| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Epirubicin (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Epirubicin (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0972769 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0819662 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0811538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0453956 |
| MKI67 | marker of proliferation Ki-67 | 0.0395983 |
| RPL4 | ribosomal protein L4 | 0.0286674 |
| CENPF | centromere protein F, 350/400kDa | 0.0285944 |
| TUBA1B | tubulin, alpha 1b | 0.0270086 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0247883 |
| YBX1 | Y box binding protein 1 | 0.0222595 |
| UBE2C | ubiquitin-conjugating enzyme E2C | 0.0208318 |
| FGB | fibrinogen beta chain | 0.0192944 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0189223 |
| ANLN | anillin, actin binding protein | 0.0187337 |
| RPS12 | ribosomal protein S12 | 0.0185179 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.017846 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0175775 |
| TPX2 | TPX2, microtubule-associated | 0.0173804 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0169762 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0169458 |
| TUBB | tubulin, beta class I | 0.0166163 |
| KNL1 | kinetochore scaffold 1 | 0.0165649 |
| TPM3 | tropomyosin 3 | 0.0156323 |
| RPS2 | ribosomal protein S2 | 0.0147639 |
| TPI1 | triosephosphate isomerase 1 | 0.0141265 |
| CENPE | centromere protein E, 312kDa | 0.0139429 |
| PFN1 | profilin 1 | 0.0133825 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.013224 |
| HMGB2 | high mobility group box 2 | 0.0131194 |
| HMGB1 | high mobility group box 1 | 0.0130855 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0127495 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0124328 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0119589 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.011787 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0116412 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0116002 |
| KLF6 | Kruppel-like factor 6 | 0.0113176 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0112822 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0112231 |
| AURKA | aurora kinase A | 0.0111586 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0109813 |
| THBS1 | thrombospondin 1 | 0.0108927 |
| SGO2 | shugoshin 2 | 0.0108383 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0108367 |
| RPL18 | ribosomal protein L18 | 0.0108016 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0107175 |
| TAGLN2 | transgelin 2 | 0.0106735 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.0104483 |
| SERF2 | small EDRK-rich factor 2 | 0.0100772 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.010016 |
| PRC1 | protein regulator of cytokinesis 1 | 0.00999811 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0099636 |
| GTSE1 | G-2 and S-phase expressed 1 | 0.00990071 |
| KIF23 | kinesin family member 23 | 0.00975344 |
| RPS3 | ribosomal protein S3 | 0.00973612 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0096643 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.00958059 |
| CLU | clusterin | 0.0091984 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.00919717 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0091712 |
| STMN1 | stathmin 1 | 0.00900943 |
| RACK1 | receptor for activated C kinase 1 | 0.00899576 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.00898301 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | 0.00896545 |
| PCBP2 | poly(rC) binding protein 2 | 0.00874935 |
| NDC80 | NDC80 kinetochore complex component | 0.00855514 |
| CMC2 | C-x(9)-C motif containing 2 | 0.00854927 |
| CLSPN | claspin | 0.00852996 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.00848789 |
| MMS22L | MMS22-like, DNA repair protein | 0.00846538 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.00845649 |
| KIF20A | kinesin family member 20A | 0.00836795 |
| WBP11 | WW domain binding protein 11 | 0.00827034 |
| CENPU | centromere protein U | 0.00824565 |
| KIF11 | kinesin family member 11 | 0.00822729 |
| RANBP1 | RAN binding protein 1 | 0.00799693 |
| FGA | fibrinogen alpha chain | 0.00791049 |
| LMNA | lamin A/C | 0.00780163 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.00772203 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00771279 |
| STIL | SCL/TAL1 interrupting locus | 0.00766093 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.00751798 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00751482 |
| KIF4A | kinesin family member 4A | 0.0074882 |
| GPX4 | glutathione peroxidase 4 | 0.00745941 |
| AXL | AXL receptor tyrosine kinase | 0.00742722 |
| ANKZF1 | ankyrin repeat and zinc finger domain containing 1 | 0.00740738 |
| DIAPH3 | diaphanous-related formin 3 | 0.0073814 |
| GANAB | glucosidase, alpha; neutral AB | 0.00738129 |
| TUBG1 | tubulin, gamma 1 | 0.00737002 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.00728154 |
| KIAA0586 | KIAA0586 | 0.00720435 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00718934 |
| CDK1 | cyclin-dependent kinase 1 | 0.00710384 |
| KIFC1 | kinesin family member C1 | 0.0070708 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.00702684 |
| PER1 | period circadian clock 1 | 0.00690835 |
| APRT | adenine phosphoribosyltransferase | 0.0069021 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.00684438 |
