| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/15951529 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Enzalutamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF175 | zinc finger protein 175 | 1.83 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.21 |
| BCL2L12 | BCL2-like 12 (proline rich) | 0.77 |
| MRPL20 | mitochondrial ribosomal protein L20 | 0.61 |
| FBXO41 | F-box protein 41 | 0.59 |
| RNF4 | ring finger protein 4 | 0.58 |
| HDAC7 | histone deacetylase 7 | 0.57 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.55 |
| PRR3 | proline rich 3 | 0.49 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.48 |
| DUOX1 | dual oxidase 1 | 0.48 |
| SLC25A39 | solute carrier family 25, member 39 | 0.47 |
| RPL31 | ribosomal protein L31 | 0.46 |
| FRRS1 | ferric-chelate reductase 1 | 0.46 |
| IL10RB | interleukin 10 receptor, beta | 0.45 |
| PRRX2 | paired related homeobox 2 | 0.45 |
| GPSM2 | G-protein signaling modulator 2 | 0.45 |
| CENPJ | centromere protein J | 0.44 |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | 0.43 |
| SP100 | SP100 nuclear antigen | 0.42 |
| ZNF354B | zinc finger protein 354B | 0.42 |
| ZNF362 | zinc finger protein 362 | 0.42 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.41 |
| PEX7 | peroxisomal biogenesis factor 7 | 0.4 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 0.4 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.4 |
| GOT2 | glutamic-oxaloacetic transaminase 2, mitochondrial | 0.39 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 0.39 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.39 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.38 |
| UBE2N | ubiquitin-conjugating enzyme E2N | 0.37 |
| UPP1 | uridine phosphorylase 1 | 0.36 |
| ZNF711 | zinc finger protein 711 | 0.36 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.36 |
| LTBP3 | latent transforming growth factor beta binding protein 3 | 0.36 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | 0.35 |
| PTPDC1 | protein tyrosine phosphatase domain containing 1 | 0.35 |
| TOX2 | TOX high mobility group box family member 2 | 0.35 |
| SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | 0.34 |
| PCBP3 | poly(rC) binding protein 3 | 0.34 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 0.34 |
| LRRK1 | leucine-rich repeat kinase 1 | 0.34 |
| ADAR | adenosine deaminase, RNA-specific | 0.33 |
| MT1F | metallothionein 1F | 0.33 |
| PSMB2 | proteasome (prosome, macropain) subunit, beta type, 2 | 0.32 |
| CCDC85B | coiled-coil domain containing 85B | 0.32 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.31 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | 0.31 |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa | 0.31 |
| HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 | 0.31 |
| ANKRD39 | ankyrin repeat domain 39 | 0.31 |
| RAD51C | RAD51 paralog C | 0.31 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.3 |
| RHOA | ras homolog family member A | 0.3 |
| SYTL2 | synaptotagmin-like 2 | 0.3 |
| ASB8 | ankyrin repeat and SOCS box containing 8 | 0.29 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.29 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.29 |
| MED28 | mediator complex subunit 28 | 0.29 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.28 |
| DCK | deoxycytidine kinase | 0.28 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.28 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.28 |
| H3C1 | H3 clustered histone 1 | 0.28 |
| MT1X | metallothionein 1X | 0.27 |
| ZNRD2 | zinc ribbon domain containing 2 | 0.27 |
| MT1E | metallothionein 1E | 0.27 |
| ZNF280B | zinc finger protein 280B | 0.27 |
| CENPL | centromere protein L | 0.27 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.27 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.26 |
| BOLA1 | bolA family member 1 | 0.26 |
| RAVER2 | ribonucleoprotein, PTB-binding 2 | 0.26 |
| FIZ1 | FLT3-interacting zinc finger 1 | 0.26 |
| MTRF1 | mitochondrial translational release factor 1 | 0.26 |
| SIX5 | SIX homeobox 5 | 0.26 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.25 |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa | 0.25 |
| PEX26 | peroxisomal biogenesis factor 26 | 0.25 |
| RNF26 | ring finger protein 26 | 0.25 |
| MANEAL | mannosidase, endo-alpha-like | 0.25 |
| HKDC1 | hexokinase domain containing 1 | 0.25 |
| CCDC112 | coiled-coil domain containing 112 | 0.25 |
| CDON | cell adhesion associated, oncogene regulated | 0.25 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.25 |
| ACTBL2 | actin, beta-like 2 | 0.25 |
| FBXO31 | F-box protein 31 | 0.25 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.25 |
| ATXN7L3B | ataxin 7-like 3B | 0.24 |
| RCAN1 | regulator of calcineurin 1 | 0.24 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.24 |
| CALD1 | caldesmon 1 | 0.24 |
| PRDM4 | PR domain containing 4 | 0.24 |
| KLHL5 | kelch-like family member 5 | 0.24 |
| DONSON | downstream neighbor of SON | 0.24 |
| IER2 | immediate early response 2 | 0.24 |
| INO80D | INO80 complex subunit D | 0.24 |
