Epirubicin (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Epirubicin (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

65 genes differentially expressed following the Epirubicin (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.202198
KRT7 keratin 7, type II 0.152316
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.142862
FTL ferritin, light polypeptide 0.139683
PDE10A phosphodiesterase 10A 0.137056
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.13238
RSL24D1 ribosomal L24 domain containing 1 0.132172
EFNA5 ephrin-A5 0.124301
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.122846
ANXA2 annexin A2 0.103645
GPC6 glypican 6 0.0776796
PTPRM protein tyrosine phosphatase, receptor type, M 0.075375
NOP58 NOP58 ribonucleoprotein 0.0705354
PSD3 pleckstrin and Sec7 domain containing 3 0.0703674
SAMD4A sterile alpha motif domain containing 4A 0.0682062
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0674071
FMN1 formin 1 0.0644396
ACTG1 actin gamma 1 0.0639291
JMJD1C jumonji domain containing 1C 0.0584432
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0508968
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0472415
NKD1 naked cuticle homolog 1 (Drosophila) 0.0465952
PUM1 pumilio RNA-binding family member 1 0.0393869
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0366114
GNAS GNAS complex locus 0.0345701
PIAS1 protein inhibitor of activated STAT, 1 0.0338232
IER3 immediate early response 3 0.0278795
MYOF myoferlin 0.0278313
THSD4 thrombospondin, type I, domain containing 4 0.0262432
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0258876
VEZT vezatin, adherens junctions transmembrane protein 0.0237656
PTMA prothymosin, alpha 0.019734
FN1 fibronectin 1 0.0173777
APP amyloid beta (A4) precursor protein 0.0171376
ZFAND3 zinc finger, AN1-type domain 3 0.0156518
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0153879
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00599472
PDE4D phosphodiesterase 4D, cAMP-specific 0.00515891

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.2684
EGFR epidermal growth factor receptor -0.253398
VIM vimentin -0.143505
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.136039
PRRC2C proline-rich coiled-coil 2C -0.0959105
KMT2C lysine (K)-specific methyltransferase 2C -0.0817156
MYO1E myosin IE -0.0810533
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0687628
RPS6 ribosomal protein S6 -0.0685781
ELL2 elongation factor, RNA polymerase II, 2 -0.0587866
ASPH aspartate beta-hydroxylase -0.0587737
CDH13 cadherin 13 -0.0585385
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0566653
PARD3 par-3 family cell polarity regulator -0.0548566
FNDC3B fibronectin type III domain containing 3B -0.051112
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0450403
TMSB10 thymosin beta 10 -0.0368769
RORA RAR-related orphan receptor A -0.0314425
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0281532
FNDC3A fibronectin type III domain containing 3A -0.0258706
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.025129
IGF2 insulin-like growth factor 2 -0.0208198
ENO1 enolase 1, (alpha) -0.0114558
PTK2 protein tyrosine kinase 2 -0.0102812
MT2A metallothionein 2A -0.00970908
ELOVL5 ELOVL fatty acid elongase 5 -0.00562693
PDLIM5 PDZ and LIM domain 5 -0.00522968