Entrectinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.392603
THSD4 thrombospondin, type I, domain containing 4 0.0816173
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0773156
YBX3 Y box binding protein 3 0.0722656
GRAMD1B GRAM domain containing 1B 0.0721924
MCL1 myeloid cell leukemia 1 0.0718891
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0611065
ERRFI1 ERBB receptor feedback inhibitor 1 0.0602171
DOCK5 dedicator of cytokinesis 5 0.0587027
EGR1 early growth response 1 0.0572134
TXNRD1 thioredoxin reductase 1 0.0496829
OSMR oncostatin M receptor 0.0494489
TRIO trio Rho guanine nucleotide exchange factor 0.0459309
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0457635
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0420927
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0416658
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0407499
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.039125
RAD51B RAD51 paralog B 0.0389968
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0383539
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373508
FMNL2 formin-like 2 0.0359126
ATP11A ATPase, class VI, type 11A 0.0347408
MYH9 myosin, heavy chain 9, non-muscle 0.0344175
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0344084
STC1 stanniocalcin 1 0.0339321
TM4SF1 transmembrane 4 L six family member 1 0.0336212
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0334946
AFF3 AF4/FMR2 family, member 3 0.0322078
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0321897
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0321572
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0314125
SMAD3 SMAD family member 3 0.0311523
EGFR epidermal growth factor receptor 0.0309289
PDE4D phosphodiesterase 4D, cAMP-specific 0.030392
RIMS2 regulating synaptic membrane exocytosis 2 0.0302876
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0290355
MACF1 microtubule-actin crosslinking factor 1 0.0286891
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279233
RNF213 ring finger protein 213 0.0276052
ANO6 anoctamin 6 0.0275775
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0274981
ELL2 elongation factor, RNA polymerase II, 2 0.027234
HMGA2 high mobility group AT-hook 2 0.0271254
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0269778
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.026838
IGF1R insulin-like growth factor 1 receptor 0.0266991
SRRM2 serine/arginine repetitive matrix 2 0.0264708
EXOC4 exocyst complex component 4 0.0263588
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.025953
PYGL phosphorylase, glycogen, liver 0.0257747
ATXN1 ataxin 1 0.0257191
ACTN1 actinin, alpha 1 0.0254005
RUNX1 runt-related transcription factor 1 0.0251864
CLTC clathrin, heavy chain (Hc) 0.0250667
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0245776
MMP12 matrix metallopeptidase 12 0.024539
TCIM transcriptional and immune response regulator 0.0244042
BASP1 brain abundant, membrane attached signal protein 1 0.0243455
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0241331
NTSR1 neurotensin receptor 1 (high affinity) 0.0240534
POTEF POTE ankyrin domain family, member F 0.0240446
SFPQ splicing factor proline/glutamine-rich 0.0238699
ADAR adenosine deaminase, RNA-specific 0.0236147
FTH1 ferritin, heavy polypeptide 1 0.0232032
MKI67 marker of proliferation Ki-67 0.0231512
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0229059
PRKCE protein kinase C, epsilon 0.0227156
ZSWIM6 zinc finger, SWIM-type containing 6 0.022681
MSN moesin 0.0226031
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0223031
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0218157
TRIP12 thyroid hormone receptor interactor 12 0.0216049
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0215747
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0214845
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0211367
SLC38A2 solute carrier family 38, member 2 0.0208188
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0206953
DST dystonin 0.0205717
LOXL2 lysyl oxidase-like 2 0.0205346
TBC1D5 TBC1 domain family, member 5 0.0204424
RPL3 ribosomal protein L3 0.0203834
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0201412
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0196683
NABP1 nucleic acid binding protein 1 0.0194789
CENPF centromere protein F, 350/400kDa 0.0192975
EPAS1 endothelial PAS domain protein 1 0.0192781
PRPF8 pre-mRNA processing factor 8 0.0191949
TTC28 tetratricopeptide repeat domain 28 0.019186
CALD1 caldesmon 1 0.0191307
SHB Src homology 2 domain containing adaptor protein B 0.0188998
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0188989
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0188204
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0188194
SDK1 sidekick cell adhesion molecule 1 0.0186981