| MAGEE1 | melanoma antigen family E1 | 0.24 |
| CCDC77 | coiled-coil domain containing 77 | 0.24 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.63 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.62 |
| SOD1 | superoxide dismutase 1, soluble | -0.61 |
| CCNE1 | cyclin E1 | -0.61 |
| PAH | phenylalanine hydroxylase | -0.61 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.54 |
| ZNF302 | zinc finger protein 302 | -0.52 |
| PIP | prolactin-induced protein | -0.51 |
| RHOD | ras homolog family member D | -0.51 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.51 |
| HDAC5 | histone deacetylase 5 | -0.47 |
| LIME1 | Lck interacting transmembrane adaptor 1 | -0.44 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.44 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -0.44 |
| ZNF224 | zinc finger protein 224 | -0.42 |
| SGCE | sarcoglycan, epsilon | -0.42 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.41 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.4 |
| TMEM219 | transmembrane protein 219 | -0.39 |
| IDUA | iduronidase, alpha-L- | -0.39 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | -0.38 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.38 |
| SLC38A2 | solute carrier family 38, member 2 | -0.36 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.36 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.36 |
| PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 | -0.35 |
| CD2BP2 | CD2 (cytoplasmic tail) binding protein 2 | -0.33 |
| LAMC3 | laminin, gamma 3 | -0.33 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.33 |
| PLK4 | polo-like kinase 4 | -0.33 |
| CEP57 | centrosomal protein 57kDa | -0.33 |
| EXT1 | exostosin glycosyltransferase 1 | -0.33 |
| LAMA3 | laminin, alpha 3 | -0.32 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.31 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.31 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.3 |
| PET117 | PET117 homolog (S. cerevisiae) | -0.3 |
| TSPAN3 | tetraspanin 3 | -0.3 |
| MCOLN1 | mucolipin 1 | -0.3 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.3 |
| CD63 | CD63 molecule | -0.3 |
| RUBCN | rubicon autophagy regulator | -0.3 |
| NCOA4 | nuclear receptor coactivator 4 | -0.3 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.29 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.28 |
| AREG | amphiregulin | -0.28 |
| MYO18B | myosin XVIIIB | -0.28 |
| TPM4 | tropomyosin 4 | -0.28 |
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | -0.28 |
| CCDC90B | coiled-coil domain containing 90B | -0.28 |
| RAB11FIP4 | RAB11 family interacting protein 4 (class II) | -0.27 |
| HEXD | hexosaminidase D | -0.27 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.27 |
| MPZL2 | myelin protein zero-like 2 | -0.27 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.27 |
| NDRG1 | N-myc downstream regulated 1 | -0.27 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.26 |
| STARD5 | StAR-related lipid transfer (START) domain containing 5 | -0.26 |
| SERINC5 | serine incorporator 5 | -0.26 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.25 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.25 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.25 |
| FAR1 | fatty acyl CoA reductase 1 | -0.24 |
| PRG4 | proteoglycan 4 | -0.24 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.24 |
| DENND3 | DENN/MADD domain containing 3 | -0.24 |
| TRIM35 | tripartite motif containing 35 | -0.24 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.24 |
| TMEM222 | transmembrane protein 222 | -0.24 |
| CYTH1 | cytohesin 1 | -0.24 |
| ZSCAN20 | zinc finger and SCAN domain containing 20 | -0.24 |
| SEMG2 | semenogelin II | -0.23 |
| TANK | TRAF family member-associated NFKB activator | -0.23 |
| MSMO1 | methylsterol monooxygenase 1 | -0.23 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.23 |
| TPM2 | tropomyosin 2 (beta) | -0.23 |
| SF1 | splicing factor 1 | -0.23 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.23 |
| STK40 | serine/threonine kinase 40 | -0.23 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.23 |
| BMERB1 | bMERB domain containing 1 | -0.23 |
| NCKAP5L | NCK-associated protein 5-like | -0.23 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -0.23 |
| SELENOM | selenoprotein M | -0.22 |
| TMEM106C | transmembrane protein 106C | -0.22 |
| VGLL4 | vestigial-like family member 4 | -0.22 |
| PDLIM5 | PDZ and LIM domain 5 | -0.22 |
| EPHX4 | epoxide hydrolase 4 | -0.22 |
| CRY2 | cryptochrome circadian clock 2 | -0.22 |
| TMEM64 | transmembrane protein 64 | -0.22 |
| ZNF121 | zinc finger protein 121 | -0.22 |
| C12ORF66 | chromosome 12 open reading frame 66 | -0.21 |
| CALU | calumenin | -0.21 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | -0.21 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.21 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | -0.21 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | -0.21 |
| ADCK5 | aarF domain containing kinase 5 | -0.21 |
| APOB | apolipoprotein B | -0.21 |
