| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Entrectinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Entrectinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0663721 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0558342 |
| GRAMD1B | GRAM domain containing 1B | 0.0542512 |
| MCL1 | myeloid cell leukemia 1 | 0.0526029 |
| NRCAM | neuronal cell adhesion molecule | 0.0488001 |
| MSN | moesin | 0.0399115 |
| MT2A | metallothionein 2A | 0.0390411 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0370435 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0367771 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0358017 |
| MFF | mitochondrial fission factor | 0.035792 |
| CENPF | centromere protein F, 350/400kDa | 0.0344036 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.033946 |
| RPL3 | ribosomal protein L3 | 0.033338 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0326971 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0326001 |
| TXNRD1 | thioredoxin reductase 1 | 0.0312783 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0312038 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.028372 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0278253 |
| CD109 | CD109 molecule | 0.0274733 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0274045 |
| POTEF | POTE ankyrin domain family, member F | 0.0265456 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.026174 |
| MKI67 | marker of proliferation Ki-67 | 0.0260081 |
| GDA | guanine deaminase | 0.0258971 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0248276 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0247316 |
| CTSC | cathepsin C | 0.0234707 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0229274 |
| DST | dystonin | 0.0225735 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0224474 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0216938 |
| PCBP2 | poly(rC) binding protein 2 | 0.0214879 |
| PRDX1 | peroxiredoxin 1 | 0.0210517 |
| PYGL | phosphorylase, glycogen, liver | 0.0207906 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0207772 |
| FLNB | filamin B, beta | 0.0207766 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.020734 |
| UBXN4 | UBX domain protein 4 | 0.0205571 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0204768 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0204528 |
| TPM3 | tropomyosin 3 | 0.0197033 |
| EFNA5 | ephrin-A5 | 0.0195942 |
| MYOF | myoferlin | 0.0192853 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0189045 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0188616 |
| VMP1 | vacuole membrane protein 1 | 0.0184314 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0183683 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0182027 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.018173 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0181295 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0180714 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0179316 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0178178 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0177938 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0177619 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0176236 |
| GPRIN3 | GPRIN family member 3 | 0.0176204 |
| DUSP4 | dual specificity phosphatase 4 | 0.0174334 |
| PRKD3 | protein kinase D3 | 0.0174202 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0174147 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0168233 |
| RPL21 | ribosomal protein L21 | 0.0165041 |
| TBXT | T-box transcription factor T | 0.0163787 |
| PFN1 | profilin 1 | 0.016293 |
| NEK7 | NIMA-related kinase 7 | 0.0160498 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0160162 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0156247 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0156055 |
| KRT19 | keratin 19, type I | 0.0154661 |
| TGFB2 | transforming growth factor, beta 2 | 0.0153508 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0150066 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0149481 |
| RTN4 | reticulon 4 | 0.0145025 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.014467 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0143639 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0143114 |
| MAP1B | microtubule-associated protein 1B | 0.0139951 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0138176 |
| NDRG1 | N-myc downstream regulated 1 | 0.0137172 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0136467 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0135403 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0135385 |
| ZNF462 | zinc finger protein 462 | 0.0133093 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0133029 |
| PTGR1 | prostaglandin reductase 1 | 0.0132926 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0132295 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0131708 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0131221 |
| RPL7 | ribosomal protein L7 | 0.0130644 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0128923 |
| ZFP36 | ZFP36 ring finger protein | 0.0127945 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0126882 |
| LAMA5 | laminin, alpha 5 | 0.012645 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.0125071 |
| BDNF | brain-derived neurotrophic factor | 0.0124655 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0124088 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0123815 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0123683 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.309076 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.233605 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.231387 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.095895 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0847863 |
| CDH13 | cadherin 13 | -0.0808047 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0784913 |
| CANX | calnexin | -0.0705124 |
| PDE10A | phosphodiesterase 10A | -0.0702805 |
| PTMA | prothymosin, alpha | -0.0673097 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0616394 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.060701 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0605981 |
| RPS24 | ribosomal protein S24 | -0.0500918 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0496983 |
| SPAG9 | sperm associated antigen 9 | -0.0482305 |
| SMYD3 | SET and MYND domain containing 3 | -0.0466763 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.045861 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0443087 |
| RPLP1 | ribosomal protein, large, P1 | -0.0427981 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.042765 |
| SMAD2 | SMAD family member 2 | -0.0418474 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0397084 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0394469 |
| MORF4L2 | mortality factor 4 like 2 | -0.0383169 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0379493 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0374899 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0369162 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0357193 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.035482 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0348001 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.033754 |
| S100A6 | S100 calcium binding protein A6 | -0.0329621 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0322959 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317382 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0314051 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0306053 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0305532 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0299894 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0297999 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0295252 |
| RPL26 | ribosomal protein L26 | -0.0291717 |
| CTBP2 | C-terminal binding protein 2 | -0.028729 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0284397 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0273774 |
| DENND1A | DENN/MADD domain containing 1A | -0.0272297 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0271537 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0269903 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0268605 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.026744 |
| GNAS | GNAS complex locus | -0.0266536 |
| AUTS2 | autism susceptibility candidate 2 | -0.026429 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0259433 |
| SQSTM1 | sequestosome 1 | -0.0257665 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0256932 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0254458 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0252156 |
| HLA-B | major histocompatibility complex, class I, B | -0.0251433 |
| ANXA2 | annexin A2 | -0.0248254 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0245577 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0243798 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0243567 |
| ARF1 | ADP-ribosylation factor 1 | -0.0237348 |
| CUX1 | cut-like homeobox 1 | -0.0237078 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0235392 |
| WAC | WW domain containing adaptor with coiled-coil | -0.023367 |
| INTS6 | integrator complex subunit 6 | -0.0231194 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0230341 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0228808 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0228241 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0226982 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0226962 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0226484 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0225499 |
| RPS8 | ribosomal protein S8 | -0.0224445 |
| ABLIM1 | actin binding LIM protein 1 | -0.0224177 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0224098 |
| RPLP0 | ribosomal protein, large, P0 | -0.0223938 |
| KYNU | kynureninase | -0.0221555 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0221035 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0218268 |
| CALR | calreticulin | -0.0215997 |
| LDHA | lactate dehydrogenase A | -0.0214783 |
| S100A10 | S100 calcium binding protein A10 | -0.0214568 |
| HDLBP | high density lipoprotein binding protein | -0.0214038 |
| VIM | vimentin | -0.0213265 |
| RAB7A | RAB7A, member RAS oncogene family | -0.021149 |
| RPL39 | ribosomal protein L39 | -0.0209485 |
| LAMA1 | laminin, alpha 1 | -0.020901 |
| USP3 | ubiquitin specific peptidase 3 | -0.0207512 |
| FMNL2 | formin-like 2 | -0.0206438 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0205779 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0204823 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0200903 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0200379 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0199537 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0199437 |
| FAM107B | family with sequence similarity 107, member B | -0.0199275 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0199106 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.019886 |
