Epirubicin (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Epirubicin (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Epirubicin (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.076025
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0461023
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0440359
RPS12 ribosomal protein S12 0.0413024
RPL37A ribosomal protein L37a 0.0281735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0252907
RPS2 ribosomal protein S2 0.0223207
PCBP2 poly(rC) binding protein 2 0.0207489
RPLP2 ribosomal protein, large, P2 0.0204037
SRRM1 serine/arginine repetitive matrix 1 0.0200744
RPL9 ribosomal protein L9 0.0199607
PTMA prothymosin, alpha 0.0176816
FTH1 ferritin, heavy polypeptide 1 0.0176446
KTN1 kinectin 1 (kinesin receptor) 0.0173664
NFE2L1 nuclear factor, erythroid 2-like 1 0.0172925
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0166646
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0163908
PRRC2C proline-rich coiled-coil 2C 0.0162401
PNN pinin, desmosome associated protein 0.0161369
RPL4 ribosomal protein L4 0.0156505
RPL36 ribosomal protein L36 0.01547
RTN4 reticulon 4 0.0152742
CCNL1 cyclin L1 0.0152723
BRD4 bromodomain containing 4 0.0150141
SRRM2 serine/arginine repetitive matrix 2 0.0138747
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0138611
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0134232
MT2A metallothionein 2A 0.0132074
RPL21 ribosomal protein L21 0.0131552
TPM3 tropomyosin 3 0.013113
PGAM4 phosphoglycerate mutase family member 4 0.0130164
GDF15 growth differentiation factor 15 0.0130048
KDM6A lysine (K)-specific demethylase 6A 0.0125423
WDR43 WD repeat domain 43 0.0122844
RAB6A RAB6A, member RAS oncogene family 0.0121609
ZNF292 zinc finger protein 292 0.0118702
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.011772
RBM39 RNA binding motif protein 39 0.0117131
MXD1 MAX dimerization protein 1 0.0117033
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0116712
VIM vimentin 0.0116249
RPL18 ribosomal protein L18 0.0115549
RPS17 ribosomal protein S17 0.0110157
RPS8 ribosomal protein S8 0.0109206
RPS18 ribosomal protein S18 0.0107739
TLN1 talin 1 0.0107723
TPI1 triosephosphate isomerase 1 0.0107578
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.0106502
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0106131
SET SET nuclear proto-oncogene 0.0105981
KMT2C lysine (K)-specific methyltransferase 2C 0.0105157
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0104283
RPS10 ribosomal protein S10 0.0102301
CRLS1 cardiolipin synthase 1 0.0101678
SUCO SUN domain containing ossification factor 0.0101568
RPS3 ribosomal protein S3 0.0100104
IL4R interleukin 4 receptor 0.0100072
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.00998694
RACK1 receptor for activated C kinase 1 0.00995313
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.00966026
BHLHE40 basic helix-loop-helix family, member e40 0.00965703
RPL35 ribosomal protein L35 0.00964895
LMTK2 lemur tyrosine kinase 2 0.00955902
TMF1 TATA element modulatory factor 1 0.00953327
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.00940184
PABPN1 poly(A) binding protein, nuclear 1 0.00937222
PA2G4 proliferation-associated 2G4, 38kDa 0.00933796
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00930854
ARHGAP9 Rho GTPase activating protein 9 0.00921231
RPL26 ribosomal protein L26 0.00898
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.00893861
SZRD1 SUZ RNA binding domain containing 1 0.00891847
RPL3 ribosomal protein L3 0.00891068
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.00890054
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.00887067
RPS7 ribosomal protein S7 0.00885637
NGLY1 N-glycanase 1 0.00857472
SERF2 small EDRK-rich factor 2 0.00855979
RANBP9 RAN binding protein 9 0.00850939
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00846516
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.00845526
MLEC malectin 0.00837633
TNIP1 TNFAIP3 interacting protein 1 0.00835116
FLNA filamin A, alpha 0.00834878
EIF5B eukaryotic translation initiation factor 5B 0.00812671
TUBA1B tubulin, alpha 1b 0.00810144
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.00805535
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.00805497
PTPRG protein tyrosine phosphatase, receptor type, G 0.00802766
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00802526
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.00793396
BLZF1 basic leucine zipper nuclear factor 1 0.00790221
FAM13A family with sequence similarity 13, member A 0.00789405
HSPA4 heat shock 70kDa protein 4 0.00784774
MAPK14 mitogen-activated protein kinase 14 0.00782425
SP3 Sp3 transcription factor 0.00780661
PDE4D phosphodiesterase 4D, cAMP-specific 0.00778943
WSB1 WD repeat and SOCS box containing 1 0.00778079
RSRC2 arginine/serine-rich coiled-coil 2 0.00769312
RPL27 ribosomal protein L27 0.00765663

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.500748
