Entrectinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0825069
PGAP1 post-GPI attachment to proteins 1 0.0595036
PHIP pleckstrin homology domain interacting protein 0.0494674
PLPP1 phospholipid phosphatase 1 0.0470828
PUM1 pumilio RNA-binding family member 1 0.0433731
CXADR coxsackie virus and adenovirus receptor 0.0430362
CDC73 cell division cycle 73 0.0425561
COL11A1 collagen, type XI, alpha 1 0.0424637
PGK1 phosphoglycerate kinase 1 0.0413314
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0400149
NCAM2 neural cell adhesion molecule 2 0.0400011
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0397322
MTF2 metal response element binding transcription factor 2 0.0367983
CKAP5 cytoskeleton associated protein 5 0.0358073
HDAC9 histone deacetylase 9 0.0346233
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0342918
KMT2E lysine (K)-specific methyltransferase 2E 0.0337372
TSC22D2 TSC22 domain family, member 2 0.0337181
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0336862
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0335403
RASAL2 RAS protein activator like 2 0.0334854
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0322917
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0322453
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0314895
ITGAV integrin, alpha V 0.0308135
STRN3 striatin, calmodulin binding protein 3 0.0297124
SPAG9 sperm associated antigen 9 0.0295472
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0293516
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0288687
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0286821
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0285718
COL3A1 collagen, type III, alpha 1 0.0285057
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0276979
MKI67 marker of proliferation Ki-67 0.0275231
H1-0 H1.0 linker histone 0.0275
FNDC3B fibronectin type III domain containing 3B 0.0269581
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263305
ZFAND3 zinc finger, AN1-type domain 3 0.0263268
USP3 ubiquitin specific peptidase 3 0.0262989
KDM3A lysine (K)-specific demethylase 3A 0.026022
H1-4 H1.4 linker histone, cluster member 0.0258942
HELZ helicase with zinc finger 0.0256966
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.025346
PDIA3 protein disulfide isomerase family A, member 3 0.0252319
CALR calreticulin 0.0252176
TPX2 TPX2, microtubule-associated 0.0251901
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0245487
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0244289
NPEPPS aminopeptidase puromycin sensitive 0.0243033
FBXO11 F-box protein 11 0.0241837
ATXN2 ataxin 2 0.0241222
NCKAP1 NCK-associated protein 1 0.0239933
MRPS30 mitochondrial ribosomal protein S30 0.0233924
RAB1A RAB1A, member RAS oncogene family 0.0228501
NAMPT nicotinamide phosphoribosyltransferase 0.022502
APP amyloid beta (A4) precursor protein 0.0220205
RAD21 RAD21 homolog (S. pombe) 0.0218801
MED13L mediator complex subunit 13-like 0.0217974
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0217497
KDM5B lysine (K)-specific demethylase 5B 0.0211166
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0208443
SFTPA2 surfactant protein A2 0.0205521
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0204916
MEMO1 mediator of cell motility 1 0.0200642
CALCR calcitonin receptor 0.0199257
EIF4H eukaryotic translation initiation factor 4H 0.0199095
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.019812
GPBP1 GC-rich promoter binding protein 1 0.0196702
CFL2 cofilin 2 (muscle) 0.0195561
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0195189
RYBP RING1 and YY1 binding protein 0.0194596
RHEB Ras homolog enriched in brain 0.0194378
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0193314
QKI QKI, KH domain containing, RNA binding 0.019177
PDIA6 protein disulfide isomerase family A, member 6 0.0191155
ENAH enabled homolog (Drosophila) 0.0189987
SRPK2 SRSF protein kinase 2 0.0189241
RPL3 ribosomal protein L3 0.0189008
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0188897
COL5A2 collagen, type V, alpha 2 0.0188802
TBC1D12 TBC1 domain family, member 12 0.0188546
CORO1C coronin, actin binding protein, 1C 0.0187995
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0186545
GPC4 glypican 4 0.0186316
KAT6A K(lysine) acetyltransferase 6A 0.0184138
PDGFC platelet derived growth factor C 0.0182963
LYST lysosomal trafficking regulator 0.0181997
PUM2 pumilio RNA-binding family member 2 0.0181972
STAG2 stromal antigen 2 0.0181594
GAB2 GRB2-associated binding protein 2 0.0181531
CCNA2 cyclin A2 0.0181297
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0181113
RAB30 RAB30, member RAS oncogene family 0.0180803
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180717
HP1BP3 heterochromatin protein 1, binding protein 3 0.0179777
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0179666
