Entrectinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Entrectinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Entrectinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0551452
MT2A metallothionein 2A 0.0504031
SNX14 sorting nexin 14 0.0455155
ZNF292 zinc finger protein 292 0.0452441
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0435142
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.03919
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0379624
KMT2E lysine (K)-specific methyltransferase 2E 0.037091
FTH1 ferritin, heavy polypeptide 1 0.0354515
ZEB1 zinc finger E-box binding homeobox 1 0.03357
ANGPTL4 angiopoietin-like 4 0.0335388
HDGF hepatoma-derived growth factor 0.0334189
GOLGB1 golgin B1 0.0332286
BIRC6 baculoviral IAP repeat containing 6 0.0327229
SETD5 SET domain containing 5 0.0318924
CALU calumenin 0.0314449
PNISR PNN-interacting serine/arginine-rich protein 0.0307964
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0302527
TXNRD1 thioredoxin reductase 1 0.0299282
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0297686
EIF1 eukaryotic translation initiation factor 1 0.0294133
RPS3 ribosomal protein S3 0.0292763
MAP2K1 mitogen-activated protein kinase kinase 1 0.0285667
YAP1 Yes-associated protein 1 0.0281637
CHD1 chromodomain helicase DNA binding protein 1 0.0279768
TSC22D2 TSC22 domain family, member 2 0.027362
XRN2 5'-3' exoribonuclease 2 0.027204
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0271545
EZR ezrin 0.0270899
HSPA4 heat shock 70kDa protein 4 0.0270166
CKAP2L cytoskeleton associated protein 2-like 0.0266468
P4HB prolyl 4-hydroxylase, beta polypeptide 0.026554
FMNL2 formin-like 2 0.026551
CREBRF CREB3 regulatory factor 0.0265482
ARHGAP21 Rho GTPase activating protein 21 0.0264508
POTEF POTE ankyrin domain family, member F 0.0258586
FCHSD2 FCH and double SH3 domains 2 0.0258551
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.02517
MSN moesin 0.0249504
PFN1 profilin 1 0.0249076
ARL15 ADP-ribosylation factor-like 15 0.0247983
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.0246229
CSNK1A1 casein kinase 1, alpha 1 0.0243036
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0242486
SFXN1 sideroflexin 1 0.0241902
ARF4 ADP-ribosylation factor 4 0.0241299
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.0239886
RPL3 ribosomal protein L3 0.0239854
IGF2R insulin-like growth factor 2 receptor 0.023849
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.023806
AKAP13 A kinase (PRKA) anchor protein 13 0.023795
HMGXB3 HMG box domain containing 3 0.0231791
NCKAP1 NCK-associated protein 1 0.0230155
IKBIP IKBKB interacting protein 0.0230103
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0228295
EPS8 epidermal growth factor receptor pathway substrate 8 0.0228087
SAFB scaffold attachment factor B 0.0227546
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0227269
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0225782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0225779
POM121 POM121 transmembrane nucleoporin 0.0225195
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0224531
RUNX1 runt-related transcription factor 1 0.022289
GALK2 galactokinase 2 0.0222747
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0221168
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0220919
PRKD3 protein kinase D3 0.0220217
TPD52 tumor protein D52 0.0219674
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.021789
AHCYL1 adenosylhomocysteinase-like 1 0.0217779
ASPH aspartate beta-hydroxylase 0.0216077
NT5E 5'-nucleotidase, ecto (CD73) 0.0215952
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0215722
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0215672
GAN gigaxonin 0.0215536
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0214872
KLHL7 kelch-like family member 7 0.021412
MED15 mediator complex subunit 15 0.0212383
ERRFI1 ERBB receptor feedback inhibitor 1 0.0212207
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0211018
OASL 2'-5'-oligoadenylate synthetase-like 0.0209564
BMERB1 bMERB domain containing 1 0.0208962
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0207696
ESYT2 extended synaptotagmin-like protein 2 0.0207171
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0204968
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0204945
TENT2 terminal nucleotidyltransferase 2 0.0202892
SRRM2 serine/arginine repetitive matrix 2 0.0202411
INSIG1 insulin induced gene 1 0.0200905
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0200578
XPO6 exportin 6 0.0200527
SRP54 signal recognition particle 54kDa 0.020048
SET SET nuclear proto-oncogene 0.0200133
ITGAV integrin, alpha V 0.0200032
RPL21 ribosomal protein L21 0.0199567
SHB Src homology 2 domain containing adaptor protein B 0.0199386
CD46 CD46 molecule, complement regulatory protein 0.0195374
SUCO SUN domain containing ossification factor 0.0194502
FTL ferritin, light polypeptide 0.0193675
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0193054

decreased expression

Symbol Name Standardized Value
LDHA lactate dehydrogenase A -0.0974346
