| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Epirubicin (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Epirubicin (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.231654 |
| RPS6 | ribosomal protein S6 | 0.0820195 |
| AXL | AXL receptor tyrosine kinase | 0.0724092 |
| RNF213 | ring finger protein 213 | 0.0711058 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0682967 |
| FLNA | filamin A, alpha | 0.0680119 |
| CA12 | carbonic anhydrase XII | 0.0639168 |
| RPS2 | ribosomal protein S2 | 0.0611984 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0602266 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0529132 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0522625 |
| ANXA4 | annexin A4 | 0.0505237 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0467791 |
| RPS19 | ribosomal protein S19 | 0.0463024 |
| RPL4 | ribosomal protein L4 | 0.0458587 |
| TPI1 | triosephosphate isomerase 1 | 0.0441684 |
| RIN2 | Ras and Rab interactor 2 | 0.0432657 |
| PCBP2 | poly(rC) binding protein 2 | 0.0427839 |
| NDRG1 | N-myc downstream regulated 1 | 0.0419741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.040807 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0386503 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.038485 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0375733 |
| AUTS2 | autism susceptibility candidate 2 | 0.0368139 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.0365574 |
| EGFR | epidermal growth factor receptor | 0.0365455 |
| PRKCA | protein kinase C, alpha | 0.03653 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0362184 |
| FBXO22 | F-box protein 22 | 0.0355325 |
| TNFRSF10A | tumor necrosis factor receptor superfamily, member 10a | 0.0352436 |
| RPS12 | ribosomal protein S12 | 0.0346004 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0345821 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0342735 |
| H1-0 | H1.0 linker histone | 0.0342373 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0338611 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0338476 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0337806 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0333 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0328442 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0326306 |
| RPS17 | ribosomal protein S17 | 0.0321243 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0303359 |
| MCL1 | myeloid cell leukemia 1 | 0.0300779 |
| NXN | nucleoredoxin | 0.0298337 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.029624 |
| AHNAK | AHNAK nucleoprotein | 0.0284394 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0284272 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0284131 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0271794 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0269131 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0268336 |
| DSPP | dentin sialophosphoprotein | 0.0265465 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0262225 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0261791 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0261681 |
| PTMA | prothymosin, alpha | 0.0260817 |
| YBX3 | Y box binding protein 3 | 0.0260212 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0260203 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0258643 |
| MORC4 | MORC family CW-type zinc finger 4 | 0.0252678 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0249718 |
| POLH | polymerase (DNA directed), eta | 0.0249339 |
| HDGF | hepatoma-derived growth factor | 0.0249277 |
| RPS3 | ribosomal protein S3 | 0.0247132 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0243787 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0243415 |
| SULF2 | sulfatase 2 | 0.02403 |
| PNN | pinin, desmosome associated protein | 0.0238899 |
| NTN1 | netrin 1 | 0.023742 |
| SRPK2 | SRSF protein kinase 2 | 0.0235266 |
| TNS1 | tensin 1 | 0.0234339 |
| NHSL1 | NHS-like 1 | 0.023415 |
| PKM | pyruvate kinase, muscle | 0.0233344 |
| PLAU | plasminogen activator, urokinase | 0.0231339 |
| GK | glycerol kinase | 0.0230338 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0228511 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0224833 |
| XPC | xeroderma pigmentosum, complementation group C | 0.0223741 |
| GSE1 | Gse1 coiled-coil protein | 0.0223258 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0222897 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0222774 |
| CCNL1 | cyclin L1 | 0.0219595 |
| MLEC | malectin | 0.0219196 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0219069 |
| ABR | active BCR-related | 0.021766 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0217332 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0216816 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0216552 |
| ZFHX3 | zinc finger homeobox 3 | 0.0212078 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.0210351 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.0208594 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.020796 |
| VEGFA | vascular endothelial growth factor A | 0.0205503 |
| PLD5 | phospholipase D family, member 5 | 0.0205276 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0204146 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0203363 |
| DSTN | destrin (actin depolymerizing factor) | 0.0202898 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0202119 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0201152 |
