Eplerenone_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Eplerenone perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Eplerenone_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0830777
FNDC3B fibronectin type III domain containing 3B 0.0719665
TRIO trio Rho guanine nucleotide exchange factor 0.0655752
GRB10 growth factor receptor-bound protein 10 0.0581753
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0577273
CDH13 cadherin 13 0.0575724
EFNA5 ephrin-A5 0.0562864
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0541368
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0539939
FAM20C family with sequence similarity 20, member C 0.0515061
SDK1 sidekick cell adhesion molecule 1 0.0486691
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0478036
SMAD3 SMAD family member 3 0.0466822
CD44 CD44 molecule (Indian blood group) 0.0370865
USP34 ubiquitin specific peptidase 34 0.0370831
NRG1 neuregulin 1 0.0363075
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0362288
DPYD dihydropyrimidine dehydrogenase 0.035669
NAMPT nicotinamide phosphoribosyltransferase 0.0356238
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0355016
DOCK5 dedicator of cytokinesis 5 0.0347914
PSD3 pleckstrin and Sec7 domain containing 3 0.0345271
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0343111
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0338429
DSCAM Down syndrome cell adhesion molecule 0.0335856
NAV2 neuron navigator 2 0.0322876
FN1 fibronectin 1 0.0318892
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0318106
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0315439
DST dystonin 0.0314889
OSMR oncostatin M receptor 0.0313183
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0296886
PARD3 par-3 family cell polarity regulator 0.0296247
EXT1 exostosin glycosyltransferase 1 0.0292743
TAS2R14 taste receptor, type 2, member 14 0.0289697
IGF1R insulin-like growth factor 1 receptor 0.0284582
MACF1 microtubule-actin crosslinking factor 1 0.0276672
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0275927
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0273039
RBM39 RNA binding motif protein 39 0.0269759
PRELID2 PRELI domain containing 2 0.026043
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0260348
ATXN1 ataxin 1 0.0254771
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0251099
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0250036
NRP1 neuropilin 1 0.0248686
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0247703
AKAP13 A kinase (PRKA) anchor protein 13 0.0245623
ANTXR2 anthrax toxin receptor 2 0.0242829
ZEB2 zinc finger E-box binding homeobox 2 0.0242107
LPP LIM domain containing preferred translocation partner in lipoma 0.0239344
ETV6 ets variant 6 0.0237442
LRMDA leucine rich melanocyte differentiation associated 0.0235232
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0232729
ADD3 adducin 3 (gamma) 0.0231694
MAML3 mastermind-like 3 (Drosophila) 0.0230435
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0227281
FAM107B family with sequence similarity 107, member B 0.0222354
ANO6 anoctamin 6 0.0219748
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0216617
MTSS1 metastasis suppressor 1 0.0215457
AOPEP aminopeptidase O (putative) 0.0212622
NPAS2 neuronal PAS domain protein 2 0.0212116
HMGA2 high mobility group AT-hook 2 0.0209359
OXR1 oxidation resistance 1 0.0207641
SIK3 SIK family kinase 3 0.0205791
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0205261
MSRB3 methionine sulfoxide reductase B3 0.0202232
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0200381
ANKRD36 ankyrin repeat domain 36 0.0196852
ZC3H12C zinc finger CCCH-type containing 12C 0.0195966
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0195493
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0194746
SEPTIN9 septin 9 0.0192376
ARHGAP5 Rho GTPase activating protein 5 0.0191969
JARID2 jumonji, AT rich interactive domain 2 0.0191942
ANKRD11 ankyrin repeat domain 11 0.0191634
EGFR epidermal growth factor receptor 0.0191202
GPC6 glypican 6 0.0190257
EXOC6B exocyst complex component 6B 0.0190246
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0189979
RAI14 retinoic acid induced 14 0.018972
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0188866
KYNU kynureninase 0.0188644
MYH9 myosin, heavy chain 9, non-muscle 0.0187414
ZFAND3 zinc finger, AN1-type domain 3 0.0184673
NBAS neuroblastoma amplified sequence 0.018325
VEGFA vascular endothelial growth factor A 0.017792
EXOC4 exocyst complex component 4 0.0175318
PTK2 protein tyrosine kinase 2 0.0173184
JMJD1C jumonji domain containing 1C 0.0172972
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0171125
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0170748
