Eplerenone_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.195414
FN1 fibronectin 1 0.135949
FBF1 Fas (TNFRSF6) binding factor 1 0.117699
APOB apolipoprotein B 0.112442
FNDC3B fibronectin type III domain containing 3B 0.0883137
EEF2 eukaryotic translation elongation factor 2 0.0741453
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0716937
VEGFA vascular endothelial growth factor A 0.066442
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0663442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0610152
LRMDA leucine rich melanocyte differentiation associated 0.0609692
NKD1 naked cuticle homolog 1 (Drosophila) 0.0565192
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0563008
GPC6 glypican 6 0.0534439
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0523179
FAT1 FAT atypical cadherin 1 0.0510639
ZFAND3 zinc finger, AN1-type domain 3 0.0487128
SLC38A2 solute carrier family 38, member 2 0.0483905
AFDN afadin, adherens junction formation factor 0.0481695
TNS1 tensin 1 0.0456277
SAMD4A sterile alpha motif domain containing 4A 0.0452913
PTPRM protein tyrosine phosphatase, receptor type, M 0.044535
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.044102
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0430401
RPL3 ribosomal protein L3 0.0429899
CCNY cyclin Y 0.0412253
MACF1 microtubule-actin crosslinking factor 1 0.0405799
DSPP dentin sialophosphoprotein 0.0400253
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0398975
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0398097
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0396056
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0392819
MYH9 myosin, heavy chain 9, non-muscle 0.0379325
RBM39 RNA binding motif protein 39 0.0373788
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0372763
KRT8 keratin 8, type II 0.0372035
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0368729
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0361676
LCOR ligand dependent nuclear receptor corepressor 0.0358245
MAML2 mastermind-like 2 (Drosophila) 0.0357618
TRIO trio Rho guanine nucleotide exchange factor 0.0352211
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0341829
MBNL3 muscleblind-like splicing regulator 3 0.0337423
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0330257
PEG10 paternally expressed 10 0.0328873
WDR43 WD repeat domain 43 0.0328792
JMJD1C jumonji domain containing 1C 0.0327582
FLNB filamin B, beta 0.0322907
ADAM9 ADAM metallopeptidase domain 9 0.0311822
ITGAV integrin, alpha V 0.0300519
NRIP1 nuclear receptor interacting protein 1 0.0298801
VMP1 vacuole membrane protein 1 0.0296237
ZMIZ1 zinc finger, MIZ-type containing 1 0.0295067
YAP1 Yes-associated protein 1 0.0294913
ASXL1 additional sex combs like transcriptional regulator 1 0.0291317
SEPTIN9 septin 9 0.0290098
TF transferrin 0.0289638
POTEF POTE ankyrin domain family, member F 0.0288534
IL6ST interleukin 6 signal transducer 0.0287967
ARHGAP9 Rho GTPase activating protein 9 0.0286651
PAPOLA poly(A) polymerase alpha 0.0286324
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0284945
MRTFA myocardin related transcription factor A 0.028351
DOCK4 dedicator of cytokinesis 4 0.028343
EIF4B eukaryotic translation initiation factor 4B 0.0280238
DSCAM Down syndrome cell adhesion molecule 0.0279402
BCL2L1 BCL2-like 1 0.0274765
DENND4A DENN/MADD domain containing 4A 0.0274328
HELZ helicase with zinc finger 0.0272341
ABTB3 ankyrin repeat and BTB domain containing 3 0.0270299
KIF1B kinesin family member 1B 0.0269831
ZEB1 zinc finger E-box binding homeobox 1 0.026917
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0268675
CPE carboxypeptidase E 0.0268378
DST dystonin 0.0267184
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0266508
ABI1 abl-interactor 1 0.0265314
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0264621
MYO1B myosin IB 0.0263188
DNAH17 dynein, axonemal, heavy chain 17 0.0253868
TTC28 tetratricopeptide repeat domain 28 0.0253455
NBAS neuroblastoma amplified sequence 0.0250334
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.024827
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0246777
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0244231
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0241615
EML4 echinoderm microtubule associated protein like 4 0.0241162
MSI2 musashi RNA-binding protein 2 0.0240966
APLP2 amyloid beta (A4) precursor-like protein 2 0.0240758
PCBP2 poly(rC) binding protein 2 0.0240559
MAPK1 mitogen-activated protein kinase 1 0.024016
PICALM phosphatidylinositol binding clathrin assembly protein 0.0239312
NCOA2 nuclear receptor coactivator 2 0.0239033
CAMTA1 calmodulin binding transcription activator 1 0.0237577
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0237461
