Eplerenone_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0830878
VCL vinculin 0.0812839
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0560114
STS steroid sulfatase (microsomal), isozyme S 0.0548869
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0532611
SMAD3 SMAD family member 3 0.0530044
DSCAM Down syndrome cell adhesion molecule 0.0519444
ANXA2 annexin A2 0.0474059
LMO7 LIM domain 7 0.0449787
LPP LIM domain containing preferred translocation partner in lipoma 0.0433093
SHB Src homology 2 domain containing adaptor protein B 0.0404481
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0403982
MSI2 musashi RNA-binding protein 2 0.0402122
EFNB2 ephrin-B2 0.0400532
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0396909
VMP1 vacuole membrane protein 1 0.0396845
MACC1 metastasis associated in colon cancer 1 0.038032
PRKCA protein kinase C, alpha 0.0378348
RNF213 ring finger protein 213 0.0376736
PLSCR2 phospholipid scramblase 2 0.0374992
AKAP13 A kinase (PRKA) anchor protein 13 0.0374762
INTS6 integrator complex subunit 6 0.0364096
SORBS1 sorbin and SH3 domain containing 1 0.0361533
STK24 serine/threonine kinase 24 0.0352467
ERRFI1 ERBB receptor feedback inhibitor 1 0.0342897
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0341966
MYH9 myosin, heavy chain 9, non-muscle 0.0341673
EZR ezrin 0.0340387
ANKRD10 ankyrin repeat domain 10 0.0336177
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0323021
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0322131
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0317769
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0317402
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0296641
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0293344
RSAD2 radical S-adenosyl methionine domain containing 2 0.0286288
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0285867
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0284276
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0282617
FAT1 FAT atypical cadherin 1 0.0280893
TJP1 tight junction protein 1 0.0276462
MYO1E myosin IE 0.027062
DUSP10 dual specificity phosphatase 10 0.0258336
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0256061
TUFT1 tuftelin 1 0.0254277
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247946
AFF1 AF4/FMR2 family, member 1 0.0243398
TM4SF19 transmembrane 4 L six family member 19 0.0236179
ETV6 ets variant 6 0.0234595
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0233518
BCLAF1 BCL2-associated transcription factor 1 0.0232228
MED13L mediator complex subunit 13-like 0.0230141
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0224401
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0221412
ARHGAP26 Rho GTPase activating protein 26 0.0219224
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0215511
NRIP1 nuclear receptor interacting protein 1 0.0215011
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.021271
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.020941
SFPQ splicing factor proline/glutamine-rich 0.0209263
DPP4 dipeptidyl-peptidase 4 0.0209051
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0207353
DIAPH1 diaphanous-related formin 1 0.0204371
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0201605
CCNL1 cyclin L1 0.0201215
MEIS2 Meis homeobox 2 0.0200445
MYO5B myosin VB 0.019907
HELZ helicase with zinc finger 0.0196579
ZDHHC20 zinc finger, DHHC-type containing 20 0.0196284
TRIP12 thyroid hormone receptor interactor 12 0.0195456
BCL2L1 BCL2-like 1 0.0195418
IFNGR1 interferon gamma receptor 1 0.0195385
WWOX WW domain containing oxidoreductase 0.0193768
FNIP1 folliculin interacting protein 1 0.0190715
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0189925
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0188193
PTBP3 polypyrimidine tract binding protein 3 0.018768
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0186674
ASPH aspartate beta-hydroxylase 0.0186208
ARB2A ARB2 cotranscriptional regulator A 0.0185886
RUNX1 runt-related transcription factor 1 0.0183749
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0181997
TSC22D1 TSC22 domain family, member 1 0.0181306
PDZD8 PDZ domain containing 8 0.018106
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0180665
EREG epiregulin 0.017961
SEPTIN9 septin 9 0.0179306
RBM26 RNA binding motif protein 26 0.0178389
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0178015
CATSPERB catsper channel auxiliary subunit beta 0.017705
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0174102
ARL5B ADP-ribosylation factor-like 5B 0.017134
DOCK1 dedicator of cytokinesis 1 0.0171103
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0168585
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0167952
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0167816