PDLIM5 PDZ and LIM domain 5 0.0185523
ZBTB20 zinc finger and BTB domain containing 20 0.0185362
IGF2 insulin-like growth factor 2 0.018527
SVIL supervillin 0.0182825
PFKP phosphofructokinase, platelet 0.0182286

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.17334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0979321
PTMA prothymosin, alpha -0.0829327
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0718578
TMSB10 thymosin beta 10 -0.0623939
RPS8 ribosomal protein S8 -0.050578
RPLP1 ribosomal protein, large, P1 -0.0462686
RPL23 ribosomal protein L23 -0.0450983
RPS21 ribosomal protein S21 -0.0385341
RPLP0 ribosomal protein, large, P0 -0.0369404
RPL35A ribosomal protein L35a -0.0368234
GOLGA4 golgin A4 -0.0361442
OGA O-GlcNAcase -0.0351353
MORF4L2 mortality factor 4 like 2 -0.0342871
NAP1L1 nucleosome assembly protein 1-like 1 -0.0333072
EIF1 eukaryotic translation initiation factor 1 -0.032792
RPL12 ribosomal protein L12 -0.0319206
RPS29 ribosomal protein S29 -0.0310342
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.030344
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0296437
RPL34 ribosomal protein L34 -0.029584
GARS1 glycyl-tRNA synthetase 1 -0.0292051
RPS19 ribosomal protein S19 -0.0282436
CANX calnexin -0.0279866
PDIA4 protein disulfide isomerase family A, member 4 -0.0268926
GNAS GNAS complex locus -0.0262608
KDM3A lysine (K)-specific demethylase 3A -0.0254433
RPL26 ribosomal protein L26 -0.0253208
CALR calreticulin -0.0251174
RPL37A ribosomal protein L37a -0.0250736
RPL5 ribosomal protein L5 -0.0248518
UBE2H ubiquitin-conjugating enzyme E2H -0.0246917
WSB1 WD repeat and SOCS box containing 1 -0.0245157
RPL19 ribosomal protein L19 -0.0242573
RPS25 ribosomal protein S25 -0.023897
RSF1 remodeling and spacing factor 1 -0.0238386
TNPO1 transportin 1 -0.023769
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0237376
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0235371
RPL36 ribosomal protein L36 -0.0234944
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0229791
LDHB lactate dehydrogenase B -0.0223306
ZFR zinc finger RNA binding protein -0.0217382
RPS16 ribosomal protein S16 -0.0216081
RPS24 ribosomal protein S24 -0.0214609
RPS12 ribosomal protein S12 -0.0214602
RPS15 ribosomal protein S15 -0.0209889
RPL37 ribosomal protein L37 -0.0206802
RPS17 ribosomal protein S17 -0.0203622
RPS27A ribosomal protein S27a -0.0203088
CAMTA1 calmodulin binding transcription activator 1 -0.0201266
PDIA6 protein disulfide isomerase family A, member 6 -0.0198269
YBX1 Y box binding protein 1 -0.0197219
SRP54 signal recognition particle 54kDa -0.0197136
LMAN1 lectin, mannose-binding, 1 -0.0196946
SEPTIN7 septin 7 -0.0196626
RPS20 ribosomal protein S20 -0.0196359
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0192224
KPNB1 karyopherin (importin) beta 1 -0.0190219
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0187316
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0185285
RPS10 ribosomal protein S10 -0.018418
XPO1 exportin 1 -0.0179551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0178035
CAMKMT calmodulin-lysine N-methyltransferase -0.0177594
RPL13A ribosomal protein L13a -0.0176998
PREPL prolyl endopeptidase-like -0.017596
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175495
OLA1 Obg-like ATPase 1 -0.0172979
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0170219
RPS3 ribosomal protein S3 -0.0170188
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0170081
WDR45B WD repeat domain 45B -0.0166471
FBXO11 F-box protein 11 -0.0166168
RPL38 ribosomal protein L38 -0.0165599
RPS6 ribosomal protein S6 -0.0164324
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0163754
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0163382
RPS27 ribosomal protein S27 -0.0160354
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0158678
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0157868
ACBD3 acyl-CoA binding domain containing 3 -0.0156428
PHIP pleckstrin homology domain interacting protein -0.0155842
AHCYL1 adenosylhomocysteinase-like 1 -0.01532
GSTP1 glutathione S-transferase pi 1 -0.0152872
MYL12B myosin, light chain 12B, regulatory -0.0150805
MARCHF6 membrane associated ring-CH-type finger 6 -0.0150379
UBE2K ubiquitin-conjugating enzyme E2K -0.0148588
ATP5F1B ATP synthase F1 subunit beta -0.014624
RPL35 ribosomal protein L35 -0.0145747
RBL1 retinoblastoma-like 1 -0.0145461
RPLP2 ribosomal protein, large, P2 -0.0145063
RPS11 ribosomal protein S11 -0.0142687
FTL ferritin, light polypeptide -0.0142593
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0142538
RAB1A RAB1A, member RAS oncogene family -0.0141848
S100A9 S100 calcium binding protein A9 -0.014159
SRP72 signal recognition particle 72kDa -0.0141271
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0140204
NACA nascent polypeptide-associated complex alpha subunit -0.0139662