Eplerenone_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Eplerenone_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.0898592
DST dystonin 0.0698108
ERRFI1 ERBB receptor feedback inhibitor 1 0.0602086
DLG1 discs, large homolog 1 (Drosophila) 0.0443648
CD44 CD44 molecule (Indian blood group) 0.0422517
MACF1 microtubule-actin crosslinking factor 1 0.0391915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0372337
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0368137
EEF2 eukaryotic translation elongation factor 2 0.0366765
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0365892
FMNL2 formin-like 2 0.0358154
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0358042
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0330136
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0321269
APP amyloid beta (A4) precursor protein 0.0320721
SLC38A2 solute carrier family 38, member 2 0.0316974
CANX calnexin 0.0312861
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0312489
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0308022
TMSB4X thymosin beta 4, X-linked 0.0307076
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0290718
ANKRD11 ankyrin repeat domain 11 0.0285729
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0285423
TSC22D1 TSC22 domain family, member 1 0.0282892
AHNAK AHNAK nucleoprotein 0.0279904
TRIO trio Rho guanine nucleotide exchange factor 0.0275122
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0264296
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0260202
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0256916
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0256533
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0254805
CALR calreticulin 0.0251568
FNIP1 folliculin interacting protein 1 0.0248514
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0248213
PLK2 polo-like kinase 2 0.0245607
PTK2 protein tyrosine kinase 2 0.0242132
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0238172
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0232509
BCAR3 breast cancer anti-estrogen resistance 3 0.0231505
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.022916
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0225942
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0225341
TPM3 tropomyosin 3 0.0225135
WDR43 WD repeat domain 43 0.0217769
MYH9 myosin, heavy chain 9, non-muscle 0.0217015
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0208096
DOCK11 dedicator of cytokinesis 11 0.0206107
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0202852
YEATS2 YEATS domain containing 2 0.0201641
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0201162
ZDHHC14 zinc finger, DHHC-type containing 14 0.019795
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0197807
EHBP1 EH domain binding protein 1 0.0197528
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0197347
P4HB prolyl 4-hydroxylase, beta polypeptide 0.019369
SFPQ splicing factor proline/glutamine-rich 0.0193231
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0192825
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0191839
XPO1 exportin 1 0.019111
KMT2C lysine (K)-specific methyltransferase 2C 0.0190792
CAPRIN2 caprin family member 2 0.018636
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.018281
TRIP12 thyroid hormone receptor interactor 12 0.0180424
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.017938
PUM2 pumilio RNA-binding family member 2 0.0177916
BRWD1 bromodomain and WD repeat domain containing 1 0.0176969
EXOC4 exocyst complex component 4 0.0176435
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0176018
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0175418
RNF213 ring finger protein 213 0.0175256
MBNL2 muscleblind-like splicing regulator 2 0.0174639
HOOK2 hook microtubule-tethering protein 2 0.0173531
SPAG9 sperm associated antigen 9 0.0173226
TNS3 tensin 3 0.017299
PIAS2 protein inhibitor of activated STAT, 2 0.0172597
SET SET nuclear proto-oncogene 0.0172181
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0171492
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0170394
DSCAM Down syndrome cell adhesion molecule 0.0169854
ZNF292 zinc finger protein 292 0.0169428
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0168632
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0167454
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0167325
PSD3 pleckstrin and Sec7 domain containing 3 0.0166205
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0165612
AFF4 AF4/FMR2 family, member 4 0.0165536
ADAR adenosine deaminase, RNA-specific 0.0165341
DNER delta/notch-like EGF repeat containing 0.0162995
DPYD dihydropyrimidine dehydrogenase 0.0162928
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0161433
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0161238