| EXO1 | exonuclease 1 | 0.00682284 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.255255 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.20445 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.168938 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.157148 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0944909 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0866761 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0854803 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0828789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0823606 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0817535 |
| ACTG1 | actin gamma 1 | -0.0716445 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0695215 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0690044 |
| GRAMD1B | GRAM domain containing 1B | -0.0643748 |
| POTEF | POTE ankyrin domain family, member F | -0.0639208 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0607989 |
| CMIP | c-Maf inducing protein | -0.0602265 |
| FMNL2 | formin-like 2 | -0.0586525 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0570779 |
| ERBIN | erbb2 interacting protein | -0.056854 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.056045 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.05589 |
| SVIL | supervillin | -0.0555235 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0554992 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0533711 |
| IER3 | immediate early response 3 | -0.0522792 |
| MCL1 | myeloid cell leukemia 1 | -0.0518327 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0507653 |
| COPA | coatomer protein complex, subunit alpha | -0.0502784 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0489246 |
| LDHA | lactate dehydrogenase A | -0.0486162 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0485368 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0480559 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0470042 |
| USP34 | ubiquitin specific peptidase 34 | -0.0469709 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0469592 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0469142 |
| PARD3 | par-3 family cell polarity regulator | -0.0459917 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0451209 |
| RBM39 | RNA binding motif protein 39 | -0.0444276 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0442228 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0433599 |
| RPL35A | ribosomal protein L35a | -0.0425493 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0425035 |
| S100A6 | S100 calcium binding protein A6 | -0.0420174 |
| DENND4A | DENN/MADD domain containing 4A | -0.0419051 |
| RPL19 | ribosomal protein L19 | -0.0417346 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.04161 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0404031 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0402646 |
| PYGL | phosphorylase, glycogen, liver | -0.0391362 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0389842 |
| TMSB10 | thymosin beta 10 | -0.0387701 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0372481 |
| FTL | ferritin, light polypeptide | -0.0371356 |
| FBXO11 | F-box protein 11 | -0.0370991 |
| EGFR | epidermal growth factor receptor | -0.0370608 |
| MYOF | myoferlin | -0.0368372 |
| RPL31 | ribosomal protein L31 | -0.0365923 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0365859 |
| GOLGA4 | golgin A4 | -0.0360317 |
| FLNB | filamin B, beta | -0.0356127 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0354954 |
| PTK2 | protein tyrosine kinase 2 | -0.0353772 |
| NDRG1 | N-myc downstream regulated 1 | -0.0353392 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0353017 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0352197 |
| RPLP1 | ribosomal protein, large, P1 | -0.0352175 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0342337 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0341689 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0338867 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0336291 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0335033 |
| GLG1 | golgi glycoprotein 1 | -0.0333613 |
| VIM | vimentin | -0.0333394 |
| HLA-B | major histocompatibility complex, class I, B | -0.033231 |
| DST | dystonin | -0.0328444 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0327069 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0325388 |
| TPM4 | tropomyosin 4 | -0.0321253 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0318858 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0318811 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0318699 |
| JMJD1C | jumonji domain containing 1C | -0.0316134 |
| RPS8 | ribosomal protein S8 | -0.031504 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0313606 |
| RPS25 | ribosomal protein S25 | -0.0313106 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0312451 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0304428 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0302444 |
| IGF2 | insulin-like growth factor 2 | -0.0301536 |
| S100A10 | S100 calcium binding protein A10 | -0.0299865 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0298376 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0297979 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0296619 |
| BRD2 | bromodomain containing 2 | -0.0293556 |
| RPL23 | ribosomal protein L23 | -0.0292611 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0292357 |
| GLIS3 | GLIS family zinc finger 3 | -0.0291543 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0289089 |
