Entrectinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.27086
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.228434
PDE4D phosphodiesterase 4D, cAMP-specific 0.0995305
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0950581
TXNRD1 thioredoxin reductase 1 0.0802272
EZR ezrin 0.0777611
ADAM10 ADAM metallopeptidase domain 10 0.0623296
PABPC1 poly(A) binding protein, cytoplasmic 1 0.053498
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0520447
PYGB phosphorylase, glycogen; brain 0.0513692
RPS6 ribosomal protein S6 0.0499124
FLNB filamin B, beta 0.0497302
SLC38A2 solute carrier family 38, member 2 0.0488727
ZBTB20 zinc finger and BTB domain containing 20 0.0468668
DUSP4 dual specificity phosphatase 4 0.0462731
EFNA5 ephrin-A5 0.0456028
SQSTM1 sequestosome 1 0.043242
SRRM2 serine/arginine repetitive matrix 2 0.0431617
TJP1 tight junction protein 1 0.0428352
RPL3 ribosomal protein L3 0.0421588
TMSB4X thymosin beta 4, X-linked 0.0417921
ARL4C ADP-ribosylation factor-like 4C 0.0415541
MINDY2 MINDY lysine 48 deubiquitinase 2 0.040281
RPS8 ribosomal protein S8 0.0397934
RPS19 ribosomal protein S19 0.0382636
PTMA prothymosin, alpha 0.037626
NBAS neuroblastoma amplified sequence 0.0374434
RPS3 ribosomal protein S3 0.0371212
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0365807
RPL35A ribosomal protein L35a 0.035624
EIF1 eukaryotic translation initiation factor 1 0.0348421
JMJD1C jumonji domain containing 1C 0.0347446
CCND1 cyclin D1 0.0337915
ANK2 ankyrin 2, neuronal 0.0333176
PRPF38B pre-mRNA processing factor 38B 0.0327886
LDHA lactate dehydrogenase A 0.0323121
PFN1 profilin 1 0.03222
EEF2 eukaryotic translation elongation factor 2 0.0321833
SOX6 SRY (sex determining region Y)-box 6 0.031955
TMEM65 transmembrane protein 65 0.0316351
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0315621
SBF2 SET binding factor 2 0.0310545
AKAP9 A kinase (PRKA) anchor protein 9 0.0309149
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0303971
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0302674
ANKRD12 ankyrin repeat domain 12 0.0299001
RB1CC1 RB1-inducible coiled-coil 1 0.0297881
PLK2 polo-like kinase 2 0.0294653
RPS14 ribosomal protein S14 0.0292591
RPL7 ribosomal protein L7 0.0290938
RAB27B RAB27B, member RAS oncogene family 0.0290146
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0286778
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0286137
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0277991
PRDX2 peroxiredoxin 2 0.0273624
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0267706
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0262788
RPL11 ribosomal protein L11 0.0262409
RPL12 ribosomal protein L12 0.0251106
DSCAM Down syndrome cell adhesion molecule 0.0250747
ZNF608 zinc finger protein 608 0.0246686
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.024567
DSTN destrin (actin depolymerizing factor) 0.0238981
RPL32 ribosomal protein L32 0.0234357
RPS2 ribosomal protein S2 0.0232101
RPL9 ribosomal protein L9 0.0230961
ZCCHC7 zinc finger, CCHC domain containing 7 0.0230063
SMYD3 SET and MYND domain containing 3 0.023005
BCAS3 breast carcinoma amplified sequence 3 0.0225749
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0223819
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0222963
SREBF2 sterol regulatory element binding transcription factor 2 0.022026
NBEAL1 neurobeachin-like 1 0.0218718
RPS12 ribosomal protein S12 0.0215927
TBC1D5 TBC1 domain family, member 5 0.0215615
PCBP2 poly(rC) binding protein 2 0.0213867
NCEH1 neutral cholesterol ester hydrolase 1 0.0213635
ENO2 enolase 2 (gamma, neuronal) 0.0212003
PKM pyruvate kinase, muscle 0.0209626
RPL13A ribosomal protein L13a 0.0208891
ALDOC aldolase C, fructose-bisphosphate 0.0208714
CLIP1 CAP-GLY domain containing linker protein 1 0.0208694
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0207007
CSF1 colony stimulating factor 1 (macrophage) 0.0206005
HMGA1 high mobility group AT-hook 1 0.0205114
RPL34 ribosomal protein L34 0.0205098
HDAC9 histone deacetylase 9 0.0204104
ATP9B ATPase, class II, type 9B 0.0203673
TRIM24 tripartite motif containing 24 0.0203579
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0203437
RPL7A ribosomal protein L7a 0.0202677
SOS1 son of sevenless homolog 1 (Drosophila) 0.0202633
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0200261
PRRC2C proline-rich coiled-coil 2C 0.0198865
RPS13 ribosomal protein S13 0.0198622
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0195687
POTEF POTE ankyrin domain family, member F 0.0195544
CCDC68 coiled-coil domain containing 68 0.0193354
NBEA neurobeachin 0.0192207
RPL21 ribosomal protein L21 0.0190015

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.201351
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.187993
SSBP2 single-stranded DNA binding protein 2 -0.0835489
