Eplerenone_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.124365
VEGFA vascular endothelial growth factor A 0.123075
MYH9 myosin, heavy chain 9, non-muscle 0.105183
FN1 fibronectin 1 0.0656205
PLEC plectin 0.0577801
TRIO trio Rho guanine nucleotide exchange factor 0.0564702
SMAD3 SMAD family member 3 0.0544855
EXT1 exostosin glycosyltransferase 1 0.0541796
FNDC3B fibronectin type III domain containing 3B 0.0511861
COL5A1 collagen, type V, alpha 1 0.0504799
FTH1 ferritin, heavy polypeptide 1 0.04042
CD44 CD44 molecule (Indian blood group) 0.0383717
COL7A1 collagen, type VII, alpha 1 0.0354225
DOCK5 dedicator of cytokinesis 5 0.0350721
ATP13A3 ATPase type 13A3 0.0349863
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0308784
WWTR1 WW domain containing transcription regulator 1 0.0305994
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0299469
EEF2 eukaryotic translation elongation factor 2 0.0297243
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289862
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0287668
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0285845
SHB Src homology 2 domain containing adaptor protein B 0.0282447
CALR calreticulin 0.0265896
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0259005
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0257839
FAT1 FAT atypical cadherin 1 0.0245535
PTK2 protein tyrosine kinase 2 0.0243818
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0232806
DPYSL3 dihydropyrimidinase-like 3 0.0232157
LOXL2 lysyl oxidase-like 2 0.0229014
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0222663
AXL AXL receptor tyrosine kinase 0.0220001
TNS1 tensin 1 0.0216385
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0215781
RUNX1 runt-related transcription factor 1 0.021468
CAMTA1 calmodulin binding transcription activator 1 0.0210187
CDH13 cadherin 13 0.0208212
NAMPT nicotinamide phosphoribosyltransferase 0.0206403
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0200936
FLNB filamin B, beta 0.0200368
SEPTIN9 septin 9 0.0197665
TNIP1 TNFAIP3 interacting protein 1 0.0192341
FAM20C family with sequence similarity 20, member C 0.0187168
CEMIP cell migration inducing protein, hyaluronan binding 0.0185476
ICAM1 intercellular adhesion molecule 1 0.0185474
ARRDC3 arrestin domain containing 3 0.0179707
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0166294
RASA2 RAS p21 protein activator 2 0.016505
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0161314
PDIA5 protein disulfide isomerase family A, member 5 0.0155655
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0154592
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0154327
NDEL1 nudE neurodevelopment protein 1-like 1 0.0153555
TPM3 tropomyosin 3 0.0152762
MYO9B myosin IXB 0.0152065
PDE10A phosphodiesterase 10A 0.0149295
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0148951
FMNL2 formin-like 2 0.0145913
PUM2 pumilio RNA-binding family member 2 0.0145825
MSN moesin 0.0145386
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0144929
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0144233
MACF1 microtubule-actin crosslinking factor 1 0.0142878
NBAS neuroblastoma amplified sequence 0.0142362
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.014166
KLC1 kinesin light chain 1 0.0141031
ZNF451 zinc finger protein 451 0.0139717
HOOK2 hook microtubule-tethering protein 2 0.0138081
OSMR oncostatin M receptor 0.0137994
KMT2E lysine (K)-specific methyltransferase 2E 0.0137218
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0137052
SFPQ splicing factor proline/glutamine-rich 0.0135834
ANO6 anoctamin 6 0.0134681
CTNND1 catenin (cadherin-associated protein), delta 1 0.013449
RASA3 RAS p21 protein activator 3 0.0133818
HSPA8 heat shock 70kDa protein 8 0.0132188
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0131831
FLNA filamin A, alpha 0.0131096
GRB10 growth factor receptor-bound protein 10 0.0130806
ZMIZ1 zinc finger, MIZ-type containing 1 0.0128929
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0124076
AFAP1 actin filament associated protein 1 0.0123942
ELL2 elongation factor, RNA polymerase II, 2 0.0123694
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0123484
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0123009
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0121267
YEATS2 YEATS domain containing 2 0.0120506
ADAM17 ADAM metallopeptidase domain 17 0.0119817
PGM3 phosphoglucomutase 3 0.0119475
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0119145
ANKRD36 ankyrin repeat domain 36 0.0119085
OGA O-GlcNAcase 0.0118885
BRD2 bromodomain containing 2 0.0118158
NFE2L1 nuclear factor, erythroid 2-like 1 0.0117896
NUMB numb homolog (Drosophila) 0.0115652
SPAG9 sperm associated antigen 9 0.0115282
