| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A steroid acid ester that has formula C24H30O6. (Chemical Entities of Biological Interest Ontology, CHEBI_31547) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/443872 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Eplerenone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF175 | zinc finger protein 175 | 1.08 |
| B2M | beta-2-microglobulin | 1.0 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.85 |
| PIP | prolactin-induced protein | 0.8 |
| CFD | complement factor D (adipsin) | 0.7 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.7 |
| ZCCHC24 | zinc finger, CCHC domain containing 24 | 0.6 |
| CEP104 | centrosomal protein 104kDa | 0.57 |
| CD81 | CD81 molecule | 0.57 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.54 |
| TEN1 | TEN1 CST complex subunit | 0.52 |
| ZNF483 | zinc finger protein 483 | 0.52 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.47 |
| TMEM14C | transmembrane protein 14C | 0.47 |
| ZNF503 | zinc finger protein 503 | 0.47 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | 0.46 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.46 |
| TBC1D14 | TBC1 domain family, member 14 | 0.45 |
| FBLIM1 | filamin binding LIM protein 1 | 0.44 |
| S100A2 | S100 calcium binding protein A2 | 0.43 |
| TMEM64 | transmembrane protein 64 | 0.43 |
| SPPL3 | signal peptide peptidase like 3 | 0.42 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.42 |
| IRS2 | insulin receptor substrate 2 | 0.41 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.4 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.39 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.38 |
| PPT2 | palmitoyl-protein thioesterase 2 | 0.37 |
| MEST | mesoderm specific transcript | 0.36 |
| SPCS1 | signal peptidase complex subunit 1 homolog (S. cerevisiae) | 0.36 |
| TMCO1 | transmembrane and coiled-coil domains 1 | 0.36 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.36 |
| MYZAP | myocardial zonula adherens protein | 0.35 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.35 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.35 |
| GGT2 | gamma-glutamyltransferase 2 | 0.35 |
| TM2D3 | TM2 domain containing 3 | 0.35 |
| DYRK2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 0.34 |
| CNTLN | centlein, centrosomal protein | 0.34 |
| RPL30 | ribosomal protein L30 | 0.34 |
| TRIM23 | tripartite motif containing 23 | 0.34 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 0.33 |
| HIPK3 | homeodomain interacting protein kinase 3 | 0.33 |
| ZNF362 | zinc finger protein 362 | 0.33 |
| TSN | translin | 0.33 |
| ZNF317 | zinc finger protein 317 | 0.32 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.32 |
| JOSD1 | Josephin domain containing 1 | 0.32 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 0.31 |
| BPTF | bromodomain PHD finger transcription factor | 0.31 |
| LMF1 | lipase maturation factor 1 | 0.31 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 0.31 |
| PRXL2A | peroxiredoxin like 2A | 0.31 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.3 |
| RTN4RL2 | reticulon 4 receptor-like 2 | 0.3 |
| ABHD13 | abhydrolase domain containing 13 | 0.3 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.3 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.29 |
| YBEY | ybeY metallopeptidase (putative) | 0.29 |
| PAH | phenylalanine hydroxylase | 0.29 |
| OTC | ornithine carbamoyltransferase | 0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.29 |
| MPHOSPH6 | M-phase phosphoprotein 6 | 0.28 |
| HMGB2 | high mobility group box 2 | 0.28 |
| LIPT1 | lipoyltransferase 1 | 0.28 |
| SARDH | sarcosine dehydrogenase | 0.27 |
| PRDM4 | PR domain containing 4 | 0.27 |
| ZNF761 | zinc finger protein 761 | 0.27 |
| SLC2A4RG | SLC2A4 regulator | 0.27 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.27 |
| RAB30 | RAB30, member RAS oncogene family | 0.27 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.27 |
| TTC14 | tetratricopeptide repeat domain 14 | 0.27 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.27 |
| TMEM63A | transmembrane protein 63A | 0.27 |
| ZNF226 | zinc finger protein 226 | 0.26 |
| SOCS7 | suppressor of cytokine signaling 7 | 0.26 |
| ARG2 | arginase 2 | 0.26 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.26 |
| RIBC2 | RIB43A domain with coiled-coils 2 | 0.26 |
| CFAP410 | cilia and flagella associated protein 410 | 0.25 |
| RPL32 | ribosomal protein L32 | 0.25 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.25 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.25 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.25 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.25 |
| FAM160A1 | family with sequence similarity 160, member A1 | 0.25 |
| ICOSLG | inducible T-cell co-stimulator ligand | 0.25 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.25 |
| SRRD | SRR1 domain containing | 0.25 |
| ZNF729 | zinc finger protein 729 | 0.24 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | 0.24 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.24 |
| RNASE4 | ribonuclease, RNase A family, 4 | 0.24 |
| MSX1 | msh homeobox 1 | 0.24 |
| PRKCH | protein kinase C, eta | 0.24 |
| RTN2 | reticulon 2 | 0.24 |
| FAAP24 | FA core complex associated protein 24 | 0.24 |
| TSLIG3B | tRNA splicing ligase complex subunit 3B | 0.23 |
