| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Epirubicin (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Epirubicin (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.121995 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0550397 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0452476 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452129 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0405721 |
| MKI67 | marker of proliferation Ki-67 | 0.0387757 |
| PEG10 | paternally expressed 10 | 0.0358936 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.034424 |
| TMSB4X | thymosin beta 4, X-linked | 0.0322829 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0309576 |
| THBS1 | thrombospondin 1 | 0.0306168 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0298486 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0295961 |
| TPM3 | tropomyosin 3 | 0.0295699 |
| RPL4 | ribosomal protein L4 | 0.0263217 |
| HMGB2 | high mobility group box 2 | 0.0256884 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0253546 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0252732 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0248652 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0232617 |
| TPX2 | TPX2, microtubule-associated | 0.0231666 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0222452 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0215516 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0213728 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.021327 |
| ANLN | anillin, actin binding protein | 0.0210272 |
| WDR43 | WD repeat domain 43 | 0.0209154 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0201014 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.0197714 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0197159 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0191181 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0187786 |
| CCNA2 | cyclin A2 | 0.0186435 |
| FLNA | filamin A, alpha | 0.0186276 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0183924 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0183326 |
| IPO7 | importin 7 | 0.0182713 |
| H1-4 | H1.4 linker histone, cluster member | 0.0182384 |
| CLTC | clathrin, heavy chain (Hc) | 0.0180862 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.018054 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0175389 |
| MAPRE1 | microtubule-associated protein, RP/EB family, member 1 | 0.0175172 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0174704 |
| MCM4 | minichromosome maintenance complex component 4 | 0.017217 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0172098 |
| CCNL1 | cyclin L1 | 0.0171811 |
| CENPF | centromere protein F, 350/400kDa | 0.0171285 |
| DIAPH3 | diaphanous-related formin 3 | 0.0170744 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0170168 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0170106 |
| TCP1 | t-complex 1 | 0.0169616 |
| ANXA1 | annexin A1 | 0.016719 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | 0.0166468 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0165371 |
| NONO | non-POU domain containing, octamer-binding | 0.0164668 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0164499 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0163054 |
| USP3 | ubiquitin specific peptidase 3 | 0.0162368 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0158661 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0158271 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0158082 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0154491 |
| MCM3 | minichromosome maintenance complex component 3 | 0.015381 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0152798 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0150956 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.0149597 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0147425 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0147417 |
| MTMR3 | myotubularin related protein 3 | 0.0146079 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0145849 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0145038 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0144704 |
| ANXA5 | annexin A5 | 0.014371 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0142689 |
| IL6ST | interleukin 6 signal transducer | 0.0141636 |
| MATR3 | matrin 3 | 0.0140527 |
| ATAD5 | ATPase family, AAA domain containing 5 | 0.0140138 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.0140012 |
| TUBB | tubulin, beta class I | 0.0139865 |
| CENPC | centromere protein C | 0.0138385 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0138373 |
| CBX3 | chromobox homolog 3 | 0.0138173 |
| ECT2 | epithelial cell transforming 2 | 0.0137457 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0136894 |
| PRRC2A | proline-rich coiled-coil 2A | 0.013652 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.0136493 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0133099 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0132533 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0132349 |
| RHEB | Ras homolog enriched in brain | 0.013231 |
| KIF5B | kinesin family member 5B | 0.0132156 |
| SERINC1 | serine incorporator 1 | 0.0131289 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0130941 |
| DMXL1 | Dmx-like 1 | 0.0130784 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0129931 |
| RTTN | rotatin | 0.0129756 |
| PNN | pinin, desmosome associated protein | 0.01296 |