PTMA prothymosin, alpha -0.0797058
TMSB10 thymosin beta 10 -0.0785141
RBM39 RNA binding motif protein 39 -0.0651523
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0593242
ANKRD11 ankyrin repeat domain 11 -0.0587223
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0585562
ZBTB20 zinc finger and BTB domain containing 20 -0.0561826
ANXA2 annexin A2 -0.0549259
FNDC3B fibronectin type III domain containing 3B -0.053964
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0533846
FMN1 formin 1 -0.0528019
SMYD3 SET and MYND domain containing 3 -0.0507929
LPP LIM domain containing preferred translocation partner in lipoma -0.0498201
ACTG1 actin gamma 1 -0.0494074
TRIO trio Rho guanine nucleotide exchange factor -0.0490349
DST dystonin -0.0480622
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0471449
CLIP1 CAP-GLY domain containing linker protein 1 -0.0458434
TPT1 tumor protein, translationally-controlled 1 -0.045171
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0436226
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0425519
CANX calnexin -0.0416109
IGF1R insulin-like growth factor 1 receptor -0.0413033
LOC112694756 uncharaterized LOC112694756 -0.0412119
ASXL1 additional sex combs like transcriptional regulator 1 -0.0398868
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0398001
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0383581
HILPDA hypoxia inducible lipid droplet-associated -0.0376782
TPM4 tropomyosin 4 -0.0371284
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0366393
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0361207
RSF1 remodeling and spacing factor 1 -0.0360111
NCEH1 neutral cholesterol ester hydrolase 1 -0.0354558
DIAPH3 diaphanous-related formin 3 -0.0353069
AHNAK AHNAK nucleoprotein -0.0352166
HMGA2 high mobility group AT-hook 2 -0.0349401
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0349088
BPTF bromodomain PHD finger transcription factor -0.0346338
PDE8A phosphodiesterase 8A -0.0345248
ANKRD28 ankyrin repeat domain 28 -0.034182
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341193
ZBTB38 zinc finger and BTB domain containing 38 -0.0339401
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0338691
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0337559
WAC WW domain containing adaptor with coiled-coil -0.0336154
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0334506
SLC38A2 solute carrier family 38, member 2 -0.0330827
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0329463
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.032461
WWTR1 WW domain containing transcription regulator 1 -0.0323843
LCORL ligand dependent nuclear receptor corepressor-like -0.0321844
THSD4 thrombospondin, type I, domain containing 4 -0.0319945
PRH1 proline-rich protein HaeIII subfamily 1 -0.0317685
DERA deoxyribose-phosphate aldolase (putative) -0.0315957
RPS25 ribosomal protein S25 -0.0315491
RACK1 receptor for activated C kinase 1 -0.0310096
SAMD4A sterile alpha motif domain containing 4A -0.0307481
RNF213 ring finger protein 213 -0.0306737
ANXA1 annexin A1 -0.0306299
EXOC6B exocyst complex component 6B -0.0304411
CUX1 cut-like homeobox 1 -0.0300047
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0299557
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0298667
NALCN sodium leak channel, non selective -0.0298228
INTS6 integrator complex subunit 6 -0.0297512
NAV3 neuron navigator 3 -0.0297162
S100A10 S100 calcium binding protein A10 -0.0296422
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0296254
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0292543
CD2AP CD2-associated protein -0.0292193
RDX radixin -0.0288339
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.02878
ELL2 elongation factor, RNA polymerase II, 2 -0.0284812
EVI5 ecotropic viral integration site 5 -0.0282809
GOLGA4 golgin A4 -0.0281604
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0280724
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0280182
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0279615
IGFBP3 insulin-like growth factor binding protein 3 -0.0277783
RAD51B RAD51 paralog B -0.0277671
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0277173
MACF1 microtubule-actin crosslinking factor 1 -0.0276829
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.027668
ECT2 epithelial cell transforming 2 -0.0275388
BASP1 brain abundant, membrane attached signal protein 1 -0.0274874
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0274251
RHEB Ras homolog enriched in brain -0.0273501
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0273089
EXT1 exostosin glycosyltransferase 1 -0.0271273
ATM ATM serine/threonine kinase -0.0270064
DPYD dihydropyrimidine dehydrogenase -0.0267148
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0266214
ANO6 anoctamin 6 -0.0264296
ZNF638 zinc finger protein 638 -0.0263012
ABI1 abl-interactor 1 -0.0261508
SMAD2 SMAD family member 2 -0.0261298
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0258652
TOM1L2 target of myb1-like 2 (chicken) -0.025759
RPS8 ribosomal protein S8 -0.0256764