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.011423
ANKRD11 ankyrin repeat domain 11 0.0113715
AGFG1 ArfGAP with FG repeats 1 0.0112498

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.207715
VIM vimentin -0.204903
MT2A metallothionein 2A -0.180634
TMSB10 thymosin beta 10 -0.140484
NDRG1 N-myc downstream regulated 1 -0.0997865
IGFBP3 insulin-like growth factor binding protein 3 -0.0977695
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0968336
FTL ferritin, light polypeptide -0.0949008
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0806702
COL1A1 collagen, type I, alpha 1 -0.0793078
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0738935
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0713354
TGFBI transforming growth factor, beta-induced, 68kDa -0.0663581
IER3 immediate early response 3 -0.0616733
COL1A2 collagen, type I, alpha 2 -0.0609793
TPM4 tropomyosin 4 -0.0606544
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0593584
LOX lysyl oxidase -0.0589033
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0581054
ENO1 enolase 1, (alpha) -0.0564022
RPL35A ribosomal protein L35a -0.0554651
RPS8 ribosomal protein S8 -0.0520418
RPS6 ribosomal protein S6 -0.0490294
RPS19 ribosomal protein S19 -0.0483783
EIF1 eukaryotic translation initiation factor 1 -0.0465973
S100A9 S100 calcium binding protein A9 -0.0463849
RPLP2 ribosomal protein, large, P2 -0.0410111
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0407305
PTMA prothymosin, alpha -0.039951
LDHA lactate dehydrogenase A -0.0387951
RPS3 ribosomal protein S3 -0.0368224
TPT1 tumor protein, translationally-controlled 1 -0.0356403
RPL23 ribosomal protein L23 -0.0352448
RPL8 ribosomal protein L8 -0.0351152
IFI6 interferon, alpha-inducible protein 6 -0.0346827
RPL36 ribosomal protein L36 -0.0344913
RPL12 ribosomal protein L12 -0.0323825
RPL37A ribosomal protein L37a -0.0321168
RPL18 ribosomal protein L18 -0.032026
S100A10 S100 calcium binding protein A10 -0.0314643
CXCL8 chemokine (C-X-C motif) ligand 8 -0.031439
RPL28 ribosomal protein L28 -0.0308578
RPL19 ribosomal protein L19 -0.0302601
RPS25 ribosomal protein S25 -0.0295684
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0290679
VCAN versican -0.0290658
RPL11 ribosomal protein L11 -0.0290344
RPS13 ribosomal protein S13 -0.0281924
RPL32 ribosomal protein L32 -0.0281419
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0276643
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0274521
RPS12 ribosomal protein S12 -0.0272619
PSD3 pleckstrin and Sec7 domain containing 3 -0.0271726
PFN1 profilin 1 -0.0268282
CALD1 caldesmon 1 -0.0267668
MTDH metadherin -0.026494
IFITM3 interferon induced transmembrane protein 3 -0.0264565
RPS23 ribosomal protein S23 -0.0264047
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0263827
RPS14 ribosomal protein S14 -0.0260862
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0258149
S100A6 S100 calcium binding protein A6 -0.0256231
LMAN1 lectin, mannose-binding, 1 -0.0255066
CAVIN1 caveolae associated protein 1 -0.0251634
RPL5 ribosomal protein L5 -0.0250887
RPLP1 ribosomal protein, large, P1 -0.0249974
RPS11 ribosomal protein S11 -0.0248202
RPL34 ribosomal protein L34 -0.0245422
ADM adrenomedullin -0.0242817
RPS27A ribosomal protein S27a -0.0241181
RPS5 ribosomal protein S5 -0.0240754
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0239781
RPL31 ribosomal protein L31 -0.0238855
ZBTB20 zinc finger and BTB domain containing 20 -0.0232279
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0232172
UBC ubiquitin C -0.0231826
RPS16 ribosomal protein S16 -0.022793
RPL26 ribosomal protein L26 -0.0224206
GNAS GNAS complex locus -0.0222286
RPS21 ribosomal protein S21 -0.0218709
HLA-B major histocompatibility complex, class I, B -0.0216419
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0215613
EGR1 early growth response 1 -0.0215397
MT1X metallothionein 1X -0.0215251
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0206299
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0204456
FAM162A family with sequence similarity 162, member A -0.0201987
GARS1 glycyl-tRNA synthetase 1 -0.0199762
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0198763
RPS17 ribosomal protein S17 -0.0193096
VDAC1 voltage-dependent anion channel 1 -0.0192674
RPL15 ribosomal protein L15 -0.0192641
RPL37 ribosomal protein L37 -0.0192203
CYB5R3 cytochrome b5 reductase 3 -0.0191906
PDIA6 protein disulfide isomerase family A, member 6 -0.0191684
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0191445
RPS24 ribosomal protein S24 -0.0188385
RPS29 ribosomal protein S29 -0.0188227
PDIA3 protein disulfide isomerase family A, member 3 -0.0187523
PGK1 phosphoglycerate kinase 1 -0.0186567