 |
| RPL37 | ribosomal protein L37 | -0.0215638 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0211381 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0207413 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0206593 |
| RPS19 | ribosomal protein S19 | -0.0206357 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0206355 |
| RAB10 | RAB10, member RAS oncogene family | -0.0205712 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0205413 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0203502 |