| RPL28 | ribosomal protein L28 | 0.0200853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ARHGAP26 | Rho GTPase activating protein 26 | -0.143083 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.128823 |
| KYNU | kynureninase | -0.127492 |
| ANXA2 | annexin A2 | -0.124674 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.120025 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.102323 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0933435 |
| PDE10A | phosphodiesterase 10A | -0.0908476 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0871317 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0821984 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0776259 |
| OSMR | oncostatin M receptor | -0.0755398 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0727108 |
| ACTG1 | actin gamma 1 | -0.071629 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0674687 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0653868 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.065154 |
| SPAG9 | sperm associated antigen 9 | -0.0632503 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0628914 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0621916 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0619131 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0613265 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0588829 |
| RPLP1 | ribosomal protein, large, P1 | -0.058475 |
| ECT2 | epithelial cell transforming 2 | -0.058277 |
| FMNL2 | formin-like 2 | -0.0565493 |
| VCL | vinculin | -0.0561686 |
| MT1X | metallothionein 1X | -0.0556178 |
| FTL | ferritin, light polypeptide | -0.0550233 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0547149 |
| TXNRD1 | thioredoxin reductase 1 | -0.0542945 |
| MORF4L2 | mortality factor 4 like 2 | -0.0531889 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0518147 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0511464 |
| USP34 | ubiquitin specific peptidase 34 | -0.0498727 |
| ACTN4 | actinin, alpha 4 | -0.0496363 |
| RASA2 | RAS p21 protein activator 2 | -0.0484262 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0482108 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0478959 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0476505 |
| PGK1 | phosphoglycerate kinase 1 | -0.047125 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0460574 |
| USP3 | ubiquitin specific peptidase 3 | -0.045883 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0458622 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0458615 |
| SP100 | SP100 nuclear antigen | -0.0452846 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0452578 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0433359 |
| SMAD3 | SMAD family member 3 | -0.0430071 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0424006 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0418902 |
| UBC | ubiquitin C | -0.041819 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0417066 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0413973 |
| NF1 | neurofibromin 1 | -0.0410283 |
| RPS24 | ribosomal protein S24 | -0.0406171 |
| ANXA1 | annexin A1 | -0.0403901 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0401395 |
| JMJD1C | jumonji domain containing 1C | -0.03976 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0386451 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0385607 |
| GLIS3 | GLIS family zinc finger 3 | -0.0385291 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.038264 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0380064 |
| NAV2 | neuron navigator 2 | -0.0373739 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0362752 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0360686 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0359138 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0356718 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0351197 |
| LDHA | lactate dehydrogenase A | -0.0351102 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0350067 |
| RAD21 | RAD21 homolog (S. pombe) | -0.034691 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0346475 |
| CLINT1 | clathrin interactor 1 | -0.0345845 |
| GOLGA4 | golgin A4 | -0.0344873 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0343792 |
| WDR45B | WD repeat domain 45B | -0.0342788 |
| RAB10 | RAB10, member RAS oncogene family | -0.0339972 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0335776 |
| RNF145 | ring finger protein 145 | -0.0331862 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0327434 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.032698 |
| CLTC | clathrin, heavy chain (Hc) | -0.0326672 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0325054 |
| KLF6 | Kruppel-like factor 6 | -0.0323637 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0323256 |
| LMAN1 | lectin, mannose-binding, 1 | -0.032174 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0313353 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0310664 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.031036 |
| RPL23 | ribosomal protein L23 | -0.0308584 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0301149 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0300817 |
| DOCK4 | dedicator of cytokinesis 4 | -0.030043 |
| MT2A | metallothionein 2A | -0.029917 |
| USP47 | ubiquitin specific peptidase 47 | -0.029418 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | -0.0294132 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0292787 |
| COG5 | component of oligomeric golgi complex 5 | -0.0290777 |