FTH1 ferritin, heavy polypeptide 1 0.016118
PUM1 pumilio RNA-binding family member 1 0.0161035
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0159384
ADGRG6 adhesion G protein-coupled receptor G6 0.0158137
CCNL1 cyclin L1 0.0157035
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0155603
HELZ helicase with zinc finger 0.015549
TMEM123 transmembrane protein 123 0.0154848
USP9X ubiquitin specific peptidase 9, X-linked 0.0154184

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.275374
MT2A metallothionein 2A -0.258366
VIM vimentin -0.144323
TMSB10 thymosin beta 10 -0.142557
RPL35A ribosomal protein L35a -0.075214
TM4SF1 transmembrane 4 L six family member 1 -0.0748393
MT1X metallothionein 1X -0.0682471
FTL ferritin, light polypeptide -0.062547
TPT1 tumor protein, translationally-controlled 1 -0.0586056
MT1E metallothionein 1E -0.0472154
RPS19 ribosomal protein S19 -0.0415057
RPLP1 ribosomal protein, large, P1 -0.039694
RPS8 ribosomal protein S8 -0.0391911
RPS6 ribosomal protein S6 -0.0385355
LOC112694756 uncharaterized LOC112694756 -0.0375311
RPL12 ribosomal protein L12 -0.0373388
PTMA prothymosin, alpha -0.0336374
EGR1 early growth response 1 -0.0318386
RPL36 ribosomal protein L36 -0.0317278
RPS23 ribosomal protein S23 -0.0317055
RPL31 ribosomal protein L31 -0.0310766
RPLP2 ribosomal protein, large, P2 -0.0297619
RPL23 ribosomal protein L23 -0.0287086
RPS29 ribosomal protein S29 -0.0285364
RPL26 ribosomal protein L26 -0.0276158
RPL5 ribosomal protein L5 -0.0252262
RPL34 ribosomal protein L34 -0.0244253
RPL19 ribosomal protein L19 -0.0241087
S100A10 S100 calcium binding protein A10 -0.023302
RPS24 ribosomal protein S24 -0.0221772
EMP1 epithelial membrane protein 1 -0.0221177
HMGA1 high mobility group AT-hook 1 -0.0219777
AREG amphiregulin -0.0208925
RPL36A ribosomal protein L36a -0.020823
RPL37A ribosomal protein L37a -0.0208226
RPS27 ribosomal protein S27 -0.0207711
RPL28 ribosomal protein L28 -0.020509
RPS13 ribosomal protein S13 -0.0203635
RPL38 ribosomal protein L38 -0.0201937
S100A6 S100 calcium binding protein A6 -0.0199816
ANGPTL4 angiopoietin-like 4 -0.0199784
RPLP0 ribosomal protein, large, P0 -0.019679
RPS14 ribosomal protein S14 -0.0193958
RPL8 ribosomal protein L8 -0.0192177
RPL32 ribosomal protein L32 -0.0186798
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0183655
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0179773
RPS16 ribosomal protein S16 -0.0179515
RPS3 ribosomal protein S3 -0.0178757
RPS27A ribosomal protein S27a -0.017809
RPL35 ribosomal protein L35 -0.0175404
RPL9 ribosomal protein L9 -0.0175111
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0173399
RPS21 ribosomal protein S21 -0.017116
EIF1 eukaryotic translation initiation factor 1 -0.0167857
PRDX1 peroxiredoxin 1 -0.0167539
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0163926
IFITM1 interferon induced transmembrane protein 1 -0.0160126
TXNRD1 thioredoxin reductase 1 -0.0159543
RPL11 ribosomal protein L11 -0.0155538
RPL18 ribosomal protein L18 -0.0155482
RPS15 ribosomal protein S15 -0.0154916
S100A11 S100 calcium binding protein A11 -0.0152131
RPS20 ribosomal protein S20 -0.0152017
RPS11 ribosomal protein S11 -0.0150551
S100A9 S100 calcium binding protein A9 -0.0150527
ACTG1 actin gamma 1 -0.0148804
RPS12 ribosomal protein S12 -0.0145665
RPS25 ribosomal protein S25 -0.0141742
RPS4X ribosomal protein S4, X-linked -0.0141657
HLA-B major histocompatibility complex, class I, B -0.0140565
RPS5 ribosomal protein S5 -0.0137775
RPL7A ribosomal protein L7a -0.0137672
RPL27 ribosomal protein L27 -0.013689
SPRY4 sprouty homolog 4 (Drosophila) -0.0136799
RACK1 receptor for activated C kinase 1 -0.0134458
RPS28 ribosomal protein S28 -0.012706
GCLM glutamate-cysteine ligase, modifier subunit -0.0120022
RPS10 ribosomal protein S10 -0.0118585
RPL13A ribosomal protein L13a -0.0118074
RPL37 ribosomal protein L37 -0.0117658
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0117645
SEC61G Sec61 gamma subunit -0.0116474
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0116035
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0113999
MYL12B myosin, light chain 12B, regulatory -0.0112336
KLF6 Kruppel-like factor 6 -0.0111216
SRGN serglycin -0.0110995
ERCC1 excision repair cross-complementation group 1 -0.0108673
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0108367
RPL27A ribosomal protein L27a -0.0106542
RPS17 ribosomal protein S17 -0.010494
TMEM41B transmembrane protein 41B -0.0100256
LHX1 LIM homeobox 1 -0.00994797
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00978761
RPL30 ribosomal protein L30 -0.00965206
HMGB1 high mobility group box 1 -0.00960403
HMOX1 heme oxygenase 1 -0.00952376
ZSWIM6 zinc finger, SWIM-type containing 6 -0.00949713
CDCP1 CUB domain containing protein 1 -0.00911531