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0179099
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0177971
MITF microphthalmia-associated transcription factor 0.0177765
NCOR1 nuclear receptor corepressor 1 0.0177608

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0987474
CADM2 cell adhesion molecule 2 -0.0713924
TMSB10 thymosin beta 10 -0.0609145
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0541034
NTM neurotrimin -0.0530248
RPL23 ribosomal protein L23 -0.0437736
PDE4D phosphodiesterase 4D, cAMP-specific -0.0407206
PCLO piccolo presynaptic cytomatrix protein -0.0396472
RPS6 ribosomal protein S6 -0.0388099
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0374129
GPC3 glypican 3 -0.0358135
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0350667
RPS16 ribosomal protein S16 -0.0350223
ZC3H12B zinc finger CCCH-type containing 12B -0.0313591
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0297606
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0295056
RPS19 ribosomal protein S19 -0.0285717
ACTG1 actin gamma 1 -0.0283605
PARD3B par-3 family cell polarity regulator beta -0.0278459
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0269992
RPLP1 ribosomal protein, large, P1 -0.0269071
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0260007
CDK6 cyclin-dependent kinase 6 -0.0259126
RPL9 ribosomal protein L9 -0.0248512
CDH19 cadherin 19, type 2 -0.0244243
THBS1 thrombospondin 1 -0.0240317
RPS12 ribosomal protein S12 -0.0240099
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0236602
SEPTIN7 septin 7 -0.0233369
CSMD3 CUB and Sushi multiple domains 3 -0.0226885
RPS27A ribosomal protein S27a -0.0226218
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0226029
NPAS3 neuronal PAS domain protein 3 -0.0224431
SMYD3 SET and MYND domain containing 3 -0.0223575
CNRIP1 cannabinoid receptor interacting protein 1 -0.0221703
RPL19 ribosomal protein L19 -0.02173
PCDH9 protocadherin 9 -0.0212358
RAB7A RAB7A, member RAS oncogene family -0.0211646
AKAP9 A kinase (PRKA) anchor protein 9 -0.021024
RPS8 ribosomal protein S8 -0.0208247
RPL26 ribosomal protein L26 -0.0205483
RPL12 ribosomal protein L12 -0.0200634
RPS21 ribosomal protein S21 -0.0197489
RPLP2 ribosomal protein, large, P2 -0.0195344
RPS4X ribosomal protein S4, X-linked -0.0195129
SYT1 synaptotagmin I -0.0195121
CALU calumenin -0.0194552
RPL5 ribosomal protein L5 -0.0193682
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0192705
TAS2R14 taste receptor, type 2, member 14 -0.0192114
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0186754
RPS13 ribosomal protein S13 -0.0185163
ARHGAP5 Rho GTPase activating protein 5 -0.0182435
PCDH7 protocadherin 7 -0.0180346
MDK midkine (neurite growth-promoting factor 2) -0.0179823
PRRC2C proline-rich coiled-coil 2C -0.0177126
RPL36A ribosomal protein L36a -0.0174715
ACTN4 actinin, alpha 4 -0.0172017
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0170217
USP34 ubiquitin specific peptidase 34 -0.0169556
EIF1 eukaryotic translation initiation factor 1 -0.016901
HMGB1 high mobility group box 1 -0.0167648
RB1 retinoblastoma 1 -0.016503
RPS25 ribosomal protein S25 -0.0164699
HM13 histocompatibility (minor) 13 -0.0163546
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0162242
ATXN1 ataxin 1 -0.0160223
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0159414
CBX3 chromobox homolog 3 -0.015894
CSNK1A1 casein kinase 1, alpha 1 -0.0154799
GLO1 glyoxalase I -0.0154622
BIRC6 baculoviral IAP repeat containing 6 -0.0154224
SLC38A2 solute carrier family 38, member 2 -0.0153287
RIMS2 regulating synaptic membrane exocytosis 2 -0.0152535
RNF216 ring finger protein 216 -0.015164
IARS1 isoleucyl-tRNA synthetase 1 -0.0150535
REST RE1-silencing transcription factor -0.0149761
S100A10 S100 calcium binding protein A10 -0.0149061
PRELID2 PRELI domain containing 2 -0.0146163
FER fer (fps/fes related) tyrosine kinase -0.0145742
MYL12B myosin, light chain 12B, regulatory -0.0145704
SERBP1 SERPINE1 mRNA binding protein 1 -0.0144951
ARHGAP24 Rho GTPase activating protein 24 -0.0144915
DOCK5 dedicator of cytokinesis 5 -0.0144149
RTN4 reticulon 4 -0.0143007
FNDC3A fibronectin type III domain containing 3A -0.0141982
CYB5D2 cytochrome b5 domain containing 2 -0.0141084
CDK12 cyclin-dependent kinase 12 -0.0139983
PA2G4 proliferation-associated 2G4, 38kDa -0.0138905
SEC31A SEC31 homolog A (S. cerevisiae) -0.0138508
SPIDR scaffolding protein involved in DNA repair -0.0138072
RPL35A ribosomal protein L35a -0.0137272
ASTN2 astrotactin 2 -0.0136992
TJP1 tight junction protein 1 -0.0136073
EXOC4 exocyst complex component 4 -0.013551
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0134658
ATP5MG ATP synthase membrane subunit g -0.0133067
COL1A2 collagen, type I, alpha 2 -0.0132928
RRBP1 ribosome binding protein 1 -0.0132067
FOXP2 forkhead box P2 -0.01313