FN1 fibronectin 1 -0.21739
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.139761
APOB apolipoprotein B -0.104494
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.100901
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0989179
GPC3 glypican 3 -0.0796542
GPC6 glypican 6 -0.0739894
EHBP1 EH domain binding protein 1 -0.0724061
PEG3 paternally expressed 3 -0.0647574
FBF1 Fas (TNFRSF6) binding factor 1 -0.0615584
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0615454
TF transferrin -0.0604166
MAML2 mastermind-like 2 (Drosophila) -0.0597167
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0565789
CP ceruloplasmin (ferroxidase) -0.0561641
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0551003
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0550728
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0550137
IGFBP1 insulin-like growth factor binding protein 1 -0.0543215
AHSG alpha-2-HS-glycoprotein -0.0542028
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0534898
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0513415
TMEM123 transmembrane protein 123 -0.04774
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0450582
SLC38A2 solute carrier family 38, member 2 -0.0450079
NKD1 naked cuticle homolog 1 (Drosophila) -0.0423825
C3 complement component 3 -0.0420347
ENO1 enolase 1, (alpha) -0.0414478
NPAS2 neuronal PAS domain protein 2 -0.0395537
EXT1 exostosin glycosyltransferase 1 -0.0386606
PDLIM5 PDZ and LIM domain 5 -0.038362
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0383069
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.037988
TM4SF1 transmembrane 4 L six family member 1 -0.0378307
SAMD4A sterile alpha motif domain containing 4A -0.0371705
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0359903
ATXN1 ataxin 1 -0.0355407
LRMDA leucine rich melanocyte differentiation associated -0.035423
PARD3 par-3 family cell polarity regulator -0.0352441
FAM107B family with sequence similarity 107, member B -0.0346134
TPM4 tropomyosin 4 -0.033957
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0337701
GK glycerol kinase -0.0334928
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0330914
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0326302
LPP LIM domain containing preferred translocation partner in lipoma -0.0320809
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0320126
ZBTB20 zinc finger and BTB domain containing 20 -0.030957
PHF3 PHD finger protein 3 -0.0306529
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0302483
DLC1 DLC1 Rho GTPase activating protein -0.0302379
TPT1 tumor protein, translationally-controlled 1 -0.0299219
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0293962
RPS24 ribosomal protein S24 -0.0289842
ITGAV integrin, alpha V -0.0286661
LMCD1 LIM and cysteine-rich domains 1 -0.0284766
NPR2 natriuretic peptide receptor 2 -0.0284612
EML4 echinoderm microtubule associated protein like 4 -0.0282697
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0278911
CCL20 chemokine (C-C motif) ligand 20 -0.0278492
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0278174
INTS6 integrator complex subunit 6 -0.0275007
KLF6 Kruppel-like factor 6 -0.026977
SVIL supervillin -0.0267889
FOXP1 forkhead box P1 -0.0267487
LCOR ligand dependent nuclear receptor corepressor -0.0267357
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0266484
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0263068
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0261386
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0259455
AHNAK AHNAK nucleoprotein -0.025922
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0257462
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0252747
USP34 ubiquitin specific peptidase 34 -0.0252507
DSPP dentin sialophosphoprotein -0.025082
ITGA1 integrin, alpha 1 -0.0249479
MSI2 musashi RNA-binding protein 2 -0.0248813
EPS8 epidermal growth factor receptor pathway substrate 8 -0.024824
DOCK4 dedicator of cytokinesis 4 -0.0246497
RAI14 retinoic acid induced 14 -0.0244474
DNAH17 dynein, axonemal, heavy chain 17 -0.0243513
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0243388
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0243184
VCL vinculin -0.0242339
OSBPL10 oxysterol binding protein-like 10 -0.0241837
GNAS GNAS complex locus -0.0241432
LOC112694756 uncharaterized LOC112694756 -0.0240816
MBNL2 muscleblind-like splicing regulator 2 -0.0237582
PAWR PRKC, apoptosis, WT1, regulator -0.0234974
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.023327
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0232802
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0228473
TNS3 tensin 3 -0.0225939
RYBP RING1 and YY1 binding protein -0.0225724
TRIO trio Rho guanine nucleotide exchange factor -0.0221872
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0217691
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.021764
EPAS1 endothelial PAS domain protein 1 -0.0217376
LDHA lactate dehydrogenase A -0.0215766