| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Entrectinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Entrectinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.104359 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0774117 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0665081 |
| VEGFA | vascular endothelial growth factor A | 0.0657163 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0649963 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0577665 |
| SFTPA2 | surfactant protein A2 | 0.0552121 |
| FTL | ferritin, light polypeptide | 0.0547268 |
| IL6 | interleukin 6 | 0.0544968 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0536101 |
| ANXA5 | annexin A5 | 0.0517617 |
| VIM | vimentin | 0.051628 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.048 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0473131 |
| IGF2 | insulin-like growth factor 2 | 0.0434001 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0430884 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.041991 |
| RNF145 | ring finger protein 145 | 0.0403607 |
| MRTFA | myocardin related transcription factor A | 0.0393991 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0391162 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0385369 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0367524 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0367362 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.036338 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0359497 |
| STK17A | serine/threonine kinase 17a | 0.035905 |
| NOP58 | NOP58 ribonucleoprotein | 0.0357575 |
| MMP2 | matrix metallopeptidase 2 | 0.0357469 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0355759 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0355507 |
| NBAS | neuroblastoma amplified sequence | 0.0351897 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0346017 |
| SMAD2 | SMAD family member 2 | 0.0337312 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0336596 |
| GOLGA4 | golgin A4 | 0.0329139 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0322608 |
| SERF2 | small EDRK-rich factor 2 | 0.0319473 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0313741 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0311997 |
| TMEM165 | transmembrane protein 165 | 0.03073 |
| USP34 | ubiquitin specific peptidase 34 | 0.0305837 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0304794 |
| OSMR | oncostatin M receptor | 0.0302937 |
| CLMP | CXADR-like membrane protein | 0.0302142 |
| TNPO3 | transportin 3 | 0.0296959 |
| PAPOLA | poly(A) polymerase alpha | 0.0296787 |
| RBM25 | RNA binding motif protein 25 | 0.029543 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0293288 |
| HLA-B | major histocompatibility complex, class I, B | 0.0292332 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | 0.0290956 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | 0.028859 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0288541 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0285865 |
| RIN2 | Ras and Rab interactor 2 | 0.0285329 |
| KLHL7 | kelch-like family member 7 | 0.0284717 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0282374 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0278884 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0277281 |
| SPPL3 | signal peptide peptidase like 3 | 0.0276952 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0276614 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0276605 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0275053 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0273068 |
| COG6 | component of oligomeric golgi complex 6 | 0.0270079 |
| NKTR | natural killer cell triggering receptor | 0.0269565 |
| SEC24A | SEC24 family member A | 0.0268007 |
| YEATS2 | YEATS domain containing 2 | 0.0263984 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0262515 |
| ATP13A3 | ATPase type 13A3 | 0.0262221 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0262095 |
| MMP12 | matrix metallopeptidase 12 | 0.0261711 |
| RPS14 | ribosomal protein S14 | 0.0260618 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0260486 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0260067 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0257799 |
| MX1 | MX dynamin-like GTPase 1 | 0.0257582 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | 0.0256502 |
| SEPTIN9 | septin 9 | 0.0255728 |
| SEC24B | SEC24 family member B | 0.0251131 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0250947 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0250094 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0249364 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0249294 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0247745 |
| MSN | moesin | 0.024739 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0245828 |
| RAI14 | retinoic acid induced 14 | 0.0245234 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0244288 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | 0.0243515 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0241586 |
| WDR43 | WD repeat domain 43 | 0.0240733 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0240083 |
| RINT1 | RAD50 interactor 1 | 0.0237666 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.023675 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0236726 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0235991 |
| TPM3 | tropomyosin 3 | 0.0235831 |
| GOLT1B | golgi transport 1B | 0.0234786 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0234488 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0234214 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.171757 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.133806 |
| COL1A2 | collagen, type I, alpha 2 | -0.0986658 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0982553 |
| CD44 | CD44 molecule (Indian blood group) | -0.0958537 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0709859 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0652041 |
| VCL | vinculin | -0.0645639 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0628875 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0628635 |
| LOXL2 | lysyl oxidase-like 2 | -0.0614745 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0580224 |
| COL1A1 | collagen, type I, alpha 1 | -0.0578792 |
| CANX | calnexin | -0.0569649 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0563341 |
| LDHA | lactate dehydrogenase A | -0.0539214 |
| AHNAK | AHNAK nucleoprotein | -0.0536759 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0520017 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.051351 |
| NRXN3 | neurexin 3 | -0.0497577 |
| FN1 | fibronectin 1 | -0.0495687 |
| PTMA | prothymosin, alpha | -0.0477162 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0472673 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0452873 |
| ARF1 | ADP-ribosylation factor 1 | -0.0451072 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0447459 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.044023 |
| TXNIP | thioredoxin interacting protein | -0.0437932 |
| CDK6 | cyclin-dependent kinase 6 | -0.043604 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0431792 |
| FUS | FUS RNA binding protein | -0.0423338 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0421995 |
| INTS6 | integrator complex subunit 6 | -0.0418173 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0415687 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0413903 |
| RAD51B | RAD51 paralog B | -0.0412843 |
| COL5A2 | collagen, type V, alpha 2 | -0.0404919 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0402084 |
| DIAPH3 | diaphanous-related formin 3 | -0.0400108 |
| VEGFC | vascular endothelial growth factor C | -0.0399848 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0397155 |
| DST | dystonin | -0.0392672 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0388424 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0386048 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0379587 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0378381 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0378375 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0374866 |
| PRSS23 | protease, serine, 23 | -0.0374344 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0373651 |
| PKM | pyruvate kinase, muscle | -0.0372626 |
| NABP1 | nucleic acid binding protein 1 | -0.0370983 |
| GLIS3 | GLIS family zinc finger 3 | -0.0370181 |
| MYOF | myoferlin | -0.0369157 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0364636 |
| PRELID2 | PRELI domain containing 2 | -0.0362577 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0359927 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0354801 |
| ANXA2 | annexin A2 | -0.0352619 |
| TENM3 | teneurin transmembrane protein 3 | -0.0348634 |
| ENO1 | enolase 1, (alpha) | -0.0347978 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0346661 |
| BRD2 | bromodomain containing 2 | -0.034504 |
| GNAS | GNAS complex locus | -0.0343715 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.034139 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0332391 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0331494 |
| THY1 | Thy-1 cell surface antigen | -0.0323963 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0320205 |
| ASPH | aspartate beta-hydroxylase | -0.0318186 |
| ANO6 | anoctamin 6 | -0.0317461 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0315311 |
| CMIP | c-Maf inducing protein | -0.0312999 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.031298 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0312718 |
| PALLD | palladin, cytoskeletal associated protein | -0.0312605 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.031241 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.031216 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0311745 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311722 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0310431 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0306867 |
| KLHDC10 | kelch domain containing 10 | -0.0305155 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.030468 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0300974 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0299813 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0299138 |
| FTO | fat mass and obesity associated | -0.0297168 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0295695 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0290258 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0284859 |
| CLIC4 | chloride intracellular channel 4 | -0.0284337 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0282684 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0282153 |
| PCM1 | pericentriolar material 1 | -0.0281371 |
| SQSTM1 | sequestosome 1 | -0.0280826 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0280572 |
| RHEB | Ras homolog enriched in brain | -0.0278314 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.027708 |
| SEPTIN7 | septin 7 | -0.0276908 |
