Eplerenone_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.206155
EGFR epidermal growth factor receptor 0.135719
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.133679
CES1 carboxylesterase 1 0.0828972
NAMPT nicotinamide phosphoribosyltransferase 0.076028
TBC1D22A TBC1 domain family, member 22A 0.0728743
PLEC plectin 0.0582345
MYH9 myosin, heavy chain 9, non-muscle 0.0570684
MKI67 marker of proliferation Ki-67 0.0555137
SMAD3 SMAD family member 3 0.0548444
GCLC glutamate-cysteine ligase, catalytic subunit 0.0518631
CAMTA1 calmodulin binding transcription activator 1 0.0496046
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0480216
RUNX1 runt-related transcription factor 1 0.0467962
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0464777
FTH1 ferritin, heavy polypeptide 1 0.0443216
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0431559
NGLY1 N-glycanase 1 0.0426837
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.041835
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0418227
DOCK5 dedicator of cytokinesis 5 0.0408108
KDM2A lysine (K)-specific demethylase 2A 0.0397477
SRRM2 serine/arginine repetitive matrix 2 0.0397329
BRWD1 bromodomain and WD repeat domain containing 1 0.039095
OSMR oncostatin M receptor 0.0388299
GRAMD1B GRAM domain containing 1B 0.0382041
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.037933
EEF2 eukaryotic translation elongation factor 2 0.0371043
LAMA4 laminin, alpha 4 0.0370823
CSNK1A1 casein kinase 1, alpha 1 0.0367652
AGO2 argonaute RISC catalytic component 2 0.0362678
RICTOR RPTOR independent companion of MTOR, complex 2 0.035125
TMEM165 transmembrane protein 165 0.035076
ARRDC3 arrestin domain containing 3 0.034705
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0345224
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0344174
FAM13A family with sequence similarity 13, member A 0.0343976
SLTM SAFB-like, transcription modulator 0.0343344
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0339586
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0336479
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0334157
EP300 E1A binding protein p300 0.0332434
BRWD3 bromodomain and WD repeat domain containing 3 0.033023
OGA O-GlcNAcase 0.0328684
ZC3H11A zinc finger CCCH-type containing 11A 0.0322448
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0320545
SPAG9 sperm associated antigen 9 0.0312482
CEMIP cell migration inducing protein, hyaluronan binding 0.0310566
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0309864
TOP1 topoisomerase (DNA) I 0.0308555
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0305982
ANKRD11 ankyrin repeat domain 11 0.0296609
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0295932
LRP1B low density lipoprotein receptor-related protein 1B 0.0295727
USP34 ubiquitin specific peptidase 34 0.0293204
TSC22D2 TSC22 domain family, member 2 0.0289143
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0287629
NDE1 nudE neurodevelopment protein 1 0.0285975
KLC1 kinesin light chain 1 0.0285435
YEATS2 YEATS domain containing 2 0.0282968
RBM39 RNA binding motif protein 39 0.0281313
UVRAG UV radiation resistance associated 0.027952
HOOK2 hook microtubule-tethering protein 2 0.0278888
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0275142
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.027467
ZNF292 zinc finger protein 292 0.0272867
ANO6 anoctamin 6 0.0272439
PRRC2C proline-rich coiled-coil 2C 0.0271449
STRN3 striatin, calmodulin binding protein 3 0.0270815
ADAM17 ADAM metallopeptidase domain 17 0.0270086
UBA6 ubiquitin-like modifier activating enzyme 6 0.0264357
PUM2 pumilio RNA-binding family member 2 0.0263186
GSK3B glycogen synthase kinase 3 beta 0.0263062
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0262228
MGST1 microsomal glutathione S-transferase 1 0.0261098
H1-0 H1.0 linker histone 0.0260197
ATP13A3 ATPase type 13A3 0.0259678
TNRC6A trinucleotide repeat containing 6A 0.0257379
JMJD1C jumonji domain containing 1C 0.0256839
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0251107
KMT2E lysine (K)-specific methyltransferase 2E 0.0251047
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0250476
MARF1 meiosis regulator and mRNA stability factor 1 0.0245901
RAB10 RAB10, member RAS oncogene family 0.0244097
CUL4A cullin 4A 0.0240984
KTN1 kinectin 1 (kinesin receptor) 0.0239927
HELZ helicase with zinc finger 0.023915
IGFBP3 insulin-like growth factor binding protein 3 0.0238388
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0238059
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0237139
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0236853
MED13 mediator complex subunit 13 0.0236679
HDLBP high density lipoprotein binding protein 0.0234527
