Eplerenone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.0599626
NRG1 neuregulin 1 0.0513272
FNDC3B fibronectin type III domain containing 3B 0.0403923
FMN1 formin 1 0.0394158
MEIS2 Meis homeobox 2 0.0375498
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0371061
DSCAM Down syndrome cell adhesion molecule 0.0311452
HELZ helicase with zinc finger 0.0304772
DST dystonin 0.0300915
CDH10 cadherin 10, type 2 (T2-cadherin) 0.028788
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0283178
EEF2 eukaryotic translation elongation factor 2 0.026203
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0260965
ITPRID2 ITPR interacting domain containing 2 0.0255924
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0250325
GPC5 glypican 5 0.0245448
ZMIZ1 zinc finger, MIZ-type containing 1 0.0245368
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.024513
CEP95 centrosomal protein 95kDa 0.0244338
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0243747
YEATS2 YEATS domain containing 2 0.0243298
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0243191
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0229058
TPST1 tyrosylprotein sulfotransferase 1 0.0227429
WAC WW domain containing adaptor with coiled-coil 0.0224587
SOS1 son of sevenless homolog 1 (Drosophila) 0.0220187
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0205549
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0200396
PDE4D phosphodiesterase 4D, cAMP-specific 0.0198922
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0194267
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0189072
TPM3 tropomyosin 3 0.0182136
NFE2L1 nuclear factor, erythroid 2-like 1 0.0179541
KDM4C lysine (K)-specific demethylase 4C 0.0179344
NCOR2 nuclear receptor corepressor 2 0.0177804
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0175808
HMBOX1 homeobox containing 1 0.0175092
TP53BP1 tumor protein p53 binding protein 1 0.0174059
COPA coatomer protein complex, subunit alpha 0.0169821
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0168031
PBX1 pre-B-cell leukemia homeobox 1 0.016711
ADGRG6 adhesion G protein-coupled receptor G6 0.0166438
LPP LIM domain containing preferred translocation partner in lipoma 0.0165652
ARHGAP32 Rho GTPase activating protein 32 0.016399
CLTC clathrin, heavy chain (Hc) 0.0162131
ZFAND3 zinc finger, AN1-type domain 3 0.0161328
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0160464
ANO6 anoctamin 6 0.016028
CEMIP cell migration inducing protein, hyaluronan binding 0.0160279
MBD5 methyl-CpG binding domain protein 5 0.0159382
SSBP3 single stranded DNA binding protein 3 0.0158872
CASC3 cancer susceptibility candidate 3 0.0158803
TENT2 terminal nucleotidyltransferase 2 0.0157387
BRWD1 bromodomain and WD repeat domain containing 1 0.0155569
KLHL13 kelch-like family member 13 0.0155535
PRRC2B proline-rich coiled-coil 2B 0.01549
PLPP1 phospholipid phosphatase 1 0.0153407
RBM26 RNA binding motif protein 26 0.0150891
NAMPT nicotinamide phosphoribosyltransferase 0.0148507
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0147919
TRIB2 tribbles pseudokinase 2 0.0147499
CD36 CD36 molecule (thrombospondin receptor) 0.0147176
PTPRE protein tyrosine phosphatase, receptor type, E 0.0146485
EIF4B eukaryotic translation initiation factor 4B 0.0145759
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0145494
AKAP13 A kinase (PRKA) anchor protein 13 0.0145183
WDR43 WD repeat domain 43 0.0143271
SIK3 SIK family kinase 3 0.014315
PLEC plectin 0.0141134
ZC3H11A zinc finger CCCH-type containing 11A 0.0139467
ANTXR1 anthrax toxin receptor 1 0.0138776
TBC1D22A TBC1 domain family, member 22A 0.0138414
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0137809
TPP2 tripeptidyl peptidase II 0.0136973
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.013672
KIDINS220 kinase D-interacting substrate, 220kDa 0.0136096
ZFHX3 zinc finger homeobox 3 0.013597
SRRM2 serine/arginine repetitive matrix 2 0.0135049
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0134733
NUMB numb homolog (Drosophila) 0.013433
DDR2 discoidin domain receptor tyrosine kinase 2 0.0134179
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0133315
ETNK1 ethanolamine kinase 1 0.0133263
MYH9 myosin, heavy chain 9, non-muscle 0.0133078
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0132861
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 0.0132193
LINGO2 leucine rich repeat and Ig domain containing 2 0.0132176
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0131704
TLK2 tousled-like kinase 2 0.0129813
MYOF myoferlin 0.0129364
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0128525
CTBP2 C-terminal binding protein 2 0.0127954
ZNF462 zinc finger protein 462 0.0127875
