Entrectinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Entrectinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0957335
FTH1 ferritin, heavy polypeptide 1 0.0636982
MYH9 myosin, heavy chain 9, non-muscle 0.0584861
FN1 fibronectin 1 0.054063
SFTPA2 surfactant protein A2 0.0307418
SOD2 superoxide dismutase 2, mitochondrial 0.0294106
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0287584
NAMPT nicotinamide phosphoribosyltransferase 0.0276643
DST dystonin 0.0235522
INSIG1 insulin induced gene 1 0.0217334
BICC1 BicC family RNA binding protein 1 0.0199697
COL8A1 collagen, type VIII, alpha 1 0.0183541
ELL2 elongation factor, RNA polymerase II, 2 0.0173188
SPTBN1 spectrin, beta, non-erythrocytic 1 0.016931
CENPF centromere protein F, 350/400kDa 0.0168803
SPAG9 sperm associated antigen 9 0.0167865
MSN moesin 0.016512
EIF4H eukaryotic translation initiation factor 4H 0.0164843
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0161896
FNIP1 folliculin interacting protein 1 0.016011
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.015909
MYOF myoferlin 0.0153253
FLNA filamin A, alpha 0.0152551
PHF3 PHD finger protein 3 0.0151091
LDLR low density lipoprotein receptor 0.0148838
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.014349
NAV2 neuron navigator 2 0.0143055
DSCAM Down syndrome cell adhesion molecule 0.0140326
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0139171
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0135755
JMJD1C jumonji domain containing 1C 0.0134547
ZMIZ1 zinc finger, MIZ-type containing 1 0.0128461
ANLN anillin, actin binding protein 0.0128021
NGLY1 N-glycanase 1 0.0124916
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0122509
MKI67 marker of proliferation Ki-67 0.0122496
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0121162
RPL3 ribosomal protein L3 0.0118728
LAMP2 lysosomal-associated membrane protein 2 0.0117657
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0117469
EZR ezrin 0.0113921
MXI1 MAX interactor 1, dimerization protein 0.0113647
ZNF292 zinc finger protein 292 0.0112359
TNIP1 TNFAIP3 interacting protein 1 0.0109678
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0109497
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0107652
ELOVL5 ELOVL fatty acid elongase 5 0.0106002
EPB41 erythrocyte membrane protein band 4.1 0.0105845
USP9X ubiquitin specific peptidase 9, X-linked 0.0105672
ATP13A3 ATPase type 13A3 0.0105665
ANKRD28 ankyrin repeat domain 28 0.0102762
ERRFI1 ERBB receptor feedback inhibitor 1 0.00999431
OPTN optineurin 0.00987193
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00978741
PDE10A phosphodiesterase 10A 0.00976822
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00976806
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00972201
RB1CC1 RB1-inducible coiled-coil 1 0.00963839
RND3 Rho family GTPase 3 0.00954881
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0093736
SDC4 syndecan 4 0.00928824
LCOR ligand dependent nuclear receptor corepressor 0.00926122
TPX2 TPX2, microtubule-associated 0.00921643
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0091033
KYNU kynureninase 0.00897339
EIF4B eukaryotic translation initiation factor 4B 0.00885449
GAS2L3 growth arrest-specific 2 like 3 0.00883562
CLTC clathrin, heavy chain (Hc) 0.0088333
LRRC7 leucine rich repeat containing 7 0.00862873
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.00862628
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00848676
IDI1 isopentenyl-diphosphate delta isomerase 1 0.00848101
FAM219A family with sequence similarity 219, member A 0.00847892
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00845035
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00843221
ESYT2 extended synaptotagmin-like protein 2 0.00836921
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00835447
MSMO1 methylsterol monooxygenase 1 0.00832983
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0083072
KLHL24 kelch-like family member 24 0.00822721
ARFGEF3 ARFGEF family member 3 0.00812921
ZHX2 zinc fingers and homeoboxes 2 0.00810393
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.00804087
ANKRD36 ankyrin repeat domain 36 0.00798115
ARRDC3 arrestin domain containing 3 0.00796243
DPYSL2 dihydropyrimidinase-like 2 0.00784948
SREBF2 sterol regulatory element binding transcription factor 2 0.00784125
ACSS2 acyl-CoA synthetase short-chain family member 2 0.00783594
RLIM ring finger protein, LIM domain interacting 0.00779328
SRRM2 serine/arginine repetitive matrix 2 0.00777481
PER3 period circadian clock 3 0.00763526
CDK19 cyclin-dependent kinase 19 0.00757009
ZNF608 zinc finger protein 608 0.00756577
ARHGAP21 Rho GTPase activating protein 21 0.00754683
ZFYVE16 zinc finger, FYVE domain containing 16 0.00754663
