Eplerenone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC6 mucin 6, oligomeric mucus/gel-forming 0.118952
VEGFA vascular endothelial growth factor A 0.0997152
NDRG1 N-myc downstream regulated 1 0.0845401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0828279
TXNIP thioredoxin interacting protein 0.0757738
FAM13A family with sequence similarity 13, member A 0.0706268
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0677034
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.062968
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0624012
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0622748
EZR ezrin 0.0602654
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0599377
ANKRD11 ankyrin repeat domain 11 0.0578734
CCNY cyclin Y 0.0577486
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0556138
WAC WW domain containing adaptor with coiled-coil 0.05544
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0551146
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0527422
ESYT2 extended synaptotagmin-like protein 2 0.0517722
KDM6A lysine (K)-specific demethylase 6A 0.0508778
FLNB filamin B, beta 0.0503155
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0490576
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0488069
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0487073
MED13L mediator complex subunit 13-like 0.0482649
KRT8 keratin 8, type II 0.0478496
ZNF292 zinc finger protein 292 0.0476986
POTEF POTE ankyrin domain family, member F 0.0470498
GRB10 growth factor receptor-bound protein 10 0.0461372
UBA6 ubiquitin-like modifier activating enzyme 6 0.0459075
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0458926
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0445314
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0426799
FTH1 ferritin, heavy polypeptide 1 0.0425177
GOLGA4 golgin A4 0.0420677
KMT2E lysine (K)-specific methyltransferase 2E 0.0416627
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0416141
FNDC3B fibronectin type III domain containing 3B 0.0413268
ITGA6 integrin, alpha 6 0.0412769
TPM3 tropomyosin 3 0.0408106
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.040611
PARD3 par-3 family cell polarity regulator 0.0397061
RREB1 ras responsive element binding protein 1 0.0385415
COPA coatomer protein complex, subunit alpha 0.0385077
RNF145 ring finger protein 145 0.0385004
MYO5B myosin VB 0.0370494
CALR calreticulin 0.0368773
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0362189
EPS8 epidermal growth factor receptor pathway substrate 8 0.03564
TFG TRK-fused gene 0.0353822
TPD52 tumor protein D52 0.0350101
CCNL1 cyclin L1 0.0341949
MACF1 microtubule-actin crosslinking factor 1 0.0338981
ZFAND3 zinc finger, AN1-type domain 3 0.0334563
SPAG9 sperm associated antigen 9 0.0326723
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0324494
NUP58 nucleoporin 58 0.0318623
SUCO SUN domain containing ossification factor 0.0317651
KDM2A lysine (K)-specific demethylase 2A 0.0309861
RAB6A RAB6A, member RAS oncogene family 0.0306587
PDIA6 protein disulfide isomerase family A, member 6 0.0299762
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0292945
KAT6B K(lysine) acetyltransferase 6B 0.0292776
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0292408
EEF2 eukaryotic translation elongation factor 2 0.0290389
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0283685
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0280628
USP3 ubiquitin specific peptidase 3 0.0279055
MXI1 MAX interactor 1, dimerization protein 0.0277228
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0276636
MYH9 myosin, heavy chain 9, non-muscle 0.0275606
ARF4 ADP-ribosylation factor 4 0.0274332
TSC22D2 TSC22 domain family, member 2 0.0273708
MXD1 MAX dimerization protein 1 0.0271109
HELZ helicase with zinc finger 0.0269042
PDS5B PDS5 cohesin associated factor B 0.0266483
ACBD3 acyl-CoA binding domain containing 3 0.0265537
PUM1 pumilio RNA-binding family member 1 0.0260527
ANXA11 annexin A11 0.0259522
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0258268
DNM2 dynamin 2 0.0256184
UGCG UDP-glucose ceramide glucosyltransferase 0.0253917
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0253906
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0253426
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.025306
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0251879
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0250904
SETD5 SET domain containing 5 0.0247085
ERRFI1 ERBB receptor feedback inhibitor 1 0.0246966
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0246147
YTHDC1 YTH domain containing 1 0.0244197
LRRC1 leucine rich repeat containing 1 0.0242484
RYBP RING1 and YY1 binding protein 0.0240385
FNBP1L formin binding protein 1-like 0.0239643