ANKRD28 ankyrin repeat domain 28 0.0170686
HIPK2 homeodomain interacting protein kinase 2 0.0170181
FNIP1 folliculin interacting protein 1 0.0169859
MYO1E myosin IE 0.0169678
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.016712
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0166926
NPC1 Niemann-Pick disease, type C1 0.0166618

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256568
VIM vimentin -0.166018
TMSB10 thymosin beta 10 -0.148779
FTL ferritin, light polypeptide -0.12091
MT2A metallothionein 2A -0.0912164
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.07283
PTMA prothymosin, alpha -0.0665455
RPS19 ribosomal protein S19 -0.0605444
RPLP1 ribosomal protein, large, P1 -0.0601762
RPS6 ribosomal protein S6 -0.0501267
C15ORF48 chromosome 15 open reading frame 48 -0.0464639
RPLP2 ribosomal protein, large, P2 -0.0458802
RPS8 ribosomal protein S8 -0.0456284
EIF1 eukaryotic translation initiation factor 1 -0.0442442
RPL35A ribosomal protein L35a -0.0441678
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0432517
RPL36 ribosomal protein L36 -0.0428407
RPL32 ribosomal protein L32 -0.0415257
RPS12 ribosomal protein S12 -0.0405243
RPS3 ribosomal protein S3 -0.0403941
RPS29 ribosomal protein S29 -0.0398177
RPL23 ribosomal protein L23 -0.0388341
RPL34 ribosomal protein L34 -0.038549
IER3 immediate early response 3 -0.0379535
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0376877
RPL37A ribosomal protein L37a -0.037382
RPS25 ribosomal protein S25 -0.0371839
RPS21 ribosomal protein S21 -0.0368267
RPL12 ribosomal protein L12 -0.0357384
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0356673
RPL31 ribosomal protein L31 -0.0355926
HMGA1 high mobility group AT-hook 1 -0.0355549
TPT1 tumor protein, translationally-controlled 1 -0.0349222
S100A6 S100 calcium binding protein A6 -0.0341318
NDRG1 N-myc downstream regulated 1 -0.0337098
RPL9 ribosomal protein L9 -0.0333081
RPL19 ribosomal protein L19 -0.0329337
RPL28 ribosomal protein L28 -0.0328018
RPS13 ribosomal protein S13 -0.0328009
PCBP2 poly(rC) binding protein 2 -0.0322738
RPS23 ribosomal protein S23 -0.0315014
B2M beta-2-microglobulin -0.0310579
S100A10 S100 calcium binding protein A10 -0.0299385
PDIA3 protein disulfide isomerase family A, member 3 -0.0296696
RPS11 ribosomal protein S11 -0.029474
PFN1 profilin 1 -0.0291919
RPL11 ribosomal protein L11 -0.0284355
RPS24 ribosomal protein S24 -0.0283072
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0280448
AKAP12 A kinase (PRKA) anchor protein 12 -0.0277567
RPS16 ribosomal protein S16 -0.0265287
BASP1 brain abundant, membrane attached signal protein 1 -0.0264529
RPS17 ribosomal protein S17 -0.0262785
RPL37 ribosomal protein L37 -0.0260889
RPLP0 ribosomal protein, large, P0 -0.0257774
RPS27 ribosomal protein S27 -0.0257402
RPL7A ribosomal protein L7a -0.0256367
SEC61G Sec61 gamma subunit -0.0255286
RPL18 ribosomal protein L18 -0.025425
S100A9 S100 calcium binding protein A9 -0.0253553
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0251499
RPS5 ribosomal protein S5 -0.0250221
LDHA lactate dehydrogenase A -0.0244174
RACK1 receptor for activated C kinase 1 -0.0226115
RPL5 ribosomal protein L5 -0.0224992
IFITM3 interferon induced transmembrane protein 3 -0.0224548
ENO1 enolase 1, (alpha) -0.0222193
ANGPTL4 angiopoietin-like 4 -0.0221018
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0210134
IFI6 interferon, alpha-inducible protein 6 -0.0206859
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.020618
GSTP1 glutathione S-transferase pi 1 -0.0204599
STC1 stanniocalcin 1 -0.0200788
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200588
RPL8 ribosomal protein L8 -0.0200387
ZFP36L1 ZFP36 ring finger protein-like 1 -0.019921
RPL30 ribosomal protein L30 -0.0198374
FTH1 ferritin, heavy polypeptide 1 -0.0197574
EGR1 early growth response 1 -0.0196093
GNAS GNAS complex locus -0.0193321
RPL13A ribosomal protein L13a -0.0192769
RPL15 ribosomal protein L15 -0.0192679
PLIN2 perilipin 2 -0.0190189
RPL35 ribosomal protein L35 -0.0189609
CLEC1B C-type lectin domain family 1, member B -0.0189214
HILPDA hypoxia inducible lipid droplet-associated -0.0185565
RPL27A ribosomal protein L27a -0.0185163
ADM adrenomedullin -0.0184912
RPL36A ribosomal protein L36a -0.0182008
DDIT3 DNA-damage-inducible transcript 3 -0.0181922
SLC38A1 solute carrier family 38, member 1 -0.018158
RPS14 ribosomal protein S14 -0.0177091
SERF2 small EDRK-rich factor 2 -0.0176375
UBC ubiquitin C -0.0176281
FAM162A family with sequence similarity 162, member A -0.0173783
HLA-B major histocompatibility complex, class I, B -0.0173666
RPS10 ribosomal protein S10 -0.0173475
TPI1 triosephosphate isomerase 1 -0.0172716
VDAC1 voltage-dependent anion channel 1 -0.016979
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0169613