Epirubicin (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Epirubicin (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Epirubicin (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0968141
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0720747
LOC102724023 ES1 protein homolog, mitochondrial 0.0610639
NAMPT nicotinamide phosphoribosyltransferase 0.0554704
PTMA prothymosin, alpha 0.0471745
RPL4 ribosomal protein L4 0.0450001
TRA2A transformer 2 alpha homolog (Drosophila) 0.044599
TPX2 TPX2, microtubule-associated 0.0433092
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0427718
BRD4 bromodomain containing 4 0.0425329
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0415211
CCNL1 cyclin L1 0.0375098
ANLN anillin, actin binding protein 0.0371589
NUP58 nucleoporin 58 0.0363448
RPL37A ribosomal protein L37a 0.0359617
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0347638
CHD1 chromodomain helicase DNA binding protein 1 0.034011
EIF1 eukaryotic translation initiation factor 1 0.033796
WAC WW domain containing adaptor with coiled-coil 0.0336041
RSRC2 arginine/serine-rich coiled-coil 2 0.0336028
IPO7 importin 7 0.0333978
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0330278
FANCI Fanconi anemia, complementation group I 0.0329943
RPS12 ribosomal protein S12 0.0328905
RBM39 RNA binding motif protein 39 0.0326268
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0324762
SET SET nuclear proto-oncogene 0.0322825
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0321146
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0314626
PCBP2 poly(rC) binding protein 2 0.0314434
HMGB2 high mobility group box 2 0.0314324
PRPF4B pre-mRNA processing factor 4B 0.0311058
NCAPD2 non-SMC condensin I complex, subunit D2 0.0308643
PFN1 profilin 1 0.0306955
EGR1 early growth response 1 0.0306416
XPO1 exportin 1 0.0303601
RPS3 ribosomal protein S3 0.0298169
RPS23 ribosomal protein S23 0.0297806
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0286018
CKAP5 cytoskeleton associated protein 5 0.0285555
DIAPH3 diaphanous-related formin 3 0.0285287
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0284936
KDM2A lysine (K)-specific demethylase 2A 0.0284799
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0283389
HSPA8 heat shock 70kDa protein 8 0.0281495
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0279993
PER1 period circadian clock 1 0.0279899
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0278366
DENND4A DENN/MADD domain containing 4A 0.0276049
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0273774
CENPF centromere protein F, 350/400kDa 0.0267739
MATR3 matrin 3 0.0265869
NBAS neuroblastoma amplified sequence 0.0264687
TXNRD1 thioredoxin reductase 1 0.0264069
RPS2 ribosomal protein S2 0.0258584
PAPOLA poly(A) polymerase alpha 0.0257193
CEP57 centrosomal protein 57kDa 0.0256031
SRRM2 serine/arginine repetitive matrix 2 0.0255809
PRRC2B proline-rich coiled-coil 2B 0.0255119
BCLAF1 BCL2-associated transcription factor 1 0.0252152
HSPA4 heat shock 70kDa protein 4 0.024857
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0248014
UBA6 ubiquitin-like modifier activating enzyme 6 0.0247869
CXCL3 chemokine (C-X-C motif) ligand 3 0.0246639
SEC63 SEC63 homolog (S. cerevisiae) 0.0245798
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0243615
YEATS2 YEATS domain containing 2 0.0243297
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0239848
TFG TRK-fused gene 0.0239065
KIAA1958 KIAA1958 0.0237001
TP53 tumor protein p53 0.0235013
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0234408
KIF5B kinesin family member 5B 0.0232237
BHLHE40 basic helix-loop-helix family, member e40 0.0231137
TNPO1 transportin 1 0.0228723
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.0227604
TMF1 TATA element modulatory factor 1 0.0226857
BIRC2 baculoviral IAP repeat containing 2 0.0226412
SNX2 sorting nexin 2 0.0226316
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.0225576
TPI1 triosephosphate isomerase 1 0.0225152
SLMAP sarcolemma associated protein 0.0223426
SFXN1 sideroflexin 1 0.021892
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0218686
WDR43 WD repeat domain 43 0.0217745
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0217005
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.0214516
SUCO SUN domain containing ossification factor 0.0214209
CXCL8 chemokine (C-X-C motif) ligand 8 0.021269
UBQLN1 ubiquilin 1 0.0212579
UBE2C ubiquitin-conjugating enzyme E2C 0.0212471
RPL12 ribosomal protein L12 0.0211738
MMP1 matrix metallopeptidase 1 0.0209179
RHEB Ras homolog enriched in brain 0.0208909
FXR1 fragile X mental retardation, autosomal homolog 1 0.020882
BUB3 BUB3 mitotic checkpoint protein 0.0208794
BRD2 bromodomain containing 2 0.0208056
SF1 splicing factor 1 0.0207903
CAMTA1 calmodulin binding transcription activator 1 0.0207431
HELZ helicase with zinc finger 0.0207087

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201669
IGFBP3 insulin-like growth factor binding protein 3 -0.125748