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0238201
TRA2A transformer 2 alpha homolog (Drosophila) 0.0236632
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0236267
NAMPT nicotinamide phosphoribosyltransferase 0.023599
PDIA3 protein disulfide isomerase family A, member 3 0.0235957
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0234892

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216249
TMSB10 thymosin beta 10 -0.162356
PTMA prothymosin, alpha -0.0984627
TPT1 tumor protein, translationally-controlled 1 -0.0933039
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0903699
RPLP2 ribosomal protein, large, P2 -0.0803548
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.072253
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0707007
RPS3 ribosomal protein S3 -0.0680386
RPL26 ribosomal protein L26 -0.0669953
RPLP1 ribosomal protein, large, P1 -0.0648425
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0638478
CADPS Ca++-dependent secretion activator -0.062189
ONECUT3 one cut homeobox 3 -0.0599612
RPL12 ribosomal protein L12 -0.0597181
NALF1 NALCN channel auxiliary factor 1 -0.0589966
RPS19 ribosomal protein S19 -0.0584606
RPL34 ribosomal protein L34 -0.0578264
RPL36 ribosomal protein L36 -0.0560319
RPS6 ribosomal protein S6 -0.0539944
NPSR1 neuropeptide S receptor 1 -0.0539469
RPL11 ribosomal protein L11 -0.0533172
RPS8 ribosomal protein S8 -0.0530197
RPS29 ribosomal protein S29 -0.0511636
RPS24 ribosomal protein S24 -0.0499288
S100P S100 calcium binding protein P -0.0497117
RPL23 ribosomal protein L23 -0.0496341
RPL35A ribosomal protein L35a -0.0487267
MYO1E myosin IE -0.0477707
VCL vinculin -0.0476628
RPL9 ribosomal protein L9 -0.0474106
RPL5 ribosomal protein L5 -0.0469104
RPL31 ribosomal protein L31 -0.0459016
RPS12 ribosomal protein S12 -0.0457749
LOC112694756 uncharaterized LOC112694756 -0.0457029
RPL19 ribosomal protein L19 -0.0452845
RNF43 ring finger protein 43 -0.0450679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0450429
RPS25 ribosomal protein S25 -0.0437408
RPS23 ribosomal protein S23 -0.0433456
LDHA lactate dehydrogenase A -0.0433164
RPS27A ribosomal protein S27a -0.0426551
RPL32 ribosomal protein L32 -0.0416497
RPL37A ribosomal protein L37a -0.041411
RPL18 ribosomal protein L18 -0.0406307
POF1B premature ovarian failure, 1B -0.040307
TNS4 tensin 4 -0.0392556
CD44 CD44 molecule (Indian blood group) -0.0364956
RACK1 receptor for activated C kinase 1 -0.0348789
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.033792
RPL13A ribosomal protein L13a -0.0326022
SMYD3 SET and MYND domain containing 3 -0.032538
KLF5 Kruppel-like factor 5 (intestinal) -0.0322801
RPS17 ribosomal protein S17 -0.0322204
AREG amphiregulin -0.0311463
FTL ferritin, light polypeptide -0.0310214
RPL27 ribosomal protein L27 -0.030997
IER3 immediate early response 3 -0.0307837
RPS11 ribosomal protein S11 -0.0303192
PKP2 plakophilin 2 -0.0299823
S100A10 S100 calcium binding protein A10 -0.0299752
MBD5 methyl-CpG binding domain protein 5 -0.029651
EIF1 eukaryotic translation initiation factor 1 -0.0295428
RPL7A ribosomal protein L7a -0.0294389
RPL30 ribosomal protein L30 -0.0293595
RPS13 ribosomal protein S13 -0.0287486
RPS27 ribosomal protein S27 -0.0280887
S100A9 S100 calcium binding protein A9 -0.0280166
RPLP0 ribosomal protein, large, P0 -0.0278488
EPCAM epithelial cell adhesion molecule -0.0278195
RPL38 ribosomal protein L38 -0.0272116
RPS14 ribosomal protein S14 -0.0270662
RPL35 ribosomal protein L35 -0.0265988
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0265251
RPL37 ribosomal protein L37 -0.0261575
RAB10 RAB10, member RAS oncogene family -0.0260513
ALCAM activated leukocyte cell adhesion molecule -0.0259713
CCND1 cyclin D1 -0.0259629
SOX9 SRY (sex determining region Y)-box 9 -0.025785
ZBTB20 zinc finger and BTB domain containing 20 -0.0257602
RPS21 ribosomal protein S21 -0.0253196
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0251986
AHNAK AHNAK nucleoprotein -0.0246351
LOC102724023 ES1 protein homolog, mitochondrial -0.0246329
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0244558
RPS15 ribosomal protein S15 -0.0244069
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.024236
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0240237
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.023934
MT2A metallothionein 2A -0.0235954
RPL27A ribosomal protein L27a -0.0230772
RPL8 ribosomal protein L8 -0.0230041
RPS10 ribosomal protein S10 -0.0228737
FBXL17 F-box and leucine-rich repeat protein 17 -0.0225501
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225267
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0224551
RRBP1 ribosome binding protein 1 -0.0223325
PTPRK protein tyrosine phosphatase, receptor type, K -0.0222861
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0221608
RPL36A ribosomal protein L36a -0.0220759