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0234334
BIRC6 baculoviral IAP repeat containing 6 0.0233746
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0229466
ZFC3H1 zinc finger, C3H1-type containing 0.02282
WDR45B WD repeat domain 45B 0.0227807
RBM26 RNA binding motif protein 26 0.0227359
MYO1B myosin IB 0.0225804

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.341327
TMSB10 thymosin beta 10 -0.189126
TPT1 tumor protein, translationally-controlled 1 -0.0935014
S100A10 S100 calcium binding protein A10 -0.0834765
EGR1 early growth response 1 -0.0624012
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0605618
RPL35A ribosomal protein L35a -0.05853
MT2A metallothionein 2A -0.0551795
ACTG1 actin gamma 1 -0.053936
INTS6 integrator complex subunit 6 -0.0536033
CST3 cystatin C -0.0528793
PTMA prothymosin, alpha -0.0471855
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0470441
FTL ferritin, light polypeptide -0.0469359
RPS3 ribosomal protein S3 -0.046027
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0459262
SEC61G Sec61 gamma subunit -0.0459001
IFI6 interferon, alpha-inducible protein 6 -0.044655
RPS25 ribosomal protein S25 -0.0441886
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0441236
RPS24 ribosomal protein S24 -0.0440859
RPLP1 ribosomal protein, large, P1 -0.0399512
CAV1 caveolin 1, caveolae protein, 22kDa -0.0397513
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0383345
RPL34 ribosomal protein L34 -0.038072
AREG amphiregulin -0.037617
LMO7 LIM domain 7 -0.03684
RPL37A ribosomal protein L37a -0.0355553
RPL31 ribosomal protein L31 -0.0351819
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0339203
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0330935
RPS27A ribosomal protein S27a -0.0326775
RPS8 ribosomal protein S8 -0.0320928
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.03196
S100P S100 calcium binding protein P -0.0310635
RPS12 ribosomal protein S12 -0.0299582
S100A6 S100 calcium binding protein A6 -0.0296006
KRT7 keratin 7, type II -0.029086
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0288805
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0288053
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0282215
RPL11 ribosomal protein L11 -0.0281101
S100A9 S100 calcium binding protein A9 -0.0276918
RPL12 ribosomal protein L12 -0.0276545
HOMER1 homer scaffolding protein 1 -0.0272681
RPS23 ribosomal protein S23 -0.0267443
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0265185
S100A11 S100 calcium binding protein A11 -0.0260333
RPL19 ribosomal protein L19 -0.025536
MYO1E myosin IE -0.0254475
NSUN6 NOP2/Sun domain family, member 6 -0.0244595
RPS6 ribosomal protein S6 -0.0243629
GNAS GNAS complex locus -0.0243392
RPL9 ribosomal protein L9 -0.0241209
RPS17 ribosomal protein S17 -0.0238991
RPLP2 ribosomal protein, large, P2 -0.0234746
KRT19 keratin 19, type I -0.0233051
IER3 immediate early response 3 -0.023118
LDHA lactate dehydrogenase A -0.0228802
KRT18 keratin 18, type I -0.0226665
RPS29 ribosomal protein S29 -0.0225465
ASPH aspartate beta-hydroxylase -0.0225011
RPL8 ribosomal protein L8 -0.022408
HLA-B major histocompatibility complex, class I, B -0.0221506
RPS27 ribosomal protein S27 -0.0217899
ENO1 enolase 1, (alpha) -0.0217648
PDLIM5 PDZ and LIM domain 5 -0.0217275
RPL30 ribosomal protein L30 -0.0214112
RPL23 ribosomal protein L23 -0.0208939
NDRG1 N-myc downstream regulated 1 -0.0204895
RPS19 ribosomal protein S19 -0.020476
RPLP0 ribosomal protein, large, P0 -0.0202533
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0194284
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0194206
C15ORF48 chromosome 15 open reading frame 48 -0.0192122
CCND1 cyclin D1 -0.0190517
AGR2 anterior gradient 2 -0.0189796
LOC112694756 uncharaterized LOC112694756 -0.0189456
RPS16 ribosomal protein S16 -0.0187195
HMGA1 high mobility group AT-hook 1 -0.018623
RPL36 ribosomal protein L36 -0.0181835
VCL vinculin -0.0179093
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0177389
RPS14 ribosomal protein S14 -0.0175345
RPS21 ribosomal protein S21 -0.017433
CATSPERB catsper channel auxiliary subunit beta -0.0173936
RPL37 ribosomal protein L37 -0.0173768
NABP1 nucleic acid binding protein 1 -0.017212
MT1X metallothionein 1X -0.0170782
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0170685
CAV2 caveolin 2 -0.0168634
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0166855
RPL5 ribosomal protein L5 -0.0166439
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0165187
RPL36A ribosomal protein L36a -0.0164935
SERF2 small EDRK-rich factor 2 -0.0164588
PTPRM protein tyrosine phosphatase, receptor type, M -0.0164372
RPS13 ribosomal protein S13 -0.0163982
RPS10 ribosomal protein S10 -0.0163357
CIB1 calcium and integrin binding 1 (calmyrin) -0.0162926