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0834618
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0654048
PDE4B phosphodiesterase 4B, cAMP-specific -0.0541616
FOXP1 forkhead box P1 -0.0525426
NAMPT nicotinamide phosphoribosyltransferase -0.0507542
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0504477
BMP10 bone morphogenetic protein 10 -0.0431834
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0396974
CALR calreticulin -0.0396749
NAV2 neuron navigator 2 -0.03862
FNDC3B fibronectin type III domain containing 3B -0.037837
QKI QKI, KH domain containing, RNA binding -0.0358279
WAC WW domain containing adaptor with coiled-coil -0.0335954
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0335113
KDM3A lysine (K)-specific demethylase 3A -0.0335087
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0334806
MSI2 musashi RNA-binding protein 2 -0.0329339
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0325727
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0314473
PUM1 pumilio RNA-binding family member 1 -0.0298858
TFG TRK-fused gene -0.0292425
PDIA3 protein disulfide isomerase family A, member 3 -0.0292094
ZNF292 zinc finger protein 292 -0.0290013
ZFAND3 zinc finger, AN1-type domain 3 -0.028698
RFC3 replication factor C (activator 1) 3, 38kDa -0.0282035
CANX calnexin -0.0280679
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.027525
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0268717
MATR3 matrin 3 -0.0265087
ZEB1 zinc finger E-box binding homeobox 1 -0.0260932
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0258834
CDC73 cell division cycle 73 -0.0258424
FBXO11 F-box protein 11 -0.0255564
EVI5 ecotropic viral integration site 5 -0.0255138
ANKRD11 ankyrin repeat domain 11 -0.0254905
AEBP2 AE binding protein 2 -0.0253008
HELZ helicase with zinc finger -0.0246183
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0244192
PDIA6 protein disulfide isomerase family A, member 6 -0.0237294
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0229929
NRF1 nuclear respiratory factor 1 -0.0227443
MKI67 marker of proliferation Ki-67 -0.0217119
ANKRD17 ankyrin repeat domain 17 -0.0215465
GSE1 Gse1 coiled-coil protein -0.0213812
PDE7B phosphodiesterase 7B -0.0208247
DOCK1 dedicator of cytokinesis 1 -0.0207095
ANKRD10 ankyrin repeat domain 10 -0.0206523
EXOC4 exocyst complex component 4 -0.0204671
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0204265
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.019768
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0194601
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0193705
PKP4 plakophilin 4 -0.0191473
NUP58 nucleoporin 58 -0.0190953
NOP58 NOP58 ribonucleoprotein -0.0189852
CAMKMT calmodulin-lysine N-methyltransferase -0.0189797
MARCHF6 membrane associated ring-CH-type finger 6 -0.0189085
NFIA nuclear factor I/A -0.0186674
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.018558
NPAS2 neuronal PAS domain protein 2 -0.0184905
RBM39 RNA binding motif protein 39 -0.0181587
GNAS GNAS complex locus -0.0181476
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0180745
DIAPH3 diaphanous-related formin 3 -0.0179263
PTK2 protein tyrosine kinase 2 -0.0179242
HYOU1 hypoxia up-regulated 1 -0.017833
TXNL1 thioredoxin-like 1 -0.0177275
ATAD2 ATPase family, AAA domain containing 2 -0.0175912
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0174647
GLS2 glutaminase 2 (liver, mitochondrial) -0.0174595
GLI3 GLI family zinc finger 3 -0.0173424
FUS FUS RNA binding protein -0.0172896
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0172104
WSB1 WD repeat and SOCS box containing 1 -0.0170722
SP100 SP100 nuclear antigen -0.0169568
TARS1 threonyl-tRNA synthetase 1 -0.0169087
VIM vimentin -0.0168662
PSPC1 paraspeckle component 1 -0.0168599
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0168425
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0167223
TPX2 TPX2, microtubule-associated -0.0166672
FAM13B family with sequence similarity 13, member B -0.0165925
TRA2A transformer 2 alpha homolog (Drosophila) -0.0165803
RBM8A RNA binding motif protein 8A -0.0165628
AHNAK AHNAK nucleoprotein -0.0164705
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0164105
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0162946
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0162731
SMC4 structural maintenance of chromosomes 4 -0.0162169
KMT2E lysine (K)-specific methyltransferase 2E -0.0162
YME1L1 YME1-like 1 ATPase -0.0159648
BZW1 basic leucine zipper and W2 domains 1 -0.015958
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.015811
RYBP RING1 and YY1 binding protein -0.0157838
PRRC1 proline-rich coiled-coil 1 -0.0157446
FAM168A family with sequence similarity 168, member A -0.0157154
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0156185