| SF1 | splicing factor 1 | 0.012946 |
| NPTN | neuroplastin | 0.0129425 |
| MYEF2 | myelin expression factor 2 | 0.012925 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.212805 |
| COL11A1 | collagen, type XI, alpha 1 | -0.211949 |
| VIM | vimentin | -0.174738 |
| TMSB10 | thymosin beta 10 | -0.146797 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.115882 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114906 |
| PHIP | pleckstrin homology domain interacting protein | -0.110972 |
| COL5A2 | collagen, type V, alpha 2 | -0.105028 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.104602 |
| TENM3 | teneurin transmembrane protein 3 | -0.102531 |
| RPS16 | ribosomal protein S16 | -0.100516 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0948121 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0947733 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0875112 |
| RPS8 | ribosomal protein S8 | -0.0864455 |
| PTMA | prothymosin, alpha | -0.0861352 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0824575 |
| CADM2 | cell adhesion molecule 2 | -0.0753036 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0725507 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0682697 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0653801 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0650662 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0644946 |
| RPL35A | ribosomal protein L35a | -0.0633443 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0627492 |
| RPS27A | ribosomal protein S27a | -0.0618609 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0608331 |
| PGK1 | phosphoglycerate kinase 1 | -0.0603099 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0596237 |
| HDAC9 | histone deacetylase 9 | -0.0594562 |
| CDH19 | cadherin 19, type 2 | -0.0584025 |
| ITGAV | integrin, alpha V | -0.0581803 |
| RPLP1 | ribosomal protein, large, P1 | -0.0580243 |
| RPL31 | ribosomal protein L31 | -0.057536 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0567766 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0560938 |
| RPS12 | ribosomal protein S12 | -0.0554003 |
| LRRC4C | leucine rich repeat containing 4C | -0.0553222 |
| NTM | neurotrimin | -0.0548935 |
| RPL37 | ribosomal protein L37 | -0.0544621 |
| RPL23 | ribosomal protein L23 | -0.0538883 |
| PLPP1 | phospholipid phosphatase 1 | -0.0519422 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0510026 |
| LDHA | lactate dehydrogenase A | -0.0498238 |
| SPAG9 | sperm associated antigen 9 | -0.0491176 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0490568 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0481879 |
| JMJD1C | jumonji domain containing 1C | -0.0477371 |
| RBM20 | RNA binding motif protein 20 | -0.0467271 |
| FTL | ferritin, light polypeptide | -0.0457566 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0453935 |
| B2M | beta-2-microglobulin | -0.0450419 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0447743 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0445185 |
| SYT1 | synaptotagmin I | -0.0443694 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0438416 |
| RPS13 | ribosomal protein S13 | -0.0437076 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0432905 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0431586 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0431543 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0427479 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0417605 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0417021 |
| RPS19 | ribosomal protein S19 | -0.0413219 |
| RPL37A | ribosomal protein L37a | -0.0411171 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0406357 |
| RPL5 | ribosomal protein L5 | -0.0404627 |
| RPL30 | ribosomal protein L30 | -0.0395816 |
| PCDH9 | protocadherin 9 | -0.0393308 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0388629 |
| ANK2 | ankyrin 2, neuronal | -0.0387086 |
| RPS6 | ribosomal protein S6 | -0.0377976 |
| ENO1 | enolase 1, (alpha) | -0.0377562 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0377235 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.037012 |
| ACTG1 | actin gamma 1 | -0.0369265 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0366271 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0365348 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0360982 |
| RPL19 | ribosomal protein L19 | -0.0358009 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0357905 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0357362 |
| UPP1 | uridine phosphorylase 1 | -0.0354035 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0347667 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0345896 |
| RPS25 | ribosomal protein S25 | -0.0344745 |
| RPS24 | ribosomal protein S24 | -0.0338622 |
| RPL11 | ribosomal protein L11 | -0.0337431 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0335906 |
| UBC | ubiquitin C | -0.0335258 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.033505 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0329823 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0328487 |
| RPL9 | ribosomal protein L9 | -0.0327112 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0327041 |
| SETD5 | SET domain containing 5 | -0.0326393 |
| SNX6 | sorting nexin 6 | -0.0325105 |
| RAD51B | RAD51 paralog B | -0.0315281 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0314479 |
| USP34 | ubiquitin specific peptidase 34 | -0.0313557 |
