| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Epirubicin (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Epirubicin (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.104056 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0781131 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0507693 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0443765 |
| RPS6 | ribosomal protein S6 | 0.0427355 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0378545 |
| RPS12 | ribosomal protein S12 | 0.0365883 |
| PCBP2 | poly(rC) binding protein 2 | 0.0297962 |
| TMSB10 | thymosin beta 10 | 0.0295409 |
| B2M | beta-2-microglobulin | 0.0293706 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0292456 |
| FTL | ferritin, light polypeptide | 0.0290945 |
| GPHN | gephyrin | 0.0289011 |
| HLA-A | major histocompatibility complex, class I, A | 0.0264799 |
| RPL37A | ribosomal protein L37a | 0.026478 |
| RPS19 | ribosomal protein S19 | 0.0257412 |
| FLNA | filamin A, alpha | 0.0247545 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0242053 |
| GNAS | GNAS complex locus | 0.0239883 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0239102 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.023198 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0230025 |
| TPI1 | triosephosphate isomerase 1 | 0.0227668 |
| SRPK2 | SRSF protein kinase 2 | 0.0226726 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.022323 |
| TOP1 | topoisomerase (DNA) I | 0.0223012 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0221985 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0219304 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0216492 |
| FBXO22 | F-box protein 22 | 0.0215559 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0214588 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0205199 |
| NTN1 | netrin 1 | 0.0201017 |
| POLH | polymerase (DNA directed), eta | 0.0198295 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0193671 |
| RPS2 | ribosomal protein S2 | 0.0188368 |
| YBX1 | Y box binding protein 1 | 0.0188235 |
| RPS4X | ribosomal protein S4, X-linked | 0.0186601 |
| PTMA | prothymosin, alpha | 0.0186346 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0185992 |
| FUS | FUS RNA binding protein | 0.0184954 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0183153 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | 0.0182684 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0178903 |
| RPL9 | ribosomal protein L9 | 0.017828 |
| PKM | pyruvate kinase, muscle | 0.0177857 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0177797 |
| CCNL1 | cyclin L1 | 0.017669 |
| YBX3 | Y box binding protein 3 | 0.0172829 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0171089 |
| ASTN2 | astrotactin 2 | 0.0170599 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0170443 |
| E2F7 | E2F transcription factor 7 | 0.0169627 |
| SFTPA2 | surfactant protein A2 | 0.0168384 |
| AK1 | adenylate kinase 1 | 0.0166783 |
| TPM3 | tropomyosin 3 | 0.0165088 |
| HLA-B | major histocompatibility complex, class I, B | 0.0164628 |
| MLEC | malectin | 0.0163605 |
| RRM2B | ribonucleotide reductase M2 B (TP53 inducible) | 0.0162717 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0162198 |
| NOPCHAP1 | NOP protein chaperone 1 | 0.0161945 |
| RPS21 | ribosomal protein S21 | 0.0161931 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0161706 |
| LMNA | lamin A/C | 0.0161699 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0159185 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0155796 |
| RPLP2 | ribosomal protein, large, P2 | 0.0154995 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.0151789 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0151765 |
| ATP5F1B | ATP synthase F1 subunit beta | 0.0150864 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0150849 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0149719 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0148325 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0145816 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0145514 |
| OGA | O-GlcNAcase | 0.0143305 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0142518 |
| PNN | pinin, desmosome associated protein | 0.0142302 |
| HELZ | helicase with zinc finger | 0.0141576 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0141574 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0141157 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0139286 |
| RPS3 | ribosomal protein S3 | 0.0139135 |
| TLE4 | transducin-like enhancer of split 4 | 0.0138818 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0137882 |
| ADAM23 | ADAM metallopeptidase domain 23 | 0.013781 |
| RPS8 | ribosomal protein S8 | 0.0137433 |
| RPS17 | ribosomal protein S17 | 0.0137213 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.0136102 |
| PRKCA | protein kinase C, alpha | 0.0135528 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0135018 |
| SERINC5 | serine incorporator 5 | 0.0135017 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0134758 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.013427 |
| WDR43 | WD repeat domain 43 | 0.0132775 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0132492 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0132299 |
| RPL12 | ribosomal protein L12 | 0.013218 |
| SPECC1 | sperm antigen with calponin homology and coiled-coil domains 1 | 0.0132177 |
| PFN1 | profilin 1 | 0.013203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.23823 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.229264 |
| EFNA5 | ephrin-A5 | -0.174917 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.162129 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.157891 |
| FN1 | fibronectin 1 | -0.14045 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.136356 |
| ASPH | aspartate beta-hydroxylase | -0.123485 |
| GDA | guanine deaminase | -0.110564 |
| PDE10A | phosphodiesterase 10A | -0.0991009 |
| DST | dystonin | -0.0854349 |
| COL5A2 | collagen, type V, alpha 2 | -0.0851005 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.084048 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0836565 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0713899 |
| CDH13 | cadherin 13 | -0.0696745 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0666917 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0634745 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0628649 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0622262 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0611763 |
| MYOF | myoferlin | -0.0607138 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0601577 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0590672 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0580001 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0561692 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0557032 |
| KYNU | kynureninase | -0.0551198 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0537863 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0537022 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0535843 |
| FNDC3B | fibronectin type III domain containing 3B | -0.053 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0527609 |
| DOCK4 | dedicator of cytokinesis 4 | -0.049934 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0499231 |
| NRCAM | neuronal cell adhesion molecule | -0.049227 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0491556 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0488011 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0484663 |
| SMYD3 | SET and MYND domain containing 3 | -0.0477033 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0466943 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0431618 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0395201 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0386409 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0378678 |
| PCBP3 | poly(rC) binding protein 3 | -0.037711 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0363308 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0361044 |
| FNDC3A | fibronectin type III domain containing 3A | -0.035637 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0347738 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0343558 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0342742 |
| CANX | calnexin | -0.0342653 |
| RTN1 | reticulon 1 | -0.0342223 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0336176 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0335412 |
| FLNB | filamin B, beta | -0.0334462 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0329683 |
| VCL | vinculin | -0.0326282 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0320868 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0320732 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0318784 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0316356 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0312382 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0302385 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0294382 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0290726 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0289491 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0286645 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.028433 |
| ATXN1 | ataxin 1 | -0.0283894 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0279902 |
| SMAD2 | SMAD family member 2 | -0.0278801 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0274458 |
| NEK7 | NIMA-related kinase 7 | -0.0273296 |
| CHL1 | cell adhesion molecule L1-like | -0.0272902 |
| PM20D1 | peptidase M20 domain containing 1 | -0.027036 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0269239 |
| MFF | mitochondrial fission factor | -0.0265343 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0260953 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0257576 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.025198 |
| GRAMD1B | GRAM domain containing 1B | -0.0245199 |
| GLIS3 | GLIS family zinc finger 3 | -0.0245091 |
| PALLD | palladin, cytoskeletal associated protein | -0.0241603 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0240964 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0238926 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0238883 |
| MAP7 | microtubule-associated protein 7 | -0.023886 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0236814 |
| CTSC | cathepsin C | -0.022785 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0226399 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0225493 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | -0.0224389 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0224057 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0220897 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0219879 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0219202 |
| TXNRD1 | thioredoxin reductase 1 | -0.0218238 |
| LDHA | lactate dehydrogenase A | -0.0211434 |
