Epirubicin (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Epirubicin (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Epirubicin (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.14645
TXNRD1 thioredoxin reductase 1 0.122631
RPS6 ribosomal protein S6 0.109612
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0886096
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0690667
FLNB filamin B, beta 0.0646151
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.063967
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0622825
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0598772
EEF2 eukaryotic translation elongation factor 2 0.0589821
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0551489
RPS2 ribosomal protein S2 0.0540866
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0531698
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0522504
PRRC2C proline-rich coiled-coil 2C 0.0482158
PCBP2 poly(rC) binding protein 2 0.047059
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0460814
ADAM10 ADAM metallopeptidase domain 10 0.0460403
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0451807
PYGB phosphorylase, glycogen; brain 0.0451467
TBC1D5 TBC1 domain family, member 5 0.045106
PTPRG protein tyrosine phosphatase, receptor type, G 0.0447315
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0422314
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0419691
RPS19 ribosomal protein S19 0.041888
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0409697
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0388548
B2M beta-2-microglobulin 0.038769
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0386025
RBM25 RNA binding motif protein 25 0.0385131
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0385129
NAMPT nicotinamide phosphoribosyltransferase 0.0383642
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0373365
HSPA8 heat shock 70kDa protein 8 0.0371976
VMP1 vacuole membrane protein 1 0.0369761
NUP58 nucleoporin 58 0.0369195
RBM39 RNA binding motif protein 39 0.0369008
CCNL1 cyclin L1 0.0360061
GCLM glutamate-cysteine ligase, modifier subunit 0.0355646
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0353309
KDM6A lysine (K)-specific demethylase 6A 0.0350832
SRRM2 serine/arginine repetitive matrix 2 0.0350574
ELOVL5 ELOVL fatty acid elongase 5 0.035024
RPL4 ribosomal protein L4 0.0349682
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0348739
ZFAND3 zinc finger, AN1-type domain 3 0.0348716
RPS3 ribosomal protein S3 0.0344934
GPHN gephyrin 0.0334553
TRIP12 thyroid hormone receptor interactor 12 0.0334295
PNN pinin, desmosome associated protein 0.0334211
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.033359
SLMAP sarcolemma associated protein 0.0326359
GOLGA4 golgin A4 0.032287
MSI2 musashi RNA-binding protein 2 0.0319984
NCOR1 nuclear receptor corepressor 1 0.031593
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.030675
SRPK2 SRSF protein kinase 2 0.0304277
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0304208
BCLAF1 BCL2-associated transcription factor 1 0.03036
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0303582
RPLP2 ribosomal protein, large, P2 0.0298973
NBAS neuroblastoma amplified sequence 0.0298324
RPS12 ribosomal protein S12 0.0297668
ZMAT3 zinc finger, matrin-type 3 0.0297604
ADAR adenosine deaminase, RNA-specific 0.0295872
TPI1 triosephosphate isomerase 1 0.0293953
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0287086
FER fer (fps/fes related) tyrosine kinase 0.0282201
ZNFX1 zinc finger, NFX1-type containing 1 0.0281339
RTN4 reticulon 4 0.0279551
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0277277
EEF1G eukaryotic translation elongation factor 1 gamma 0.0276913
PTK2 protein tyrosine kinase 2 0.0274298
SET SET nuclear proto-oncogene 0.0271656
WSB1 WD repeat and SOCS box containing 1 0.0271167
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0270013
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0269798
PRRC2B proline-rich coiled-coil 2B 0.0269543
MED13L mediator complex subunit 13-like 0.0269326
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0269076
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0267712
YBX1 Y box binding protein 1 0.0267326
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0262458
RPL37A ribosomal protein L37a 0.0260964
RPL3 ribosomal protein L3 0.0258634
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0257658
ZNF37A zinc finger protein 37A 0.0255898
DSTN destrin (actin depolymerizing factor) 0.0254885
RPS23 ribosomal protein S23 0.0254171
CEP85L centrosomal protein 85kDa-like 0.0253979
RNF213 ring finger protein 213 0.0252425
SPAG9 sperm associated antigen 9 0.0247222
RPS17 ribosomal protein S17 0.0244495
MON2 MON2 homolog (S. cerevisiae) 0.0244433
TRIO trio Rho guanine nucleotide exchange factor 0.0241945
MACF1 microtubule-actin crosslinking factor 1 0.024154
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0240042
ZNF638 zinc finger protein 638 0.0239436
COG5 component of oligomeric golgi complex 5 0.023889
CSF1 colony stimulating factor 1 (macrophage) 0.023792

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.26313