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0127714
ANKRD17 ankyrin repeat domain 17 0.0126675
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.012643
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0125995
TOP2B topoisomerase (DNA) II beta 180kDa 0.0125897
VCP valosin containing protein 0.0125562
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0125383

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.270409
PTMA prothymosin, alpha -0.126707
RPL23 ribosomal protein L23 -0.121081
VIM vimentin -0.116895
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.109589
IGF2 insulin-like growth factor 2 -0.101396
RPL19 ribosomal protein L19 -0.0963892
RPLP1 ribosomal protein, large, P1 -0.0928905
RPS6 ribosomal protein S6 -0.0878539
TMSB10 thymosin beta 10 -0.083933
RPL35A ribosomal protein L35a -0.0804271
EIF1 eukaryotic translation initiation factor 1 -0.078414
RPL38 ribosomal protein L38 -0.076253
TPT1 tumor protein, translationally-controlled 1 -0.0734158
RPL37A ribosomal protein L37a -0.069156
RPL34 ribosomal protein L34 -0.0687833
ACTG1 actin gamma 1 -0.0624608
RPL32 ribosomal protein L32 -0.0599684
RPS19 ribosomal protein S19 -0.0592303
RPL12 ribosomal protein L12 -0.0572713
RPS12 ribosomal protein S12 -0.0562657
RPL36 ribosomal protein L36 -0.0545183
RPS3 ribosomal protein S3 -0.0523075
RPS24 ribosomal protein S24 -0.0503848
FTL ferritin, light polypeptide -0.0495852
RPS8 ribosomal protein S8 -0.0475159
RPS17 ribosomal protein S17 -0.0469603
S100A9 S100 calcium binding protein A9 -0.0466612
RPS11 ribosomal protein S11 -0.0454788
RPL26 ribosomal protein L26 -0.0444407
RPS27A ribosomal protein S27a -0.0440779
RPS27 ribosomal protein S27 -0.0437574
RPL31 ribosomal protein L31 -0.0434464
B2M beta-2-microglobulin -0.043182
RPS23 ribosomal protein S23 -0.0426894
RPL27 ribosomal protein L27 -0.0403438
RPS21 ribosomal protein S21 -0.0400771
RPS14 ribosomal protein S14 -0.0382817
RPL9 ribosomal protein L9 -0.0368536
RPLP2 ribosomal protein, large, P2 -0.0358816
RPS29 ribosomal protein S29 -0.0349902
RPL7 ribosomal protein L7 -0.0347413
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0347083
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0343139
NDRG1 N-myc downstream regulated 1 -0.0339205
S100A6 S100 calcium binding protein A6 -0.0326485
RPS5 ribosomal protein S5 -0.0326102
VCL vinculin -0.0325205
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.032506
IER3 immediate early response 3 -0.0321751
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.03169
RPL28 ribosomal protein L28 -0.031575
RPL35 ribosomal protein L35 -0.0315272
PKM pyruvate kinase, muscle -0.0312789
RPS13 ribosomal protein S13 -0.0311824
GNAS GNAS complex locus -0.0311431
RPL5 ribosomal protein L5 -0.0304509
RPS16 ribosomal protein S16 -0.0304289
RPS20 ribosomal protein S20 -0.0301098
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0300284
RACK1 receptor for activated C kinase 1 -0.0298426
H3-3B H3.3 histone B -0.0286119
TBX2 T-box 2 -0.0284296
DCAF7 DDB1 and CUL4 associated factor 7 -0.0277713
RPL18 ribosomal protein L18 -0.0277544
RPL11 ribosomal protein L11 -0.0276025
RPS25 ribosomal protein S25 -0.0275246
RPL8 ribosomal protein L8 -0.0275232
RPL30 ribosomal protein L30 -0.027189
COL1A1 collagen, type I, alpha 1 -0.0263652
RPLP0 ribosomal protein, large, P0 -0.025575
NACA nascent polypeptide-associated complex alpha subunit -0.0252069
RPS15 ribosomal protein S15 -0.0248299
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0247046
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0245781
KLF6 Kruppel-like factor 6 -0.0245592
RPL36A ribosomal protein L36a -0.0245558
RPL7A ribosomal protein L7a -0.0245345
AKAP12 A kinase (PRKA) anchor protein 12 -0.0242245
IFI16 interferon, gamma-inducible protein 16 -0.0240895
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0233875
MDK midkine (neurite growth-promoting factor 2) -0.0232223
RSL1D1 ribosomal L1 domain containing 1 -0.0231862
PTPRD protein tyrosine phosphatase, receptor type, D -0.023082
WSB1 WD repeat and SOCS box containing 1 -0.0230296
SOX4 SRY (sex determining region Y)-box 4 -0.0226373
ATF4 activating transcription factor 4 -0.0226074
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.022546
TLE4 transducin-like enhancer of split 4 -0.0223992
RPL37 ribosomal protein L37 -0.0222951
LOC112694756 uncharaterized LOC112694756 -0.0222324
RTN4 reticulon 4 -0.0219826
RPS10 ribosomal protein S10 -0.0219485
ENO1 enolase 1, (alpha) -0.0218414
MT2A metallothionein 2A -0.0217783
TPI1 triosephosphate isomerase 1 -0.0217049
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0214334
RPL15 ribosomal protein L15 -0.0213273
CSDE1 cold shock domain containing E1, RNA-binding -0.0211292
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0210375