Eplerenone_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.141497
HMGA2 high mobility group AT-hook 2 0.127046
EHBP1 EH domain binding protein 1 0.0853305
POTEF POTE ankyrin domain family, member F 0.0827497
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0826072
YAP1 Yes-associated protein 1 0.0823553
DST dystonin 0.0770937
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0761513
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0747723
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0607547
MARCHF4 membrane associated ring-CH-type finger 4 0.0605136
CCN2 cellular communication network factor 2 0.0603198
CMIP c-Maf inducing protein 0.0599601
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0569032
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0567236
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0554403
NLGN1 neuroligin 1 0.0528131
ASPH aspartate beta-hydroxylase 0.0525077
EEF2 eukaryotic translation elongation factor 2 0.0511055
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.050458
MKI67 marker of proliferation Ki-67 0.0504319
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0497143
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0476174
PCDH7 protocadherin 7 0.0466211
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0461561
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0449762
BRD2 bromodomain containing 2 0.044602
AKAP12 A kinase (PRKA) anchor protein 12 0.044343
INTS6 integrator complex subunit 6 0.0433868
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0413602
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.041219
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0406466
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403112
ACTG1 actin gamma 1 0.0396966
NHSL1 NHS-like 1 0.0396702
CALR calreticulin 0.039667
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0391584
HDGF hepatoma-derived growth factor 0.0389772
BPTF bromodomain PHD finger transcription factor 0.0387553
MACF1 microtubule-actin crosslinking factor 1 0.0383477
LPP LIM domain containing preferred translocation partner in lipoma 0.0383476
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0382009
WNK1 WNK lysine deficient protein kinase 1 0.0380589
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0378614
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.037732
EGR1 early growth response 1 0.037069
ANKRD17 ankyrin repeat domain 17 0.0370411
RAB10 RAB10, member RAS oncogene family 0.0365515
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0361678
EXOC4 exocyst complex component 4 0.0360131
TPM3 tropomyosin 3 0.0352277
ZCCHC7 zinc finger, CCHC domain containing 7 0.0347837
NUP98 nucleoporin 98kDa 0.0343856
SRRM2 serine/arginine repetitive matrix 2 0.0343296
SOS1 son of sevenless homolog 1 (Drosophila) 0.0343199
CSNK1A1 casein kinase 1, alpha 1 0.0342923
KDM2A lysine (K)-specific demethylase 2A 0.0342627
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0338403
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0338237
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.033742
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0333869
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0331369
VMP1 vacuole membrane protein 1 0.0327871
ZNF804A zinc finger protein 804A 0.0327358
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.032583
ANXA1 annexin A1 0.0324121
MSRB3 methionine sulfoxide reductase B3 0.0324048
PCBP2 poly(rC) binding protein 2 0.0323132
SYT1 synaptotagmin I 0.0321375
BIRC6 baculoviral IAP repeat containing 6 0.032096
DTNA dystrobrevin, alpha 0.0317377
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0316742
RAB7A RAB7A, member RAS oncogene family 0.0316315
CUX1 cut-like homeobox 1 0.0316131
TAS2R14 taste receptor, type 2, member 14 0.0314067
JMJD1C jumonji domain containing 1C 0.0313462
TGM2 transglutaminase 2 0.0313303
WDPCP WD repeat containing planar cell polarity effector 0.0310545
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0305872
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0305441
RASAL2 RAS protein activator like 2 0.030501
EFNA5 ephrin-A5 0.0304237
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0302358
RCOR1 REST corepressor 1 0.0301035
PHACTR4 phosphatase and actin regulator 4 0.0297052
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0295945
HSPA8 heat shock 70kDa protein 8 0.0294307
SPATS2 spermatogenesis associated, serine-rich 2 0.0294163
ADIPOR2 adiponectin receptor 2 0.0294108
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0292267
DOCK1 dedicator of cytokinesis 1 0.0287327
DENND1A DENN/MADD domain containing 1A 0.028719
TAOK1 TAO kinase 1 0.0285553
NCAPD2 non-SMC condensin I complex, subunit D2 0.0285184
PACS1 phosphofurin acidic cluster sorting protein 1 0.0283881