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.162902
CPED1 cadherin-like and PC-esterase domain containing 1 -0.148519
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111611
PDE4D phosphodiesterase 4D, cAMP-specific -0.102271
VCL vinculin -0.0864074
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0789514
SSBP2 single-stranded DNA binding protein 2 -0.0739354
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0732438
NPAS2 neuronal PAS domain protein 2 -0.071951
FOXP1 forkhead box P1 -0.0655763
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0654852
BMP10 bone morphogenetic protein 10 -0.0647672
ZEB1 zinc finger E-box binding homeobox 1 -0.0641887
TJP1 tight junction protein 1 -0.0629649
HDAC9 histone deacetylase 9 -0.0570025
TMSB4X thymosin beta 4, X-linked -0.053106
PDGFC platelet derived growth factor C -0.052255
INTS6 integrator complex subunit 6 -0.0517426
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0392072
IARS1 isoleucyl-tRNA synthetase 1 -0.0388473
NBEA neurobeachin -0.0388047
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0387981
TPT1 tumor protein, translationally-controlled 1 -0.0380911
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0377216
ACTG1 actin gamma 1 -0.0371096
CAMKMT calmodulin-lysine N-methyltransferase -0.0371009
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0370941
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0356146
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0349738
LPP LIM domain containing preferred translocation partner in lipoma -0.0344526
GARS1 glycyl-tRNA synthetase 1 -0.033996
ZNF608 zinc finger protein 608 -0.0338201
FER1L6 fer-1-like family member 6 -0.033483
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0323594
CRPPA CDP-L-ribitol pyrophosphorylase A -0.032182
MYO5C myosin VC -0.031099
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0304969
ANXA1 annexin A1 -0.0293096
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.028771
IFI16 interferon, gamma-inducible protein 16 -0.0281942
SOX6 SRY (sex determining region Y)-box 6 -0.0280022
RAB27B RAB27B, member RAS oncogene family -0.0271743
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0270131
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0270124
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -0.0260186
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0258519
TMEM65 transmembrane protein 65 -0.0253096
SLC38A2 solute carrier family 38, member 2 -0.0248096
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0246808
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0245879
PDE7B phosphodiesterase 7B -0.0245583
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0244424
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0239148
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0236164
MACROD2 MACRO domain containing 2 -0.0232761
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0227366
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0218081
LCORL ligand dependent nuclear receptor corepressor-like -0.0217275
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0214904
BCL2 B-cell CLL/lymphoma 2 -0.021488
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0214235
EGFR epidermal growth factor receptor -0.021386
AHNAK AHNAK nucleoprotein -0.0212791
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0212629
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0209281
ASXL1 additional sex combs like transcriptional regulator 1 -0.0207453
CDC73 cell division cycle 73 -0.0207401
CREB5 cAMP responsive element binding protein 5 -0.020097
TAS2R14 taste receptor, type 2, member 14 -0.0200533
BCOR BCL6 corepressor -0.0200165
TTC3 tetratricopeptide repeat domain 3 -0.0199477
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0198867
RTN3 reticulon 3 -0.0195633
ADAM32 ADAM metallopeptidase domain 32 -0.0195374
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.019334
MSRB3 methionine sulfoxide reductase B3 -0.0192811
SPRY2 sprouty homolog 2 (Drosophila) -0.0191679
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0190429
LOC102724023 ES1 protein homolog, mitochondrial -0.0189171
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0188789
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0188314
KLF3 Kruppel-like factor 3 (basic) -0.0188011
NRF1 nuclear respiratory factor 1 -0.0187792
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0185313
LDHA lactate dehydrogenase A -0.0184876
CCDC138 coiled-coil domain containing 138 -0.018378
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0183506
ARL4C ADP-ribosylation factor-like 4C -0.0183499
ECT2 epithelial cell transforming 2 -0.0181213
CENATAC centrosomal AT-AC splicing factor -0.0181175
NFIA nuclear factor I/A -0.0180924
TMEM135 transmembrane protein 135 -0.01803
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.0179686
GLI2 GLI family zinc finger 2 -0.017932
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0178092
RPL35A ribosomal protein L35a -0.0177871
SMC4 structural maintenance of chromosomes 4 -0.0177161
TXK TXK tyrosine kinase -0.0174619
TRIOBP TRIO and F-actin binding protein -0.017443