Epirubicin (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Epirubicin (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Epirubicin (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0886042
TXNIP thioredoxin interacting protein 0.0719475
FTH1 ferritin, heavy polypeptide 1 0.068159
MKI67 marker of proliferation Ki-67 0.0604297
RPS6 ribosomal protein S6 0.0535018
PRRC2C proline-rich coiled-coil 2C 0.052607
CENPF centromere protein F, 350/400kDa 0.0516423
RPS12 ribosomal protein S12 0.049015
RPS2 ribosomal protein S2 0.0435264
TPI1 triosephosphate isomerase 1 0.0391987
NAP1L1 nucleosome assembly protein 1-like 1 0.0388136
RACK1 receptor for activated C kinase 1 0.0383381
PGAM4 phosphoglycerate mutase family member 4 0.0372559
RPL37A ribosomal protein L37a 0.0369702
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0358592
EIF1 eukaryotic translation initiation factor 1 0.0350286
ETV6 ets variant 6 0.034699
OGA O-GlcNAcase 0.0346516
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0345976
RPL26 ribosomal protein L26 0.034511
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0328803
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0306026
H1-0 H1.0 linker histone 0.0288221
PNN pinin, desmosome associated protein 0.0279979
RPS19 ribosomal protein S19 0.0274722
PCLO piccolo presynaptic cytomatrix protein 0.0270354
FLNA filamin A, alpha 0.0268228
RPS3 ribosomal protein S3 0.0267424
STC2 stanniocalcin 2 0.0257624
BHLHE40 basic helix-loop-helix family, member e40 0.0253029
TNIP1 TNFAIP3 interacting protein 1 0.0250784
HDGF hepatoma-derived growth factor 0.0250268
SRRM2 serine/arginine repetitive matrix 2 0.024687
RPS29 ribosomal protein S29 0.0235403
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0233026
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0229364
EEF2 eukaryotic translation elongation factor 2 0.0217243
NFE2L1 nuclear factor, erythroid 2-like 1 0.0217047
SFTPA2 surfactant protein A2 0.0216889
ZC3H12C zinc finger CCCH-type containing 12C 0.0214831
TXNRD1 thioredoxin reductase 1 0.0208911
RPL31 ribosomal protein L31 0.0207554
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0206616
RPL4 ribosomal protein L4 0.0205584
HSPA8 heat shock 70kDa protein 8 0.0205474
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0204834
SMAD3 SMAD family member 3 0.0202751
RPS17 ribosomal protein S17 0.0199662
ACADVL acyl-CoA dehydrogenase, very long chain 0.0198408
FAM13A family with sequence similarity 13, member A 0.0195536
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0195394
RPL32 ribosomal protein L32 0.0193789
EIF4H eukaryotic translation initiation factor 4H 0.0192834
ANKZF1 ankyrin repeat and zinc finger domain containing 1 0.0192164
ERRFI1 ERBB receptor feedback inhibitor 1 0.0190393
RPS8 ribosomal protein S8 0.0189292
RPS27 ribosomal protein S27 0.0187619
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0187002
FOSL2 FOS-like antigen 2 0.01854
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.0184102
RPL18 ribosomal protein L18 0.0182028
ARID1A AT rich interactive domain 1A (SWI-like) 0.0181592
KTN1 kinectin 1 (kinesin receptor) 0.0181371
SLC38A1 solute carrier family 38, member 1 0.0179196
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0178817
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0177881
RPL36 ribosomal protein L36 0.0173276
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0173042
DCAF7 DDB1 and CUL4 associated factor 7 0.0171915
TLN1 talin 1 0.0169073
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0166574
RPL28 ribosomal protein L28 0.0166051
RAB8B RAB8B, member RAS oncogene family 0.0165041
CEP152 centrosomal protein 152kDa 0.016454
WDR43 WD repeat domain 43 0.0162475
FNBP1 formin binding protein 1 0.0162428
IWS1 IWS1 homolog (S. cerevisiae) 0.0161454
CAB39 calcium binding protein 39 0.0161377
CREBRF CREB3 regulatory factor 0.0160124
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0159138
PRELID1 PRELI domain containing 1 0.0157151
HMGB2 high mobility group box 2 0.015633
CIRSR corepressor of RBPJ and splicing regulator 0.0155959
NOP58 NOP58 ribonucleoprotein 0.0153721
RPL13A ribosomal protein L13a 0.0153505
YBX3 Y box binding protein 3 0.0150742
BCLAF1 BCL2-associated transcription factor 1 0.0150734
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0148247
WBP11 WW domain binding protein 11 0.0147778
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0147436
RPL12 ribosomal protein L12 0.0146641
E2F7 E2F transcription factor 7 0.0144896
BUB3 BUB3 mitotic checkpoint protein 0.014467
RPL37 ribosomal protein L37 0.0144518
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0143394
TPR translocated promoter region, nuclear basket protein 0.0142991
LMTK2 lemur tyrosine kinase 2 0.0142984
BRD4 bromodomain containing 4 0.0142561
PNISR PNN-interacting serine/arginine-rich protein 0.0141106
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0140239

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.328112
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.201