OSBPL8 oxysterol binding protein-like 8 0.028381
LRRC23 leucine rich repeat containing 23 0.0281829
ATP11A ATPase, class VI, type 11A 0.0276776
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0274139
SRBD1 S1 RNA binding domain 1 0.0272028

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.207593
AREG amphiregulin -0.0964584
RPS19 ribosomal protein S19 -0.0723022
RPL35A ribosomal protein L35a -0.069051
RPLP2 ribosomal protein, large, P2 -0.0676372
MYL12B myosin, light chain 12B, regulatory -0.0671654
TPT1 tumor protein, translationally-controlled 1 -0.0657694
PDE4D phosphodiesterase 4D, cAMP-specific -0.0636725
MGAT4C MGAT4 family, member C -0.06052
VIM vimentin -0.0585018
RPS27A ribosomal protein S27a -0.0576971
RPL19 ribosomal protein L19 -0.0570954
RPS12 ribosomal protein S12 -0.056222
RPL26 ribosomal protein L26 -0.0546612
RPL34 ribosomal protein L34 -0.0534084
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.052843
RPL37A ribosomal protein L37a -0.0524199
CNRIP1 cannabinoid receptor interacting protein 1 -0.0506049
RPS21 ribosomal protein S21 -0.0483533
RPL12 ribosomal protein L12 -0.0478299
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0470951
RPS29 ribosomal protein S29 -0.0460556
RPLP1 ribosomal protein, large, P1 -0.0453584
RPL23 ribosomal protein L23 -0.0450842
RPS8 ribosomal protein S8 -0.0447267
RPL11 ribosomal protein L11 -0.0442566
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0438262
RPS3 ribosomal protein S3 -0.0435594
ZNF217 zinc finger protein 217 -0.0421994
RPS23 ribosomal protein S23 -0.0406715
RPS24 ribosomal protein S24 -0.0398258
RPS27 ribosomal protein S27 -0.0397464
RPS16 ribosomal protein S16 -0.0396975
FTL ferritin, light polypeptide -0.0395204
RPL38 ribosomal protein L38 -0.0392945
EIF1 eukaryotic translation initiation factor 1 -0.0385137
RPL5 ribosomal protein L5 -0.038142
RPS6 ribosomal protein S6 -0.0380597
RPL32 ribosomal protein L32 -0.0361073
RPL27 ribosomal protein L27 -0.0360535
RPL9 ribosomal protein L9 -0.0357839
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0352708
RPS15 ribosomal protein S15 -0.0349667
TNPO1 transportin 1 -0.0345388
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0343654
RPL36 ribosomal protein L36 -0.0340456
NEK7 NIMA-related kinase 7 -0.033684
BCHE butyrylcholinesterase -0.0331224
RPS5 ribosomal protein S5 -0.0327732
RPS11 ribosomal protein S11 -0.0326156
XPO1 exportin 1 -0.0321539
RPS14 ribosomal protein S14 -0.0318511
RPS20 ribosomal protein S20 -0.0315209
RPL37 ribosomal protein L37 -0.0310509
RPL31 ribosomal protein L31 -0.0306978
RPL36A ribosomal protein L36a -0.0295172
MARCHF6 membrane associated ring-CH-type finger 6 -0.0294552
RBM25 RNA binding motif protein 25 -0.0278878
RPS13 ribosomal protein S13 -0.026751
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.026298
RPL13A ribosomal protein L13a -0.0260289
MTAP methylthioadenosine phosphorylase -0.0258682
RSF1 remodeling and spacing factor 1 -0.0256151
NAP1L1 nucleosome assembly protein 1-like 1 -0.0255255
IFIH1 interferon induced with helicase C domain 1 -0.0253135
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0248303
HMGA1 high mobility group AT-hook 1 -0.0246065
RPS25 ribosomal protein S25 -0.0245628
PREPL prolyl endopeptidase-like -0.0244791
RPLP0 ribosomal protein, large, P0 -0.0240893
RPS2 ribosomal protein S2 -0.0236907
SERF2 small EDRK-rich factor 2 -0.0233396
VCL vinculin -0.0231153
GASK1B golgi associated kinase 1B -0.0230712
CLDN1 claudin 1 -0.0229411
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0220677
KDM3A lysine (K)-specific demethylase 3A -0.0218613
RPS10 ribosomal protein S10 -0.0212728
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0207269
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.0202826
KLHL24 kelch-like family member 24 -0.0202388
UBL5 ubiquitin-like 5 -0.0202174
TMEM41B transmembrane protein 41B -0.0201259
BTG3 BTG family, member 3 -0.0200493
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0200404
ADGRG6 adhesion G protein-coupled receptor G6 -0.020009
CPOX coproporphyrinogen oxidase -0.0193352
TMEM123 transmembrane protein 123 -0.0192884
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0191282
TIGAR TP53 induced glycolysis regulatory phosphatase -0.0191215
RACK1 receptor for activated C kinase 1 -0.0190559
MXI1 MAX interactor 1, dimerization protein -0.0190222
RPL35 ribosomal protein L35 -0.0188539
RPL30 ribosomal protein L30 -0.0187409
CCDC14 coiled-coil domain containing 14 -0.0186965
ZFAND6 zinc finger, AN1-type domain 6 -0.0186061
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0184763
IMMT inner membrane protein, mitochondrial -0.0183779
S100A9 S100 calcium binding protein A9 -0.0183687
RPS4X ribosomal protein S4, X-linked -0.0182181