| BHLHA15 | basic helix-loop-helix family, member a15 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSH2D | hematopoietic SH2 domain containing | -0.93 |
| TMEM39B | transmembrane protein 39B | -0.73 |
| MYO1G | myosin IG | -0.71 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.65 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.63 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.54 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | -0.54 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.54 |
| CALD1 | caldesmon 1 | -0.49 |
| ABHD3 | abhydrolase domain containing 3 | -0.47 |
| SVIP | small VCP/p97-interacting protein | -0.45 |
| EPHA1 | EPH receptor A1 | -0.45 |
| VASN | vasorin | -0.44 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.44 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.44 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.44 |
| RNASET2 | ribonuclease T2 | -0.43 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.43 |
| ANKRD46 | ankyrin repeat domain 46 | -0.41 |
| FZD7 | frizzled class receptor 7 | -0.41 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.41 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | -0.4 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | -0.4 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | -0.4 |
| AFG1L | AFG1 like ATPase | -0.4 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | -0.39 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | -0.39 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.39 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.38 |
| LMOD1 | leiomodin 1 (smooth muscle) | -0.38 |
| SATB2 | SATB homeobox 2 | -0.37 |
| BBS1 | Bardet-Biedl syndrome 1 | -0.36 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.36 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | -0.36 |
| FBXO44 | F-box protein 44 | -0.35 |
| MISP3 | MISP family member 3 | -0.34 |
| KLHL29 | kelch-like family member 29 | -0.34 |
| PHYH | phytanoyl-CoA 2-hydroxylase | -0.34 |
| DYSF | dysferlin | -0.33 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.33 |
| C14ORF119 | chromosome 14 open reading frame 119 | -0.33 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | -0.32 |
| RPGR | retinitis pigmentosa GTPase regulator | -0.32 |
| PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | -0.32 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.32 |
| LRRC58 | leucine rich repeat containing 58 | -0.32 |
| PITX1 | paired-like homeodomain 1 | -0.32 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.32 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | -0.31 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.31 |
| FAM110C | family with sequence similarity 110, member C | -0.31 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.3 |
| TSTD1 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 | -0.3 |
| MEX3A | mex-3 RNA binding family member A | -0.3 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | -0.3 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.3 |
| RAB28 | RAB28, member RAS oncogene family | -0.29 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.29 |
| SDHAF4 | succinate dehydrogenase complex assembly factor 4 | -0.29 |
| WSB2 | WD repeat and SOCS box containing 2 | -0.29 |
| MBP | myelin basic protein | -0.29 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.29 |
| KIZ | kizuna centrosomal protein | -0.29 |
| RANBP17 | RAN binding protein 17 | -0.29 |
| UTP23 | UTP23, small subunit (SSU) processome component, homolog (yeast) | -0.28 |
| AASS | aminoadipate-semialdehyde synthase | -0.28 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.28 |
| GSKIP | GSK3B interacting protein | -0.28 |
| TMEM104 | transmembrane protein 104 | -0.28 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.28 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.28 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.28 |
| ERCC8 | excision repair cross-complementation group 8 | -0.28 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.28 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.27 |
| MID2 | midline 2 | -0.27 |
| MID1IP1 | MID1 interacting protein 1 | -0.27 |
| EVA1C | eva-1 homolog C (C. elegans) | -0.27 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.26 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | -0.26 |
| SYCP1 | synaptonemal complex protein 1 | -0.26 |
| NRP1 | neuropilin 1 | -0.26 |
| NOTCH3 | notch 3 | -0.26 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.26 |
| SRD5A3 | steroid 5 alpha-reductase 3 | -0.26 |
| GAB1 | GRB2-associated binding protein 1 | -0.25 |
| HDAC5 | histone deacetylase 5 | -0.25 |
| PYGM | phosphorylase, glycogen, muscle | -0.25 |
| POMT1 | protein-O-mannosyltransferase 1 | -0.25 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.25 |
| YBX3 | Y box binding protein 3 | -0.25 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | -0.25 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.25 |
| SPRYD3 | SPRY domain containing 3 | -0.24 |
| FN1 | fibronectin 1 | -0.24 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.24 |
| ZNF296 | zinc finger protein 296 | -0.24 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.23 |
| ADIRF | adipogenesis regulatory factor | -0.23 |
| FHIT | fragile histidine triad | -0.23 |