NRG1 neuregulin 1 -0.161694
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.133124
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.100288
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0962388
ASPH aspartate beta-hydroxylase -0.085769
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0844322
CANX calnexin -0.08006
NDRG1 N-myc downstream regulated 1 -0.0799443
HMGA2 high mobility group AT-hook 2 -0.0772155
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0706654
ITGA1 integrin, alpha 1 -0.0687183
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0677729
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0673441
GLIS3 GLIS family zinc finger 3 -0.0645578
GRB10 growth factor receptor-bound protein 10 -0.0547117
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0538918
VCL vinculin -0.0538021
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0515707
PLIN2 perilipin 2 -0.0496065
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0466897
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0463022
POTEF POTE ankyrin domain family, member F -0.04627
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0461944
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0448573
SYT1 synaptotagmin I -0.0448327
GPC6 glypican 6 -0.0432254
SPDYA speedy/RINGO cell cycle regulator family member A -0.042986
HILPDA hypoxia inducible lipid droplet-associated -0.0428546
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0421626
BIRC6 baculoviral IAP repeat containing 6 -0.0415356
LIMCH1 LIM and calponin homology domains 1 -0.0410342
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0409096
CALU calumenin -0.0408048
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0401704
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0398855
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0378735
USP34 ubiquitin specific peptidase 34 -0.0377634
VEGFA vascular endothelial growth factor A -0.0377272
PGK1 phosphoglycerate kinase 1 -0.0372383
SOD2 superoxide dismutase 2, mitochondrial -0.0365741
COPA coatomer protein complex, subunit alpha -0.0365254
INTS6 integrator complex subunit 6 -0.0364917
PDIA3 protein disulfide isomerase family A, member 3 -0.0359714
AEBP2 AE binding protein 2 -0.0355248
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0351696
RAI14 retinoic acid induced 14 -0.03506
ACTG1 actin gamma 1 -0.0350563
PDE4D phosphodiesterase 4D, cAMP-specific -0.0348519
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0348122
KLHL5 kelch-like family member 5 -0.034783
IGFBP3 insulin-like growth factor binding protein 3 -0.0347291
FNDC3B fibronectin type III domain containing 3B -0.0344904
ACTN4 actinin, alpha 4 -0.0344317
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0341801
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.034153
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0340884
SPAG9 sperm associated antigen 9 -0.0330141
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0326817
SEC31A SEC31 homolog A (S. cerevisiae) -0.0326051
TPM4 tropomyosin 4 -0.032391
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0322418
TMSB4X thymosin beta 4, X-linked -0.0315501
FTL ferritin, light polypeptide -0.031249
TM9SF3 transmembrane 9 superfamily member 3 -0.031233
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0309575
S100A6 S100 calcium binding protein A6 -0.0308602
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0306409
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0304202
KMT2E lysine (K)-specific methyltransferase 2E -0.0297979
NRP1 neuropilin 1 -0.0296132
ZBTB20 zinc finger and BTB domain containing 20 -0.0289524
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.028836
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0283195
LOC102724023 ES1 protein homolog, mitochondrial -0.0280878
PTK2 protein tyrosine kinase 2 -0.028011
OSMR oncostatin M receptor -0.0277463
MRPS6 mitochondrial ribosomal protein S6 -0.0276227
HPCAL1 hippocalcin-like 1 -0.0275415
DUSP6 dual specificity phosphatase 6 -0.0269943
RAB31 RAB31, member RAS oncogene family -0.0269936
TMEM156 transmembrane protein 156 -0.0269453
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0269296
FOSL1 FOS-like antigen 1 -0.0260181
HMGA1 high mobility group AT-hook 1 -0.025818
IER3 immediate early response 3 -0.0252623
BSG basigin (Ok blood group) -0.0251317
PALLD palladin, cytoskeletal associated protein -0.0250858
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0245812
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0243869
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0243673
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0241541
HIPK2 homeodomain interacting protein kinase 2 -0.0241384
TSC22D1 TSC22 domain family, member 1 -0.0240341
NTN4 netrin 4 -0.0239278
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0238707
PDLIM5 PDZ and LIM domain 5 -0.0237463
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0236167
PELO pelota homolog (Drosophila) -0.0235087