LDHA lactate dehydrogenase A -0.0919276
FNDC3B fibronectin type III domain containing 3B -0.0916477
OSMR oncostatin M receptor -0.0849956
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0829728
MACF1 microtubule-actin crosslinking factor 1 -0.0790482
CD44 CD44 molecule (Indian blood group) -0.0781097
DST dystonin -0.0749039
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0747299
ZBTB20 zinc finger and BTB domain containing 20 -0.0697158
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0658138
HMGA2 high mobility group AT-hook 2 -0.0626588
FMN1 formin 1 -0.0579408
SMYD3 SET and MYND domain containing 3 -0.0570855
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0538373
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0538013
INTS6 integrator complex subunit 6 -0.0537572
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0535063
NALCN sodium leak channel, non selective -0.0530308
FMNL2 formin-like 2 -0.0506745
GPC6 glypican 6 -0.0502051
ANKRD28 ankyrin repeat domain 28 -0.0492403
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0488334
VCL vinculin -0.0488196
DNER delta/notch-like EGF repeat containing -0.0480804
AHNAK AHNAK nucleoprotein -0.0476533
BCAR3 breast cancer anti-estrogen resistance 3 -0.0472974
ANXA2 annexin A2 -0.0467407
SLC38A2 solute carrier family 38, member 2 -0.046693
ACTG1 actin gamma 1 -0.0460618
LOC112694756 uncharaterized LOC112694756 -0.0454702
ATM ATM serine/threonine kinase -0.0443483
TAS2R14 taste receptor, type 2, member 14 -0.0441746
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0439984
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0436092
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0434407
ANO6 anoctamin 6 -0.0422107
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0419752
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0414865
ELL2 elongation factor, RNA polymerase II, 2 -0.0407079
FLNB filamin B, beta -0.0399724
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0398482
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0397711
LPP LIM domain containing preferred translocation partner in lipoma -0.0397478
DPYD dihydropyrimidine dehydrogenase -0.0396613
TM4SF1 transmembrane 4 L six family member 1 -0.0392117
DSCAM Down syndrome cell adhesion molecule -0.0391188
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0390524
EFNA5 ephrin-A5 -0.0389717
BASP1 brain abundant, membrane attached signal protein 1 -0.038956
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0387436
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0385573
EGFR epidermal growth factor receptor -0.0383665
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0373154
NCEH1 neutral cholesterol ester hydrolase 1 -0.0366572
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0365124
EXOC6B exocyst complex component 6B -0.0357596
USP34 ubiquitin specific peptidase 34 -0.0354216
BIRC6 baculoviral IAP repeat containing 6 -0.0345764
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345429
AKAP12 A kinase (PRKA) anchor protein 12 -0.0343719
BICD1 bicaudal D homolog 1 (Drosophila) -0.0342893
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.034138
TPT1 tumor protein, translationally-controlled 1 -0.0338856
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0337976
AKAP13 A kinase (PRKA) anchor protein 13 -0.033354
THSD4 thrombospondin, type I, domain containing 4 -0.0330125
RNF213 ring finger protein 213 -0.0328689
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0327667
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0323663
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0322571
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.032046
NAV2 neuron navigator 2 -0.0319638
SVIL supervillin -0.0318372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0316792
NBEA neurobeachin -0.0316587
TCF12 transcription factor 12 -0.0314822
BIRC3 baculoviral IAP repeat containing 3 -0.0313616
EPAS1 endothelial PAS domain protein 1 -0.0312588
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0310304
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.031006
SAMD4A sterile alpha motif domain containing 4A -0.030846
ZBTB38 zinc finger and BTB domain containing 38 -0.030191
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0299372
MBNL1 muscleblind-like splicing regulator 1 -0.0295806
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0295116
SH3KBP1 SH3-domain kinase binding protein 1 -0.0293975
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0293022
DOCK4 dedicator of cytokinesis 4 -0.0292004
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0287811
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0287575
PRH1 proline-rich protein HaeIII subfamily 1 -0.0286005
NIBAN2 niban apoptosis regulator 2 -0.0284068
ATXN1 ataxin 1 -0.0284043
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0283615
ATG7 autophagy related 7 -0.0283241
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.028119
TPM4 tropomyosin 4 -0.0280322
RIGI RNA sensor RIG-I -0.0277801