KDM6A lysine (K)-specific demethylase 6A 0.0236693
IQSEC1 IQ motif and Sec7 domain 1 0.0233841
FGA fibrinogen alpha chain 0.0233117
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.023284
TNS3 tensin 3 0.0232333

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.212461
MT2A metallothionein 2A -0.208947
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.164498
RPS24 ribosomal protein S24 -0.10789
APOA2 apolipoprotein A-II -0.106012
RPS8 ribosomal protein S8 -0.102389
AKAP12 A kinase (PRKA) anchor protein 12 -0.100972
RPS6 ribosomal protein S6 -0.0972342
RPLP1 ribosomal protein, large, P1 -0.096457
RPS19 ribosomal protein S19 -0.0919785
RPL37A ribosomal protein L37a -0.0891244
FTL ferritin, light polypeptide -0.087439
TMSB10 thymosin beta 10 -0.0868962
RPL35A ribosomal protein L35a -0.0865112
RPL34 ribosomal protein L34 -0.077383
RPL23 ribosomal protein L23 -0.0771752
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0756408
ENO1 enolase 1, (alpha) -0.0741572
RPL12 ribosomal protein L12 -0.073053
RPLP2 ribosomal protein, large, P2 -0.0723375
TM4SF1 transmembrane 4 L six family member 1 -0.0714073
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0704429
RPS27A ribosomal protein S27a -0.0701372
RPL31 ribosomal protein L31 -0.0680795
RPS29 ribosomal protein S29 -0.0661525
IGFBP1 insulin-like growth factor binding protein 1 -0.0635344
RPLP0 ribosomal protein, large, P0 -0.0634017
RPL11 ribosomal protein L11 -0.0592831
RPS23 ribosomal protein S23 -0.0585787
RPS12 ribosomal protein S12 -0.0577054
RPS21 ribosomal protein S21 -0.0558835
HMGA1 high mobility group AT-hook 1 -0.0499048
RPL26 ribosomal protein L26 -0.0496258
RPL37 ribosomal protein L37 -0.0495088
RPL32 ribosomal protein L32 -0.0478677
RPL9 ribosomal protein L9 -0.0474994
RPS14 ribosomal protein S14 -0.0466884
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0461249
RPL5 ribosomal protein L5 -0.0459587
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0458931
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0442472
RPS3 ribosomal protein S3 -0.0440214
FRMD5 FERM domain containing 5 -0.0433302
RPS13 ribosomal protein S13 -0.0428796
S100A9 S100 calcium binding protein A9 -0.0422219
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0413851
KDM3A lysine (K)-specific demethylase 3A -0.0411203
H1-0 H1.0 linker histone -0.0409279
RPL19 ribosomal protein L19 -0.0407408
RPS16 ribosomal protein S16 -0.0401742
RPL27 ribosomal protein L27 -0.0398439
RPL36 ribosomal protein L36 -0.039689
RPS11 ribosomal protein S11 -0.0381626
ZMYND8 zinc finger, MYND-type containing 8 -0.0379353
RPS10 ribosomal protein S10 -0.0376351
PTMA prothymosin, alpha -0.0371073
S100A10 S100 calcium binding protein A10 -0.0362845
RPL38 ribosomal protein L38 -0.035869
RPL28 ribosomal protein L28 -0.0355142
EXT1 exostosin glycosyltransferase 1 -0.0349914
IFITM1 interferon induced transmembrane protein 1 -0.0348422
RPL7A ribosomal protein L7a -0.0345494
RPS5 ribosomal protein S5 -0.0344932
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0344883
EIF1 eukaryotic translation initiation factor 1 -0.0336821
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0334285
CCL20 chemokine (C-C motif) ligand 20 -0.0332175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0330179
RPS25 ribosomal protein S25 -0.0321619
APOE apolipoprotein E -0.0319906
IFI6 interferon, alpha-inducible protein 6 -0.0319884
RPL18 ribosomal protein L18 -0.0318804
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0318609
APOC1 apolipoprotein C-I -0.0317409
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0306805
PGK1 phosphoglycerate kinase 1 -0.0302642
RPL8 ribosomal protein L8 -0.0299902
RPS27 ribosomal protein S27 -0.0297055
LOC112694756 uncharaterized LOC112694756 -0.0291395
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0284257
ANGPTL8 angiopoietin like 8 -0.0283752
VIM vimentin -0.0282643
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0278881
RPL30 ribosomal protein L30 -0.0272242
RACK1 receptor for activated C kinase 1 -0.0271944
IER3 immediate early response 3 -0.0270939
PLIN2 perilipin 2 -0.027042
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0264404
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0263041
GNAS GNAS complex locus -0.0261545
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0252205
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0251102
NDRG1 N-myc downstream regulated 1 -0.0248061
NPR2 natriuretic peptide receptor 2 -0.0247947
STAU1 staufen double-stranded RNA binding protein 1 -0.0247283
CP ceruloplasmin (ferroxidase) -0.0246489
RPL36A ribosomal protein L36a -0.0246298
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0245043
RPL4 ribosomal protein L4 -0.0239102
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.023525