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.00748133
SEC23A Sec23 homolog A (S. cerevisiae) 0.00747229
NDE1 nudE neurodevelopment protein 1 0.00744931
RASEF RAS and EF-hand domain containing 0.00743132
LONRF3 LON peptidase N-terminal domain and ring finger 3 0.00742551

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.158009
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128331
HLA-B major histocompatibility complex, class I, B -0.108296
TMSB10 thymosin beta 10 -0.0926438
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0891818
FTL ferritin, light polypeptide -0.0854642
MT2A metallothionein 2A -0.0688722
RPS6 ribosomal protein S6 -0.0634958
GLIS3 GLIS family zinc finger 3 -0.0557905
IER3 immediate early response 3 -0.0544755
B2M beta-2-microglobulin -0.0527946
TPT1 tumor protein, translationally-controlled 1 -0.0510802
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0507933
RPL23 ribosomal protein L23 -0.0501955
RPL35A ribosomal protein L35a -0.0495873
RPLP1 ribosomal protein, large, P1 -0.0468077
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0457841
RPS24 ribosomal protein S24 -0.0448344
HLA-A major histocompatibility complex, class I, A -0.040815
LDHA lactate dehydrogenase A -0.0393333
AKAP12 A kinase (PRKA) anchor protein 12 -0.0386652
RPS12 ribosomal protein S12 -0.0384718
RPS8 ribosomal protein S8 -0.0376544
RPLP2 ribosomal protein, large, P2 -0.0364568
CDH13 cadherin 13 -0.0347436
RPS19 ribosomal protein S19 -0.034488
FRMD4A FERM domain containing 4A -0.0335868
ENO1 enolase 1, (alpha) -0.0323989
RPL37A ribosomal protein L37a -0.0323125
HMGA2 high mobility group AT-hook 2 -0.032142
RPS13 ribosomal protein S13 -0.0317648
CD44 CD44 molecule (Indian blood group) -0.0308113
RPS23 ribosomal protein S23 -0.0306256
RPS21 ribosomal protein S21 -0.0305873
COL1A2 collagen, type I, alpha 2 -0.0304054
PTMA prothymosin, alpha -0.0303469
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0299718
IFITM3 interferon induced transmembrane protein 3 -0.0294488
PKM pyruvate kinase, muscle -0.029204
ACTG1 actin gamma 1 -0.0290646
RPL19 ribosomal protein L19 -0.0280681
RPL9 ribosomal protein L9 -0.0276728
RPS4X ribosomal protein S4, X-linked -0.0275797
RPL11 ribosomal protein L11 -0.026742
EXT1 exostosin glycosyltransferase 1 -0.0263733
IFI6 interferon, alpha-inducible protein 6 -0.026191
S100A9 S100 calcium binding protein A9 -0.0261149
RPLP0 ribosomal protein, large, P0 -0.0257057
RPS3 ribosomal protein S3 -0.0254143
WSB1 WD repeat and SOCS box containing 1 -0.0253971
IGFBP3 insulin-like growth factor binding protein 3 -0.0253293
RPL26 ribosomal protein L26 -0.0249903
CALR calreticulin -0.0249818
EIF1 eukaryotic translation initiation factor 1 -0.0249397
RPL36 ribosomal protein L36 -0.0247115
RPS25 ribosomal protein S25 -0.0245175
BASP1 brain abundant, membrane attached signal protein 1 -0.0245092
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0244695
RPL36A ribosomal protein L36a -0.0244507
CTSD cathepsin D -0.0239963
RPL12 ribosomal protein L12 -0.0229948
RPL31 ribosomal protein L31 -0.0228695
BTG1 B-cell translocation gene 1, anti-proliferative -0.0227718
RPL27A ribosomal protein L27a -0.0226429
RPL7A ribosomal protein L7a -0.0225963
ASPH aspartate beta-hydroxylase -0.0219442
RPS27A ribosomal protein S27a -0.0218643
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0218195
RPL5 ribosomal protein L5 -0.0217907
IFI16 interferon, gamma-inducible protein 16 -0.0215546
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.021475
PGK1 phosphoglycerate kinase 1 -0.0214322
RPS10 ribosomal protein S10 -0.0212914
TXNIP thioredoxin interacting protein -0.0210246
SFRP1 secreted frizzled-related protein 1 -0.0209188
IFITM1 interferon induced transmembrane protein 1 -0.020714
NAV1 neuron navigator 1 -0.0206427
GNAS GNAS complex locus -0.0201604
RPL35 ribosomal protein L35 -0.0196747
RPL37 ribosomal protein L37 -0.0196679
ANXA2 annexin A2 -0.0196625
ZMYND8 zinc finger, MYND-type containing 8 -0.0196387
PLIN2 perilipin 2 -0.0193581
ENO2 enolase 2 (gamma, neuronal) -0.0193236
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0190992
COL1A1 collagen, type I, alpha 1 -0.0190577
ARL4C ADP-ribosylation factor-like 4C -0.0190464
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0186804
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0185426
RPL34 ribosomal protein L34 -0.018338
HMGA1 high mobility group AT-hook 1 -0.018266
ADM adrenomedullin -0.0181213
TENM2 teneurin transmembrane protein 2 -0.0178837
NAP1L1 nucleosome assembly protein 1-like 1 -0.0178728
RPL38 ribosomal protein L38 -0.0177206
VDAC1 voltage-dependent anion channel 1 -0.0175969
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0175295
RPL39 ribosomal protein L39 -0.0174331
KPNB1 karyopherin (importin) beta 1 -0.0173712
TPM4 tropomyosin 4 -0.0172144