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0167663
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0167138
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0166572
USP53 ubiquitin specific peptidase 53 0.0165805

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.239968
PTMA prothymosin, alpha -0.163533
B2M beta-2-microglobulin -0.14551
HLA-B major histocompatibility complex, class I, B -0.140638
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140133
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.119699
RPS6 ribosomal protein S6 -0.113577
FTL ferritin, light polypeptide -0.108656
ZMYND8 zinc finger, MYND-type containing 8 -0.107018
EIF1 eukaryotic translation initiation factor 1 -0.0945382
RPL35A ribosomal protein L35a -0.08969
TMSB10 thymosin beta 10 -0.0891295
LCN2 lipocalin 2 -0.0860275
IFI6 interferon, alpha-inducible protein 6 -0.076684
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0743757
IFI27 interferon, alpha-inducible protein 27 -0.0711794
RPL23 ribosomal protein L23 -0.064734
LYZ lysozyme -0.063532
LOC102724023 ES1 protein homolog, mitochondrial -0.0620519
MBNL2 muscleblind-like splicing regulator 2 -0.062047
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0616011
RPS3 ribosomal protein S3 -0.0590982
RPL37A ribosomal protein L37a -0.059096
RPS29 ribosomal protein S29 -0.0585515
RPLP1 ribosomal protein, large, P1 -0.0584656
RPL19 ribosomal protein L19 -0.0574945
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0559987
RPL26 ribosomal protein L26 -0.0559793
MT2A metallothionein 2A -0.0551944
RPL34 ribosomal protein L34 -0.0547906
RPL31 ribosomal protein L31 -0.0546186
RPS8 ribosomal protein S8 -0.053684
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0535588
EPSTI1 epithelial stromal interaction 1 (breast) -0.0531211
RPS13 ribosomal protein S13 -0.0525807
RPS19 ribosomal protein S19 -0.0524724
HLA-C major histocompatibility complex, class I, C -0.0515131
NDRG1 N-myc downstream regulated 1 -0.0493823
RPL9 ribosomal protein L9 -0.0490292
RPL12 ribosomal protein L12 -0.0485014
ENO1 enolase 1, (alpha) -0.0478059
RPL11 ribosomal protein L11 -0.0477827
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0467559
RPS27 ribosomal protein S27 -0.0466252
HLA-E major histocompatibility complex, class I, E -0.0449293
RPS12 ribosomal protein S12 -0.0435896
GCC2 GRIP and coiled-coil domain containing 2 -0.0431839
WSB1 WD repeat and SOCS box containing 1 -0.0426597
CSTB cystatin B (stefin B) -0.042481
SLC38A1 solute carrier family 38, member 1 -0.0424465
HLA-A major histocompatibility complex, class I, A -0.0404987
MPHOSPH8 M-phase phosphoprotein 8 -0.040004
TMC5 transmembrane channel-like 5 -0.0399296
VIM vimentin -0.0399105
RPS23 ribosomal protein S23 -0.0396998
XAF1 XIAP associated factor 1 -0.0396642
IGFBP3 insulin-like growth factor binding protein 3 -0.0394669
RPLP2 ribosomal protein, large, P2 -0.0391734
UBC ubiquitin C -0.0391153
PRRC2C proline-rich coiled-coil 2C -0.0387059
PKM pyruvate kinase, muscle -0.038561
RPS24 ribosomal protein S24 -0.0384594
RPL38 ribosomal protein L38 -0.0381952
RPS27A ribosomal protein S27a -0.0378122
PERP PERP, TP53 apoptosis effector -0.037458
RPS11 ribosomal protein S11 -0.037447
GNAS GNAS complex locus -0.0371046
ACTG1 actin gamma 1 -0.03685
GOLGB1 golgin B1 -0.0355542
PDIA3 protein disulfide isomerase family A, member 3 -0.0352275
VDAC1 voltage-dependent anion channel 1 -0.035225
S100P S100 calcium binding protein P -0.0352207
RPL37 ribosomal protein L37 -0.034842
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0347786
RPS16 ribosomal protein S16 -0.0344471
PATJ PATJ crumbs cell polarity complex component -0.0344399
IFITM3 interferon induced transmembrane protein 3 -0.0341256
RPS14 ribosomal protein S14 -0.0340713
RPL36A ribosomal protein L36a -0.0340681
MUC20 mucin 20, cell surface associated -0.0337563
PGK1 phosphoglycerate kinase 1 -0.0337102
TPI1 triosephosphate isomerase 1 -0.0336973
RRBP1 ribosome binding protein 1 -0.0335062
KRT19 keratin 19, type I -0.033486
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0330693
CST3 cystatin C -0.0329886
RPS17 ribosomal protein S17 -0.0327219
LOC112694756 uncharaterized LOC112694756 -0.0324966
RPS25 ribosomal protein S25 -0.0322926
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0320165
S100A6 S100 calcium binding protein A6 -0.0319012
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0317148
BACE2 beta-site APP-cleaving enzyme 2 -0.0309326
S100A9 S100 calcium binding protein A9 -0.0307146
S100A10 S100 calcium binding protein A10 -0.0306668
EPCAM epithelial cell adhesion molecule -0.0306182
RAB6A RAB6A, member RAS oncogene family -0.0300807
RPL8 ribosomal protein L8 -0.0299724
DSTN destrin (actin depolymerizing factor) -0.0298287
RPL28 ribosomal protein L28 -0.0297992